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PSYCHOCELL SIGNED

Cellular substrate of abnormal network maturation in neuropsychiatric disorders

Total Cost €

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EC-Contrib. €

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Partnership

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 PSYCHOCELL project word cloud

Explore the words cloud of the PSYCHOCELL project. It provides you a very rough idea of what is the project "PSYCHOCELL" about.

causing    investigation    synaptic    immature    underlying    disease    therapeutic    excitation    cortex    adult    neonatal    devastating    juvenile    prefrontal    mechanism    neuropsychiatric    brain    mouse    accounting    daily    organization    onset    electro    wiring    interactions    combines    models    abnormal    ascertained    networks    behavior    monitored    invasive    imbalance    behavioral    cognitive    anatomy    etiology    life    circuit    clinical    pioneered    multidisciplinary    selectively    impairment    disruption    lasting    hippocampus    de    investigations    network    initiated    basis    ethical    performance    ontogenetic    first    mechanisms    executive    precluded    dysfunction    function    disorders    limitations    burden    symptoms    deficits    pathophysiology    manipulated    outcome    vivo    infants    coupling    elucidation    substrate    rescue    weaker    dynamics    hypothesized    cellular    optophysiology    hippocampal    inhibition    risk    maturation    emerges    mnemonic    perspectives   

Project "PSYCHOCELL" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF 

Organization address
address: Martinistrasse 52
city: HAMBURG
postcode: 20251
website: www.uke.uni-hamburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.opatzlab.com
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) coordinator 2˙000˙000.00

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 Project objective

The long-lasting burden of major neuropsychiatric disorders results from disruption of cognitive performance in daily life. Impairment of long-range coupling between prefrontal cortex and hippocampus represents the substrate of disease-specific mnemonic and executive deficits. While it has been hypothesized that this impairment emerges long before the first clinical symptoms, technical and ethical limitations of non-invasive investigations in high-risk infants precluded the elucidation of ontogenetic mechanisms underlying the pathophysiology of disease. In previous studies, I pioneered the investigation of long-range coupling in the immature brain by developing a multidisciplinary approach that combines electro- and optophysiology in vivo with behavior, anatomy and analysis of network dynamics. Using mouse models of disease’s etiology, we recently identified the de-coupling of prefrontal-hippocampal networks during early development as potential mechanism underlying adult circuit dysfunction. These findings represent the basis for the current proposal, which aims at understanding the cellular mechanisms accounting for abnormal network maturation in neuropsychiatric disorders. First, the role of excitation/inhibition imbalance in the neonatal prefrontal cortex for disease-specific network impairment will be assessed. Second, the synaptic organization and wiring deficits within neonatal prefrontal-hippocampal networks will be monitored. Third, the cellular substrate of abnormal hippocampal activity causing weaker prefrontal-hippocampal interactions will be ascertained. Finally, the identified cellular elements underlying early network dysfunction will be selectively manipulated to rescue the juvenile circuit function and behavioral performance. Understanding the mechanisms of network dysfunction during early development may open new therapeutic perspectives that, when initiated before the onset of clinical symptoms, may improve the devastating outcome of disease.

 Publications

year authors and title journal last update
List of publications.
2019 Mattia Chini, Sabine Gretenkord, Johanna K. Kostka, Jastyn A. Pöpplau, Laura Cornelissen, Charles B. Berde, Ileana L. Hanganu-Opatz, Sebastian H. Bitzenhofer
Neural Correlates of Anesthesia in Newborn Mice and Humans
published pages: , ISSN: 1662-5110, DOI: 10.3389/fncir.2019.00038
Frontiers in Neural Circuits 13 2019-09-02
2019 Sabine Gretenkord, Johanna K. Kostka, Henrike Hartung, Katja Watznauer, David Fleck, Angélica Minier-Toribio, Marc Spehr, Ileana L. Hanganu-Opatz
Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice
published pages: e2006994, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.2006994
PLOS Biology 17/1 2019-09-02
2019 Victoria C. Oberlander, Xiaxia Xu, Mattia Chini, Ileana L. Hanganu‐Opatz
Developmental dysfunction of prefrontal–hippocampal networks in mouse models of mental illness
published pages: , ISSN: 0953-816X, DOI: 10.1111/ejn.14436
European Journal of Neuroscience 2019-09-02
2017 Malte Bieler, Kay Sieben, Nicole Cichon, Sandra Schildt, Brigitte Röder, Ileana L. Hanganu-Opatz
Rate and Temporal Coding Convey Multisensory Information in Primary Sensory Cortices
published pages: ENEURO.0037-17.2, ISSN: 2373-2822, DOI: 10.1523/ENEURO.0037-17.2017
eneuro 4/2 2019-09-02
2017 Sebastian H Bitzenhofer, Joachim Ahlbeck, Amy Wolff, J. Simon Wiegert, Christine E. Gee, Thomas G. Oertner, Ileana L. Hanganu-Opatz
Layer-specific optogenetic activation of pyramidal neurons causes beta–gamma entrainment of neonatal networks
published pages: 14563, ISSN: 2041-1723, DOI: 10.1038/ncomms14563
Nature Communications 8 2019-09-02
2017 Sebastian H. Bitzenhofer, Joachim Ahlbeck, Ileana L. Hanganu-Opatz
Methodological Approach for Optogenetic Manipulation of Neonatal Neuronal Networks
published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2017.00239
Frontiers in Cellular Neuroscience 11 2019-09-02
2016 Henrike Hartung, Nicole Cichon, Vito De Feo, Stephanie Riemann, Sandra Schildt, Christoph Lindemann, Christoph Mulert, Joseph A. Gogos, Ileana L. Hanganu-Opatz
From Shortage to Surge: A Developmental Switch in Hippocampal–Prefrontal Coupling in a Gene–Environment Model of Neuropsychiatric Disorders
published pages: 4265-4281, ISSN: 1047-3211, DOI: 10.1093/cercor/bhw274
Cerebral Cortex 26/11 2019-09-02
2018 Leonardo Sileo, Sebastian H. Bitzenhofer, Barbara Spagnolo, Jastyn A. Pöpplau, Tobias Holzhammer, Marco Pisanello, Filippo Pisano, Elisa Bellistri, Emanuela Maglie, Massimo De Vittorio, Patrick Ruther, Ileana L. Hanganu-Opatz, Ferruccio Pisanello
Tapered Fibers Combined With a Multi-Electrode Array for Optogenetics in Mouse Medial Prefrontal Cortex
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2018.00771
Frontiers in Neuroscience 12 2019-09-02
2019 Xiaxia Xu, Mattia Chini, Sebastian H. Bitzenhofer, Ileana L. Hanganu-Opatz
Transient knock-down of prefrontal DISC1 in immune-challenged mice causes abnormal long-range coupling and cognitive dysfunction throughout development
published pages: 2170-18, ISSN: 0270-6474, DOI: 10.1523/jneurosci.2170-18.2018
The Journal of Neuroscience 2019-09-02
2018 Joachim Ahlbeck, Lingzhen Song, Mattia Chini, Sebastian H Bitzenhofer, Ileana L Hanganu-Opatz
Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.33158
eLife 7 2019-09-02
2018 Malte Bieler, Xiaxia Xu, Annette Marquardt, Ileana L. Hanganu-Opatz
Multisensory integration in rodent tactile but not visual thalamus
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-33815-y
Scientific Reports 8/1 2019-09-02

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