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PRIMOGAIA SIGNED

Prepolarized MRI at Earth Field to seek new contrasts linked to molecular events for very early detection of pathologies

Total Cost €

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EC-Contrib. €

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Partnership

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 PRIMOGAIA project word cloud

Explore the words cloud of the PRIMOGAIA project. It provides you a very rough idea of what is the project "PRIMOGAIA" about.

marseille    sme    transition    teams    suitable    interdisciplinary    radical    enzyme    mons    surfaces    water    prodrugs    physiology    diseases    prognosis    reflect    sufficiently    vivo    containing    polarized    transferred    signal    therapeutic    lines    overhauser    irradiated    map    magnitude    torino    activation    generate    cnrs    mri    countries    frequency    aix    tissue    companies    boundaries    70mhz    precursors    developping    building    epr    detection    electron    imaging    scanners    treatment    physics    saturating    protons    designed    accomplished    nanodiamond    concentration    monitoring    molecules    reagents    university    biology    overcome    enzymatic    stelar    sequences    academics    reports    primogaia    pure    impurities    resonance    paramagnetic    nitroxyl    omri    quantify    effect    selectively    molecular    orders    earth    clinical    innovative    local    radicals    brings    expensive    opens    fraunhofer    saturation    magnetic    enhancement    absorption    human    precursor    yields    initiating    methodology    pathological    generating    bordeaux    action    probes    instrumentation    polarization   

Project "PRIMOGAIA" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 3˙387˙821 €
 EC max contribution 3˙387˙821 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 727˙883.00
2    UNIVERSITE DE MONS BE (MONS) participant 475˙750.00
3    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) participant 447˙000.00
4    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) participant 444˙466.00
5    PURE DEVICES GMBH DE (RIMPAR) participant 440˙400.00
6    UNIVERSITE D'AIX MARSEILLE FR (Marseille) participant 434˙821.00
7    STELAR SRL IT (MEDE) participant 417˙500.00

Map

 Project objective

PrimoGaia opens up a new pathway in Magnetic Resonance Imaging (MRI) by initiating the concept of in vivo “enzymatic imaging” for a better understanding of human physiology, early detection and prognosis of diseases, monitoring of therapeutic treatment. The main objective is to overcome current boundaries by making it possible to map and quantify the activity of an enzyme in a pathological tissue. It will be accomplished by building an MRI instrumentation operating at earth field in order to allow the use of 70MHz frequency for saturating the Electron Paramagnetic Resonance (EPR) transition of Nitroxyl radicals. Enzyme activity is assessed by the use of suitable probes designed to generate the radical upon action of the enzyme of interest. Upon saturation of the radical EPR resonance, polarization is transferred to the protons of the water molecules (Overhauser MRI). The enhancement factor will be high (more than two orders of magnitude). The polarized water signal thus reports on the local concentration of the radicals that reflect the enzymatic activity. 3 lines of activity will be addressed to generate the radicals of interest, namely: i) using a radical-containing molecular precursor that, upon the action of specific enzyme, yields a radical whose absorption frequency is sufficiently different to be selectively irradiated; ii) the use of paramagnetic impurities on nanodiamond surfaces to increase the OMRI effect; iii) the use of radical precursors as “prodrugs” generating a signal only after their activation. The overall methodology will be much less expensive than the current clinical scanners and will allow distribution in developping countries. PrimoGaia brings together an interdisciplinary consortium of research teams from 4 academics: Aix-Marseille University, U Mons, U Torino (reagents), CNRS Bordeaux (EPR unit, sequences, biology); Fraunhofer (Physics) and 2 companies: “Stelar” (magnetic unit) and “Pure Devices” an innovative SME (MRI instrumentation).

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The information about "PRIMOGAIA" are provided by the European Opendata Portal: CORDIS opendata.

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