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aDDRess SIGNED

Joint Training and Research Program on Chromatin Dynamics and the DNA Damage Response

Total Cost €

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EC-Contrib. €

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Partnership

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 aDDRess project word cloud

Explore the words cloud of the aDDRess project. It provides you a very rough idea of what is the project "aDDRess" about.

architecture    esrs    series    pushed    damage    multidisciplinary    battery    age    genes    light    paths    reveals    direct    causal    employment    dna    counteract    remodeling    stronger    developmental    successful    shed    premature    abnormalities    metabolic    reprogramming    collaborations    human    discoveries    functionally    diseases    transcription    links    roles    participating    cells    prospects    intact    additional    socioeconomic    relevance    onset    ranging    onto    create    threatening    independent    careers    translational    rare    biological    transform    carefully    disease    basis    cancer    transmitted    basic    network    faithfully    rna    nucleosome    industry    grounds    progeny    activation    biogenesis    training    cellular    neurodegeneration    scientific    smes    platform    excellence    mechanisms    requiring    health    integrating    defects    sophisticated    repair    instability    vital    individual    life    syndrome    functional    play    action    complications    genome    chromatin    maintenance    quality    durable    designed    devastating    intellectual    labs    trigger   

Project "aDDRess" data sheet

The following table provides information about the project.

Coordinator
IDRYMA TECHNOLOGIAS KAI EREVNAS 

Organization address
address: N PLASTIRA STR 100
city: IRAKLEIO
postcode: 70013
website: www.forth.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 4˙011˙939 €
 EC max contribution 4˙011˙939 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) coordinator 486˙035.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 297˙522.00
3    NORGENOTECH AS NO (OSLO) participant 292˙342.00
4    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 281˙982.00
5    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) participant 281˙276.00
6    GENEVIA TECHNOLOGIES OY FI (TAMPERE) participant 280˙805.00
7    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 274˙802.00
8    LXREPAIR FR (LA TRONCHE) participant 274˙802.00
9    UNIVERSITE DE PARIS FR (PARIS) participant 274˙802.00
10    STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS NL (AMSTERDAM) participant 265˙619.00
11    IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE IT (MILANO) participant 261˙499.00
12    KLINIKUM DER UNIVERSITAET ZU KOELN DE (KOELN) participant 252˙788.00
13    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 252˙788.00
14    FAKULTNI NEMOCNICE U SV. ANNY V BRNE CZ (Brno) participant 234˙871.00
15    UNIVERSITE PARIS DIDEROT - PARIS 7 FR (PARIS) participant 0.00
16    ETAIRIA DIACHIRISIS KAI ANAPTIXIS EPISTIMONIKOU KAI TECHNOLOGIKOU PARKOU KRITIS AE EL (HERAKLION) partner 0.00
17    PANEPISTIMIO KRITIS EL (RETHIMNO) partner 0.00
18    SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE IT (TRIESTE) partner 0.00
19    UNIVERSITAET ZU KOELN DE (KOELN) partner 0.00
20    UNIVERSITE DE GENEVE CH (GENEVE) partner 0.00

Map

 Project objective

Defects in DNA repair trigger a number of devastating health complications ranging from developmental abnormalities to the premature onset of age-related diseases, including the metabolic syndrome, neurodegeneration and cancer. To counteract genome instability, cells have evolved a battery of DNA repair mechanisms ensuring that their genome remains functionally intact and is faithfully transmitted to progeny. Recent work reveals that DNA repair factors play additional roles in vital biological processes, including nucleosome remodeling, chromatin architecture, RNA biogenesis or the transcription activation of genes involved in cellular reprogramming and growth. These recent discoveries have pushed the DNA repair field forward and towards new grounds requiring a series of sophisticated functional and multidisciplinary approaches. Based on these novel scientific paths, we have carefully designed the “aDDRess” consortium on the basis of past excellence of the individual participants and their relevance to the proposed field. The action addresses a major research topic i.e. DNA damage in development and disease with great socioeconomic impact in Europe and direct relevance to human health. The objectives of the program are: i. to create a European research platform of excellence in the field of DNA repair by integrating research from basic mechanisms to translational research applications, ii. to establish a Network dedicated to the high-quality training of ESRs promoting their independent careers and future employment prospects, iii. to transform our current successful, long-term collaborations into a stronger intellectual network and build durable links between the participating labs and the industry (SMEs). Understanding the relevance of genome maintenance pathways to human health will shed light onto the causal mechanisms of rare and widespread life-threatening diseases, including cancer.

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