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NEUROTILES SIGNED

Bioengineered hippocampal organoids for epilepsy treatment

Total Cost €

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EC-Contrib. €

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Partnership

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 NEUROTILES project word cloud

Explore the words cloud of the NEUROTILES project. It provides you a very rough idea of what is the project "NEUROTILES" about.

lobe    memory    frequent    disorder    stems    organoids    heal    crucially    medicine    advent    deep    engage    unprecedented    interventions    push    pursue    ensues    linked    learning    thanks    neural    replacement    biohybrid    morbidities    thrive    co    ultimately    revolutionary    least    temporal    interaction    life    tools    tle    engineering    human    disease    dialogue    social    parts    ground    options    enhanced    transplants    innovative    regenerative    repairing    diseased    synergetic    uncontrolled    invasive    establishment    stem    hippocampus    stigma    cognitive    drug    demands    severe    artificial    nanotechnology    central    unexplored    generate    brains    syndrome    idea    neurosurgery    carefully    carries    structure    breaking    epilepsy    tissue    appealing    ignite    intelligence    surrogate    resistance    generating    first    dish    repair    urgent    complementary    cells    framework    nowadays    strategies    organoid    burden    mammalian    responsive    stimulation    progressive    engineered    psychiatric    era    neurotiles    remarkably    brain    causing    time    mini    seizure    threatening    foundation    treatment    medications    highest   

Project "NEUROTILES" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 177˙598.00

Map

 Project objective

Epilepsy is a life-threatening progressive disorder causing uncontrolled activity of the brain (seizure); it carries among the highest burden of disease and significant social stigma. Temporal lobe epilepsy (TLE) is the most frequent syndrome, the least responsive to medications and the most linked to severe psychiatric and cognitive co-morbidities. When drug resistance ensues, neurosurgery and deep-brain stimulation are invasive options to carefully consider. Thus, TLE treatment demands urgent innovative interventions.

Is it possible to generate ‘replacement parts’ to heal the diseased brain? The idea of repairing the brain using engineered transplants is nowadays more appealing than ever thanks to the ground-breaking advent of ‘mini-brains in a dish’ (brain organoids). Remarkably, brain organoids can be derived from human stem cells, thus carrying unique potential for targeted studies. However, their application in regenerative medicine has yet to thrive. Therefore, the interaction of brain organoids with mammalian brain tissue remains unexplored.

In this project, I engage in the challenge of generating surrogate brain areas as transplants for epilepsy treatment. Specifically, I will focus on the hippocampus, a central structure in learning and memory which is crucially involved in TLE. I will push an unprecedented biohybrid design based on the synergetic exploitation of organoid technology and innovative neural engineering tools to pursue, for the first time ever, the establishment of a dialogue between engineered and mammalian brain tissue. The foundation of NEUROTILES stems in the emerging concept that brain repair strategies from regenerative medicine and neural engineering are distinct yet complementary. In the era of artificial intelligence and nanotechnology, NEUROTILES will promote a revolutionary framework for brain repair strategies and ultimately ignite the establishment of the novel field of ‘enhanced’ regenerative medicine.

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The information about "NEUROTILES" are provided by the European Opendata Portal: CORDIS opendata.

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