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HelpUS SIGNED

Pioneering focused Ultrasounds as a new non-invasive deep brain stimulation for a causal investigation of empathy related brain processes in moral learning and decision making

Total Cost €

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EC-Contrib. €

0

Partnership

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 HelpUS project word cloud

Explore the words cloud of the HelpUS project. It provides you a very rough idea of what is the project "HelpUS" about.

provides    depends    neural    successful    remained    humans    brake    social    behavior    ultrasounds    stop    outcomes    balance    transform    neuroscience    fmri    transformed    mechanistic    untreatable    regions    associating    brand    kicking    pain    models    brain    affective    currency    insula    benefits    cognition    compare    barrier    individuals    transforming    decision    cooperate    had    deep    hypothesis    select    facial    feel    context    modulate    unleash    prosociality    self    interventions    equation    kicked    painful    expression    powerless    limbic    anterior    harm    hypotheses    generally    showing    frustratingly    tools    suggesting    alter    nature    optimize    friend    negative    computational    testable    emotions    disorders    representation    captures    cingulate    empathy    themselves    selectively    learning    pave    explore    motivating    causal    kick    actions    noninvasively    cooperation    altering    thereby    relationship    push    us    stimulation    deeper    incorporate    inform    structures    vicarious    leaning    stead    antisocial   

Project "HelpUS" data sheet

The following table provides information about the project.

Coordinator
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW 

Organization address
address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS
city: AMSTERDAM
postcode: 1011 JV
website: www.knaw.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL (AMSTERDAM) coordinator 1˙500˙000.00

Map

 Project objective

The success of humans depends on their ability to cooperate. Cooperation requires learning to avoid actions that harm others and select those that balance benefits for self and others. Reinforcement leaning captures how individuals learn to optimize benefits for themselves, by associating actions and outcomes for the self. The social context requires to incorporate outcomes for others into that equation by transforming them into the currency used to value our own outcomes. Research on empathy, by suggesting that we transform the emotions of others into neural representation of how we would feel in their stead, provides testable mechanistic hypotheses of how we do that. The painful facial expression of our friend after we kick him would be transformed into the pain we would feel when kicked, associating kicking with negative value, thereby motivating us to stop kicking. Testing this hypothesis would require altering brain activity in the anterior insula and cingulate involved in this process, and showing that these changes alter decision making. Because current tools in humans cannot selectively modulate activity in these deeper regions we however remain frustratingly powerless to do so. Here we will develop a brand new method using ultrasounds to modulate brain activity at any depth to brake down this barrier. Using fmri, we will measure vicarious activity and compare it with computational models. This will push our understanding of our social nature to a new computational level, and pave the way to a more causal understanding of prosociality that can inform successful interventions for so far untreatable antisocial disorders. More generally deep brain stimulation via US, and the understanding of how US modulate brain activity, will unleash affective neuroscience to noninvasively explore what had remained beyond our reach: the causal relationship between deeper (limbic) structures and behavior and cognition.

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The information about "HELPUS" are provided by the European Opendata Portal: CORDIS opendata.

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