Opendata, web and dolomites

ADIMMUNE SIGNED

Decoding interactions between adipose tissue immune cells, metabolic function, and the intestinal microbiome in obesity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ADIMMUNE project word cloud

Explore the words cloud of the ADIMMUNE project. It provides you a very rough idea of what is the project "ADIMMUNE" about.

explore    principles    wat    co    shapes    disease    cells    gut    interrogation    elusive    genomic    likewise    white    mediated    cues    suggested    generate    etiology    adipose    bacterial    microbiota    species    decipher    vivo    critical    homeostasis    regulation    governing    unknown    hundreds    molecular    integrative    organismal    cell    inflammation    regulatory    crosstalk    conceptual    complications    microbial    newly    amenability    entirely    metabolic    personalized    unraveling    host    resident    leap    culturomics    global    individuals    expanding    environmental    metabolites    tools    integrate    immune    mechanisms    microbiome    tissue    therapy    models    millions    worldwide    landscape    pandemic    single    diet    mouse    networks    morbidities    syndrome    platform    lacking    communication    function    gene    circuits    mediators    pathogenesis    concomitantly    influence    hematopoietic    obesity    physiology    decode    genetic    throughput    regulator    crispr    highlighted    contributions    gnotobiotic    interactions    metabolism    interaction    causes   

Project "ADIMMUNE" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙000˙000.00

Map

 Project objective

Obesity and its metabolic co-morbidities have given rise to a rapidly expanding ‘metabolic syndrome’ pandemic affecting hundreds of millions of individuals worldwide. The integrative genetic and environmental causes of the obesity pandemic remain elusive. White adipose tissue (WAT)-resident immune cells have recently been highlighted as important factors contributing to metabolic complications. However, a comprehensive understanding of the regulatory circuits governing their function and the cell type-specific mechanisms by which they contribute to the development of metabolic syndrome is lacking. Likewise, the gut microbiome has been suggested as a critical regulator of obesity, but the bacterial species and metabolites that influence WAT inflammation are entirely unknown. We propose to use our recently developed high-throughput genomic and gnotobiotic tools, integrated with CRISPR-mediated interrogation of gene function, microbial culturomics, and in-vivo metabolic analysis in newly generated mouse models, in order to achieve a new level of molecular understanding of how WAT immune cells integrate environmental cues into their crosstalk with organismal metabolism, and to explore the microbial contributions to the molecular etiology of WAT inflammation in the pathogenesis of diet-induced obesity. Specifically, we aim to (a) decipher the global regulatory landscape and interaction networks of WAT hematopoietic cells at the single-cell level, (b) identify new mediators of WAT immune cell contributions to metabolic homeostasis, and (c) decode how host-microbiome communication shapes the development of WAT inflammation and obesity. Unraveling the principles of WAT immune cell regulation and their amenability to change by host-microbiota interactions may lead to a conceptual leap forward in our understanding of metabolic physiology and disease. Concomitantly, it may generate a platform for microbiome-based personalized therapy against obesity and its complications.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ADIMMUNE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ADIMMUNE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ENUF (2019)

Evaluation of Novel Ultra-Fast selective III-V Epitaxy

Read More  

PonD (2019)

Particles-on-Demand for Multiscale Fluid Dynamics

Read More  

REAL (2019)

Rights and Egalitarianism

Read More