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4DBIOSERS SIGNED

Four-Dimensional Monitoring of Tumour Growth by Surface Enhanced Raman Scattering

Total Cost €

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EC-Contrib. €

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Partnership

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 4DBIOSERS project word cloud

Explore the words cloud of the 4DBIOSERS project. It provides you a very rough idea of what is the project "4DBIOSERS" about.

labelled    surface    tumour    fourth    multiplexed    near    realistic    models    tumours    scope    fate    generate    building    monitoring    multidisciplinary    cells    printing    bioimaging    offers    tags    tomography    light    ir    dimension    variety    cell    4dbiosers    raman    biological    incubated    intensity    nanoparticle    accessible    biomarkers    combine    extended    simulate    indicators    dimensional    penetration    visible    release    animal    tissues    nanocomposites    limited    sers    breast    acquiring    monitor    standard    simultaneous    metabolites    stable    ultra    possibility    transparency    monitored    microscopy    excited    recording    optimization    overcome    co    cellular    healthy    3d    stability    drawbacks    bioanalytes    cancer    fluorescent    adding    signals    readily    optical    2d    dyes    culture    tissue    cultures    bright    time    scaffolds    experimentation    hybrid    periods    avoiding    scattering    detection    enhanced    diseases    encoded    window    melanoma    drugs    correlated    environment    dynamics    confocal   

Project "4DBIOSERS" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙410˙771 €
 EC max contribution 2˙410˙771 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 2˙410˙771.00

Map

 Project objective

Optical bioimaging is limited by visible light penetration depth and stability of fluorescent dyes over extended periods of time. Surface enhanced Raman scattering (SERS) offers the possibility to overcome these drawbacks, through SERS-encoded nanoparticle tags, which can be excited with near-IR light (within the biological transparency window), providing high intensity, stable, multiplexed signals. SERS can also be used to monitor relevant bioanalytes within cells and tissues, during the development of diseases, such as tumours. In 4DBIOSERS we shall combine both capabilities of SERS, to go well beyond the current state of the art, by building three-dimensional scaffolds that support tissue (tumour) growth within a controlled environment, so that not only the fate of each (SERS-labelled) cell within the tumour can be monitored in real time (thus adding a fourth dimension to SERS bioimaging), but also recording the release of tumour metabolites and other indicators of cellular activity. Although 4DBIOSERS can be applied to a variety of diseases, we shall focus on cancer, melanoma and breast cancer in particular, as these are readily accessible by optical methods. We aim at acquiring a better understanding of tumour growth and dynamics, while avoiding animal experimentation. 3D printing will be used to generate hybrid scaffolds where tumour and healthy cells will be co-incubated to simulate a more realistic environment, thus going well beyond the potential of 2D cell cultures. Each cell type will be encoded with ultra-bright SERS tags, so that real-time monitoring can be achieved by confocal SERS microscopy. Tumour development will be correlated with simultaneous detection of various cancer biomarkers, during standard conditions and upon addition of selected drugs. The scope of 4DBIOSERS is multidisciplinary, as it involves the design of high-end nanocomposites, development of 3D cell culture models and optimization of emerging SERS tomography methods.

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The information about "4DBIOSERS" are provided by the European Opendata Portal: CORDIS opendata.

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