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ONCOBIOME SIGNED

Gut OncoMicrobiome Signatures (GOMS) associated with cancer incidence, prognosis and prediction of treatment response.

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ONCOBIOME project word cloud

Explore the words cloud of the ONCOBIOME project. It provides you a very rough idea of what is the project "ONCOBIOME" about.

immunity    gut    oncobiome    microbiome    implicated    interdisciplinary    regulating    validation    cell    commensal    checkpoint    cohorts    ema    immunomics    functional    lung    arsenal    preventive    functions    fingerprints    beyond    hence    types    spective    mode    regulation    action    decipher    predict    urgent    prognosis    plays    pro    personalization    polychemotherapy    host    patients    clinics    approvals    oncomicrobiome    inhibitors    hallmarks    immune    pursue    companion    metagenome    oncogenesis    vaccines    metabolism    tests    adverse    initiation    intestinal    frequent    health    fda    genomics    ancillary    breast    carat    validate    relevance    extraintestinal    ecosystems    unravel    adjusting    ongoing    colorectal    expects    tools    innovative    diagnosis    optimal    discovery    physbeyond    therapies    trials    clinical    gt    melanoma    biotics    signatures    neoplasia    occurrence    therapy    minimalist    cancers    goms    retro    experts    oncology    core    progression    functionally    cancer    optimization    physiological    integrate    dendritic    platforms    countries    multiple    enrolling    campaigns    lending    oncological    metabolomics    covariates   

Project "ONCOBIOME" data sheet

The following table provides information about the project.

Coordinator
INSTITUT GUSTAVE ROUSSY 

Organization address
address: Rue Camille Desmoulins 39
city: VILLEJUIF
postcode: 94805
website: http://www.igr.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 14˙994˙551 €
 EC max contribution 14˙994˙551 € (100%)
 Programme 1. H2020-EU.3.1.2. (Preventing disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT GUSTAVE ROUSSY FR (VILLEJUIF) coordinator 2˙332˙500.00
2    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 2˙801˙953.00
3    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) participant 1˙502˙618.00
4    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 898˙275.00
5    Masarykova univerzita CZ (BRNO STRED) participant 885˙546.00
6    IIGM FOUNDATION IT (TORINO) participant 850˙436.00
7    UNIVERSITATSKLINIKUM ERLANGEN DE (ERLANGEN) participant 847˙125.00
8    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) participant 791˙358.00
9    PHILIPPS UNIVERSITAET MARBURG DE (MARBURG) participant 703˙062.00
10    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 666˙498.00
11    GBG FORSCHUNGS GMBH DE (NEU-ISENBURG) participant 619˙312.00
12    HALIODX FR (MARSEILLE) participant 521˙322.00
13    EVERIMMUNE FR (VILLEJUIF) participant 519˙000.00
14    UNICANCER FR (PARIS) participant 431˙978.00
15    ALGOE SA FR (ECULLY CEDEX) participant 399˙812.00
16    FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI IT (Milan) participant 223˙750.00
17    CENTRE HOSPITALIER DE L'UNIVERSITEDE MONTREAL CA (MONTREAL QUEBEC) participant 0.00
18    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 0.00

Map

 Project objective

Beyond the role the intestinal metagenome plays in regulating multiple physBeyond its role in regulating multiple physiological functions that impact health, the intestinal metagenome is implicated in cancer initiation, progression and responses to therapies, even for extraintestinal neoplasia. Hence, there is an urgent need to fully identify and functionally characterize minimalist commensal ecosystems relevant to cancer, with reliable and robust methods, to validate cancer-associated gut microbiome fingerprints of high clinical relevance, and to develop diagnosis tools that will become part of the oncological arsenal for the optimization and personalization of therapy. Based on retro-and pro-spective studies, with large discovery and validation cohorts enrolling >9,000 cancer patients across 10 countries, ancillary to ongoing innovative clinical trials or FDA/EMA approvals across 4 frequent cancer types, ONCOBIOME will pursue the following aims: 1/ identify and validate core or cancer-specific Gut OncoMicrobiome Signatures (GOMS) associated with cancer occurrence, prognosis, response to, or progression on, therapy (polychemotherapy, immune checkpoint inhibitors, dendritic cell vaccines) or adverse effects, 2/ decipher the functional relevance of these cancer-associated gut commensal ecosystems in the regulation of host metabolism, immunity and oncogenesis, 3/ integrate these GOMS with other oncology hallmarks (clinics, genomics, immunomics, metabolomics) 4/ design optimal companion tests, based on those integrated signatures to predict cancer occurrence and progression. With high carat interdisciplinary experts, ONCOBIOME expects to validate cancer or therapy-specific Gut OncoMicrobiome Signatures (GOMS) across breast, colorectal, melanoma and lung cancers adjusting for covariates, to unravel the mode of action of these GOMS in innovative platforms, thus lending support to the design of cancer preventive campaigns using well characterized pre-and pro-biotics.

 Deliverables

List of deliverables.
ONCOBIOME logo and graphic chart Websites, patent fillings, videos etc. 2020-02-18 10:08:13
Communication plan and website Documents, reports 2020-01-14 14:59:08

Take a look to the deliverables list in detail:  detailed list of ONCOBIOME deliverables.

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The information about "ONCOBIOME" are provided by the European Opendata Portal: CORDIS opendata.

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