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4DBIOSERS SIGNED

Four-Dimensional Monitoring of Tumour Growth by Surface Enhanced Raman Scattering

Total Cost €

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EC-Contrib. €

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Partnership

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 4DBIOSERS project word cloud

Explore the words cloud of the 4DBIOSERS project. It provides you a very rough idea of what is the project "4DBIOSERS" about.

4dbiosers    fluorescent    light    cancer    tumour    window    tissues    signals    building    tumours    melanoma    monitored    overcome    near    intensity    drugs    nanocomposites    experimentation    excited    readily    stability    release    multidisciplinary    incubated    animal    tomography    fourth    accessible    printing    realistic    acquiring    cellular    multiplexed    simultaneous    periods    enhanced    extended    ir    avoiding    cell    dimension    scattering    dyes    bioimaging    sers    metabolites    scaffolds    tags    nanoparticle    monitor    healthy    3d    recording    visible    models    adding    dimensional    2d    biological    possibility    microscopy    biomarkers    tissue    time    encoded    optimization    cultures    transparency    variety    monitoring    diseases    detection    limited    bioanalytes    indicators    co    culture    scope    penetration    generate    optical    correlated    fate    raman    dynamics    environment    hybrid    stable    drawbacks    surface    labelled    offers    combine    standard    bright    simulate    confocal    cells    breast    ultra   

Project "4DBIOSERS" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙410˙771 €
 EC max contribution 2˙410˙771 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 2˙410˙771.00

Map

 Project objective

Optical bioimaging is limited by visible light penetration depth and stability of fluorescent dyes over extended periods of time. Surface enhanced Raman scattering (SERS) offers the possibility to overcome these drawbacks, through SERS-encoded nanoparticle tags, which can be excited with near-IR light (within the biological transparency window), providing high intensity, stable, multiplexed signals. SERS can also be used to monitor relevant bioanalytes within cells and tissues, during the development of diseases, such as tumours. In 4DBIOSERS we shall combine both capabilities of SERS, to go well beyond the current state of the art, by building three-dimensional scaffolds that support tissue (tumour) growth within a controlled environment, so that not only the fate of each (SERS-labelled) cell within the tumour can be monitored in real time (thus adding a fourth dimension to SERS bioimaging), but also recording the release of tumour metabolites and other indicators of cellular activity. Although 4DBIOSERS can be applied to a variety of diseases, we shall focus on cancer, melanoma and breast cancer in particular, as these are readily accessible by optical methods. We aim at acquiring a better understanding of tumour growth and dynamics, while avoiding animal experimentation. 3D printing will be used to generate hybrid scaffolds where tumour and healthy cells will be co-incubated to simulate a more realistic environment, thus going well beyond the potential of 2D cell cultures. Each cell type will be encoded with ultra-bright SERS tags, so that real-time monitoring can be achieved by confocal SERS microscopy. Tumour development will be correlated with simultaneous detection of various cancer biomarkers, during standard conditions and upon addition of selected drugs. The scope of 4DBIOSERS is multidisciplinary, as it involves the design of high-end nanocomposites, development of 3D cell culture models and optimization of emerging SERS tomography methods.

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The information about "4DBIOSERS" are provided by the European Opendata Portal: CORDIS opendata.

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