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MicroLightProtoCell SIGNED

Microfluidics-assisted design and construction of light-responsive protocells

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MicroLightProtoCell project word cloud

Explore the words cloud of the MicroLightProtoCell project. It provides you a very rough idea of what is the project "MicroLightProtoCell" about.

societal    add    inherent    actuated    ph    locally    microfluidics    baret    alternative    remote    responsive    exhibiting    materials    types    drug    cellularity    protocell    space    attractive    synthetic    powerful    cutting    forms    photo    chemicals    hosting    time    benefit    christophe    dr    models    navailles    groups    protocells    cells    prof    inertia    extremely    minimal    functions    expertise    precise    date    harnessed    class    few    spatiotemporal    manipulated    provides    micromachines    clean    energy    protocellular    sensitivity    activation    replication    structurally    assembly    activated    laurence    edge    actuation    performed    construct    understand    skills    precisely    jean    manipulation    origin    life    sensing    leadership    conventional    exploited    progress    last    tackle    compartmentalization    reliability    rudimentary    fine    smart    unattainable    made    light    cnrs    constitute    multidisciplinary    resolution    precedent    primitive    interactions    guidance    literature    environmental    remarkable    architectures    modularity    silenced    biology   

Project "MicroLightProtoCell" data sheet

The following table provides information about the project.

Coordinator		 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 173˙076.00

Map

 Project objective

Protocells are synthetic models of cells exhibiting rudimentary life-like properties, such as compartmentalization, sensing or replication, and constitute as such primitive forms of cellularity that could help to understand the origin of life. The remarkable properties of these smart micromachines can also be harnessed to tackle key societal challenges, including environmental clean-up, energy production, or drug delivery. Advances in this field would greatly benefit from the precise activation of protocells in both space and time. However, fine control over protocellular functions has been minimal to date. Conventional types of actuation (e.g. T, pH) do not allow spatiotemporal guidance due to their inherent inertia or the need to add chemicals. Light provides an attractive alternative for the remote manipulation of protocells with an extremely high spatiotemporal resolution. However, there is no precedent of light-actuated protocells in the literature. The aim of this proposal is precisely to design and construct a new class of photo-responsive protocells capable of being manipulated, activated or silenced quickly and locally in response to light. The bottom-up protocell assembly will be performed by microfluidics, whose powerful abilities in terms of modularity, reliability or sensitivity will be exploited to produce structurally well-defined architectures, and study interactions between protocells in a way unattainable with traditional methods. The expertise and skills of the applicant in the field of protocell design and light-responsive materials will be applied to the multidisciplinary and cutting-edge fields of microfluidics and synthetic biology in which the hosting groups at CNRS (under the leadership of Prof. Jean-Christophe Baret and Dr. Laurence Navailles) have made significant progress in the last few years.

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The information about "MICROLIGHTPROTOCELL" are provided by the European Opendata Portal: CORDIS opendata.

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