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BESIDE SIGNED

Bile acids and epithelial stem cells in intestinal development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BESIDE project word cloud

Explore the words cloud of the BESIDE project. It provides you a very rough idea of what is the project "BESIDE" about.

coincident    period    vivo    metabolic    experiments    rapid    understand    salt    continue    human    function    microorganisms    cutting    additional    bacterial    company    beside    multinational    bsh    acids    fellowship    apc    hypothesis    functional    culture    world    imaging    critically    conduct    centre    model    continues    stem    morphological    elmer    bile    perkin    birth    colonisation    cell    professional    influence    cells    microbiome    intestinal    mechanisms    iescs    cytometry    economy    microbiota    colonisers    biotech    gastrointestinal    git    deconjugates    skills    tract    conjugated    stakeholders    therapeutics    moment    innovative    proliferation    barrier    first    gain    contributions    antenatal    extrapolate    relationship    host    public    neonate    underlying    division    influences    metabolites    bacteria    life    flow    society    msca    maturation    she    amino    suggesting    line    career    hydrolase    scientist    independent    community    gut    functions    transfer    begins    edge    inform    secondment    series   

Project "BESIDE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 175˙866.00

Map

 Project objective

This project will investigate how gut bacteria (the microbiota) influence development of the human gastrointestinal tract (GIT) through innovative research at a world leading research centre (the APC Microbiome Institute) and secondment to the R&D division of a leading multinational biotech company (Perkin Elmer). The gut microbiota comprises a complex community of microorganisms that provide essential metabolic functions in the host. The colonisation of the gut begins during the antenatal period, continues after the moment of birth and is coincident with rapid morphological and functional gut maturation suggesting that these early colonisers and their metabolites have an impact on GIT barrier development. Bile salt hydrolase (BSH) activity (which deconjugates amino-conjugated bile acids in the gut), is present among the first colonisers of the GIT. Thus, the BESIDE project hypothesis is that this bacterial BSH activity critically affects GIT development and maturation in early life. To understand the mechanisms underlying this relationship, BESIDE will conduct a series of experiments to i) determine how BSH activity influences intestinal stem cells (IESCs); ii) identify the effects on proliferation of these IESCs and iii) extrapolate the obtained results using an in vivo model. BESIDE presents a novel approach using methods based on cutting-edge cell culture, flow cytometry and cell imaging to gain knowledge which is likely to inform the future development of therapeutics to improve barrier function in the neonate. Additional objectives of BESIDE include dissemination and transfer of knowledge to relevant stakeholders (as well as to the general public) and the development of management and career development skills. This, in line with the Work Programme for the MSCA fellowship, will help the applicant to become an independent professional scientist in the field so that she will continue to make significant contributions to the European society and economy.

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The information about "BESIDE" are provided by the European Opendata Portal: CORDIS opendata.

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