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RESTORE SIGNED

User-centred smart nanobiomaterial-based 3D matrices for chondral repair

Total Cost €

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EC-Contrib. €

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Partnership

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 RESTORE project word cloud

Explore the words cloud of the RESTORE project. It provides you a very rough idea of what is the project "RESTORE" about.

tissue    nanobiomaterials    smes    degradation    edge    surgeons    generation    fit    knee    copla    stimulus    interventions    monitoring    commercial    engineered    clinical    wireless    orthopaedic    million    threats    242    extracellular    people    monitor    smart    ageing    microtissues    nanobiomaterial    osteoarthritis    scaffold    electromagnetic    physical    bioprinting    restore    wellbeing    3d    2017    medicine    matrices    infection    regenerative    engineers    device    cells    globally    onset    realize    animal    commercialised    diminish    stimulate    functional    repair    hospitalization    hold    boost    bioink    untreated    scientists    invasive    treat    matrix    lesion    undesirable    stimuli    correctly    material    delay    health    cell    time    events    burden    radiofrequency    proofs    tuned    external    wearable    ips    cartilage    remote    biologists    cutting    solutions    nanocarriers    striving    alginate    progress    regeneration    surgeon    therapeutic    geometry    remotely    trl5    reducing    off    biological    modulate    active    reduce    chondral    452    nanoenabled    outcomes    create    shortfalls    substantial    competitiveness    companies    severe    care    responsive    inflammatory    efficient    patient    oa    unmet    nanocellulose    lesions    meet    mild   

Project "RESTORE" data sheet

The following table provides information about the project.

Coordinator
INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA 

Organization address
address: RUA ALFREDO ALLEN 208
city: PORTO
postcode: 4200 135
website: www.ineb.up.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 5˙539˙736 €
 EC max contribution 5˙539˙736 € (100%)
 Programme 1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-TR-IND-2018
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA PT (PORTO) coordinator 933˙243.00
2    OULUN YLIOPISTO FI (OULU) participant 918˙802.00
3    SINTEF AS NO (TRONDHEIM) participant 699˙705.00
4    FUNDACION CIDETEC ES (SAN SEBASTIAN) participant 554˙375.00
5    GOETEBORGS UNIVERSITET SE (GOETEBORG) participant 553˙050.00
6    UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO IT (VERCELLI) participant 449˙937.00
7    UNIVERSITAET ULM DE (ULM) participant 409˙312.00
8    3DTECH OY FI (SALO) participant 399˙375.00
9    HASKOLINN I REYKJAVIK EHF IS (REYKJAVIK) participant 318˙185.00
10    ASKEL HEALTHCARE OY FI (HELSINKI) participant 303˙750.00

Map

 Project objective

The RESTORE project aims at developing an effective approach to manage the specific unmet clinical needs to treat knee chondral lesions. RESTORE, built upon the consortium’s proofs-of-concept and discussions between orthopaedic surgeons, tissue engineers, material scientists, cell biologists and SMEs, will realize a new generation of smart nanoenabled 3D matrices able to fit into complex lesion geometry, modulate undesirable biological events, and remotely control, stimulate and monitor cartilage repair. To create smart and functional 3D matrices, RESTORE will develop (i) nanobiomaterial-based nanocarriers to modulate inflammatory, cartilage extracellular matrix degradation and infection threats, (ii) stimuli-responsive nanobiomaterials tuned via external physical stimulus using radiofrequency and electromagnetic fields, and (iii) non-invasive wearable and wireless device for remote stimulus and regeneration monitoring. The nanobiomaterials will be integrated into cutting-edge 3D matrices that meet the needs of severe and mild chondral lesions: 1) the COPLA Scaffold commercialised since 2017 for animal health use and 2) 3D cartilage microtissues engineered via 3D bioprinting of iPS cells in a nanocellulose and alginate bioink. The technology development in RESTORE will reach TRL5 and enable substantial clinical advances in regenerative medicine. Untreated or not-correctly treated chondral lesions are likely to progress towards osteoarthritis (OA), which affects 242 million people globally (costs/patient/year: 10,452€). RESTORE will address the shortfalls of current therapeutic solutions while aiming to reduce the overall burden of OA. RESTORE’s outcomes hold high exploitation and commercial potential to boost the competitiveness of European companies, striving to diminish or delay the onset of OA, reducing hospitalization, number of surgeon interventions and time off work, thus leading to more cost-efficient health care and promote wellbeing and active ageing.

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The information about "RESTORE" are provided by the European Opendata Portal: CORDIS opendata.

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