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Orgasome SIGNED

Protein synthesis in organelles

Total Cost €


EC-Contrib. €






 Orgasome project word cloud

Explore the words cloud of the Orgasome project. It provides you a very rough idea of what is the project "Orgasome" about.

trna    chemical    translation    protuberance    chloroplasts    mito    ultimately    head    intrinsic    questions    ribosomes    compartments    insights    whereas    dynamic    energy    protein    mitoribosomes    coupled    subunit    divaricate    sunlight    counterpart    showed    operations    process    analyze    parallel    translational    evolution    organelles    functional    complexity    synthesizing    organellar    spatiotemporally    organic    produces    regulatory    pigments    chlororibosomes    first    particle    regarding    stall    exit    antibiotics    gtpase    bioenergetics    glimpses    central    structural    mutants    put    converts    chlororibosomal    core    single    context    cytosol    ribosomal    components    incorporation    small    understand    exhibit    mechanisms    organelle    elucidate    proteins    maturated    systematically    assembly    oxygen    val    tunnels    species    specialized    reconstitute    membrane    reveal    stages    evolve    pausing    fundamental    machineries    synthesis    almost    molecular    functionally    action    trans    pull    hydrophobic    imported    samples    mitochondria    incorporated    co    tomography    dynamics    combine    contemplation    assembled    responsible    rrna    exclusively   

Project "Orgasome" data sheet

The following table provides information about the project.


Organization address
postcode: 10691

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙331˙300 €
 EC max contribution 1˙331˙300 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) coordinator 1˙331˙300.00


 Project objective

Protein synthesis in mitochondria is essential for the bioenergetics, whereas its counterpart in chloroplasts is responsible for the synthesis of the core proteins that ultimately converts sunlight into the chemical energy that produces oxygen and organic matter. Recent insights into the mito- and chlororibosomes have provided the first glimpses into the distinct and specialized machineries that involved in synthesizing almost exclusively hydrophobic membrane proteins. Our findings showed: 1) mitoribosomes have different exit tunnels, intrinsic GTPase in the head of the small subunit, tRNA-Val incorporated into the central protuberance; 2) chlororibosomes have divaricate tunnels; 3) ribosomes from both organelles exhibit parallel evolution. This allows contemplation of questions regarding the next level of complexity: How these ribosomes work and evolve? How the ribosomal components imported from cytosol are assembled with the organellar rRNA into a functional unit being maturated in different compartments in organelles? Which trans-factors are involved in this process? How the chlororibosomal activity is spatiotemporally coupled to the synthesis and incorporation of functionally essential pigments? What are the specific regulatory mechanisms? To address these questions, there is a need to first to characterize the process of translation in organelles on the structural level. To reveal molecular mechanisms of action, we will use antibiotics and mutants for pausing in different stages. To reconstitute the assembly, we will systematically pull-down pre-ribosomes and combine single particle with tomography to put the dynamic process in the context of the whole organelle. To understand co-translational operations, we will stall ribosomes and characterize their partner factors. To elucidate the evolution, we will analyze samples from different species. Taken together, this will provide fundamental insights into the structural and functional dynamics of organelles.

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The information about "ORGASOME" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2021-03-07 2:17:14) correctly updated