Opendata, web and dolomites

ADIMMUNE SIGNED

Decoding interactions between adipose tissue immune cells, metabolic function, and the intestinal microbiome in obesity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ADIMMUNE project word cloud

Explore the words cloud of the ADIMMUNE project. It provides you a very rough idea of what is the project "ADIMMUNE" about.

obesity    platform    immune    entirely    microbiota    homeostasis    metabolism    complications    microbiome    personalized    single    crispr    cell    amenability    decode    governing    integrative    influence    concomitantly    organismal    mediated    millions    interrogation    leap    principles    function    species    regulation    global    suggested    expanding    inflammation    unraveling    elusive    metabolic    syndrome    newly    hundreds    tissue    crosstalk    regulatory    landscape    interaction    gene    diet    environmental    decipher    integrate    individuals    pandemic    mechanisms    gut    microbial    molecular    co    causes    culturomics    mediators    etiology    circuits    host    throughput    tools    models    networks    vivo    physiology    worldwide    white    critical    contributions    disease    highlighted    cues    mouse    shapes    cells    communication    conceptual    pathogenesis    hematopoietic    lacking    morbidities    generate    metabolites    likewise    unknown    adipose    bacterial    genetic    interactions    genomic    regulator    wat    therapy    gnotobiotic    resident    explore   

Project "ADIMMUNE" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙000˙000.00

Map

 Project objective

Obesity and its metabolic co-morbidities have given rise to a rapidly expanding ‘metabolic syndrome’ pandemic affecting hundreds of millions of individuals worldwide. The integrative genetic and environmental causes of the obesity pandemic remain elusive. White adipose tissue (WAT)-resident immune cells have recently been highlighted as important factors contributing to metabolic complications. However, a comprehensive understanding of the regulatory circuits governing their function and the cell type-specific mechanisms by which they contribute to the development of metabolic syndrome is lacking. Likewise, the gut microbiome has been suggested as a critical regulator of obesity, but the bacterial species and metabolites that influence WAT inflammation are entirely unknown. We propose to use our recently developed high-throughput genomic and gnotobiotic tools, integrated with CRISPR-mediated interrogation of gene function, microbial culturomics, and in-vivo metabolic analysis in newly generated mouse models, in order to achieve a new level of molecular understanding of how WAT immune cells integrate environmental cues into their crosstalk with organismal metabolism, and to explore the microbial contributions to the molecular etiology of WAT inflammation in the pathogenesis of diet-induced obesity. Specifically, we aim to (a) decipher the global regulatory landscape and interaction networks of WAT hematopoietic cells at the single-cell level, (b) identify new mediators of WAT immune cell contributions to metabolic homeostasis, and (c) decode how host-microbiome communication shapes the development of WAT inflammation and obesity. Unraveling the principles of WAT immune cell regulation and their amenability to change by host-microbiota interactions may lead to a conceptual leap forward in our understanding of metabolic physiology and disease. Concomitantly, it may generate a platform for microbiome-based personalized therapy against obesity and its complications.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ADIMMUNE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ADIMMUNE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

EXTREME (2020)

The Epistemology and Ethics of Fundamentalism

Read More  

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

HyperCube (2020)

HyperCube: Gram scale production of ferrite nanocubes and thermo-responsive polymer coated nanocubes for medical applications and further exploitation in other hyperthermia fields

Read More