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DYNAFLUORS SIGNED

Dynamic Activatable Fluorophores

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EC-Contrib. €

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Project "DYNAFLUORS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙986˙650 €
 EC max contribution 1˙986˙650 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 1˙986˙650.00

Map

 Project objective

In DYNAFLUORS I will develop the first chemical toolbox for imaging in real time the activity of immune cells in tumours. Although the management of cancer has improved over the years, the cure rates for patients with metastasis and advanced tumours remain low due to lack of appropriate therapies. Recent studies suggest that drugs empowering host immune cells (i.e. immunotherapies) are promising approaches for intractable tumours. However, there are no tools to visualise and understand how host immune cells stop cancer progression in vivo. This important unmet challenge drives the ambitious targets of this proposal.

Over the past 10 years, I have pioneered the development of chemical fluorophores that allow unparalleled analysis of biological systems. In this project, I will implement an innovative approach to unify cutting-edge methodologies in chemistry and biology and develop Dynamic Activatable Fluorophores (DYNAFLUORS) as a chemical toolbox with enhanced imaging capabilities over current technologies.

The cross-disciplinary and ambitious nature of this project will open multiple avenues for broad impact in many areas of chemistry as well as in basic biology, imaging and medicine. DYNAFLUORS will allow us to image, from the molecular level to human tissue, the activity of immune cells in tumours and the response to therapy in real time. This ground-breaking chemical platform will represent a step forward in the forefront of chemical imaging and will create new opportunities in the personalised management of cancer.

In the long term, DYNAFLUORS will become a transformative toolbox for monitoring disease in humans. The integration of functional fluorophores into imaging technologies to perform ‘optical biopsies’ in vivo and to create patient-specific drug-response assays has the potential to revolutionise the diagnosis, stratification and personalised treatment of disease.

 Publications

year authors and title journal last update
List of publications.
2019 Matteo Virelli, Wei Wang, Rositha Kuniyil, Jun Wu, Giuseppe Zanoni, Antonio Fernandez, Jamie Scott, Marc Vendrell, Lutz Ackermann
BODIPY‐Labeled Cyclobutanes by Secondary C(sp 3 )−H Arylations for Live‐Cell Imaging
published pages: 12712-12718, ISSN: 0947-6539, DOI: 10.1002/chem.201903461
Chemistry – A European Journal 25/55 2020-03-05
2019 Zhiming Cheng, Wagner O. Valença, Gleiston G. Dias, Jamie Scott, Nicole D. Barth, Fabio de Moliner, Gabriela B.P. Souza, Richard J. Mellanby, Marc Vendrell, Eufrânio N. da Silva Júnior
Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues
published pages: 3938-3946, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2019.07.017
Bioorganic & Medicinal Chemistry 27/17 2020-03-05
2019 Evita Ning, Gareth Turnbull, Jon Clarke, Fred Picard, Philip Riches, Marc Vendrell, Duncan Graham, Alastair W Wark, Karen Faulds, Wenmiao Shu
3D bioprinting of mature bacterial biofilms for antimicrobial resistance drug testing
published pages: 45018, ISSN: 1758-5090, DOI: 10.1088/1758-5090/ab37a0
Biofabrication 11/4 2020-03-05
2019 Can Zhao, Lorena Mendive-Tapia, Marc Vendrell
Fluorescent peptides for imaging of fungal cells
published pages: 187-195, ISSN: 0003-9861, DOI: 10.1016/j.abb.2018.11.018
Archives of Biochemistry and Biophysics 661 2020-02-28
2018 Fabio de Moliner, Aaron King, Gleiston G. Dias, Guilherme F. de Lima, Carlos A. de Simone, Eufrânio N. da Silva Júnior, Marc Vendrell
Quinone-Derived π-Extended Phenazines as New Fluorogenic Probes for Live-Cell Imaging of Lipid Droplets
published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2018.00339
Frontiers in Chemistry 6 2020-02-28
2019 Antonio Fernandez, Emily J. Thompson, Jeffrey W. Pollard, Takanori Kitamura, Marc Vendrell
A Fluorescent Activatable AND-Gate Chemokine CCL2 Enables In Vivo Detection of Metastasis-Associated Macrophages
published pages: 16894-16898, ISSN: 1433-7851, DOI: 10.1002/anie.201910955
Angewandte Chemie International Edition 58/47 2020-02-28
2019 Zhigao Yi, Zichao Luo, Nicole D. Barth, Xianfu Meng, Hong Liu, Wenbo Bu, Angelo All, Marc Vendrell, Xiaogang Liu
In Vivo Tumor Visualization through MRI Off‐On Switching of NaGdF 4 –CaCO 3 Nanoconjugates
published pages: 1901851, ISSN: 0935-9648, DOI: 10.1002/adma.201901851
Advanced Materials 31/37 2020-02-28
2019 Marc Vendrell, Antonio Fernandez, Richard Mellanby, Jamie Scott, Iris Mair, Claudia Garcia-Guzman, Baljean Dhillon, Pierre Bagnaninchi
Near-infrared chromophores, process of preparation and methods of use
published pages: , ISSN: , DOI:
2020-02-28
2019 Sam Benson, Antonio Fernandez, Nicole D. Barth, Fabio de Moliner, Mathew H. Horrocks, C. Simon Herrington, Jose Luis Abad, Antonio Delgado, Lisa Kelly, Ziyuan Chang, Yi Feng, Miyako Nishiura, Yuichiro Hori, Kazuya Kikuchi, Marc Vendrell
SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism
published pages: 6911-6915, ISSN: 1433-7851, DOI: 10.1002/anie.201900465
Angewandte Chemie International Edition 58/21 2020-02-28
2018 Richard J. Mellanby, Jamie I. Scott, Iris Mair, Antonio Fernandez, Louise Saul, Jochen Arlt, Monica Moral, Marc Vendrell
Tricarbocyanine N -triazoles: the scaffold-of-choice for long-term near-infrared imaging of immune cells in vivo
published pages: 7261-7270, ISSN: 2041-6520, DOI: 10.1039/c8sc00900g
Chemical Science 9/36 2020-02-28

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