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Orgasome SIGNED

Protein synthesis in organelles

Total Cost €

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EC-Contrib. €

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Partnership

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 Orgasome project word cloud

Explore the words cloud of the Orgasome project. It provides you a very rough idea of what is the project "Orgasome" about.

intrinsic    single    dynamic    converts    synthesis    action    translation    fundamental    components    organic    mutants    produces    whereas    specialized    context    evolve    ultimately    organelle    incorporation    combine    bioenergetics    reveal    showed    protuberance    tunnels    tomography    imported    machineries    hydrophobic    parallel    operations    trna    mitochondria    membrane    rrna    assembled    molecular    chemical    almost    maturated    pigments    ribosomal    glimpses    incorporated    functionally    ribosomes    exit    mitoribosomes    cytosol    exhibit    chloroplasts    responsible    compartments    core    synthesizing    functional    first    systematically    elucidate    evolution    analyze    proteins    species    mito    understand    stages    chlororibosomes    antibiotics    stall    divaricate    pull    chlororibosomal    questions    reconstitute    central    trans    assembly    put    exclusively    spatiotemporally    regulatory    val    insights    small    regarding    protein    counterpart    contemplation    energy    organellar    structural    subunit    process    complexity    organelles    sunlight    co    samples    head    oxygen    coupled    pausing    particle    dynamics    mechanisms    translational    gtpase   

Project "Orgasome" data sheet

The following table provides information about the project.

Coordinator
STOCKHOLMS UNIVERSITET 

Organization address
address: UNIVERSITETSVAGEN 10
city: STOCKHOLM
postcode: 10691
website: www.su.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙331˙300 €
 EC max contribution 1˙331˙300 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) coordinator 1˙331˙300.00

Map

 Project objective

Protein synthesis in mitochondria is essential for the bioenergetics, whereas its counterpart in chloroplasts is responsible for the synthesis of the core proteins that ultimately converts sunlight into the chemical energy that produces oxygen and organic matter. Recent insights into the mito- and chlororibosomes have provided the first glimpses into the distinct and specialized machineries that involved in synthesizing almost exclusively hydrophobic membrane proteins. Our findings showed: 1) mitoribosomes have different exit tunnels, intrinsic GTPase in the head of the small subunit, tRNA-Val incorporated into the central protuberance; 2) chlororibosomes have divaricate tunnels; 3) ribosomes from both organelles exhibit parallel evolution. This allows contemplation of questions regarding the next level of complexity: How these ribosomes work and evolve? How the ribosomal components imported from cytosol are assembled with the organellar rRNA into a functional unit being maturated in different compartments in organelles? Which trans-factors are involved in this process? How the chlororibosomal activity is spatiotemporally coupled to the synthesis and incorporation of functionally essential pigments? What are the specific regulatory mechanisms? To address these questions, there is a need to first to characterize the process of translation in organelles on the structural level. To reveal molecular mechanisms of action, we will use antibiotics and mutants for pausing in different stages. To reconstitute the assembly, we will systematically pull-down pre-ribosomes and combine single particle with tomography to put the dynamic process in the context of the whole organelle. To understand co-translational operations, we will stall ribosomes and characterize their partner factors. To elucidate the evolution, we will analyze samples from different species. Taken together, this will provide fundamental insights into the structural and functional dynamics of organelles.

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