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Self-Control SIGNED

Interplay between genetic control and self-organization during embryo morphogenesis

Total Cost €

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EC-Contrib. €

0

Partnership

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 Self-Control project word cloud

Explore the words cloud of the Self-Control project. It provides you a very rough idea of what is the project "Self-Control" about.

amplifying    geometric    legacies    cell    emerge    biological    flow    imaging    understand    genetic    pulses    organization    time    computational    combining    mediated    molecular    positional    cellular    contribution    mechanics    capturing    spatial    chemical    acquire    unravel    interplay    behaviors    upstream    nature    multicellular    3d    embryos    explore    geometry    patterning    space    tissue    drosophila    coupling    drive    underlying    morphogenetic    ask    cells    geometrical    asymmetries    explained    emergence    dynamics    conceptual    patterns    contractility    interdisciplinary    newly    waves    mechano    mechanical    regulated    mechanism    theoretical    shed    curvature    model    effect    interactions    apical    tissues    optogenetic    light    morphogenesis    trigger    feedback    live    variety    self    parallel    physical    accounted    controls    description    reported    networks    actomyosin    occurring    contractile    invagination    basal    developmental    shape    poorly    endoderm    flows    biochemical    wave    explains    perturbations    intertwined    framework    local   

Project "Self-Control" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙862˙571 €
 EC max contribution 2˙862˙571 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 2˙862˙571.00

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 Project objective

Morphogenesis seeks to understand how information and mechanics emerge from molecular interactions and how they are regulated in space and time. Two parallel legacies are now intertwined: the conceptual framework of developmental patterning that explains how cells acquire positional information during development and control cell behaviors, and the description of biological processes in physical terms. The current framework explains how genetic and biochemical information controls cellular mechanics, in particular contractility mediated by actomyosin networks, and thus cell and tissue shape changes. However, newly reported contractile dynamics, namely pulses, flows and waves, cannot be explained in this framework: they are self-organized in that they depend on local mechano-chemical interactions and feedback that cannot be accounted for by upstream genetic control. This project will explore the interplay between genetic control and self-organization in Drosophila embryos. We will study the emergence of multicellular flow and the mechanism of newly characterized tissue-level trigger wave dynamics associated with endoderm invagination, a poorly studied process. We will ask: 1) how do patterns of apical and basal contractility drive cell dynamics; 2) what is the contribution of geometrical feedback, e.g. tissue curvature, in amplifying the effect of contractile asymmetries; and 3) what is the nature of mechanical feedback and cell spatial coupling underlying trigger wave dynamics in the tissue? We will use an interdisciplinary approach, combining live imaging, capturing the 3D shape of cells/tissues, genetic/optogenetic/mechanical perturbations and theoretical/computational methods to model mechanics and geometry. We expect to unravel how organized multicellular dynamics emerge from genetic, mechanical and geometric “information”, and feedback during morphogenesis. This work will shed new light on a variety of morphogenetic processes occurring during development.

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The information about "SELF-CONTROL" are provided by the European Opendata Portal: CORDIS opendata.

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