RESTORE SIGNED
User-centred smart nanobiomaterial-based 3D matrices for chondral repair
Total Cost €
0EC-Contrib. €
0Partnership
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0RESTORE project word cloud
Explore the words cloud of the RESTORE project. It provides you a very rough idea of what is the project "RESTORE" about.
Project "RESTORE" data sheet
The following table provides information about the project.
| Coordinator |
INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA
Organization address contact info |
| Coordinator Country | Portugal [PT] |
| Total cost | 5˙539˙736 € |
| EC max contribution | 5˙539˙736 € (100%) |
| Programme |
1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials) 2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies) |
| Code Call | H2020-NMBP-TR-IND-2018 |
| Funding Scheme | RIA |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-01-01 to 2022-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA | PT (PORTO) | coordinator | 933˙243.00 |
| 2 | OULUN YLIOPISTO | FI (OULU) | participant | 918˙802.00 |
| 3 | SINTEF AS | NO (TRONDHEIM) | participant | 699˙705.00 |
| 4 | FUNDACION CIDETEC | ES (SAN SEBASTIAN) | participant | 554˙375.00 |
| 5 | GOETEBORGS UNIVERSITET | SE (GOETEBORG) | participant | 553˙050.00 |
| 6 | UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO | IT (VERCELLI) | participant | 449˙937.00 |
| 7 | UNIVERSITAET ULM | DE (ULM) | participant | 409˙312.00 |
| 8 | 3DTECH OY | FI (SALO) | participant | 399˙375.00 |
| 9 | HASKOLINN I REYKJAVIK EHF | IS (REYKJAVIK) | participant | 318˙185.00 |
| 10 | ASKEL HEALTHCARE OY | FI (HELSINKI) | participant | 303˙750.00 |
Map
Project objective
The RESTORE project aims at developing an effective approach to manage the specific unmet clinical needs to treat knee chondral lesions. RESTORE, built upon the consortium’s proofs-of-concept and discussions between orthopaedic surgeons, tissue engineers, material scientists, cell biologists and SMEs, will realize a new generation of smart nanoenabled 3D matrices able to fit into complex lesion geometry, modulate undesirable biological events, and remotely control, stimulate and monitor cartilage repair. To create smart and functional 3D matrices, RESTORE will develop (i) nanobiomaterial-based nanocarriers to modulate inflammatory, cartilage extracellular matrix degradation and infection threats, (ii) stimuli-responsive nanobiomaterials tuned via external physical stimulus using radiofrequency and electromagnetic fields, and (iii) non-invasive wearable and wireless device for remote stimulus and regeneration monitoring. The nanobiomaterials will be integrated into cutting-edge 3D matrices that meet the needs of severe and mild chondral lesions: 1) the COPLA Scaffold commercialised since 2017 for animal health use and 2) 3D cartilage microtissues engineered via 3D bioprinting of iPS cells in a nanocellulose and alginate bioink. The technology development in RESTORE will reach TRL5 and enable substantial clinical advances in regenerative medicine. Untreated or not-correctly treated chondral lesions are likely to progress towards osteoarthritis (OA), which affects 242 million people globally (costs/patient/year: 10,452€). RESTORE will address the shortfalls of current therapeutic solutions while aiming to reduce the overall burden of OA. RESTORE’s outcomes hold high exploitation and commercial potential to boost the competitiveness of European companies, striving to diminish or delay the onset of OA, reducing hospitalization, number of surgeon interventions and time off work, thus leading to more cost-efficient health care and promote wellbeing and active ageing.
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