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EpiRIME SIGNED

Epigenetic Reprogramming, Inheritance and Memory: Dissect epigenetic transitions at fertilisation and early embryogenesis

Total Cost €

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EC-Contrib. €

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Partnership

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 EpiRIME project word cloud

Explore the words cloud of the EpiRIME project. It provides you a very rough idea of what is the project "EpiRIME" about.

contributions    transitions    first    de    epigenetically    principles    condensation    newly    resolved    contrast    al    types    histone    gamete    mechanism    investigations    insights    essentially    zenk    generating    reorganisation    inheritance    constitutive    et    suggests    adding    life    during    reprogram    vivo    reprogrammed    fundamental    h3k27me3    reprogramming    mechanisms    unknown    epigenome    science    nevertheless    germ    zygote    erased    ultimately    examine    formed    generation    undergo    convey    reveal    cells    dissect    regenerative    proteins    chromatin    discovered    totipotent    nature    heterochromatin    gametes    genetically    2017    offspring    transcriptional    novo    cell    sperm    establishment    unravel    parental    profound    transmit    epigenetic    modification    underlying    zygotic    suggesting    gametogenesis    totipotency    dogma    adult    fertilization    shutdown    organism    medicine    drosophila    dna    paternal    critically    reproductive    maternal    give    germline   

Project "EpiRIME" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙500 €
 EC max contribution 1˙997˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2024-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙997˙500.00

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 Project objective

During gametogenesis, germ cells undergo profound chromatin reorganisation, condensation and transcriptional shutdown. Upon fertilization, gamete chromatin is epigenetically reprogrammed, generating a totipotent zygote that can give rise to all cell types of the adult organism. The maternal factors that reprogram gametes to totipotency are unknown. The current dogma suggests that the parental epigenetic information must be erased in order to establish totipotency. In contrast, we have recently discovered that maternal gametes transmit the epigenetic H3K27me3 histone modification to the next generation (Zenk et al., Science, 2017) adding to increasing evidence suggesting that gametes convey more than just DNA to the offspring. Nevertheless, the underlying mechanisms and the impact of epigenetic inheritance through the gametes are not yet fully resolved. Critically, the mechanisms and impact of (i) paternal gamete reprogramming, (ii) paternal epigenetic inheritance and (iii) de novo establishment of the zygotic epigenome remain essentially unknown. The objective of this proposal is to unravel the fundamental principles underlying these three major epigenetic transitions in vivo in Drosophila. We will achieve our objective via three aims: (i) We will investigate the mechanisms underlying the reprogramming of sperm chromatin at fertilization. Specifically, we will determine the nature and extent of the contributions of two proteins essential for sperm chromatin reprogramming (ii) We will examine the mechanism of histone H3K27me3 inheritance through the paternal germline (iii) We will genetically dissect the de novo establishment of constitutive heterochromatin in the newly formed zygote. Our investigations of these epigenetic transitions are expected to reveal novel insights into the first steps in the formation of life, and to ultimately advance reproductive and regenerative medicine.

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