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Orgasome SIGNED

Protein synthesis in organelles

Total Cost €

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EC-Contrib. €

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Partnership

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 Orgasome project word cloud

Explore the words cloud of the Orgasome project. It provides you a very rough idea of what is the project "Orgasome" about.

stall    regulatory    chloroplasts    chlororibosomes    systematically    co    organelle    ultimately    evolve    sunlight    pigments    mitochondria    specialized    insights    proteins    ribosomes    core    functionally    first    exclusively    synthesis    hydrophobic    samples    process    oxygen    pausing    showed    context    almost    imported    operations    responsible    fundamental    contemplation    exit    evolution    structural    chlororibosomal    protein    tunnels    mitoribosomes    membrane    ribosomal    produces    compartments    exhibit    organelles    coupled    dynamic    elucidate    stages    rrna    regarding    tomography    whereas    incorporation    understand    energy    combine    chemical    counterpart    species    subunit    organic    assembled    particle    spatiotemporally    trans    incorporated    questions    complexity    functional    single    divaricate    machineries    put    synthesizing    organellar    mechanisms    analyze    antibiotics    mutants    converts    assembly    glimpses    action    translation    trna    reconstitute    translational    dynamics    maturated    val    pull    reveal    cytosol    molecular    parallel    intrinsic    small    gtpase    central    protuberance    components    mito    head    bioenergetics   

Project "Orgasome" data sheet

The following table provides information about the project.

Coordinator
STOCKHOLMS UNIVERSITET 

Organization address
address: UNIVERSITETSVAGEN 10
city: STOCKHOLM
postcode: 10691
website: www.su.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙331˙300 €
 EC max contribution 1˙331˙300 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) coordinator 1˙331˙300.00

Map

 Project objective

Protein synthesis in mitochondria is essential for the bioenergetics, whereas its counterpart in chloroplasts is responsible for the synthesis of the core proteins that ultimately converts sunlight into the chemical energy that produces oxygen and organic matter. Recent insights into the mito- and chlororibosomes have provided the first glimpses into the distinct and specialized machineries that involved in synthesizing almost exclusively hydrophobic membrane proteins. Our findings showed: 1) mitoribosomes have different exit tunnels, intrinsic GTPase in the head of the small subunit, tRNA-Val incorporated into the central protuberance; 2) chlororibosomes have divaricate tunnels; 3) ribosomes from both organelles exhibit parallel evolution. This allows contemplation of questions regarding the next level of complexity: How these ribosomes work and evolve? How the ribosomal components imported from cytosol are assembled with the organellar rRNA into a functional unit being maturated in different compartments in organelles? Which trans-factors are involved in this process? How the chlororibosomal activity is spatiotemporally coupled to the synthesis and incorporation of functionally essential pigments? What are the specific regulatory mechanisms? To address these questions, there is a need to first to characterize the process of translation in organelles on the structural level. To reveal molecular mechanisms of action, we will use antibiotics and mutants for pausing in different stages. To reconstitute the assembly, we will systematically pull-down pre-ribosomes and combine single particle with tomography to put the dynamic process in the context of the whole organelle. To understand co-translational operations, we will stall ribosomes and characterize their partner factors. To elucidate the evolution, we will analyze samples from different species. Taken together, this will provide fundamental insights into the structural and functional dynamics of organelles.

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The information about "ORGASOME" are provided by the European Opendata Portal: CORDIS opendata.

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