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ADIMMUNE SIGNED

Decoding interactions between adipose tissue immune cells, metabolic function, and the intestinal microbiome in obesity

Total Cost €

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EC-Contrib. €

0

Partnership

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 ADIMMUNE project word cloud

Explore the words cloud of the ADIMMUNE project. It provides you a very rough idea of what is the project "ADIMMUNE" about.

therapy    tools    throughput    gut    influence    hematopoietic    crosstalk    newly    species    etiology    single    models    networks    conceptual    concomitantly    mediators    wat    interaction    mediated    organismal    amenability    adipose    hundreds    entirely    regulator    metabolic    pandemic    cell    lacking    microbiota    individuals    vivo    white    contributions    expanding    diet    co    function    interrogation    likewise    microbiome    physiology    worldwide    circuits    interactions    highlighted    obesity    inflammation    gene    microbial    leap    homeostasis    mechanisms    shapes    unknown    communication    global    millions    regulatory    principles    integrate    morbidities    integrative    explore    cues    critical    mouse    complications    culturomics    cells    elusive    syndrome    host    unraveling    suggested    molecular    bacterial    gnotobiotic    resident    landscape    environmental    pathogenesis    metabolites    platform    tissue    genetic    decipher    disease    governing    decode    crispr    immune    causes    genomic    generate    personalized    regulation    metabolism   

Project "ADIMMUNE" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙000˙000.00

Map

 Project objective

Obesity and its metabolic co-morbidities have given rise to a rapidly expanding ‘metabolic syndrome’ pandemic affecting hundreds of millions of individuals worldwide. The integrative genetic and environmental causes of the obesity pandemic remain elusive. White adipose tissue (WAT)-resident immune cells have recently been highlighted as important factors contributing to metabolic complications. However, a comprehensive understanding of the regulatory circuits governing their function and the cell type-specific mechanisms by which they contribute to the development of metabolic syndrome is lacking. Likewise, the gut microbiome has been suggested as a critical regulator of obesity, but the bacterial species and metabolites that influence WAT inflammation are entirely unknown. We propose to use our recently developed high-throughput genomic and gnotobiotic tools, integrated with CRISPR-mediated interrogation of gene function, microbial culturomics, and in-vivo metabolic analysis in newly generated mouse models, in order to achieve a new level of molecular understanding of how WAT immune cells integrate environmental cues into their crosstalk with organismal metabolism, and to explore the microbial contributions to the molecular etiology of WAT inflammation in the pathogenesis of diet-induced obesity. Specifically, we aim to (a) decipher the global regulatory landscape and interaction networks of WAT hematopoietic cells at the single-cell level, (b) identify new mediators of WAT immune cell contributions to metabolic homeostasis, and (c) decode how host-microbiome communication shapes the development of WAT inflammation and obesity. Unraveling the principles of WAT immune cell regulation and their amenability to change by host-microbiota interactions may lead to a conceptual leap forward in our understanding of metabolic physiology and disease. Concomitantly, it may generate a platform for microbiome-based personalized therapy against obesity and its complications.

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The information about "ADIMMUNE" are provided by the European Opendata Portal: CORDIS opendata.

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