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NEUROTILES SIGNED

Bioengineered hippocampal organoids for epilepsy treatment

Total Cost €

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EC-Contrib. €

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Partnership

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 NEUROTILES project word cloud

Explore the words cloud of the NEUROTILES project. It provides you a very rough idea of what is the project "NEUROTILES" about.

dish    ignite    learning    structure    surrogate    establishment    co    temporal    ground    stimulation    threatening    stems    unexplored    disease    stem    foundation    uncontrolled    medications    complementary    appealing    medicine    disorder    era    nowadays    biohybrid    advent    options    tools    first    neurotiles    replacement    organoid    epilepsy    interaction    repairing    strategies    nanotechnology    ensues    time    highest    innovative    engineered    tissue    ultimately    progressive    interventions    idea    synergetic    memory    framework    least    cognitive    neural    neurosurgery    repair    severe    push    brain    thanks    carries    syndrome    burden    morbidities    social    generate    revolutionary    artificial    hippocampus    human    pursue    lobe    mammalian    brains    crucially    mini    parts    regenerative    transplants    generating    tle    frequent    urgent    intelligence    engineering    heal    carefully    central    breaking    invasive    treatment    enhanced    thrive    deep    stigma    cells    linked    remarkably    psychiatric    dialogue    demands    engage    drug    unprecedented    diseased    causing    organoids    resistance    responsive    seizure    life   

Project "NEUROTILES" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 177˙598.00

Map

 Project objective

Epilepsy is a life-threatening progressive disorder causing uncontrolled activity of the brain (seizure); it carries among the highest burden of disease and significant social stigma. Temporal lobe epilepsy (TLE) is the most frequent syndrome, the least responsive to medications and the most linked to severe psychiatric and cognitive co-morbidities. When drug resistance ensues, neurosurgery and deep-brain stimulation are invasive options to carefully consider. Thus, TLE treatment demands urgent innovative interventions.

Is it possible to generate ‘replacement parts’ to heal the diseased brain? The idea of repairing the brain using engineered transplants is nowadays more appealing than ever thanks to the ground-breaking advent of ‘mini-brains in a dish’ (brain organoids). Remarkably, brain organoids can be derived from human stem cells, thus carrying unique potential for targeted studies. However, their application in regenerative medicine has yet to thrive. Therefore, the interaction of brain organoids with mammalian brain tissue remains unexplored.

In this project, I engage in the challenge of generating surrogate brain areas as transplants for epilepsy treatment. Specifically, I will focus on the hippocampus, a central structure in learning and memory which is crucially involved in TLE. I will push an unprecedented biohybrid design based on the synergetic exploitation of organoid technology and innovative neural engineering tools to pursue, for the first time ever, the establishment of a dialogue between engineered and mammalian brain tissue. The foundation of NEUROTILES stems in the emerging concept that brain repair strategies from regenerative medicine and neural engineering are distinct yet complementary. In the era of artificial intelligence and nanotechnology, NEUROTILES will promote a revolutionary framework for brain repair strategies and ultimately ignite the establishment of the novel field of ‘enhanced’ regenerative medicine.

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The information about "NEUROTILES" are provided by the European Opendata Portal: CORDIS opendata.

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