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Orgasome SIGNED

Protein synthesis in organelles

Total Cost €

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EC-Contrib. €

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Partnership

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 Orgasome project word cloud

Explore the words cloud of the Orgasome project. It provides you a very rough idea of what is the project "Orgasome" about.

co    ribosomal    parallel    val    trna    species    mechanisms    hydrophobic    analyze    assembled    central    oxygen    energy    functional    small    ultimately    exhibit    head    combine    synthesis    ribosomes    translation    subunit    mutants    sunlight    operations    stall    cytosol    particle    core    dynamics    fundamental    structural    action    organelle    counterpart    synthesizing    organelles    components    gtpase    spatiotemporally    mitochondria    protuberance    pausing    elucidate    evolve    tunnels    trans    showed    incorporation    context    first    machineries    molecular    coupled    chloroplasts    incorporated    chlororibosomes    assembly    compartments    contemplation    maturated    translational    process    pigments    stages    regarding    chlororibosomal    responsible    divaricate    tomography    specialized    reconstitute    systematically    bioenergetics    samples    evolution    membrane    glimpses    dynamic    whereas    proteins    intrinsic    single    rrna    functionally    questions    exit    produces    pull    organic    converts    antibiotics    organellar    reveal    regulatory    understand    mitoribosomes    complexity    chemical    exclusively    imported    put    mito    almost    protein    insights   

Project "Orgasome" data sheet

The following table provides information about the project.

Coordinator
STOCKHOLMS UNIVERSITET 

Organization address
address: UNIVERSITETSVAGEN 10
city: STOCKHOLM
postcode: 10691
website: www.su.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙331˙300 €
 EC max contribution 1˙331˙300 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) coordinator 1˙331˙300.00

Map

 Project objective

Protein synthesis in mitochondria is essential for the bioenergetics, whereas its counterpart in chloroplasts is responsible for the synthesis of the core proteins that ultimately converts sunlight into the chemical energy that produces oxygen and organic matter. Recent insights into the mito- and chlororibosomes have provided the first glimpses into the distinct and specialized machineries that involved in synthesizing almost exclusively hydrophobic membrane proteins. Our findings showed: 1) mitoribosomes have different exit tunnels, intrinsic GTPase in the head of the small subunit, tRNA-Val incorporated into the central protuberance; 2) chlororibosomes have divaricate tunnels; 3) ribosomes from both organelles exhibit parallel evolution. This allows contemplation of questions regarding the next level of complexity: How these ribosomes work and evolve? How the ribosomal components imported from cytosol are assembled with the organellar rRNA into a functional unit being maturated in different compartments in organelles? Which trans-factors are involved in this process? How the chlororibosomal activity is spatiotemporally coupled to the synthesis and incorporation of functionally essential pigments? What are the specific regulatory mechanisms? To address these questions, there is a need to first to characterize the process of translation in organelles on the structural level. To reveal molecular mechanisms of action, we will use antibiotics and mutants for pausing in different stages. To reconstitute the assembly, we will systematically pull-down pre-ribosomes and combine single particle with tomography to put the dynamic process in the context of the whole organelle. To understand co-translational operations, we will stall ribosomes and characterize their partner factors. To elucidate the evolution, we will analyze samples from different species. Taken together, this will provide fundamental insights into the structural and functional dynamics of organelles.

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