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BESIDE SIGNED

Bile acids and epithelial stem cells in intestinal development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BESIDE project word cloud

Explore the words cloud of the BESIDE project. It provides you a very rough idea of what is the project "BESIDE" about.

proliferation    function    conduct    microbiome    host    microbiota    biotech    fellowship    antenatal    period    centre    beside    intestinal    influences    experiments    series    acids    skills    elmer    understand    colonisers    career    line    professional    edge    tract    metabolites    gastrointestinal    continues    rapid    additional    maturation    deconjugates    culture    hypothesis    she    neonate    cytometry    amino    underlying    microorganisms    community    critically    division    colonisation    bile    gut    company    stem    gain    imaging    hydrolase    suggesting    msca    multinational    continue    iescs    coincident    git    mechanisms    public    innovative    apc    world    life    barrier    secondment    perkin    morphological    transfer    flow    relationship    bacterial    model    cutting    therapeutics    functions    vivo    influence    human    bacteria    birth    extrapolate    begins    conjugated    contributions    society    stakeholders    cell    salt    economy    scientist    inform    moment    first    cells    metabolic    independent    functional    bsh   

Project "BESIDE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 175˙866.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

This project will investigate how gut bacteria (the microbiota) influence development of the human gastrointestinal tract (GIT) through innovative research at a world leading research centre (the APC Microbiome Institute) and secondment to the R&D division of a leading multinational biotech company (Perkin Elmer). The gut microbiota comprises a complex community of microorganisms that provide essential metabolic functions in the host. The colonisation of the gut begins during the antenatal period, continues after the moment of birth and is coincident with rapid morphological and functional gut maturation suggesting that these early colonisers and their metabolites have an impact on GIT barrier development. Bile salt hydrolase (BSH) activity (which deconjugates amino-conjugated bile acids in the gut), is present among the first colonisers of the GIT. Thus, the BESIDE project hypothesis is that this bacterial BSH activity critically affects GIT development and maturation in early life. To understand the mechanisms underlying this relationship, BESIDE will conduct a series of experiments to i) determine how BSH activity influences intestinal stem cells (IESCs); ii) identify the effects on proliferation of these IESCs and iii) extrapolate the obtained results using an in vivo model. BESIDE presents a novel approach using methods based on cutting-edge cell culture, flow cytometry and cell imaging to gain knowledge which is likely to inform the future development of therapeutics to improve barrier function in the neonate. Additional objectives of BESIDE include dissemination and transfer of knowledge to relevant stakeholders (as well as to the general public) and the development of management and career development skills. This, in line with the Work Programme for the MSCA fellowship, will help the applicant to become an independent professional scientist in the field so that she will continue to make significant contributions to the European society and economy.

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