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pHioniC SIGNED

pH and Ion Transport in Pancreatic Cancer

Total Cost €

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EC-Contrib. €

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Partnership

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 pHioniC project word cloud

Explore the words cloud of the pHioniC project. It provides you a very rough idea of what is the project "pHioniC" about.

nanocarrier    driver    cancer    team    facilitates    grounding    therapeutic    acid    indicator    forefront    stroma    oncological    initiation    leads    aggressive    acidic    central    meet    extensive    frequent    doctoral    thereby    normal    clinical    normally    landscape    exocrine    basic    tools    transferable    physiology    alkaline    combination    bespoke    secretion    mutations    lifetime    digestion    training    mouse    skills    translational    complementary    utilize    complemented    contribution    record    synergistic    discoveries    selecting    personalised    adenocarcinoma    map    pancreas    first    phenotypes    acidifications    microenvironment    intersectoral    esrs    pdac    provides    innovative    phionic    combines    track    laboratories    excellent    lasting    imaging    ing    expertise    models    antibody    seed    hypothesis    progression    brings    treatment    diagnostic    transport    covers    facilities    ductal    incurable    pancreatic    ion    industrial    cells    silico    oncology    interplay    diseased    bioinformatics    ph    interdisciplinary    juice   

Project "pHioniC" data sheet

The following table provides information about the project.

Coordinator
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER 

Organization address
address: SCHLOSSPLATZ 2
city: MUENSTER
postcode: 48149
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 4˙027˙619 €
 EC max contribution 4˙027˙619 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (MUENSTER) coordinator 252˙788.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 892˙566.00
3    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 505˙576.00
4    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 303˙172.00
5    UNIVERSITE DE LILLE FR (LILLE) participant 274˙802.00
6    UNIVERSITE DE PICARDIE JULES VERNE FR (AMIENS) participant 274˙802.00
7    PERCUROS BV NL (LEIDEN) participant 265˙619.00
8    UNIVERSITA DEGLI STUDI DI BARI ALDO MORO IT (BARI) participant 261˙499.00
9    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) participant 261˙499.00
10    CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL DE (KIEL) participant 252˙788.00
11    HEIDELBERG PHARMA RESEARCH GMBH DE (LADENBURG) participant 252˙788.00
12    DEBRECENI EGYETEM HU (DEBRECEN) participant 229˙715.00
13    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) partner 0.00
14    GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS DE (GOTTINGEN) partner 0.00
15    TYPEONE S.R.L. IT (Lecce) partner 0.00
16    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) partner 0.00
17    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) partner 0.00

Map

 Project objective

pHioniC brings together highly synergistic expertise, research and training facilities to investigate pancreatic ductal adenocarcinoma (PDAC), a frequent and aggressive cancer that is still incurable. The programme’s central hypothesis has a strong grounding in the physiology of the exocrine pancreas. Secretion of the alkaline pancreatic juice, normally associated with digestion, leads to acidifications of the pancreas stroma resulting in an acid adaptation of pancreatic cells. We are first to propose that this adaptation facilitates PDAC initiation and progression by selecting for more aggressive phenotypes in interplay with PDAC driver mutations. pHioniC will: (i) develop models (e.g. pancreas-/PDAC-specific pH-indicator mouse) to map the pH landscape in the normal and diseased pancreas, (ii) characterize the impact of the acidic microenvironment in PDAC development and (iii) design bespoke approaches to the treatment of PDAC that exploit the unique physiology of the pancreas and utilize a combination of nanocarrier and antibody technology for targeting. Thereby, pHioniC provides an innovative interdisciplinary and intersectoral training for ESRs at the forefront of oncological research. pHioniC comprises excellent complementary basic-research, clinical, and in silico laboratories that provided the seed discoveries for this novel concept, and industrial partners with a track record in therapeutic and diagnostic development in oncology. This highly synergistic team combines the state-of-the-art research tools and translational opportunities needed to meet the most ambitious doctoral programmes. pHioniC training for ESRs covers the fields of ion transport, oncology, imaging, bioinformatics and antibody technology, and is complemented by extensive transferable skills and personalised training elements. pHioniC will establish a lasting contribution towards European doctoral training beyond the lifetime of the project.

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The information about "PHIONIC" are provided by the European Opendata Portal: CORDIS opendata.

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