Opendata, web and dolomites

LIMBo SIGNED

Zooming the link between diet and brain health: how phenolic metabolites modulate brain inflammation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LIMBo project word cloud

Explore the words cloud of the LIMBo project. It provides you a very rough idea of what is the project "LIMBo" about.

cellular    vision    trials    validate    prodrugs    diseases    public    gap    mechanistic    society    prevention    treatment    microglia    metabolites    limbo    acting    actions    vs    nutrition    overlooked    therapeutics    reached    data    effect    big    central    molecular    preliminary    onset    impacts    view    metabolomics    creates    insights    neuroinflammation    expertise    brain    generating    healthy    ultimately    action    beneficial    anti    neuroactive    diets    prevalent    diet    position    diversity    multidisciplinary    neurodegeneration    strategies    aging    either    group    synthesis    biology    scientific    delay    immune    reaching    pro    status    health    shared    inflammatory    influences    progressively    metabolite    functions    attain    fruits    organic    cells    compounds    nervous    paradigm    indeterminate    wish    communicating    nature    currently    break    incidence    alone    valuable    unknown    fundamental    neurodegenerative    analysing    candidate    innate    phenolics    mice    dietary    phenolic    rising    provides   

Project "LIMBo" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE NOVA DE LISBOA 

Organization address
address: CAMPUS DE CAMPOLIDE
city: LISBOA
postcode: 1099 085
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 1˙496˙022 €
 EC max contribution 1˙496˙022 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2024-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 1˙199˙697.00
2    INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA PT (OEIRAS) participant 296˙325.00

Map

 Project objective

Currently a big concern of our aging society is to efficiently delay the onset of neurodegenerative diseases which are progressively rising in incidence. The paradigm that a diet rich in the phenolics, prevalent e.g. in fruits, is beneficial to brain health has reached the public. However their mechanistic actions in brain functions remain to be seen, particularly since the nature of those acting in the brain remains overlooked. I wish to address this gap by identifying candidate compounds that can support development of effective strategies to delay neurodegeneration.

Specifically, I will be analysing the potential of dietary phenolics in both prevention and treatment (i.e delay) of neuroinflammation – key process shared in neurodegenerative diseases. To break down the current indeterminate status of “cause vs effect”, my vision is to focus my research on metabolites derived from dietary phenolics that reach the brain. I will be investigating their effects in both established and unknown response pathways of microglia cells - the innate immune cells of the central nervous system, either alone or when communicating with other brain cells. Ultimately, to attain an integrated view of their effects I will establish nutrition trials in mice. LIMBo considers both pro- and anti- inflammatory processes to preliminary validate the action of any promising metabolite in prevention and/or therapeutics.

LIMBo provides valuable scientific insights for future implementation of healthy brain diets. My group is in a unique position to address LIMBo objectives due to multidisciplinary expertise in organic synthesis, metabolomics and molecular and cellular biology, together with our previous data on novel neuroactive metabolites.

LIMBo also creates far-reaching opportunities by generating knowledge that impacts our fundamental understanding on the diversity of phenolic metabolites and their specific influences in neuroinflammation and potential use as prodrugs.

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The information about "LIMBO" are provided by the European Opendata Portal: CORDIS opendata.

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