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ADIMMUNE SIGNED

Decoding interactions between adipose tissue immune cells, metabolic function, and the intestinal microbiome in obesity

Total Cost €

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EC-Contrib. €

0

Partnership

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 ADIMMUNE project word cloud

Explore the words cloud of the ADIMMUNE project. It provides you a very rough idea of what is the project "ADIMMUNE" about.

microbiota    cues    contributions    generate    suggested    worldwide    amenability    host    inflammation    mechanisms    interaction    critical    etiology    disease    gut    crosstalk    expanding    resident    pathogenesis    likewise    regulatory    concomitantly    tools    interactions    environmental    syndrome    culturomics    conceptual    newly    hundreds    vivo    landscape    principles    governing    decipher    diet    immune    millions    mouse    bacterial    communication    leap    species    therapy    interrogation    gnotobiotic    molecular    wat    platform    obesity    mediated    explore    metabolism    pandemic    mediators    homeostasis    regulator    organismal    unraveling    tissue    individuals    crispr    global    elusive    models    networks    adipose    microbiome    decode    regulation    causes    personalized    microbial    hematopoietic    physiology    lacking    metabolites    circuits    influence    co    morbidities    integrate    gene    unknown    complications    genetic    throughput    single    white    cell    metabolic    highlighted    genomic    function    cells    entirely    shapes    integrative   

Project "ADIMMUNE" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙000˙000.00

Map

 Project objective

Obesity and its metabolic co-morbidities have given rise to a rapidly expanding ‘metabolic syndrome’ pandemic affecting hundreds of millions of individuals worldwide. The integrative genetic and environmental causes of the obesity pandemic remain elusive. White adipose tissue (WAT)-resident immune cells have recently been highlighted as important factors contributing to metabolic complications. However, a comprehensive understanding of the regulatory circuits governing their function and the cell type-specific mechanisms by which they contribute to the development of metabolic syndrome is lacking. Likewise, the gut microbiome has been suggested as a critical regulator of obesity, but the bacterial species and metabolites that influence WAT inflammation are entirely unknown. We propose to use our recently developed high-throughput genomic and gnotobiotic tools, integrated with CRISPR-mediated interrogation of gene function, microbial culturomics, and in-vivo metabolic analysis in newly generated mouse models, in order to achieve a new level of molecular understanding of how WAT immune cells integrate environmental cues into their crosstalk with organismal metabolism, and to explore the microbial contributions to the molecular etiology of WAT inflammation in the pathogenesis of diet-induced obesity. Specifically, we aim to (a) decipher the global regulatory landscape and interaction networks of WAT hematopoietic cells at the single-cell level, (b) identify new mediators of WAT immune cell contributions to metabolic homeostasis, and (c) decode how host-microbiome communication shapes the development of WAT inflammation and obesity. Unraveling the principles of WAT immune cell regulation and their amenability to change by host-microbiota interactions may lead to a conceptual leap forward in our understanding of metabolic physiology and disease. Concomitantly, it may generate a platform for microbiome-based personalized therapy against obesity and its complications.

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The information about "ADIMMUNE" are provided by the European Opendata Portal: CORDIS opendata.

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