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makingtheretina SIGNED

Principles of retinal neuronal lamination from zebrafish to humans

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 makingtheretina project word cloud

Explore the words cloud of the makingtheretina project. It provides you a very rough idea of what is the project "makingtheretina" about.

integrative    cross    lamination    perform    molecular    parts    thereby    neural    despite    imaging    tissue    position    combined    unveil    explore    fill    developmental    adhesion    light    types    interdisciplinary    versus    ex    zebrafish    changing    understand    systematic    explored    principles    successful    rare    interspecies    biomechanics    ordered    disciplinary    neuronal    brain    basis    diverse    sheet    scarcely    neurons    date    inspire    expertise    generate    cell    transcriptomics    expand    retinal    vivo    efficient    extracellular    influence    brillouin    emergence    human    gap    circuit    humans    dissect    compare    migration    significance    arranged    stiffness    pattern    microscopy    retina    cues    model    similarities    employ    combination    reveal    species    initially    denominators    interactions    insights    excellent    biophysical    programs    hallmark    cellular    differential    vertebrate    wiring    dissection    organoids   

Project "makingtheretina" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO CALOUSTE GULBENKIAN 

Organization address
address: AVENIDA BERNA 45
city: LISBOA
postcode: 1000
website: www.igc.gulbenkian.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 1˙923˙750 €
 EC max contribution 1˙923˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO CALOUSTE GULBENKIAN PT (LISBOA) coordinator 1˙923˙750.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 0.00

Map

 Project objective

Neuronal lamination is a hallmark of many diverse brain areas where it is important for efficient circuit formation and neuronal wiring. Despite this significance, the cellular and tissue scale principles that ensure successful and robust lamination are not fully understood. In particular, how cell-tissue interactions and biomechanics influence neuronal lamination is only scarcely explored. To fill this gap, we will use the vertebrate retina with its five neuronal cell types arranged in a highly ordered pattern to investigate the emergence of neuronal lamination. We will initially use the zebrafish system and employ long term light sheet imaging to reveal the migration behaviour of the different retinal neurons. Based on this, transcriptomics approaches will enable the dissection of cellular pathways and extracellular cues involved in neuronal migration and overall lamination. To dissect how biomechanics influence lamination, we will use Brillouin microscopy to explore the influence of changing tissue stiffness on lamination and test the role of differential adhesion. These combined results will be the basis to expand studies to the human system and ex vivo human organoids to generate insights into human retinal development. To date, systematic studies investigating molecular pathways in combination with biophysical parameters to understand brain formation across model systems are rare. Due to our previous expertise, we are in an excellent position to perform such interdisciplinary, integrative and interspecies approach. This will unveil common denominators of retinal neuronal lamination in zebrafish, humans and human organoids and thereby reveal the similarities of retinal development in different species and how developmental programs compare in vivo versus ex vivo. In addition, while this proposal focuses on neural lamination in the retina, findings will also inspire future cross-disciplinary studies investigating neuronal lamination in other parts of the brain.

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The information about "MAKINGTHERETINA" are provided by the European Opendata Portal: CORDIS opendata.

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