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RESTORE SIGNED

User-centred smart nanobiomaterial-based 3D matrices for chondral repair

Total Cost €

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EC-Contrib. €

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Partnership

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RESTORE project word cloud

Explore the words cloud of the RESTORE project. It provides you a very rough idea of what is the project "RESTORE" about.

monitoring tuned stimulus hold matrix million chondral people hospitalization stimulate monitor reduce physical external 2017 smart therapeutic mild lesion lesions 242 severe active striving geometry animal orthopaedic boost reducing cell trl5 meet degradation events biologists scaffold care surgeons radiofrequency wellbeing proofs remotely commercial ageing 3d material commercialised time diminish repair engineers shortfalls device oa surgeon cells invasive bioink electromagnetic scientists regenerative cartilage competitiveness burden patient off bioprinting regeneration restore alginate nanoenabled threats globally nanobiomaterial knee progress functional untreated medicine matrices efficient remote inflammatory substantial cutting osteoarthritis clinical tissue fit nanobiomaterials undesirable biological nanocarriers delay edge engineered ips correctly onset generation modulate realize microtissues outcomes create unmet companies wearable solutions 452 copla health nanocellulose responsive wireless treat infection smes extracellular interventions stimuli

Project "RESTORE" data sheet

The following table provides information about the project.

Coordinator	INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA Organization address address: RUA ALFREDO ALLEN 208 city: PORTO postcode: 4200 135 website: www.ineb.up.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Total cost	5˙539˙736 €
EC max contribution	5˙539˙736 € (100%)
Programme	1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials) 2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
Code Call	H2020-NMBP-TR-IND-2018
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2022-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA Organization address address: RUA ALFREDO ALLEN 208 city: PORTO postcode: 4200 135 website: www.ineb.up.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (PORTO)	coordinator	933˙243.00
2	OULUN YLIOPISTO OULUN YLIOPISTO Organization address address: PENTTI KAITERAN KATU 1 city: OULU postcode: 90014 website: www.oulu.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (OULU)	participant	918˙802.00
3	SINTEF AS SINTEF AS Organization address address: STRINDVEGEN 4 city: TRONDHEIM postcode: 7034 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (TRONDHEIM)	participant	699˙705.00
4	FUNDACION CIDETEC FUNDACION CIDETEC Organization address address: PASEO MIRAMON 196 PARQUE TECNOLOGICO DE MIRAMON city: SAN SEBASTIAN postcode: 20014 website: www.cidetec.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SAN SEBASTIAN)	participant	554˙375.00
5	GOETEBORGS UNIVERSITET GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 website: www.gu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	participant	553˙050.00
6	UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO Organization address address: DUOMO 6 city: VERCELLI postcode: 13100 website: www.unipmn.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (VERCELLI)	participant	449˙937.00
7	UNIVERSITAET ULM UNIVERSITAET ULM Organization address address: HELMHOLTZSTRASSE 16 city: ULM postcode: 89081 website: www.uni-ulm.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ULM)	participant	409˙312.00
8	3DTECH OY 3DTECH OY Organization address address: HYVONINKATU 1 city: SALO postcode: 24240 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (SALO)	participant	399˙375.00
9	HASKOLINN I REYKJAVIK EHF HASKOLINN I REYKJAVIK EHF Organization address address: MENNTAVEGUR 1 city: REYKJAVIK postcode: 101 website: www.ru.is contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IS (REYKJAVIK)	participant	318˙185.00
10	ASKEL HEALTHCARE OY ASKEL HEALTHCARE OY Organization address address: KUORTANEENKATU 2 city: HELSINKI postcode: 510 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINKI)	participant	303˙750.00

Map

Project objective

The RESTORE project aims at developing an effective approach to manage the specific unmet clinical needs to treat knee chondral lesions. RESTORE, built upon the consortium’s proofs-of-concept and discussions between orthopaedic surgeons, tissue engineers, material scientists, cell biologists and SMEs, will realize a new generation of smart nanoenabled 3D matrices able to fit into complex lesion geometry, modulate undesirable biological events, and remotely control, stimulate and monitor cartilage repair. To create smart and functional 3D matrices, RESTORE will develop (i) nanobiomaterial-based nanocarriers to modulate inflammatory, cartilage extracellular matrix degradation and infection threats, (ii) stimuli-responsive nanobiomaterials tuned via external physical stimulus using radiofrequency and electromagnetic fields, and (iii) non-invasive wearable and wireless device for remote stimulus and regeneration monitoring. The nanobiomaterials will be integrated into cutting-edge 3D matrices that meet the needs of severe and mild chondral lesions: 1) the COPLA Scaffold commercialised since 2017 for animal health use and 2) 3D cartilage microtissues engineered via 3D bioprinting of iPS cells in a nanocellulose and alginate bioink. The technology development in RESTORE will reach TRL5 and enable substantial clinical advances in regenerative medicine. Untreated or not-correctly treated chondral lesions are likely to progress towards osteoarthritis (OA), which affects 242 million people globally (costs/patient/year: 10,452€). RESTORE will address the shortfalls of current therapeutic solutions while aiming to reduce the overall burden of OA. RESTORE’s outcomes hold high exploitation and commercial potential to boost the competitiveness of European companies, striving to diminish or delay the onset of OA, reducing hospitalization, number of surgeon interventions and time off work, thus leading to more cost-efficient health care and promote wellbeing and active ageing.

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The information about "RESTORE" are provided by the European Opendata Portal: CORDIS opendata.

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