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ReCoDE SIGNED

Reshaping cortical circuits to decrease binge eating

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ReCoDE project word cloud

Explore the words cloud of the ReCoDE project. It provides you a very rough idea of what is the project "ReCoDE" about.

cutting    combine    feeding    fiber    treatments    threefold    plasticity    circuits    cope    synapses    cortex    optogenetics    mouse    engenders    vivo    innervates    humans    optogenetic    society    gap    altered    neural    functionally    rodents    circuitry    pathologies    protocols    concurrent    rebalances    orchestrating    hypothalamus    disorders    critical    therapeutic    pfc    intake    stress    limits    pathology    lha    lateral    alters    dysfunction    network    brain    electrophysiology    prefrontal    normalizing    edge    link    tracing    multiple    binge    gain    unravel    neurobiology    moving    photometric    models    engage    restored    regulation    calcium    output    eating    diseases    hypotheses    mice    recordings    normalized    circuit    strategy    function    disruptions    obesity    limit    food    predict    sites    ravenous    urgently    prominently    maintains    combining    functional    unclear    patients    little    unknown    reorganization    cortical    hindered    region    successful   

Project "ReCoDE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙499˙966 €
 EC max contribution 1˙499˙966 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2024-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 1˙499˙966.00

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 Project objective

Obesity and eating disorders are critical problems in society. Many patients with these brain diseases cope with stress by ravenous food intake (binge eating), which engenders new stress and maintains the pathology. Evidence-based treatments for this are urgently needed, but their implementation is hindered by a knowledge gap on: (i) which stress-driven neural disruptions cause binge eating, and (ii) whether these neural circuit changes can be normalized for therapeutic gain. Studies in humans and rodents link binge eating to dysfunction of the prefrontal cortex (PFC), a brain region orchestrating the stress response. However, it is unknown how effects of stress on PFC output cause binge eating. The PFC prominently innervates the lateral hypothalamus (LHA), a region with a crucial role in managing food intake, yet little is known about the function of PFC regulation of the LHA. I predict that stress-induced binge eating requires a functional reorganization of prefrontal cortical control over lateral hypothalamus feeding circuits, and that this control can be restored to limit binge eating.

I propose a cutting-edge threefold strategy to address these hypotheses in mouse models: 1. I will unravel the make-up of PFC-LHA circuitry, combining electrophysiology, optogenetics and neural tracing. I will assess how stress functionally alters this complex network.

2. I will determine the concurrent activity at multiple sites within PFC-LHA circuitry as mice engage in stress-driven binge eating, using fiber photometric calcium recordings.

3. I will assess if normalizing stress-altered PFC-LHA synapses rebalances this circuitry in vivo and limits binge eating. For this I will combine optogenetic plasticity protocols, with fiber photometric measurements in freely moving mice.

Overall, this challenging project aims to unravel the unclear neurobiology of stress-induced binge eating. If successful, this would provide a key advance in understanding binge eating pathologies.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "RECODE" project.

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Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

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The information about "RECODE" are provided by the European Opendata Portal: CORDIS opendata.

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