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makingtheretina SIGNED

Principles of retinal neuronal lamination from zebrafish to humans

Total Cost €


EC-Contrib. €






 makingtheretina project word cloud

Explore the words cloud of the makingtheretina project. It provides you a very rough idea of what is the project "makingtheretina" about.

imaging    brain    perform    microscopy    zebrafish    integrative    denominators    interactions    stiffness    insights    ex    rare    principles    cellular    sheet    hallmark    molecular    scarcely    light    migration    generate    dissect    model    expertise    wiring    developmental    tissue    date    pattern    dissection    fill    arranged    biophysical    thereby    compare    combined    basis    adhesion    neuronal    cross    circuit    employ    interspecies    vertebrate    cell    explored    transcriptomics    disciplinary    brillouin    changing    interdisciplinary    programs    excellent    systematic    humans    expand    reveal    extracellular    human    despite    combination    similarities    species    parts    lamination    types    significance    initially    position    versus    inspire    neural    differential    ordered    organoids    biomechanics    influence    cues    successful    retina    explore    retinal    diverse    neurons    unveil    efficient    gap    vivo    understand    emergence   

Project "makingtheretina" data sheet

The following table provides information about the project.


Organization address
address: AVENIDA BERNA 45
city: LISBOA
postcode: 1000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 1˙923˙750 €
 EC max contribution 1˙923˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO CALOUSTE GULBENKIAN PT (LISBOA) coordinator 1˙923˙750.00


 Project objective

Neuronal lamination is a hallmark of many diverse brain areas where it is important for efficient circuit formation and neuronal wiring. Despite this significance, the cellular and tissue scale principles that ensure successful and robust lamination are not fully understood. In particular, how cell-tissue interactions and biomechanics influence neuronal lamination is only scarcely explored. To fill this gap, we will use the vertebrate retina with its five neuronal cell types arranged in a highly ordered pattern to investigate the emergence of neuronal lamination. We will initially use the zebrafish system and employ long term light sheet imaging to reveal the migration behaviour of the different retinal neurons. Based on this, transcriptomics approaches will enable the dissection of cellular pathways and extracellular cues involved in neuronal migration and overall lamination. To dissect how biomechanics influence lamination, we will use Brillouin microscopy to explore the influence of changing tissue stiffness on lamination and test the role of differential adhesion. These combined results will be the basis to expand studies to the human system and ex vivo human organoids to generate insights into human retinal development. To date, systematic studies investigating molecular pathways in combination with biophysical parameters to understand brain formation across model systems are rare. Due to our previous expertise, we are in an excellent position to perform such interdisciplinary, integrative and interspecies approach. This will unveil common denominators of retinal neuronal lamination in zebrafish, humans and human organoids and thereby reveal the similarities of retinal development in different species and how developmental programs compare in vivo versus ex vivo. In addition, while this proposal focuses on neural lamination in the retina, findings will also inspire future cross-disciplinary studies investigating neuronal lamination in other parts of the brain.

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The information about "MAKINGTHERETINA" are provided by the European Opendata Portal: CORDIS opendata.

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