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AIR-NB SIGNED

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AIR-NB project word cloud

Explore the words cloud of the AIR-NB project. It provides you a very rough idea of what is the project "AIR-NB" about.

data    postnatal    mainly    interventions    levels    placental    sensors    women    contrasting    cognitive    pollution    vascular    inadequate    urban    placenta    measuring    causality    underlying    total    vulnerable    protect    impulse    gestation    health    connectivity    prenatal    neonates    myelination    forming    structure    utero    pregnancy    context    900    dysfunction    impairs    mediation    independently    time    genuinely    cohort    paternal    anatomical    period    regional    school    structures    nanoparticles    exposure    least    policy    establishing    effect    hazard    appears    external    pregnant    natal    replication    mathematical    noise    personal    profound    postulate    particulate    post    stress    imaging    pollutants    inhaled    detecting    permanent    brain    citizens    airborne    motor    environmental    injury    function    windows    air    neo    stressors    foetal    mediated    translocation    dose    lack    create    samplers    age    stages   

Project "AIR-NB" data sheet

The following table provides information about the project.

Coordinator
FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA 

Organization address
address: C ROSSELLO 132 PLANTA 05
city: BARCELONA
postcode: 8036
website: www.isglobal.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙499˙992 €
 EC max contribution 2˙499˙992 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA ES (BARCELONA) coordinator 2˙499˙992.00

Map

 Project objective

Air pollution is the main urban-related environmental hazard. It appears to affect brain development, although current evidence is inadequate given the lack of studies during the most vulnerable stages of brain development and the lack of brain anatomical structure and regional connectivity data underlying these effects. Of particular interest is the prenatal period, when brain structures are forming and growing, and when the effect of in utero exposure to environmental factors may cause permanent brain injury. I and others have conducted studies focused on effects during school age which could be less profound. I postulate that: pre-natal exposure to urban air pollution during pregnancy impairs foetal and postnatal brain development, mainly by affecting myelination; these effects are at least partially mediated by translocation of airborne particulate matter to the placenta and by placental dysfunction; and prenatal exposure to air pollution impairs post-natal brain development independently of urban context and post-natal exposure to air pollution. I aim to evaluate the effect of pre-natal exposure to urban air pollution on pre- and post-natal brain structure and function by following 900 pregnant women and their neonates with contrasting levels of pre-natal exposure to air pollutants by: i) establishing a new pregnancy cohort and evaluating brain imaging (pre-natal and neo-natal brain structure, connectivity and function), and post-natal motor and cognitive development; ii) measuring total personal exposure and inhaled dose of air pollutants during specific time-windows of gestation, noise, paternal stress and other stressors, using personal samplers and sensors; iii) detecting nanoparticles in placenta and its vascular function; iv) modelling mathematical causality and mediation, including a replication study in an external cohort. The expected results will create an impulse to implement policy interventions that genuinely protect the health of urban citizens.

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The information about "AIR-NB" are provided by the European Opendata Portal: CORDIS opendata.

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