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BIONICbacteria SIGNED

Integrating a novel layer of synthetic biology tools in Pseudomonas, inspired by bacterial viruses

Total Cost €

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EC-Contrib. €

0

Partnership

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 BIONICbacteria project word cloud

Explore the words cloud of the BIONICbacteria project. It provides you a very rough idea of what is the project "BIONICbacteria" about.

nature    protein    perspective    pioneer    xenogeneic    bacteria    biologists    modifications    source    parts    direct    molecular    domesticate    microbiology    society    post    chassis    modify    building    metabolisms    synthetic    peripheral    inspired    goals    first    adapt    modules    tapping    metabolism    intricate    ways    subvert    principal    opt    proofs    industry    circuits    evade    pseudomonas    metabolite    strains    radically    create    rna    interactions    tools    gene    technologies    unlimited    proof    gain    encoded    host    industrial    insights    manipulation    plug    perform    billions    solutions    hosts    translational    mechanisms    modulators    fermentations    central    evolutionary    dna    bioengineers    biology    manner    as    concentrations    potentially    modern    vaccine    bacterial    expression    bionicbacteria    aspire    layer    integrating    conceptual    spms    containing    co    unconventional    bacteriophages    silencing    genetic    phage    payloads    designer    stability    biotechnological   

Project "BIONICbacteria" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙998˙750 €
 EC max contribution 1˙998˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 1˙998˙750.00

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 Project objective

As nature’s first bioengineers, bacteriophages have evolved to modify, adapt and control their bacterial hosts through billions of years of interactions. Indeed, like modern synthetic biologists aspire to do, bacteriophages already evade bacterial silencing of their xenogeneic DNA, subvert host gene expression, and co-opt both the central and peripheral metabolisms of their hosts. Studying these key insights from a molecular systems biology perspective, inspired us to develop these evolutionary fully-adapted phage mechanisms as a next-level layer of synthetic biology tools. Thus, BIONICbacteria will provide conceptual novel synthetic biology tools that allow direct manipulation of specific protein activity, post-translational modifications, RNA stability, and metabolite concentrations.

The goal of BIONICbacteria is to pioneer an unconventional way to perform synthetic biology, tapping an unlimited source of novel phage tools genetic circuits and phage modulators. To achieve these goals, we will apply and develop state-of-the-art technologies in molecular microbiology and focus on three principal aims:

(1) To exploit new phage-encoded genetic circuits as synthetic biology parts and as intricate biotechnological chassis.

(2) To build synthetic phage modulators (SPMs) as novel payloads to directly impact the bacterial metabolism in a targeted manner.

(3) To create designer bacteria by integrating SPMs-containing circuits into bacterial strains as proof-of-concepts for applications in industrial fermentations and vaccine design.

This proposed “plug-in” approach of evolutionary-adapted synthetic modules, will allow us to domesticate Pseudomonas strains in radically new ways. By building proofs-of-concept for applications in industrial fermentations and vaccine development, we address key problem in these areas with potentially high-gain solutions for society and industry.

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The information about "BIONICBACTERIA" are provided by the European Opendata Portal: CORDIS opendata.

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