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SYNPATH SIGNED

Regulation of synaptic development and plasticity by molecular pathways linked to human evolution

Total Cost €

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EC-Contrib. €

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Partnership

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 SYNPATH project word cloud

Explore the words cloud of the SYNPATH project. It provides you a very rough idea of what is the project "SYNPATH" about.

cortical    molecule    densely    cells    mammalian    nanoscale    disorders    mass    cognitive    advantage    cell    stores    engineering    thread    function    synapse    maturation    transmission    traits    pluripotent    activating    single    primate    multimolecular    mouse    shape    brain    governing    robo    rho    supporting    underlying    spectrometry    integrates    uncover    synapses    rodent    manipulations    slit    networks    protein    vivo    dendrites    combination    microscopy    implicated    regulation    neurobiology    mechanisms    intact    employ    evolution    framework    live    humans    models    period    genes    neurodevelopmental    gap    super    distributed    body    cellular    understand    differ    protracted    disciplinary    bridge    fundamental    srgap2    specialized    relies    transfers    dynamics    stem    few    regulations    rules    human    machine    molecular    dysfunctions    synaptic    species    neurons    linked    duplications    circuits    resolution    takes    goals    composition    plasticity    gtpase    duplicated    indicates    electrophysiology    interactions   

Project "SYNPATH" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙500˙000.00

Map

 Project objective

The synapse is a nanoscale machine, which transfers, integrates and stores information in brain circuits. Its function relies on multimolecular networks of interactions whose composition and dynamics shape synaptic transmission. A large body of evidence indicates that synapses specialized in humans. Human synapses are more densely distributed along dendrites and their period of maturation is protracted compared to rodent or non-human primate synapses. The rules governing their plasticity also differ from the other mammalian species studied so far. These traits contribute to the formation and function of complex circuits supporting human cognitive abilities. Yet, the underlying molecular mechanisms are not known. Here we will investigate the role of molecular pathways linked to human evolution in the regulation of synaptic development and plasticity. The proposed research takes advantage of my previous work on Slit-Robo Rho GTPAse-activating protein 2 (SRGAP2), one of the few genes specifically duplicated in humans, and the only one implicated at synapses so far. We will use the duplications of SRGAP2 as a thread to uncover i) fundamental mechanisms of synaptic development and plasticity, and ii) regulations specific to human synapses. To achieve our goals, we will employ a multi-disciplinary approach based on in vivo manipulations in intact mouse cortical circuits, mass spectrometry, live-cell single-molecule super-resolution microscopy, electrophysiology, and engineering of cortical neurons derived from human pluripotent stem cells. The combination of mouse and human models will allow us to establish a robust framework to bridge the gap in knowledge between cellular neurobiology and human brain evolution, and better understand synaptic dysfunctions in neurodevelopmental disorders.

 Deliverables

List of deliverables.
Data Management Plan Open Research Data Pilot 2020-02-12 18:04:20

Take a look to the deliverables list in detail:  detailed list of SYNPATH deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Matteo Fossati, Nora Assendorp, Olivier Gemin, Sabrina Colasse, Florent Dingli, Guillaume Arras, Damarys Loew, Cécile Charrier
Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons
published pages: , ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.09.027 		Neuron 2019-11-22

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