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BIONICbacteria SIGNED

Integrating a novel layer of synthetic biology tools in Pseudomonas, inspired by bacterial viruses

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BIONICbacteria project word cloud

Explore the words cloud of the BIONICbacteria project. It provides you a very rough idea of what is the project "BIONICbacteria" about.

synthetic    translational    goals    source    technologies    inspired    modify    biologists    aspire    as    domesticate    solutions    payloads    tapping    expression    pioneer    building    bionicbacteria    vaccine    protein    xenogeneic    chassis    principal    billions    subvert    pseudomonas    integrating    interactions    unlimited    industry    peripheral    opt    containing    co    industrial    biotechnological    intricate    layer    encoded    post    proof    metabolism    strains    first    genetic    manipulation    nature    plug    adapt    modulators    create    dna    potentially    hosts    molecular    modern    biology    evade    tools    gene    microbiology    fermentations    modifications    concentrations    mechanisms    spms    metabolisms    bacteriophages    perspective    parts    unconventional    modules    designer    direct    proofs    rna    ways    silencing    bacteria    evolutionary    central    bacterial    circuits    host    gain    perform    stability    metabolite    phage    manner    radically    bioengineers    society    conceptual    insights   

Project "BIONICbacteria" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙998˙750 €
 EC max contribution 1˙998˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 1˙998˙750.00

Map

 Project objective

As nature’s first bioengineers, bacteriophages have evolved to modify, adapt and control their bacterial hosts through billions of years of interactions. Indeed, like modern synthetic biologists aspire to do, bacteriophages already evade bacterial silencing of their xenogeneic DNA, subvert host gene expression, and co-opt both the central and peripheral metabolisms of their hosts. Studying these key insights from a molecular systems biology perspective, inspired us to develop these evolutionary fully-adapted phage mechanisms as a next-level layer of synthetic biology tools. Thus, BIONICbacteria will provide conceptual novel synthetic biology tools that allow direct manipulation of specific protein activity, post-translational modifications, RNA stability, and metabolite concentrations.

The goal of BIONICbacteria is to pioneer an unconventional way to perform synthetic biology, tapping an unlimited source of novel phage tools genetic circuits and phage modulators. To achieve these goals, we will apply and develop state-of-the-art technologies in molecular microbiology and focus on three principal aims:

(1) To exploit new phage-encoded genetic circuits as synthetic biology parts and as intricate biotechnological chassis.

(2) To build synthetic phage modulators (SPMs) as novel payloads to directly impact the bacterial metabolism in a targeted manner.

(3) To create designer bacteria by integrating SPMs-containing circuits into bacterial strains as proof-of-concepts for applications in industrial fermentations and vaccine design.

This proposed “plug-in” approach of evolutionary-adapted synthetic modules, will allow us to domesticate Pseudomonas strains in radically new ways. By building proofs-of-concept for applications in industrial fermentations and vaccine development, we address key problem in these areas with potentially high-gain solutions for society and industry.

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The information about "BIONICBACTERIA" are provided by the European Opendata Portal: CORDIS opendata.

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