EU H2020 Project "SYNPATH (Regulation of synaptic development and plasticity by molecular pathways..)": description, partecipants, costs and EC-fundings

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SYNPATH project word cloud

Explore the words cloud of the SYNPATH project. It provides you a very rough idea of what is the project "SYNPATH" about.

duplicated combination circuits live regulations stem transfers super bridge cells electrophysiology mechanisms rules neurons linked integrates synapse stores cognitive traits rodent employ gap implicated species single networks activating vivo srgap2 synapses transmission cortical duplications advantage function specialized disciplinary synaptic rho shape brain dynamics dysfunctions cellular disorders indicates goals differ relies machine distributed protracted maturation fundamental robo human molecule primate regulation mouse takes few thread densely gtpase multimolecular interactions neurodevelopmental spectrometry mass underlying genes slit microscopy engineering dendrites manipulations protein evolution supporting pluripotent understand neurobiology governing resolution body plasticity molecular models humans mammalian framework nanoscale composition uncover cell period intact

Project "SYNPATH" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	1˙500˙000 €
EC max contribution	1˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-STG
Funding Scheme	ERC-STG
Starting year	2019
Duration (year-month-day)	from 2019-06-01 to 2024-05-31

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE	FR (PARIS)	coordinator	1˙500˙000.00

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

FR (PARIS)

coordinator

1˙500˙000.00

Project objective

The synapse is a nanoscale machine, which transfers, integrates and stores information in brain circuits. Its function relies on multimolecular networks of interactions whose composition and dynamics shape synaptic transmission. A large body of evidence indicates that synapses specialized in humans. Human synapses are more densely distributed along dendrites and their period of maturation is protracted compared to rodent or non-human primate synapses. The rules governing their plasticity also differ from the other mammalian species studied so far. These traits contribute to the formation and function of complex circuits supporting human cognitive abilities. Yet, the underlying molecular mechanisms are not known. Here we will investigate the role of molecular pathways linked to human evolution in the regulation of synaptic development and plasticity. The proposed research takes advantage of my previous work on Slit-Robo Rho GTPAse-activating protein 2 (SRGAP2), one of the few genes specifically duplicated in humans, and the only one implicated at synapses so far. We will use the duplications of SRGAP2 as a thread to uncover i) fundamental mechanisms of synaptic development and plasticity, and ii) regulations specific to human synapses. To achieve our goals, we will employ a multi-disciplinary approach based on in vivo manipulations in intact mouse cortical circuits, mass spectrometry, live-cell single-molecule super-resolution microscopy, electrophysiology, and engineering of cortical neurons derived from human pluripotent stem cells. The combination of mouse and human models will allow us to establish a robust framework to bridge the gap in knowledge between cellular neurobiology and human brain evolution, and better understand synaptic dysfunctions in neurodevelopmental disorders.

List of deliverables.
Data Management Plan	Open Research Data Pilot	2020-02-12 18:04:20

Publications

List of publications.
year	authors and title	journal	last update
2019	Matteo Fossati, Nora Assendorp, Olivier Gemin, Sabrina Colasse, Florent Dingli, Guillaume Arras, Damarys Loew, CÃ©cile Charrier Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons published pages: , ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.09.027	Neuron	2019-11-22

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