Opendata, web and dolomites


Zooming the link between diet and brain health: how phenolic metabolites modulate brain inflammation

Total Cost €


EC-Contrib. €






 LIMBo project word cloud

Explore the words cloud of the LIMBo project. It provides you a very rough idea of what is the project "LIMBo" about.

onset    aging    fruits    incidence    status    cellular    communicating    actions    phenolic    delay    big    molecular    multidisciplinary    preliminary    expertise    progressively    prevention    neurodegenerative    indeterminate    analysing    reached    gap    treatment    generating    health    innate    vs    shared    wish    metabolite    dietary    mechanistic    valuable    pro    metabolites    insights    limbo    acting    impacts    action    inflammatory    creates    attain    therapeutics    immune    diversity    organic    candidate    view    diets    rising    break    brain    alone    position    biology    neuroactive    central    provides    vision    public    prevalent    paradigm    microglia    mice    beneficial    neuroinflammation    diet    cells    healthy    synthesis    ultimately    strategies    anti    nature    prodrugs    nutrition    trials    diseases    metabolomics    currently    overlooked    data    functions    reaching    phenolics    effect    group    fundamental    neurodegeneration    society    validate    either    nervous    influences    compounds    unknown    scientific   

Project "LIMBo" data sheet

The following table provides information about the project.


Organization address
city: LISBOA
postcode: 1099 085
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 1˙496˙022 €
 EC max contribution 1˙496˙022 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2024-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 1˙199˙697.00


 Project objective

Currently a big concern of our aging society is to efficiently delay the onset of neurodegenerative diseases which are progressively rising in incidence. The paradigm that a diet rich in the phenolics, prevalent e.g. in fruits, is beneficial to brain health has reached the public. However their mechanistic actions in brain functions remain to be seen, particularly since the nature of those acting in the brain remains overlooked. I wish to address this gap by identifying candidate compounds that can support development of effective strategies to delay neurodegeneration.

Specifically, I will be analysing the potential of dietary phenolics in both prevention and treatment (i.e delay) of neuroinflammation – key process shared in neurodegenerative diseases. To break down the current indeterminate status of “cause vs effect”, my vision is to focus my research on metabolites derived from dietary phenolics that reach the brain. I will be investigating their effects in both established and unknown response pathways of microglia cells - the innate immune cells of the central nervous system, either alone or when communicating with other brain cells. Ultimately, to attain an integrated view of their effects I will establish nutrition trials in mice. LIMBo considers both pro- and anti- inflammatory processes to preliminary validate the action of any promising metabolite in prevention and/or therapeutics.

LIMBo provides valuable scientific insights for future implementation of healthy brain diets. My group is in a unique position to address LIMBo objectives due to multidisciplinary expertise in organic synthesis, metabolomics and molecular and cellular biology, together with our previous data on novel neuroactive metabolites.

LIMBo also creates far-reaching opportunities by generating knowledge that impacts our fundamental understanding on the diversity of phenolic metabolites and their specific influences in neuroinflammation and potential use as prodrugs.

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The information about "LIMBO" are provided by the European Opendata Portal: CORDIS opendata.

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