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pHioniC SIGNED

pH and Ion Transport in Pancreatic Cancer

Total Cost €

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EC-Contrib. €

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Partnership

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 pHioniC project word cloud

Explore the words cloud of the pHioniC project. It provides you a very rough idea of what is the project "pHioniC" about.

laboratories    incurable    map    team    provides    clinical    industrial    bioinformatics    skills    secretion    covers    diseased    intersectoral    lasting    transport    acidic    extensive    translational    combination    esrs    oncology    cells    selecting    juice    innovative    cancer    adenocarcinoma    acidifications    alkaline    bespoke    training    pdac    exocrine    central    acid    pancreas    diagnostic    silico    interplay    ductal    complemented    brings    phionic    frequent    thereby    landscape    ing    excellent    discoveries    progression    indicator    pancreatic    physiology    personalised    initiation    mouse    hypothesis    facilitates    digestion    imaging    expertise    contribution    driver    grounding    utilize    normal    transferable    oncological    stroma    lifetime    treatment    nanocarrier    meet    basic    leads    doctoral    phenotypes    antibody    forefront    seed    interdisciplinary    normally    therapeutic    mutations    tools    first    facilities    synergistic    ion    ph    models    record    complementary    aggressive    track    microenvironment    combines   

Project "pHioniC" data sheet

The following table provides information about the project.

Coordinator
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER 

Organization address
address: SCHLOSSPLATZ 2
city: MUENSTER
postcode: 48149
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 4˙027˙619 €
 EC max contribution 4˙027˙619 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (MUENSTER) coordinator 252˙788.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 892˙566.00
3    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 505˙576.00
4    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 303˙172.00
5    UNIVERSITE DE LILLE FR (LILLE) participant 274˙802.00
6    UNIVERSITE DE PICARDIE JULES VERNE FR (AMIENS) participant 274˙802.00
7    PERCUROS BV NL (LEIDEN) participant 265˙619.00
8    UNIVERSITA DEGLI STUDI DI BARI ALDO MORO IT (BARI) participant 261˙499.00
9    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) participant 261˙499.00
10    CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL DE (KIEL) participant 252˙788.00
11    HEIDELBERG PHARMA RESEARCH GMBH DE (LADENBURG) participant 252˙788.00
12    DEBRECENI EGYETEM HU (DEBRECEN) participant 229˙715.00
13    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) partner 0.00
14    GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS DE (GOTTINGEN) partner 0.00
15    TYPEONE S.R.L. IT (Lecce) partner 0.00
16    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) partner 0.00
17    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) partner 0.00

Map

 Project objective

pHioniC brings together highly synergistic expertise, research and training facilities to investigate pancreatic ductal adenocarcinoma (PDAC), a frequent and aggressive cancer that is still incurable. The programme’s central hypothesis has a strong grounding in the physiology of the exocrine pancreas. Secretion of the alkaline pancreatic juice, normally associated with digestion, leads to acidifications of the pancreas stroma resulting in an acid adaptation of pancreatic cells. We are first to propose that this adaptation facilitates PDAC initiation and progression by selecting for more aggressive phenotypes in interplay with PDAC driver mutations. pHioniC will: (i) develop models (e.g. pancreas-/PDAC-specific pH-indicator mouse) to map the pH landscape in the normal and diseased pancreas, (ii) characterize the impact of the acidic microenvironment in PDAC development and (iii) design bespoke approaches to the treatment of PDAC that exploit the unique physiology of the pancreas and utilize a combination of nanocarrier and antibody technology for targeting. Thereby, pHioniC provides an innovative interdisciplinary and intersectoral training for ESRs at the forefront of oncological research. pHioniC comprises excellent complementary basic-research, clinical, and in silico laboratories that provided the seed discoveries for this novel concept, and industrial partners with a track record in therapeutic and diagnostic development in oncology. This highly synergistic team combines the state-of-the-art research tools and translational opportunities needed to meet the most ambitious doctoral programmes. pHioniC training for ESRs covers the fields of ion transport, oncology, imaging, bioinformatics and antibody technology, and is complemented by extensive transferable skills and personalised training elements. pHioniC will establish a lasting contribution towards European doctoral training beyond the lifetime of the project.

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The information about "PHIONIC" are provided by the European Opendata Portal: CORDIS opendata.

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