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RESTORE SIGNED

User-centred smart nanobiomaterial-based 3D matrices for chondral repair

Total Cost €

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EC-Contrib. €

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Partnership

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 RESTORE project word cloud

Explore the words cloud of the RESTORE project. It provides you a very rough idea of what is the project "RESTORE" about.

commercialised    people    realize    delay    efficient    interventions    million    cutting    solutions    nanoenabled    wellbeing    stimulus    remote    tuned    burden    engineered    fit    biological    monitoring    external    correctly    stimulate    competitiveness    undesirable    regenerative    ips    time    striving    infection    cell    progress    2017    stimuli    nanobiomaterial    nanocellulose    care    3d    treat    events    create    nanobiomaterials    edge    electromagnetic    proofs    chondral    responsive    degradation    wireless    biologists    scaffold    242    copla    knee    off    device    osteoarthritis    patient    health    outcomes    severe    cartilage    functional    smes    452    animal    remotely    cells    clinical    shortfalls    commercial    lesion    meet    scientists    inflammatory    boost    untreated    diminish    microtissues    restore    extracellular    active    matrices    reduce    substantial    ageing    matrix    material    surgeons    bioprinting    geometry    radiofrequency    generation    bioink    monitor    companies    medicine    mild    modulate    orthopaedic    hold    repair    regeneration    onset    alginate    invasive    globally    tissue    nanocarriers    engineers    reducing    trl5    threats    oa    unmet    wearable    therapeutic    surgeon    smart    hospitalization    physical    lesions   

Project "RESTORE" data sheet

The following table provides information about the project.

Coordinator
INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA 

Organization address
address: RUA ALFREDO ALLEN 208
city: PORTO
postcode: 4200 135
website: www.ineb.up.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 5˙539˙736 €
 EC max contribution 5˙539˙736 € (100%)
 Programme 1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-TR-IND-2018
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA PT (PORTO) coordinator 933˙243.00
2    OULUN YLIOPISTO FI (OULU) participant 918˙802.00
3    SINTEF AS NO (TRONDHEIM) participant 699˙705.00
4    FUNDACION CIDETEC ES (SAN SEBASTIAN) participant 554˙375.00
5    GOETEBORGS UNIVERSITET SE (GOETEBORG) participant 553˙050.00
6    UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO IT (VERCELLI) participant 449˙937.00
7    UNIVERSITAET ULM DE (ULM) participant 409˙312.00
8    3DTECH OY FI (SALO) participant 399˙375.00
9    HASKOLINN I REYKJAVIK EHF IS (REYKJAVIK) participant 318˙185.00
10    ASKEL HEALTHCARE OY FI (HELSINKI) participant 303˙750.00

Map

 Project objective

The RESTORE project aims at developing an effective approach to manage the specific unmet clinical needs to treat knee chondral lesions. RESTORE, built upon the consortium’s proofs-of-concept and discussions between orthopaedic surgeons, tissue engineers, material scientists, cell biologists and SMEs, will realize a new generation of smart nanoenabled 3D matrices able to fit into complex lesion geometry, modulate undesirable biological events, and remotely control, stimulate and monitor cartilage repair. To create smart and functional 3D matrices, RESTORE will develop (i) nanobiomaterial-based nanocarriers to modulate inflammatory, cartilage extracellular matrix degradation and infection threats, (ii) stimuli-responsive nanobiomaterials tuned via external physical stimulus using radiofrequency and electromagnetic fields, and (iii) non-invasive wearable and wireless device for remote stimulus and regeneration monitoring. The nanobiomaterials will be integrated into cutting-edge 3D matrices that meet the needs of severe and mild chondral lesions: 1) the COPLA Scaffold commercialised since 2017 for animal health use and 2) 3D cartilage microtissues engineered via 3D bioprinting of iPS cells in a nanocellulose and alginate bioink. The technology development in RESTORE will reach TRL5 and enable substantial clinical advances in regenerative medicine. Untreated or not-correctly treated chondral lesions are likely to progress towards osteoarthritis (OA), which affects 242 million people globally (costs/patient/year: 10,452€). RESTORE will address the shortfalls of current therapeutic solutions while aiming to reduce the overall burden of OA. RESTORE’s outcomes hold high exploitation and commercial potential to boost the competitiveness of European companies, striving to diminish or delay the onset of OA, reducing hospitalization, number of surgeon interventions and time off work, thus leading to more cost-efficient health care and promote wellbeing and active ageing.

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The information about "RESTORE" are provided by the European Opendata Portal: CORDIS opendata.

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