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Orgasome SIGNED

Protein synthesis in organelles

Total Cost €

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EC-Contrib. €

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Partnership

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 Orgasome project word cloud

Explore the words cloud of the Orgasome project. It provides you a very rough idea of what is the project "Orgasome" about.

single    combine    membrane    exclusively    sunlight    incorporated    synthesis    protein    mitoribosomes    action    ribosomes    organelles    exhibit    produces    regulatory    almost    stall    gtpase    cytosol    assembled    structural    responsible    protuberance    whereas    ultimately    ribosomal    analyze    complexity    converts    pausing    pigments    incorporation    subunit    species    organellar    core    energy    systematically    dynamics    small    mito    regarding    reveal    counterpart    coupled    glimpses    maturated    trna    mutants    parallel    specialized    imported    synthesizing    questions    stages    translation    put    contemplation    bioenergetics    chlororibosomal    pull    molecular    components    chlororibosomes    evolve    reconstitute    antibiotics    process    translational    evolution    head    val    machineries    particle    assembly    oxygen    functionally    central    hydrophobic    showed    mechanisms    functional    exit    elucidate    chloroplasts    organic    first    proteins    mitochondria    spatiotemporally    intrinsic    fundamental    understand    insights    compartments    dynamic    trans    organelle    samples    rrna    co    tunnels    operations    tomography    chemical    divaricate    context   

Project "Orgasome" data sheet

The following table provides information about the project.

Coordinator
STOCKHOLMS UNIVERSITET 

Organization address
address: UNIVERSITETSVAGEN 10
city: STOCKHOLM
postcode: 10691
website: www.su.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙331˙300 €
 EC max contribution 1˙331˙300 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) coordinator 1˙331˙300.00

Map

 Project objective

Protein synthesis in mitochondria is essential for the bioenergetics, whereas its counterpart in chloroplasts is responsible for the synthesis of the core proteins that ultimately converts sunlight into the chemical energy that produces oxygen and organic matter. Recent insights into the mito- and chlororibosomes have provided the first glimpses into the distinct and specialized machineries that involved in synthesizing almost exclusively hydrophobic membrane proteins. Our findings showed: 1) mitoribosomes have different exit tunnels, intrinsic GTPase in the head of the small subunit, tRNA-Val incorporated into the central protuberance; 2) chlororibosomes have divaricate tunnels; 3) ribosomes from both organelles exhibit parallel evolution. This allows contemplation of questions regarding the next level of complexity: How these ribosomes work and evolve? How the ribosomal components imported from cytosol are assembled with the organellar rRNA into a functional unit being maturated in different compartments in organelles? Which trans-factors are involved in this process? How the chlororibosomal activity is spatiotemporally coupled to the synthesis and incorporation of functionally essential pigments? What are the specific regulatory mechanisms? To address these questions, there is a need to first to characterize the process of translation in organelles on the structural level. To reveal molecular mechanisms of action, we will use antibiotics and mutants for pausing in different stages. To reconstitute the assembly, we will systematically pull-down pre-ribosomes and combine single particle with tomography to put the dynamic process in the context of the whole organelle. To understand co-translational operations, we will stall ribosomes and characterize their partner factors. To elucidate the evolution, we will analyze samples from different species. Taken together, this will provide fundamental insights into the structural and functional dynamics of organelles.

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The information about "ORGASOME" are provided by the European Opendata Portal: CORDIS opendata.

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