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TopSpec SIGNED

Next generation precision antibody profiling - from science fiction to reality

Total Cost €

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EC-Contrib. €

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Partnership

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 TopSpec project word cloud

Explore the words cloud of the TopSpec project. It provides you a very rough idea of what is the project "TopSpec" about.

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Project "TopSpec" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 3˙991˙500 €
 EC max contribution 3˙991˙500 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 989˙500.00
2    FASMATECH EPISTIMONIKI KAI TECHNOLOGIKI ANONYMI ETAIREIA EL (AFIDNES ATTIKIS) participant 860˙500.00
3    THERMO FISHER SCIENTIFIC (BREMEN) GMBH DE (BREMEN) participant 695˙500.00
4    SPECTROSWISS SARL CH (LAUSANNE) participant 430˙500.00
5    BIOMOTIF AB SE (STOCKHOLM) participant 325˙000.00
6    THE NOTTINGHAM TRENT UNIVERSITY UK (NOTTINGHAM) participant 306˙500.00
7    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 278˙500.00
8    SPECTROMETRY VISION BV NL (ALMERE) participant 105˙500.00

Map

 Project objective

One of the major challenges of modern medicine is to understand how the human organism defends itself against invasions and diseases. The biggest mystery is the human immune system, and understanding this ultimately requires knowledge of the sequence repertoire of human antibodies and their respective antigens. The purpose of the TopSpec project is to be the first in the world to solve this challenge, opening up opportunities in medical research and drug development that are today only dreamt about. We will create a breakthrough technology that will revolutionize academic, clinical and industrial proteomics and dramatically advance the development of new generation antibody- and protein-based therapeutics. Antibodies represent the most sophisticated line of natural defense against disease. Knowing exactly which antibodies are produced in response to a particular disease enables us not only to better understand the cause of the disease but also to provide new-generation cures in the form of personalized therapeutic antibodies. The limiting factor for this to truly be achieved is to find a way to analyze and sequence large molecules in the gas phase, and this represents a formidable challenge. The TopSpec project will develop ground-breaking TOP-down tandem mass SPECtrometry (MS/MS) approaches based on novel radical gas-phase ion-electron and ion-atom reactions, and implement them on a unique, hyphenated, ultrahigh-resolution MS platform. Another “killer innovation” is the ability to greatly simplify MS/MS spectra of large molecules by adding another dimension of separation – collisional cross-sections of fragment ions using two parallel approaches. TopSpec will be the first project to implement de-convolution of massively overlapping isotopic clusters, solving one of the greatest challenges in top-down MS of large molecules.

 Deliverables

List of deliverables.
Logo and Website launch and public accessibility Other 2020-04-02 08:54:45
IP protection strategy finalized Other 2020-04-02 08:55:00
Draft Exploitation plan and Business strategy document Documents, reports 2020-04-02 08:52:36
Data management plan Open Research Data Pilot 2020-04-02 08:53:12

Take a look to the deliverables list in detail:  detailed list of TopSpec deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Christoph Gstöttner, Dietmar Reusch, Markus Haberger, Irina Dragan, Peter Van Veelen, David P. A. Kilgour, Yury O. Tsybin, Yuri E. M. van der Burgt, Manfred Wuhrer, Simone Nicolardi
Monitoring glycation levels of a bispecific monoclonal antibody at subunit level by ultrahigh-resolution MALDI FT-ICR mass spectrometry
published pages: 1682403, ISSN: 1942-0870, DOI: 10.1080/19420862.2019.1682403
mAbs 12/1 2020-03-05

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The information about "TOPSPEC" are provided by the European Opendata Portal: CORDIS opendata.

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