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pHioniC SIGNED

pH and Ion Transport in Pancreatic Cancer

Total Cost €

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EC-Contrib. €

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Partnership

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 pHioniC project word cloud

Explore the words cloud of the pHioniC project. It provides you a very rough idea of what is the project "pHioniC" about.

acid    cells    exocrine    models    laboratories    interdisciplinary    silico    phionic    ing    acidifications    leads    seed    translational    pdac    stroma    provides    contribution    training    basic    complemented    frequent    tools    imaging    intersectoral    landscape    mutations    extensive    personalised    record    industrial    treatment    interplay    transport    brings    normal    progression    excellent    selecting    initiation    antibody    doctoral    microenvironment    utilize    phenotypes    incurable    lifetime    acidic    normally    esrs    grounding    adenocarcinoma    transferable    innovative    digestion    skills    cancer    driver    clinical    ion    central    expertise    meet    combines    first    ductal    covers    therapeutic    bespoke    diagnostic    physiology    alkaline    indicator    mouse    secretion    discoveries    hypothesis    complementary    ph    oncology    synergistic    aggressive    pancreatic    juice    bioinformatics    team    nanocarrier    thereby    facilitates    diseased    facilities    map    forefront    oncological    track    lasting    pancreas    combination   

Project "pHioniC" data sheet

The following table provides information about the project.

Coordinator
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER 

Organization address
address: SCHLOSSPLATZ 2
city: MUENSTER
postcode: 48149
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 4˙027˙619 €
 EC max contribution 4˙027˙619 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (MUENSTER) coordinator 252˙788.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 892˙566.00
3    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 505˙576.00
4    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 303˙172.00
5    UNIVERSITE DE LILLE FR (LILLE) participant 274˙802.00
6    UNIVERSITE DE PICARDIE JULES VERNE FR (AMIENS) participant 274˙802.00
7    PERCUROS BV NL (LEIDEN) participant 265˙619.00
8    UNIVERSITA DEGLI STUDI DI BARI ALDO MORO IT (BARI) participant 261˙499.00
9    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) participant 261˙499.00
10    CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL DE (KIEL) participant 252˙788.00
11    HEIDELBERG PHARMA RESEARCH GMBH DE (LADENBURG) participant 252˙788.00
12    DEBRECENI EGYETEM HU (DEBRECEN) participant 229˙715.00
13    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) partner 0.00
14    GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS DE (GOTTINGEN) partner 0.00
15    TYPEONE S.R.L. IT (Lecce) partner 0.00
16    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) partner 0.00
17    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) partner 0.00

Map

 Project objective

pHioniC brings together highly synergistic expertise, research and training facilities to investigate pancreatic ductal adenocarcinoma (PDAC), a frequent and aggressive cancer that is still incurable. The programme’s central hypothesis has a strong grounding in the physiology of the exocrine pancreas. Secretion of the alkaline pancreatic juice, normally associated with digestion, leads to acidifications of the pancreas stroma resulting in an acid adaptation of pancreatic cells. We are first to propose that this adaptation facilitates PDAC initiation and progression by selecting for more aggressive phenotypes in interplay with PDAC driver mutations. pHioniC will: (i) develop models (e.g. pancreas-/PDAC-specific pH-indicator mouse) to map the pH landscape in the normal and diseased pancreas, (ii) characterize the impact of the acidic microenvironment in PDAC development and (iii) design bespoke approaches to the treatment of PDAC that exploit the unique physiology of the pancreas and utilize a combination of nanocarrier and antibody technology for targeting. Thereby, pHioniC provides an innovative interdisciplinary and intersectoral training for ESRs at the forefront of oncological research. pHioniC comprises excellent complementary basic-research, clinical, and in silico laboratories that provided the seed discoveries for this novel concept, and industrial partners with a track record in therapeutic and diagnostic development in oncology. This highly synergistic team combines the state-of-the-art research tools and translational opportunities needed to meet the most ambitious doctoral programmes. pHioniC training for ESRs covers the fields of ion transport, oncology, imaging, bioinformatics and antibody technology, and is complemented by extensive transferable skills and personalised training elements. pHioniC will establish a lasting contribution towards European doctoral training beyond the lifetime of the project.

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The information about "PHIONIC" are provided by the European Opendata Portal: CORDIS opendata.

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