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Orgasome SIGNED

Protein synthesis in organelles

Total Cost €

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EC-Contrib. €

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Partnership

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 Orgasome project word cloud

Explore the words cloud of the Orgasome project. It provides you a very rough idea of what is the project "Orgasome" about.

translational    insights    incorporated    molecular    specialized    action    sunlight    trans    stall    almost    understand    combine    energy    questions    incorporation    trna    regarding    protuberance    parallel    produces    machineries    mutants    hydrophobic    tomography    reveal    cytosol    organelle    stages    oxygen    structural    tunnels    ultimately    evolve    intrinsic    maturated    val    samples    core    translation    particle    dynamic    exhibit    pausing    exclusively    put    functionally    pigments    showed    single    bioenergetics    proteins    central    rrna    process    glimpses    synthesizing    imported    elucidate    antibiotics    mito    chloroplasts    regulatory    fundamental    subunit    components    synthesis    systematically    spatiotemporally    evolution    small    chlororibosomal    protein    operations    first    ribosomal    species    divaricate    context    exit    dynamics    counterpart    mitochondria    analyze    chlororibosomes    contemplation    assembly    organic    converts    complexity    membrane    reconstitute    functional    chemical    gtpase    organelles    pull    mitoribosomes    mechanisms    whereas    head    co    ribosomes    organellar    responsible    compartments    coupled    assembled   

Project "Orgasome" data sheet

The following table provides information about the project.

Coordinator
STOCKHOLMS UNIVERSITET 

Organization address
address: UNIVERSITETSVAGEN 10
city: STOCKHOLM
postcode: 10691
website: www.su.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙331˙300 €
 EC max contribution 1˙331˙300 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) coordinator 1˙331˙300.00

Map

 Project objective

Protein synthesis in mitochondria is essential for the bioenergetics, whereas its counterpart in chloroplasts is responsible for the synthesis of the core proteins that ultimately converts sunlight into the chemical energy that produces oxygen and organic matter. Recent insights into the mito- and chlororibosomes have provided the first glimpses into the distinct and specialized machineries that involved in synthesizing almost exclusively hydrophobic membrane proteins. Our findings showed: 1) mitoribosomes have different exit tunnels, intrinsic GTPase in the head of the small subunit, tRNA-Val incorporated into the central protuberance; 2) chlororibosomes have divaricate tunnels; 3) ribosomes from both organelles exhibit parallel evolution. This allows contemplation of questions regarding the next level of complexity: How these ribosomes work and evolve? How the ribosomal components imported from cytosol are assembled with the organellar rRNA into a functional unit being maturated in different compartments in organelles? Which trans-factors are involved in this process? How the chlororibosomal activity is spatiotemporally coupled to the synthesis and incorporation of functionally essential pigments? What are the specific regulatory mechanisms? To address these questions, there is a need to first to characterize the process of translation in organelles on the structural level. To reveal molecular mechanisms of action, we will use antibiotics and mutants for pausing in different stages. To reconstitute the assembly, we will systematically pull-down pre-ribosomes and combine single particle with tomography to put the dynamic process in the context of the whole organelle. To understand co-translational operations, we will stall ribosomes and characterize their partner factors. To elucidate the evolution, we will analyze samples from different species. Taken together, this will provide fundamental insights into the structural and functional dynamics of organelles.

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The information about "ORGASOME" are provided by the European Opendata Portal: CORDIS opendata.

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