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SYNPATH SIGNED

Regulation of synaptic development and plasticity by molecular pathways linked to human evolution

Total Cost €

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EC-Contrib. €

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Partnership

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 SYNPATH project word cloud

Explore the words cloud of the SYNPATH project. It provides you a very rough idea of what is the project "SYNPATH" about.

rodent    transfers    body    srgap2    traits    specialized    framework    cellular    evolution    robo    disorders    understand    mouse    plasticity    governing    underlying    resolution    synapses    employ    function    implicated    uncover    neurodevelopmental    mass    engineering    regulations    species    nanoscale    supporting    thread    single    live    protracted    transmission    integrates    human    gtpase    intact    protein    vivo    gap    rho    goals    activating    shape    microscopy    neurobiology    molecular    cortical    electrophysiology    humans    stem    fundamental    models    cell    primate    period    duplicated    multimolecular    neurons    composition    manipulations    rules    super    machine    dysfunctions    differ    networks    densely    slit    combination    circuits    linked    spectrometry    distributed    dynamics    pluripotent    mammalian    synaptic    few    bridge    genes    disciplinary    molecule    cells    advantage    indicates    duplications    brain    maturation    dendrites    regulation    mechanisms    stores    cognitive    synapse    takes    relies    interactions   

Project "SYNPATH" data sheet

The following table provides information about the project.

Coordinator		 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙500˙000.00

Map

 Project objective

The synapse is a nanoscale machine, which transfers, integrates and stores information in brain circuits. Its function relies on multimolecular networks of interactions whose composition and dynamics shape synaptic transmission. A large body of evidence indicates that synapses specialized in humans. Human synapses are more densely distributed along dendrites and their period of maturation is protracted compared to rodent or non-human primate synapses. The rules governing their plasticity also differ from the other mammalian species studied so far. These traits contribute to the formation and function of complex circuits supporting human cognitive abilities. Yet, the underlying molecular mechanisms are not known. Here we will investigate the role of molecular pathways linked to human evolution in the regulation of synaptic development and plasticity. The proposed research takes advantage of my previous work on Slit-Robo Rho GTPAse-activating protein 2 (SRGAP2), one of the few genes specifically duplicated in humans, and the only one implicated at synapses so far. We will use the duplications of SRGAP2 as a thread to uncover i) fundamental mechanisms of synaptic development and plasticity, and ii) regulations specific to human synapses. To achieve our goals, we will employ a multi-disciplinary approach based on in vivo manipulations in intact mouse cortical circuits, mass spectrometry, live-cell single-molecule super-resolution microscopy, electrophysiology, and engineering of cortical neurons derived from human pluripotent stem cells. The combination of mouse and human models will allow us to establish a robust framework to bridge the gap in knowledge between cellular neurobiology and human brain evolution, and better understand synaptic dysfunctions in neurodevelopmental disorders.

 Deliverables

List of deliverables.
Data Management Plan Open Research Data Pilot 2020-02-12 18:04:20

Take a look to the deliverables list in detail:  detailed list of SYNPATH deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Matteo Fossati, Nora Assendorp, Olivier Gemin, Sabrina Colasse, Florent Dingli, Guillaume Arras, Damarys Loew, Cécile Charrier
Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons
published pages: , ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.09.027 		Neuron 2019-11-22

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