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TopSpec SIGNED

Next generation precision antibody profiling - from science fiction to reality

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

TopSpec project word cloud

Explore the words cloud of the TopSpec project. It provides you a very rough idea of what is the project "TopSpec" about.

disease therapeutics generation dramatically industrial ultimately reactions opening create collisional clinical cures ion defense ms separation solving ions purpose breaking biggest respective medicine sections itself human breakthrough mystery platform tandem analyze ground exactly isotopic form limiting knowing innovation invasions killer therapeutic resolution ultrahigh clusters convolution spectrometry greatest fragment truly modern medical antibodies natural academic world antibody repertoire dreamt proteomics overlapping parallel adding defends gas topspec drug atom radical massively de molecules organism first cross mass line dimension personalized hyphenated sequence sophisticated protein antigens electron simplify spectra immune understand one formidable diseases revolutionize

Project "TopSpec" data sheet

The following table provides information about the project.

Coordinator	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Total cost	3˙991˙500 €
EC max contribution	3˙991˙500 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-2018-2019-2020-01
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	989˙500.00
2	FASMATECH EPISTIMONIKI KAI TECHNOLOGIKI ANONYMI ETAIREIA FASMATECH EPISTIMONIKI KAI TECHNOLOGIKI ANONYMI ETAIREIA Organization address address: 28TH KLM ATHINA LAMIA NATIONAL ROAD city: AFIDNES ATTIKIS postcode: 19014 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (AFIDNES ATTIKIS)	participant	860˙500.00
3	THERMO FISHER SCIENTIFIC (BREMEN) GMBH THERMO FISHER SCIENTIFIC (BREMEN) GMBH Organization address address: HANNA KUNATH STRASSE 11 city: BREMEN postcode: 28199 website: www.thermofisher.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BREMEN)	participant	695˙500.00
4	SPECTROSWISS SARL SPECTROSWISS SARL Organization address address: EPFL INNOVATION PARK BUILDING I city: LAUSANNE postcode: 1015 website: www.spectroswiss.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	430˙500.00
5	BIOMOTIF AB BIOMOTIF AB Organization address address: WANNING KOMETVAGEN 17 city: STOCKHOLM postcode: 18348 website: www.biomotif.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	325˙000.00
6	THE NOTTINGHAM TRENT UNIVERSITY THE NOTTINGHAM TRENT UNIVERSITY Organization address address: 50 SHAKESPEARE STREET city: NOTTINGHAM postcode: NG1 4FQ website: www.ntu.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NOTTINGHAM)	participant	306˙500.00
7	INSTITUT PASTEUR INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 15)	participant	278˙500.00
8	SPECTROMETRY VISION BV SPECTROMETRY VISION BV Organization address address: TELEVISIEWEG 40 city: ALMERE postcode: 1322 AM website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ALMERE)	participant	105˙500.00

Map

Project objective

One of the major challenges of modern medicine is to understand how the human organism defends itself against invasions and diseases. The biggest mystery is the human immune system, and understanding this ultimately requires knowledge of the sequence repertoire of human antibodies and their respective antigens. The purpose of the TopSpec project is to be the first in the world to solve this challenge, opening up opportunities in medical research and drug development that are today only dreamt about. We will create a breakthrough technology that will revolutionize academic, clinical and industrial proteomics and dramatically advance the development of new generation antibody- and protein-based therapeutics. Antibodies represent the most sophisticated line of natural defense against disease. Knowing exactly which antibodies are produced in response to a particular disease enables us not only to better understand the cause of the disease but also to provide new-generation cures in the form of personalized therapeutic antibodies. The limiting factor for this to truly be achieved is to find a way to analyze and sequence large molecules in the gas phase, and this represents a formidable challenge. The TopSpec project will develop ground-breaking TOP-down tandem mass SPECtrometry (MS/MS) approaches based on novel radical gas-phase ion-electron and ion-atom reactions, and implement them on a unique, hyphenated, ultrahigh-resolution MS platform. Another “killer innovation” is the ability to greatly simplify MS/MS spectra of large molecules by adding another dimension of separation – collisional cross-sections of fragment ions using two parallel approaches. TopSpec will be the first project to implement de-convolution of massively overlapping isotopic clusters, solving one of the greatest challenges in top-down MS of large molecules.

Deliverables

List of deliverables.
Logo and Website launch and public accessibility	Other	2020-04-02 08:54:45
IP protection strategy finalized	Other	2020-04-02 08:55:00
Draft Exploitation plan and Business strategy document	Documents, reports	2020-04-02 08:52:36
Data management plan	Open Research Data Pilot	2020-04-02 08:53:12

Take a look to the deliverables list in detail: detailed list of TopSpec deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Christoph GstÃ¶ttner, Dietmar Reusch, Markus Haberger, Irina Dragan, Peter Van Veelen, David P. A. Kilgour, Yury O. Tsybin, Yuri E. M. van der Burgt, Manfred Wuhrer, Simone Nicolardi Monitoring glycation levels of a bispecific monoclonal antibody at subunit level by ultrahigh-resolution MALDI FT-ICR mass spectrometry published pages: 1682403, ISSN: 1942-0870, DOI: 10.1080/19420862.2019.1682403	mAbs 12/1	2020-03-05

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The information about "TOPSPEC" are provided by the European Opendata Portal: CORDIS opendata.