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ADIMMUNE SIGNED

Decoding interactions between adipose tissue immune cells, metabolic function, and the intestinal microbiome in obesity

Total Cost €

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EC-Contrib. €

0

Partnership

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 ADIMMUNE project word cloud

Explore the words cloud of the ADIMMUNE project. It provides you a very rough idea of what is the project "ADIMMUNE" about.

physiology    environmental    tissue    resident    individuals    personalized    shapes    models    interrogation    regulation    communication    complications    homeostasis    interactions    throughput    landscape    mechanisms    decipher    suggested    critical    explore    function    generate    causes    mediators    co    gnotobiotic    principles    organismal    culturomics    hematopoietic    vivo    integrative    single    concomitantly    morbidities    platform    crosstalk    disease    microbiome    regulatory    unknown    obesity    mediated    cells    etiology    species    metabolic    contributions    mouse    influence    highlighted    gut    lacking    global    therapy    inflammation    integrate    worldwide    entirely    metabolism    immune    metabolites    genomic    white    adipose    newly    crispr    networks    likewise    interaction    millions    cell    amenability    wat    pathogenesis    tools    conceptual    syndrome    host    decode    elusive    genetic    gene    molecular    hundreds    unraveling    bacterial    circuits    microbial    pandemic    microbiota    governing    diet    expanding    regulator    leap    cues   

Project "ADIMMUNE" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙000˙000.00

Map

 Project objective

Obesity and its metabolic co-morbidities have given rise to a rapidly expanding ‘metabolic syndrome’ pandemic affecting hundreds of millions of individuals worldwide. The integrative genetic and environmental causes of the obesity pandemic remain elusive. White adipose tissue (WAT)-resident immune cells have recently been highlighted as important factors contributing to metabolic complications. However, a comprehensive understanding of the regulatory circuits governing their function and the cell type-specific mechanisms by which they contribute to the development of metabolic syndrome is lacking. Likewise, the gut microbiome has been suggested as a critical regulator of obesity, but the bacterial species and metabolites that influence WAT inflammation are entirely unknown. We propose to use our recently developed high-throughput genomic and gnotobiotic tools, integrated with CRISPR-mediated interrogation of gene function, microbial culturomics, and in-vivo metabolic analysis in newly generated mouse models, in order to achieve a new level of molecular understanding of how WAT immune cells integrate environmental cues into their crosstalk with organismal metabolism, and to explore the microbial contributions to the molecular etiology of WAT inflammation in the pathogenesis of diet-induced obesity. Specifically, we aim to (a) decipher the global regulatory landscape and interaction networks of WAT hematopoietic cells at the single-cell level, (b) identify new mediators of WAT immune cell contributions to metabolic homeostasis, and (c) decode how host-microbiome communication shapes the development of WAT inflammation and obesity. Unraveling the principles of WAT immune cell regulation and their amenability to change by host-microbiota interactions may lead to a conceptual leap forward in our understanding of metabolic physiology and disease. Concomitantly, it may generate a platform for microbiome-based personalized therapy against obesity and its complications.

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The information about "ADIMMUNE" are provided by the European Opendata Portal: CORDIS opendata.

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