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AIR-NB SIGNED

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AIR-NB project word cloud

Explore the words cloud of the AIR-NB project. It provides you a very rough idea of what is the project "AIR-NB" about.

anatomical    gestation    contrasting    hazard    create    personal    external    pregnant    protect    causality    mathematical    interventions    inadequate    cohort    policy    citizens    vascular    stressors    forming    pollution    least    exposure    samplers    particulate    neo    health    postnatal    total    windows    noise    imaging    motor    establishing    lack    profound    placental    vulnerable    dysfunction    sensors    pollutants    genuinely    connectivity    stages    mediation    impulse    myelination    function    airborne    pregnancy    dose    900    structures    age    women    translocation    impairs    appears    urban    prenatal    environmental    structure    paternal    mediated    postulate    regional    air    context    time    cognitive    underlying    placenta    measuring    injury    independently    brain    period    permanent    school    inhaled    effect    stress    foetal    levels    mainly    utero    nanoparticles    replication    data    neonates    post    detecting    natal   

Project "AIR-NB" data sheet

The following table provides information about the project.

Coordinator
FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA 

Organization address
address: C ROSSELLO 132 PLANTA 05
city: BARCELONA
postcode: 8036
website: www.isglobal.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙499˙992 €
 EC max contribution 2˙499˙992 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA ES (BARCELONA) coordinator 2˙499˙992.00

Map

 Project objective

Air pollution is the main urban-related environmental hazard. It appears to affect brain development, although current evidence is inadequate given the lack of studies during the most vulnerable stages of brain development and the lack of brain anatomical structure and regional connectivity data underlying these effects. Of particular interest is the prenatal period, when brain structures are forming and growing, and when the effect of in utero exposure to environmental factors may cause permanent brain injury. I and others have conducted studies focused on effects during school age which could be less profound. I postulate that: pre-natal exposure to urban air pollution during pregnancy impairs foetal and postnatal brain development, mainly by affecting myelination; these effects are at least partially mediated by translocation of airborne particulate matter to the placenta and by placental dysfunction; and prenatal exposure to air pollution impairs post-natal brain development independently of urban context and post-natal exposure to air pollution. I aim to evaluate the effect of pre-natal exposure to urban air pollution on pre- and post-natal brain structure and function by following 900 pregnant women and their neonates with contrasting levels of pre-natal exposure to air pollutants by: i) establishing a new pregnancy cohort and evaluating brain imaging (pre-natal and neo-natal brain structure, connectivity and function), and post-natal motor and cognitive development; ii) measuring total personal exposure and inhaled dose of air pollutants during specific time-windows of gestation, noise, paternal stress and other stressors, using personal samplers and sensors; iii) detecting nanoparticles in placenta and its vascular function; iv) modelling mathematical causality and mediation, including a replication study in an external cohort. The expected results will create an impulse to implement policy interventions that genuinely protect the health of urban citizens.

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The information about "AIR-NB" are provided by the European Opendata Portal: CORDIS opendata.

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