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Molecular Signaling in Health and Disease - Interdisciplinary Centre of Excellence

Total Cost €


EC-Contrib. €






Project "MOSaIC" data sheet

The following table provides information about the project.


Organization address
address: ks. Trojdena 4
city: Warsaw
postcode: 02-109

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Poland [PL]
 Total cost 2˙498˙887 €
 EC max contribution 2˙498˙887 € (100%)
 Programme 1. H2020-EU.4.c. (Establishing ‚ERA Chairs')
 Code Call H2020-WIDESPREAD-03-2017-ERAChairs
 Funding Scheme CSA
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The International Institute of Molecular and Cell Biology (IIMCB) is included among the best Polish research institutes in the life sciences and has the highest score in national evaluations to date. With modern organizational patterns, excellent staff, state-of-the-art equipment, and an international work environment, IIMCB is positioned to achieve a level of excellence tantamount to the best European entities. To realize this goal, we created the Interdisciplinary Centre of Excellence in Molecular Signalling in Health and Disease (MOSaIC). The ERA Chairs scheme gives us a unique opportunity to improve our performance by attracting an outstanding principal investigator in molecular signalling. This investigator will complement and strengthen the current research lines at IIMCB and will influence structural changes for responsible research and effective science management. The MOSaIC has 5 objectives. The first is recruitment of an ERA Chair holder and affiliates in an open process that involves a set of incentives for the successful candidate to establish an excellent research group. The second is to augment scientific research and innovation in IIMCB and surrounding region through the work of the ERA Chair holder in molecular signalling, a field with great promise for medical advancement. The third and fourth involve structural improvements in science management and consolidated HR activities to develop a research environment that meets the highest international standards, including those set in the EU Charter and Code. Dissemination and communication activities will enable us to achieve the fifth objective: widespread recognition of the MOSaIC and IIMCB among national and European stakeholders. Thanks to the MOSaIC, IIMCB scientists will lead innovative and internationally competitive research in an environment of excellent organizational standards and support. They will engage in European partnerships, and their projects will lead to practical inventions.


year authors and title journal last update
List of publications.
2017 Paweł Piątkowski, Jagoda Jabłońska, Adriana Żyła, Dorota Niedziałek, Dorota Matelska, Elżbieta Jankowska, Tomasz Waleń, Wayne K. Dawson, Janusz M. Bujnicki
SupeRNAlign: a new tool for flexible superposition of homologous RNA structures and inference of accurate structure-based sequence alignments
published pages: e150-e150, ISSN: 0305-1048, DOI: 10.1093/nar/gkx631
Nucleic Acids Research 45/16 2020-02-13
2017 Małgorzata Figiel, Miroslav Krepl, Jarosław Poznański, Agnieszka Gołąb, Jiří Šponer, Marcin Nowotny
Coordination between the polymerase and RNase H activity of HIV-1 reverse transcriptase
published pages: gkx004, ISSN: 0305-1048, DOI: 10.1093/nar/gkx004
Nucleic Acids Research 2020-02-13
2015 Piotr Bragoszewski, Michal Wasilewski, Paulina Sakowska, Agnieszka Gornicka, Lena Böttinger, Jian Qiu, Nils Wiedemann, Agnieszka Chacinska
Retro-translocation of mitochondrial intermembrane space proteins
published pages: 7713-7718, ISSN: 0027-8424, DOI: 10.1073/pnas.1504615112
Proceedings of the National Academy of Sciences 112/25 2020-02-13
2016 Leszek P. Pryszcz, Toni Gabaldón
Redundans: an assembly pipeline for highly heterozygous genomes
published pages: e113-e113, ISSN: 0305-1048, DOI: 10.1093/nar/gkw294
Nucleic Acids Research 44/12 2020-02-13
2016 Karolina Mierzejewska, Matthias Bochtler, Honorata Czapinska
On the role of steric clashes in methylation control of restriction endonuclease activity
published pages: 485-495, ISSN: 0305-1048, DOI: 10.1093/nar/gkv1341
Nucleic Acids Research 44/1 2020-02-13
2016 Ulrike Topf, Lidia Wrobel, Agnieszka Chacinska
Chatty Mitochondria: Keeping Balance in Cellular Protein Homeostasis
published pages: 577-586, ISSN: 0962-8924, DOI: 10.1016/j.tcb.2016.03.002
Trends in Cell Biology 26/8 2020-02-13
2016 Marcin Magnus, Michał J. Boniecki, Wayne Dawson, Janusz M. Bujnicki
SimRNAweb: a web server for RNA 3D structure modeling with optional restraints
published pages: W315-W319, ISSN: 0305-1048, DOI: 10.1093/nar/gkw279
Nucleic Acids Research 44/W1 2020-02-13
2015 Filip Stefaniak, Ewa I. Chudyk, Michael Bodkin, Wayne K. Dawson, Janusz M. Bujnicki
Modeling of ribonucleic acid-ligand interactions
published pages: 425-439, ISSN: 1759-0876, DOI: 10.1002/wcms.1226
Wiley Interdisciplinary Reviews: Computational Molecular Science 5/6 2020-02-13
2015 Lidia Wrobel, Ulrike Topf, Piotr Bragoszewski, Sebastian Wiese, Malgorzata E. Sztolsztener, Silke Oeljeklaus, Aksana Varabyova, Maciej Lirski, Piotr Chroscicki, Seweryn Mroczek, Elzbieta Januszewicz, Andrzej Dziembowski, Marta Koblowska, Bettina Warscheid, Agnieszka Chacinska
Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol
published pages: 485-488, ISSN: 0028-0836, DOI: 10.1038/nature14951
Nature 524/7566 2020-02-13
2015 Dawid Głów, Dariusz Pianka, Agata A. Sulej, Łukasz P. Kozłowski, Justyna Czarnecka, Grzegorz Chojnowski, Krzysztof J. Skowronek, Janusz M. Bujnicki
Sequence-specific cleavage of dsRNA by Mini-III RNase
published pages: 2864-2873, ISSN: 0305-1048, DOI: 10.1093/nar/gkv009
Nucleic Acids Research 43/5 2020-02-13
2015 Irina Tuszynska, Marcin Magnus, Katarzyna Jonak, Wayne Dawson, Janusz M. Bujnicki
NPDock: a web server for protein–nucleic acid docking
published pages: W425-W430, ISSN: 0305-1048, DOI: 10.1093/nar/gkv493
Nucleic Acids Research 43/W1 2020-02-13

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