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Bacterial regulation of Apis neurophysiology

Total Cost €


EC-Contrib. €






 BRAIN project word cloud

Explore the words cloud of the BRAIN project. It provides you a very rough idea of what is the project "BRAIN" about.

symbiont    disciplinary    secure    benefits    neurological    microbiota    synergistic    economic    function    bees    microbes    transcriptomics    gut    cultured    insects    theory    neurophysiology    ants    hosts    harvest    microbiome    microscopy    apis    genome    bacteria    host    evolutionary    gene    elusive    mammalian    considerable    mellifera    primary    published    previously    isotope    food    molecular    think    realize    modifications    area    insemination    organization    sequencing    brain    health    easily    ecologist    investigations    social    interactions    map    characterization    regions    phenotypes    little    microbial    traits    data    bioinformatics    understand    animal    training    transfer    exponentially    expression    none    metabolic    symbionts    symbioses    extended    tangible    feasible    neurotranscriptomics    physiological    axis    predict    tracking    inter    bacterial    he    experimental    groups    species    manipulation    ambitions    behavioural    symbiosis    labelling    diversity    honeybee    conceptual    metabolites    ecology    fish    microbiology    grown    biologists    domesticated   

Project "BRAIN" data sheet

The following table provides information about the project.


Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
postcode: 1015

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 175˙419.00


 Project objective

Gut microbes are known to affect the neurophysiology of their hosts and genome sequencing now easily allows metabolic characterization of elusive microbial diversity that cannot be cultured. While investigations on the neurological and behavioural consequences of mammalian gut symbionts have grown exponentially in recent years, little is known about the ‘gut microbiota–brain axis’ in insects of major economic interest. The applicant is a molecular evolutionary ecologist who previously used gene expression data to predict physiological modifications in the honeybee after insemination and published a comparative analysis of bacterial symbionts across ants. He now aims to realize an inter-disciplinary program to map the neurological and behavioural extended phenotypes of gut symbionts in bees. Through experimental approaches of microbiome manipulation, neurotranscriptomics, behavioural-tracking, FISH, and isotope-labelling of bacterial metabolites, the project seeks to understand: (i) the extent to which Apis mellifera gut symbionts affect host brain function by identifying the specific bacteria, their metabolic products, and the brain regions involved in host-symbiont interactions, and (ii) assess whether these processes affect behavioural traits relevant for the social organization of bees. None of these objectives have been addressed before and achieving them has high potential to change the way in which biologists think about bacterial symbioses and animal behaviour. The project includes training-through-research for the applicant in microbiology, behavioural ecology, microscopy and bioinformatics, and considerable knowledge transfer in transcriptomics and conceptual symbiosis theory from the applicant to the host groups. Although challenging in its ambitions, the project is synergistic and feasible, and will allow the European Research Area to harvest tangible benefits to improve the health of a domesticated species of primary importance to secure food production.

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The information about "BRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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