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Self-Control SIGNED

Interplay between genetic control and self-organization during embryo morphogenesis

Total Cost €

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EC-Contrib. €

0

Partnership

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 Self-Control project word cloud

Explore the words cloud of the Self-Control project. It provides you a very rough idea of what is the project "Self-Control" about.

regulated    combining    invagination    embryos    capturing    tissue    unravel    morphogenesis    molecular    newly    intertwined    reported    mechanical    asymmetries    curvature    explained    drive    geometrical    drosophila    acquire    model    nature    interactions    ask    theoretical    shed    feedback    contribution    perturbations    morphogenetic    contractility    geometric    local    biochemical    light    emergence    spatial    optogenetic    patterning    self    live    mechanics    multicellular    explains    cellular    shape    understand    amplifying    upstream    effect    geometry    apical    flows    poorly    occurring    interplay    biological    underlying    waves    developmental    framework    dynamics    tissues    imaging    flow    patterns    coupling    chemical    interdisciplinary    3d    behaviors    space    legacies    mechanism    contractile    mechano    networks    accounted    cell    basal    parallel    pulses    conceptual    trigger    explore    wave    variety    emerge    physical    controls    endoderm    mediated    computational    actomyosin    cells    organization    time    description    positional    genetic   

Project "Self-Control" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙862˙571 €
 EC max contribution 2˙862˙571 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 2˙862˙571.00

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 Project objective

Morphogenesis seeks to understand how information and mechanics emerge from molecular interactions and how they are regulated in space and time. Two parallel legacies are now intertwined: the conceptual framework of developmental patterning that explains how cells acquire positional information during development and control cell behaviors, and the description of biological processes in physical terms. The current framework explains how genetic and biochemical information controls cellular mechanics, in particular contractility mediated by actomyosin networks, and thus cell and tissue shape changes. However, newly reported contractile dynamics, namely pulses, flows and waves, cannot be explained in this framework: they are self-organized in that they depend on local mechano-chemical interactions and feedback that cannot be accounted for by upstream genetic control. This project will explore the interplay between genetic control and self-organization in Drosophila embryos. We will study the emergence of multicellular flow and the mechanism of newly characterized tissue-level trigger wave dynamics associated with endoderm invagination, a poorly studied process. We will ask: 1) how do patterns of apical and basal contractility drive cell dynamics; 2) what is the contribution of geometrical feedback, e.g. tissue curvature, in amplifying the effect of contractile asymmetries; and 3) what is the nature of mechanical feedback and cell spatial coupling underlying trigger wave dynamics in the tissue? We will use an interdisciplinary approach, combining live imaging, capturing the 3D shape of cells/tissues, genetic/optogenetic/mechanical perturbations and theoretical/computational methods to model mechanics and geometry. We expect to unravel how organized multicellular dynamics emerge from genetic, mechanical and geometric “information”, and feedback during morphogenesis. This work will shed new light on a variety of morphogenetic processes occurring during development.

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The information about "SELF-CONTROL" are provided by the European Opendata Portal: CORDIS opendata.

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