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iDysChart SIGNED

Charting key molecules and mechanisms of human immune Dysregulation

Total Cost €

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EC-Contrib. €

0

Partnership

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 iDysChart project word cloud

Explore the words cloud of the iDysChart project. It provides you a very rough idea of what is the project "iDysChart" about.

initial    discovery    modulation    elucidation    counteract    community    gene    interaction    autoinflammation    mechanisms    core    tools    screens    mapping    power    lack    erc    idyschart    strategy    imaging    entire    diseases    recognize    avenues    chemical    disease    fails    claim    resolution    first    biochemical    central    pathophysiological    latter    create    epistatic    data    causes    appreciation    autoinflammatory    disconnected    assays    dysregulation    validated    informatics    endeavor    anchor    logic    signposts    grant    preposterous    reconcile    complement    employing    mining    regulatory    once    autoimmunity    dysregulome    integration    genetic    predicting    certain    contextualization    relationships    immune    protecting    relevance    synergistic    hypothesize    identification    observations    network    monogenic    chart    goals    proteomics    human    therapeutic    autoimmune    molecular    antigen    sufficient    mount    though    onto    exists    mechanistic    satisfactory    self    accuracy    territory    universe    interplay    foreign    finite    neutralize    coalesce    fundamental    immensely    feasibility    genes   

Project "iDysChart" data sheet

The following table provides information about the project.

Coordinator
LUDWIG BOLTZMANN GESELLSCHAFT GMBH 

Organization address
address: NUSSDORFER STRASSE 64 6 STOCK
city: WIEN
postcode: 1090
website: www.lbg.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙999˙263 €
 EC max contribution 1˙999˙263 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG BOLTZMANN GESELLSCHAFT GMBH AT (WIEN) coordinator 757˙291.00
2    ST. ANNA KINDERKREBSFORSCHUNG AT (WIEN) participant 1˙241˙971.00

Map

 Project objective

The central challenge for the immune system is to efficiently recognize and neutralize foreign antigen while protecting self. If the latter fails, autoimmunity and/or autoinflammation may occur, as observed in many human diseases. Though several human genes involved in the process have been identified we still lack: i) a comprehensive appreciation of all contributing molecular pathways, ii) an understanding of the interplay and epistatic relationships among the various elements and iii) a satisfactory strategy to counteract dysregulation based on an understanding of the regulatory logic. I hypothesize that there is only a finite number of pathways involved and that it should be possible to mount a synergistic strategy to create a first chart of the entire “territory”. Key to this endeavor is the identification of sufficient elements by mapping immune dysregulation genes to “anchor” the chart onto signposts of which the human pathophysiological relevance is certain. From these signposts, contextualization and integration is achieved by interaction proteomics and network informatics mining the existing data universe, validated through biochemical and imaging tools to power an established set of immune assays. While it may be preposterous to claim feasibility with one ERC grant, I propose that once such a chart exists, even at initial low resolution, it can help reconcile disconnected observations and coalesce future work while being immensely improved in accuracy and mechanistic understanding by the entire community. iDysChart will work towards these goals by 1) identifying novel monogenic causes of autoimmune/autoinflammatory diseases, enabling elucidation of fundamental mechanisms, 2) creating a network-level understanding of molecular pathways of immune dysregulation and 3) employing chemical and genetic screens to complement human disease gene discovery in predicting the core human immune dysregulome and investigating potential avenues for therapeutic modulation.

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The information about "IDYSCHART" are provided by the European Opendata Portal: CORDIS opendata.

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