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HelpUS SIGNED

Pioneering focused Ultrasounds as a new non-invasive deep brain stimulation for a causal investigation of empathy related brain processes in moral learning and decision making

Total Cost €

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EC-Contrib. €

0

Partnership

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 HelpUS project word cloud

Explore the words cloud of the HelpUS project. It provides you a very rough idea of what is the project "HelpUS" about.

generally    interventions    select    us    balance    social    barrier    outcomes    alter    equation    provides    affective    brain    representation    optimize    individuals    pain    fmri    disorders    brake    themselves    currency    cognition    stimulation    cingulate    hypothesis    inform    context    incorporate    antisocial    had    modulate    frustratingly    insula    regions    depends    unleash    painful    noninvasively    pave    nature    actions    motivating    vicarious    limbic    stead    negative    thereby    altering    untreatable    remained    anterior    kicked    associating    compare    push    kick    models    emotions    explore    humans    successful    facial    captures    kicking    transforming    self    tools    transform    deeper    behavior    ultrasounds    friend    suggesting    neural    transformed    expression    cooperation    testable    causal    relationship    stop    showing    empathy    selectively    harm    powerless    prosociality    benefits    neuroscience    cooperate    deep    decision    hypotheses    leaning    mechanistic    computational    feel    structures    brand    learning   

Project "HelpUS" data sheet

The following table provides information about the project.

Coordinator
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW 

Organization address
address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS
city: AMSTERDAM
postcode: 1011 JV
website: www.knaw.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL (AMSTERDAM) coordinator 1˙500˙000.00

Map

 Project objective

The success of humans depends on their ability to cooperate. Cooperation requires learning to avoid actions that harm others and select those that balance benefits for self and others. Reinforcement leaning captures how individuals learn to optimize benefits for themselves, by associating actions and outcomes for the self. The social context requires to incorporate outcomes for others into that equation by transforming them into the currency used to value our own outcomes. Research on empathy, by suggesting that we transform the emotions of others into neural representation of how we would feel in their stead, provides testable mechanistic hypotheses of how we do that. The painful facial expression of our friend after we kick him would be transformed into the pain we would feel when kicked, associating kicking with negative value, thereby motivating us to stop kicking. Testing this hypothesis would require altering brain activity in the anterior insula and cingulate involved in this process, and showing that these changes alter decision making. Because current tools in humans cannot selectively modulate activity in these deeper regions we however remain frustratingly powerless to do so. Here we will develop a brand new method using ultrasounds to modulate brain activity at any depth to brake down this barrier. Using fmri, we will measure vicarious activity and compare it with computational models. This will push our understanding of our social nature to a new computational level, and pave the way to a more causal understanding of prosociality that can inform successful interventions for so far untreatable antisocial disorders. More generally deep brain stimulation via US, and the understanding of how US modulate brain activity, will unleash affective neuroscience to noninvasively explore what had remained beyond our reach: the causal relationship between deeper (limbic) structures and behavior and cognition.

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The information about "HELPUS" are provided by the European Opendata Portal: CORDIS opendata.

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