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Self-Control SIGNED

Interplay between genetic control and self-organization during embryo morphogenesis

Total Cost €

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EC-Contrib. €

0

Partnership

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 Self-Control project word cloud

Explore the words cloud of the Self-Control project. It provides you a very rough idea of what is the project "Self-Control" about.

shape    reported    apical    feedback    variety    geometry    self    parallel    organization    behaviors    tissue    geometric    networks    geometrical    molecular    combining    newly    basal    mediated    patterning    interactions    flows    chemical    wave    dynamics    tissues    description    trigger    imaging    unravel    morphogenetic    invagination    accounted    time    nature    flow    drosophila    upstream    intertwined    drive    emergence    computational    contractility    perturbations    ask    acquire    live    capturing    conceptual    regulated    theoretical    emerge    explore    amplifying    light    cell    space    framework    endoderm    contribution    explains    explained    local    legacies    curvature    biological    effect    positional    controls    spatial    morphogenesis    genetic    pulses    shed    optogenetic    mechanics    cells    mechano    underlying    mechanism    embryos    cellular    understand    interdisciplinary    interplay    actomyosin    mechanical    occurring    multicellular    coupling    asymmetries    developmental    patterns    poorly    physical    3d    model    biochemical    waves    contractile   

Project "Self-Control" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙862˙571 €
 EC max contribution 2˙862˙571 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 2˙862˙571.00

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 Project objective

Morphogenesis seeks to understand how information and mechanics emerge from molecular interactions and how they are regulated in space and time. Two parallel legacies are now intertwined: the conceptual framework of developmental patterning that explains how cells acquire positional information during development and control cell behaviors, and the description of biological processes in physical terms. The current framework explains how genetic and biochemical information controls cellular mechanics, in particular contractility mediated by actomyosin networks, and thus cell and tissue shape changes. However, newly reported contractile dynamics, namely pulses, flows and waves, cannot be explained in this framework: they are self-organized in that they depend on local mechano-chemical interactions and feedback that cannot be accounted for by upstream genetic control. This project will explore the interplay between genetic control and self-organization in Drosophila embryos. We will study the emergence of multicellular flow and the mechanism of newly characterized tissue-level trigger wave dynamics associated with endoderm invagination, a poorly studied process. We will ask: 1) how do patterns of apical and basal contractility drive cell dynamics; 2) what is the contribution of geometrical feedback, e.g. tissue curvature, in amplifying the effect of contractile asymmetries; and 3) what is the nature of mechanical feedback and cell spatial coupling underlying trigger wave dynamics in the tissue? We will use an interdisciplinary approach, combining live imaging, capturing the 3D shape of cells/tissues, genetic/optogenetic/mechanical perturbations and theoretical/computational methods to model mechanics and geometry. We expect to unravel how organized multicellular dynamics emerge from genetic, mechanical and geometric “information”, and feedback during morphogenesis. This work will shed new light on a variety of morphogenetic processes occurring during development.

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The information about "SELF-CONTROL" are provided by the European Opendata Portal: CORDIS opendata.

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