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ONCOBIOME SIGNED

Gut OncoMicrobiome Signatures (GOMS) associated with cancer incidence, prognosis and prediction of treatment response.

Total Cost €

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EC-Contrib. €

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Partnership

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ONCOBIOME project word cloud

Explore the words cloud of the ONCOBIOME project. It provides you a very rough idea of what is the project "ONCOBIOME" about.

genomics immunomics platforms carat oncobiome immune experts melanoma metagenome inhibitors cohorts health oncogenesis initiation commensal vaccines cancer functionally regulation multiple tools fingerprints occurrence companion functional oncology adverse unravel physiological host colorectal types microbiome retro countries mode regulating dendritic arsenal functions clinics interdisciplinary metabolism hallmarks gut gt decipher therapy hence cell intestinal trials validate minimalist neoplasia plays therapies personalization lung patients pro implicated oncomicrobiome optimal ecosystems clinical signatures approvals goms lending discovery tests urgent frequent enrolling breast extraintestinal cancers biotics relevance action expects prognosis ema campaigns integrate innovative covariates adjusting validation core predict pursue beyond metabolomics oncological spective physbeyond ancillary immunity ongoing diagnosis checkpoint progression polychemotherapy optimization fda preventive

Project "ONCOBIOME" data sheet

The following table provides information about the project.

Coordinator	INSTITUT GUSTAVE ROUSSY Organization address address: Rue Camille Desmoulins 39 city: VILLEJUIF postcode: 94805 website: http://www.igr.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	14˙994˙551 €
EC max contribution	14˙994˙551 € (100%)
Programme	1. H2020-EU.3.1.2. (Preventing disease)
Code Call	H2020-SC1-2018-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT GUSTAVE ROUSSY INSTITUT GUSTAVE ROUSSY Organization address address: Rue Camille Desmoulins 39 city: VILLEJUIF postcode: 94805 website: http://www.igr.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEJUIF)	coordinator	2˙332˙500.00
2	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	2˙801˙953.00
3	UNIVERSITA DEGLI STUDI DI TRENTO UNIVERSITA DEGLI STUDI DI TRENTO Organization address address: VIA CALEPINA 14 city: TRENTO postcode: 38122 website: www.unitn.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TRENTO)	participant	1˙502˙618.00
4	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	898˙275.00
5	Masarykova univerzita Masarykova univerzita Organization address address: Zerotinovo namesti 9 city: BRNO STRED postcode: 60177 website: http://www.muni.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (BRNO STRED)	participant	885˙546.00
6	IIGM FOUNDATION IIGM FOUNDATION Organization address address: PIAZZA BERNINI 5 city: TORINO postcode: 10138 website: http://www.hugef-torino.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	participant	850˙436.00
7	UNIVERSITATSKLINIKUM ERLANGEN UNIVERSITATSKLINIKUM ERLANGEN Organization address address: MAXIMILIANSPLATZ 2 city: ERLANGEN postcode: 91054 website: www.uk-erlangen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ERLANGEN)	participant	847˙125.00
8	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	791˙358.00
9	PHILIPPS UNIVERSITAET MARBURG PHILIPPS UNIVERSITAET MARBURG Organization address address: BIEGENSTRASSE 10 city: MARBURG postcode: 35037 website: www.uni-marburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MARBURG)	participant	703˙062.00
10	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	666˙498.00
11	GBG FORSCHUNGS GMBH GBG FORSCHUNGS GMBH Organization address address: MARTIN BEHAIM STRASSE 12 city: NEU-ISENBURG postcode: 63263 website: www.germanbreastgroup.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (NEU-ISENBURG)	participant	619˙312.00
12	HALIODX HALIODX Organization address address: 163 AVENUE DE LUMINY PARC SCIENTIFIQUE DE LUMINY LUMINY BIOTEC ENTREPRISES city: MARSEILLE postcode: 13288 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (MARSEILLE)	participant	521˙322.00
13	EVERIMMUNE EVERIMMUNE Organization address address: 39 RUE CAMILLE DESMOULINS city: VILLEJUIF postcode: 94800 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VILLEJUIF)	participant	519˙000.00
14	UNICANCER UNICANCER Organization address address: 101 RUE DE TOLBIAC city: PARIS postcode: 75013 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	431˙978.00
15	ALGOE SA ALGOE SA Organization address address: ROUTE DE CHAMPAGNE 9 BIS city: ECULLY CEDEX postcode: 69134 website: www.algoe.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (ECULLY CEDEX)	participant	399˙812.00
16	FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI Organization address address: Via Venezian 1 city: Milan postcode: 20133 website: www.istitutotumori.mi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Milan)	participant	223˙750.00
17	CENTRE HOSPITALIER DE L'UNIVERSITEDE MONTREAL CENTRE HOSPITALIER DE L'UNIVERSITEDE MONTREAL Organization address address: 850 RUE SAINT-DENIS city: MONTREAL QUEBEC postcode: H2XOA9 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CA (MONTREAL QUEBEC)	participant	0.00
18	CHARITE - UNIVERSITAETSMEDIZIN BERLIN CHARITE - UNIVERSITAETSMEDIZIN BERLIN Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 website: www.charite.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	0.00

Map

Project objective

Beyond the role the intestinal metagenome plays in regulating multiple physBeyond its role in regulating multiple physiological functions that impact health, the intestinal metagenome is implicated in cancer initiation, progression and responses to therapies, even for extraintestinal neoplasia. Hence, there is an urgent need to fully identify and functionally characterize minimalist commensal ecosystems relevant to cancer, with reliable and robust methods, to validate cancer-associated gut microbiome fingerprints of high clinical relevance, and to develop diagnosis tools that will become part of the oncological arsenal for the optimization and personalization of therapy. Based on retro-and pro-spective studies, with large discovery and validation cohorts enrolling >9,000 cancer patients across 10 countries, ancillary to ongoing innovative clinical trials or FDA/EMA approvals across 4 frequent cancer types, ONCOBIOME will pursue the following aims: 1/ identify and validate core or cancer-specific Gut OncoMicrobiome Signatures (GOMS) associated with cancer occurrence, prognosis, response to, or progression on, therapy (polychemotherapy, immune checkpoint inhibitors, dendritic cell vaccines) or adverse effects, 2/ decipher the functional relevance of these cancer-associated gut commensal ecosystems in the regulation of host metabolism, immunity and oncogenesis, 3/ integrate these GOMS with other oncology hallmarks (clinics, genomics, immunomics, metabolomics) 4/ design optimal companion tests, based on those integrated signatures to predict cancer occurrence and progression. With high carat interdisciplinary experts, ONCOBIOME expects to validate cancer or therapy-specific Gut OncoMicrobiome Signatures (GOMS) across breast, colorectal, melanoma and lung cancers adjusting for covariates, to unravel the mode of action of these GOMS in innovative platforms, thus lending support to the design of cancer preventive campaigns using well characterized pre-and pro-biotics.

Deliverables

List of deliverables.
ONCOBIOME logo and graphic chart	Websites, patent fillings, videos etc.	2020-02-18 10:08:13
Communication plan and website	Documents, reports	2020-01-14 14:59:08

Take a look to the deliverables list in detail: detailed list of ONCOBIOME deliverables.

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