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makingtheretina SIGNED

Principles of retinal neuronal lamination from zebrafish to humans

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 makingtheretina project word cloud

Explore the words cloud of the makingtheretina project. It provides you a very rough idea of what is the project "makingtheretina" about.

expand    principles    reveal    despite    neuronal    interdisciplinary    neurons    retina    dissection    vivo    inspire    significance    stiffness    dissect    similarities    disciplinary    cues    transcriptomics    differential    expertise    adhesion    compare    types    imaging    ordered    interactions    thereby    basis    model    date    species    generate    employ    cross    ex    versus    zebrafish    denominators    systematic    explored    explore    pattern    programs    parts    humans    rare    insights    biomechanics    wiring    brillouin    combined    circuit    combination    developmental    light    vertebrate    position    molecular    influence    diverse    gap    migration    unveil    biophysical    retinal    successful    brain    hallmark    initially    excellent    neural    efficient    arranged    emergence    cellular    cell    perform    organoids    tissue    changing    sheet    scarcely    integrative    microscopy    understand    human    extracellular    lamination    fill    interspecies   

Project "makingtheretina" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO CALOUSTE GULBENKIAN 

Organization address
address: AVENIDA BERNA 45
city: LISBOA
postcode: 1000
website: www.igc.gulbenkian.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 1˙923˙750 €
 EC max contribution 1˙923˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO CALOUSTE GULBENKIAN PT (LISBOA) coordinator 1˙923˙750.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 0.00

Map

 Project objective

Neuronal lamination is a hallmark of many diverse brain areas where it is important for efficient circuit formation and neuronal wiring. Despite this significance, the cellular and tissue scale principles that ensure successful and robust lamination are not fully understood. In particular, how cell-tissue interactions and biomechanics influence neuronal lamination is only scarcely explored. To fill this gap, we will use the vertebrate retina with its five neuronal cell types arranged in a highly ordered pattern to investigate the emergence of neuronal lamination. We will initially use the zebrafish system and employ long term light sheet imaging to reveal the migration behaviour of the different retinal neurons. Based on this, transcriptomics approaches will enable the dissection of cellular pathways and extracellular cues involved in neuronal migration and overall lamination. To dissect how biomechanics influence lamination, we will use Brillouin microscopy to explore the influence of changing tissue stiffness on lamination and test the role of differential adhesion. These combined results will be the basis to expand studies to the human system and ex vivo human organoids to generate insights into human retinal development. To date, systematic studies investigating molecular pathways in combination with biophysical parameters to understand brain formation across model systems are rare. Due to our previous expertise, we are in an excellent position to perform such interdisciplinary, integrative and interspecies approach. This will unveil common denominators of retinal neuronal lamination in zebrafish, humans and human organoids and thereby reveal the similarities of retinal development in different species and how developmental programs compare in vivo versus ex vivo. In addition, while this proposal focuses on neural lamination in the retina, findings will also inspire future cross-disciplinary studies investigating neuronal lamination in other parts of the brain.

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The information about "MAKINGTHERETINA" are provided by the European Opendata Portal: CORDIS opendata.

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