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BESIDE SIGNED

Bile acids and epithelial stem cells in intestinal development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BESIDE project word cloud

Explore the words cloud of the BESIDE project. It provides you a very rough idea of what is the project "BESIDE" about.

division    metabolic    line    acids    relationship    colonisers    culture    beside    mechanisms    independent    conjugated    influence    amino    society    proliferation    imaging    inform    understand    bacteria    human    microbiota    cell    begins    maturation    skills    economy    vivo    function    cytometry    microbiome    birth    public    cutting    tract    centre    elmer    series    career    multinational    first    microorganisms    fellowship    conduct    community    gut    neonate    world    continue    morphological    colonisation    gain    transfer    contributions    bacterial    model    flow    hypothesis    influences    critically    functional    metabolites    perkin    life    deconjugates    host    therapeutics    bile    coincident    bsh    secondment    extrapolate    biotech    barrier    stakeholders    salt    iescs    antenatal    she    professional    rapid    underlying    git    suggesting    scientist    functions    edge    apc    intestinal    gastrointestinal    additional    hydrolase    innovative    period    continues    msca    stem    company    experiments    cells    moment   

Project "BESIDE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 175˙866.00

Map

 Project objective

This project will investigate how gut bacteria (the microbiota) influence development of the human gastrointestinal tract (GIT) through innovative research at a world leading research centre (the APC Microbiome Institute) and secondment to the R&D division of a leading multinational biotech company (Perkin Elmer). The gut microbiota comprises a complex community of microorganisms that provide essential metabolic functions in the host. The colonisation of the gut begins during the antenatal period, continues after the moment of birth and is coincident with rapid morphological and functional gut maturation suggesting that these early colonisers and their metabolites have an impact on GIT barrier development. Bile salt hydrolase (BSH) activity (which deconjugates amino-conjugated bile acids in the gut), is present among the first colonisers of the GIT. Thus, the BESIDE project hypothesis is that this bacterial BSH activity critically affects GIT development and maturation in early life. To understand the mechanisms underlying this relationship, BESIDE will conduct a series of experiments to i) determine how BSH activity influences intestinal stem cells (IESCs); ii) identify the effects on proliferation of these IESCs and iii) extrapolate the obtained results using an in vivo model. BESIDE presents a novel approach using methods based on cutting-edge cell culture, flow cytometry and cell imaging to gain knowledge which is likely to inform the future development of therapeutics to improve barrier function in the neonate. Additional objectives of BESIDE include dissemination and transfer of knowledge to relevant stakeholders (as well as to the general public) and the development of management and career development skills. This, in line with the Work Programme for the MSCA fellowship, will help the applicant to become an independent professional scientist in the field so that she will continue to make significant contributions to the European society and economy.

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The information about "BESIDE" are provided by the European Opendata Portal: CORDIS opendata.

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