Explore the words cloud of the NeuralCellTypeEvo project. It provides you a very rough idea of what is the project "NeuralCellTypeEvo" about.
The following table provides information about the project.
EUROPEAN MOLECULAR BIOLOGY LABORATORY
|Coordinator Country||Germany [DE]|
|Total cost||2˙500˙000 €|
|EC max contribution||2˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-06-01 to 2023-05-31|
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|1||EUROPEAN MOLECULAR BIOLOGY LABORATORY||DE (HEIDELBERG)||coordinator||2˙500˙000.00|
Nervous system evolution involved multiple cellular innovations, enabling fast synaptic transmission, novel sensory modalities, and complex forms of neural connectivity. These innovations were distributed to an ever-increasing number of neural cell types, each specified and maintained by the combinatorial activity of transcription factors. When, where, and how did this complexity arise? This proposal aims at resolving the history of cell type diversification that led to this complexity, from the birth of the first neurons to the many families of neuron types that exist today. Our emphasis will be on reconstructing the cellular diversity in the ancestor of bilaterian animals and finding the key molecular innovations that drove early nervous system complexity. Towards this aim, we will first use whole-body single-cell RNAseq, in combination with a spatial expression atlas at cellular resolution, to comprehensively characterise cell types in the model annelid Platynereis dumerilii, a genetically tractable, slow-evolving bilaterian. We will then generate and compare similar datasets from diverse bilaterians and non-bilaterian outgroups to map the history of neuronal cell type diversification and infer the key regulatory and functional innovations that gave rise to the first bilaterian nervous system. For several such regulatory innovations, we will experimentally validate transcription factor binding to effector gene loci via superresolution microscopy and chromatin immunoprecipitation. We will also investigate neuron family-specific protein complexes, their subcellular localization, and neural functions via biochemical and proteomics approaches, correlative microscopy and loss-of-function analyses. This analysis of neuronal cell type diversity will for the first time trace the evolutionary history of nervous system complexity, unravelling when, where and how key neuronal innovations have driven the success of bilaterian nervous systems.
|year||authors and title||journal||last update|
Tim Wollesena, Sonia Victoria RodrÃguez Monje, Adam Phillip Oel, and Detlev Arendt
Characterization of eyes, photoreceptors and opsins in developmental stages of the chaetognath Spadella cephaloptera
published pages: , ISSN: , DOI: 10.1101/871111
Jacob M. Musser, Klaske J. Schippers, Michael Nickel, Giulia Mizzon, Andrea
B. Kohn, Constantin Pape, JÃ¶rg U. Hammel, Florian Wolf, Cong Liang, Ana HernÃ¡ndez-
Plaza, Kaia Achim, Nicole L. Schieber, Warren R. Francis, Sergio Vargas R., Svenja
Kling, Maike Renkert, Roberto Feuda, Imre Gaspar, Pawel Burkhardt, Peer Bork, Martin Beck, Anna Kreshuk, Gert WÃ¶rheide, Jaime Huerta-Cepas, Yannick Schwab,
Profiling cellular diversity in sponges informs animal cell type and nervoussystem evolution
published pages: , ISSN: , DOI: 10.1101/758276
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