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Self-Control SIGNED

Interplay between genetic control and self-organization during embryo morphogenesis

Total Cost €

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EC-Contrib. €

0

Partnership

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 Self-Control project word cloud

Explore the words cloud of the Self-Control project. It provides you a very rough idea of what is the project "Self-Control" about.

tissues    genetic    3d    acquire    variety    framework    model    upstream    controls    morphogenetic    cells    tissue    geometry    conceptual    positional    ask    embryos    flows    feedback    multicellular    time    waves    patterns    patterning    perturbations    theoretical    live    understand    molecular    coupling    mechanics    explained    unravel    explore    physical    reported    light    cellular    occurring    basal    chemical    regulated    emerge    computational    emergence    contractility    mechano    interactions    intertwined    flow    developmental    contribution    self    geometrical    organization    accounted    biochemical    explains    geometric    behaviors    local    pulses    asymmetries    space    imaging    mechanical    mediated    biological    networks    morphogenesis    mechanism    curvature    description    amplifying    dynamics    invagination    newly    actomyosin    parallel    effect    interdisciplinary    poorly    trigger    drive    apical    drosophila    contractile    cell    nature    capturing    interplay    underlying    spatial    shape    endoderm    optogenetic    wave    combining    legacies    shed   

Project "Self-Control" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙862˙571 €
 EC max contribution 2˙862˙571 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 2˙862˙571.00

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 Project objective

Morphogenesis seeks to understand how information and mechanics emerge from molecular interactions and how they are regulated in space and time. Two parallel legacies are now intertwined: the conceptual framework of developmental patterning that explains how cells acquire positional information during development and control cell behaviors, and the description of biological processes in physical terms. The current framework explains how genetic and biochemical information controls cellular mechanics, in particular contractility mediated by actomyosin networks, and thus cell and tissue shape changes. However, newly reported contractile dynamics, namely pulses, flows and waves, cannot be explained in this framework: they are self-organized in that they depend on local mechano-chemical interactions and feedback that cannot be accounted for by upstream genetic control. This project will explore the interplay between genetic control and self-organization in Drosophila embryos. We will study the emergence of multicellular flow and the mechanism of newly characterized tissue-level trigger wave dynamics associated with endoderm invagination, a poorly studied process. We will ask: 1) how do patterns of apical and basal contractility drive cell dynamics; 2) what is the contribution of geometrical feedback, e.g. tissue curvature, in amplifying the effect of contractile asymmetries; and 3) what is the nature of mechanical feedback and cell spatial coupling underlying trigger wave dynamics in the tissue? We will use an interdisciplinary approach, combining live imaging, capturing the 3D shape of cells/tissues, genetic/optogenetic/mechanical perturbations and theoretical/computational methods to model mechanics and geometry. We expect to unravel how organized multicellular dynamics emerge from genetic, mechanical and geometric “information”, and feedback during morphogenesis. This work will shed new light on a variety of morphogenetic processes occurring during development.

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