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RESTORE SIGNED

User-centred smart nanobiomaterial-based 3D matrices for chondral repair

Total Cost €

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EC-Contrib. €

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Partnership

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 RESTORE project word cloud

Explore the words cloud of the RESTORE project. It provides you a very rough idea of what is the project "RESTORE" about.

nanocarriers    burden    chondral    stimulus    solutions    trl5    threats    tissue    nanocellulose    correctly    onset    commercialised    competitiveness    create    restore    cartilage    outcomes    bioprinting    material    nanobiomaterials    engineers    mild    fit    nanobiomaterial    proofs    events    scientists    hold    efficient    microtissues    lesion    matrices    untreated    globally    ips    million    repair    reduce    progress    edge    realize    tuned    reducing    companies    surgeon    generation    therapeutic    clinical    shortfalls    monitor    242    modulate    engineered    patient    copla    remote    cutting    scaffold    inflammatory    smart    health    nanoenabled    meet    radiofrequency    device    invasive    unmet    bioink    ageing    interventions    external    undesirable    medicine    time    oa    remotely    lesions    physical    geometry    smes    wearable    surgeons    cells    off    extracellular    stimuli    regenerative    matrix    wireless    wellbeing    commercial    care    2017    cell    animal    biologists    biological    infection    monitoring    regeneration    functional    severe    3d    active    knee    osteoarthritis    substantial    electromagnetic    responsive    treat    people    striving    alginate    boost    degradation    delay    hospitalization    stimulate    orthopaedic    diminish    452   

Project "RESTORE" data sheet

The following table provides information about the project.

Coordinator
INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA 

Organization address
address: RUA ALFREDO ALLEN 208
city: PORTO
postcode: 4200 135
website: www.ineb.up.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 5˙539˙736 €
 EC max contribution 5˙539˙736 € (100%)
 Programme 1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-TR-IND-2018
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA PT (PORTO) coordinator 933˙243.00
2    OULUN YLIOPISTO FI (OULU) participant 918˙802.00
3    SINTEF AS NO (TRONDHEIM) participant 699˙705.00
4    FUNDACION CIDETEC ES (SAN SEBASTIAN) participant 554˙375.00
5    GOETEBORGS UNIVERSITET SE (GOETEBORG) participant 553˙050.00
6    UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO IT (VERCELLI) participant 449˙937.00
7    UNIVERSITAET ULM DE (ULM) participant 409˙312.00
8    3DTECH OY FI (SALO) participant 399˙375.00
9    HASKOLINN I REYKJAVIK EHF IS (REYKJAVIK) participant 318˙185.00
10    ASKEL HEALTHCARE OY FI (HELSINKI) participant 303˙750.00

Map

 Project objective

The RESTORE project aims at developing an effective approach to manage the specific unmet clinical needs to treat knee chondral lesions. RESTORE, built upon the consortium’s proofs-of-concept and discussions between orthopaedic surgeons, tissue engineers, material scientists, cell biologists and SMEs, will realize a new generation of smart nanoenabled 3D matrices able to fit into complex lesion geometry, modulate undesirable biological events, and remotely control, stimulate and monitor cartilage repair. To create smart and functional 3D matrices, RESTORE will develop (i) nanobiomaterial-based nanocarriers to modulate inflammatory, cartilage extracellular matrix degradation and infection threats, (ii) stimuli-responsive nanobiomaterials tuned via external physical stimulus using radiofrequency and electromagnetic fields, and (iii) non-invasive wearable and wireless device for remote stimulus and regeneration monitoring. The nanobiomaterials will be integrated into cutting-edge 3D matrices that meet the needs of severe and mild chondral lesions: 1) the COPLA Scaffold commercialised since 2017 for animal health use and 2) 3D cartilage microtissues engineered via 3D bioprinting of iPS cells in a nanocellulose and alginate bioink. The technology development in RESTORE will reach TRL5 and enable substantial clinical advances in regenerative medicine. Untreated or not-correctly treated chondral lesions are likely to progress towards osteoarthritis (OA), which affects 242 million people globally (costs/patient/year: 10,452€). RESTORE will address the shortfalls of current therapeutic solutions while aiming to reduce the overall burden of OA. RESTORE’s outcomes hold high exploitation and commercial potential to boost the competitiveness of European companies, striving to diminish or delay the onset of OA, reducing hospitalization, number of surgeon interventions and time off work, thus leading to more cost-efficient health care and promote wellbeing and active ageing.

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The information about "RESTORE" are provided by the European Opendata Portal: CORDIS opendata.

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