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NeuralCellTypeEvo SIGNED

Cellular innovation driving nervous system evolution

Total Cost €

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EC-Contrib. €

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Partnership

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 NeuralCellTypeEvo project word cloud

Explore the words cloud of the NeuralCellTypeEvo project. It provides you a very rough idea of what is the project "NeuralCellTypeEvo" about.

function    dumerilii    tractable    annelid    functions    generate    transmission    characterise    resolving    families    trace    atlas    biochemical    diversity    transcription    compare    arise    bilaterians    cellular    effector    resolution    chromatin    regulatory    drove    molecular    evolutionary    gene    subcellular    synaptic    animals    neurons    connectivity    reconstructing    diversification    complexes    led    diverse    evolution    bilaterian    types    neuronal    binding    forms    spatial    family    complexity    maintained    protein    localization    genetically    unravelling    expression    history    neural    model    exist    rnaseq    platynereis    datasets    multiple    cell    correlative    superresolution    first    slow    proteomics    comprehensively    outgroups    modalities    validate    distributed    functional    microscopy    sensory    innovations    ancestor    experimentally    emphasis    loci    combination    birth    map    nervous    time    neuron    immunoprecipitation    fast    infer    single    did    gave    specified    combinatorial    body   

Project "NeuralCellTypeEvo" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.embl.de/research/units/dev_biology/arendt/
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 2˙500˙000.00

Map

 Project objective

Nervous system evolution involved multiple cellular innovations, enabling fast synaptic transmission, novel sensory modalities, and complex forms of neural connectivity. These innovations were distributed to an ever-increasing number of neural cell types, each specified and maintained by the combinatorial activity of transcription factors. When, where, and how did this complexity arise? This proposal aims at resolving the history of cell type diversification that led to this complexity, from the birth of the first neurons to the many families of neuron types that exist today. Our emphasis will be on reconstructing the cellular diversity in the ancestor of bilaterian animals and finding the key molecular innovations that drove early nervous system complexity. Towards this aim, we will first use whole-body single-cell RNAseq, in combination with a spatial expression atlas at cellular resolution, to comprehensively characterise cell types in the model annelid Platynereis dumerilii, a genetically tractable, slow-evolving bilaterian. We will then generate and compare similar datasets from diverse bilaterians and non-bilaterian outgroups to map the history of neuronal cell type diversification and infer the key regulatory and functional innovations that gave rise to the first bilaterian nervous system. For several such regulatory innovations, we will experimentally validate transcription factor binding to effector gene loci via superresolution microscopy and chromatin immunoprecipitation. We will also investigate neuron family-specific protein complexes, their subcellular localization, and neural functions via biochemical and proteomics approaches, correlative microscopy and loss-of-function analyses. This analysis of neuronal cell type diversity will for the first time trace the evolutionary history of nervous system complexity, unravelling when, where and how key neuronal innovations have driven the success of bilaterian nervous systems.

 Publications

year authors and title journal last update
List of publications.
2019 Tim Wollesena, Sonia Victoria Rodríguez Monje, Adam Phillip Oel, and Detlev Arendt
Characterization of eyes, photoreceptors and opsins in developmental stages of the chaetognath Spadella cephaloptera
published pages: , ISSN: , DOI: 10.1101/871111
bioXriv 2020-02-05
2019 Jacob M. Musser, Klaske J. Schippers, Michael Nickel, Giulia Mizzon, Andrea B. Kohn, Constantin Pape, Jörg U. Hammel, Florian Wolf, Cong Liang, Ana Hernández- Plaza, Kaia Achim, Nicole L. Schieber, Warren R. Francis, Sergio Vargas R., Svenja Kling, Maike Renkert, Roberto Feuda, Imre Gaspar, Pawel Burkhardt, Peer Bork, Martin Beck, Anna Kreshuk, Gert Wörheide, Jaime Huerta-Cepas, Yannick Schwab,
Profiling cellular diversity in sponges informs animal cell type and nervoussystem evolution
published pages: , ISSN: , DOI: 10.1101/758276
bioRxiv 2020-02-05

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