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RGD-Diabetes SIGNED

Development of RGD-therapeutics for cardio-metabolic disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 RGD-Diabetes project word cloud

Explore the words cloud of the RGD-Diabetes project. It provides you a very rough idea of what is the project "RGD-Diabetes" about.

quality    profiling    throughput    contingency    sensitisation    pancreatic    small    islets    intolerance    receptors    surface    therapeutically    mediated    consistently    macrovascular    36    vitro    cardiovascular    morbidity    innovation    repair    virtual    grant    subsequently    first    people    electrostatic    blood    ectodomain    insulin    living    starting    integrin    events    library    mimics    commercially    vivo    possesses    adme    glucose    molecules    too    amelioration    cells    hence    circulating    therapeutic    cell    proof    igfbp1    interaction    bind    shape    molecule    ligands    binding    therapies    pharmaceutical    pipeline    agonists    predicted    lowering    domain    therapeutics    me    idea    alpha    anticipate    disease    discovery    beta    skeletal    progressed    commonest    mortality    diabetes    million    secretion    carry    analogues    atherosclerosis    industry    silico    igf    reduce    stimulated    matching       risk    drug    discovered    failed    hits    muscle    validate    designing    rgd    vascular    structures    screening    protein    pressure    exploited    translation    commercialisation    58    schemes   

Project "RGD-Diabetes" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 150˙000.00

Map

 Project objective

In Europe, 58 million people are living with type 2 diabetes and 36 million people are at risk of developing the condition. Macrovascular disease is the commonest cause of morbidity and mortality in type 2 diabetes, yet current diabetes therapies have failed to consistently reduce cardiovascular events. In my Starting Grant, I discovered that a circulating protein, IGF binding protein-1, possesses several favourable characteristics– including insulin sensitisation, amelioration of glucose intolerance, blood pressure lowering, reduced atherosclerosis and increased vascular repair. These effects are mediated by interaction of the protein’s RGD-domain with cell-surface α5β1 integrin receptors, which increases insulin-stimulated glucose uptake in skeletal muscle cells and glucose-stimulated insulin secretion in pancreatic islets. Hence the ‘idea’ from my Starting Grant is that RGD-integrin interaction could be exploited therapeutically in diabetes. In this Proof-of-Concept grant, we will take the first step towards commercialisation of the idea by designing and testing small molecule mimics of the RGD domain of IGFBP1 as diabetes therapeutics. Using in silico modelling based on the known structures of IGFBP1 and the α5β1 integrin ectodomain, we will design a small molecule library of commercially available potential agonists. We will carry out virtual high throughput screening of the library for molecules matching the shape and electrostatic potential of the RGD domain of IGFBP1 as predicted to bind to α5β1 integrin. As contingency, we will also identify in silico ‘me-too’ analogues of known integrin ligands. We will test the best quality hits through ADME profiling and validate therapeutic activity in vitro and in vivo. At the end of the project, we anticipate we will have identified small molecule RGD mimics which can subsequently be progressed through the drug-discovery pipeline through translation grant funding or pharmaceutical industry Open Innovation schemes.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "RGD-DIABETES" project.

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Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

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The information about "RGD-DIABETES" are provided by the European Opendata Portal: CORDIS opendata.

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