Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. synpath

SYNPATH SIGNED

Regulation of synaptic development and plasticity by molecular pathways linked to human evolution

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SYNPATH project word cloud

Explore the words cloud of the SYNPATH project. It provides you a very rough idea of what is the project "SYNPATH" about.

regulation    humans    activating    nanoscale    specialized    multimolecular    duplications    interactions    human    takes    genes    slit    differ    manipulations    robo    gap    regulations    cognitive    microscopy    goals    electrophysiology    neurons    fundamental    mass    mechanisms    understand    combination    stem    governing    thread    few    synaptic    disciplinary    molecule    gtpase    neurodevelopmental    period    pluripotent    supporting    disorders    rodent    circuits    bridge    protracted    transfers    single    implicated    engineering    dynamics    rho    molecular    framework    indicates    super    neurobiology    resolution    intact    mouse    cortical    integrates    networks    srgap2    underlying    primate    uncover    body    linked    machine    cell    shape    cells    traits    plasticity    rules    vivo    live    transmission    evolution    employ    dysfunctions    protein    dendrites    densely    distributed    mammalian    function    relies    duplicated    stores    maturation    models    composition    synapse    species    cellular    advantage    synapses    brain    spectrometry   

Project "SYNPATH" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙500˙000.00

Map

 Project objective

The synapse is a nanoscale machine, which transfers, integrates and stores information in brain circuits. Its function relies on multimolecular networks of interactions whose composition and dynamics shape synaptic transmission. A large body of evidence indicates that synapses specialized in humans. Human synapses are more densely distributed along dendrites and their period of maturation is protracted compared to rodent or non-human primate synapses. The rules governing their plasticity also differ from the other mammalian species studied so far. These traits contribute to the formation and function of complex circuits supporting human cognitive abilities. Yet, the underlying molecular mechanisms are not known. Here we will investigate the role of molecular pathways linked to human evolution in the regulation of synaptic development and plasticity. The proposed research takes advantage of my previous work on Slit-Robo Rho GTPAse-activating protein 2 (SRGAP2), one of the few genes specifically duplicated in humans, and the only one implicated at synapses so far. We will use the duplications of SRGAP2 as a thread to uncover i) fundamental mechanisms of synaptic development and plasticity, and ii) regulations specific to human synapses. To achieve our goals, we will employ a multi-disciplinary approach based on in vivo manipulations in intact mouse cortical circuits, mass spectrometry, live-cell single-molecule super-resolution microscopy, electrophysiology, and engineering of cortical neurons derived from human pluripotent stem cells. The combination of mouse and human models will allow us to establish a robust framework to bridge the gap in knowledge between cellular neurobiology and human brain evolution, and better understand synaptic dysfunctions in neurodevelopmental disorders.

 Deliverables

List of deliverables.
Data Management Plan Open Research Data Pilot 2020-02-12 18:04:20

Take a look to the deliverables list in detail:  detailed list of SYNPATH deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Matteo Fossati, Nora Assendorp, Olivier Gemin, Sabrina Colasse, Florent Dingli, Guillaume Arras, Damarys Loew, Cécile Charrier
Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons
published pages: , ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.09.027 		Neuron 2019-11-22

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SYNPATH" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SYNPATH" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

HEIST (2020)

High-temperature Electrochemical Impedance Spectroscopy Transmission electron microscopy on energy materials

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More