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iDysChart SIGNED

Charting key molecules and mechanisms of human immune Dysregulation

Total Cost €

0

EC-Contrib. €

0

Partnership

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 iDysChart project word cloud

Explore the words cloud of the iDysChart project. It provides you a very rough idea of what is the project "iDysChart" about.

onto    elucidation    mechanisms    fundamental    observations    mining    coalesce    counteract    integration    complement    mechanistic    latter    lack    validated    territory    assays    interaction    exists    contextualization    autoinflammation    dysregulome    monogenic    antigen    central    fails    imaging    disconnected    chart    mapping    chemical    data    finite    foreign    therapeutic    autoinflammatory    grant    appreciation    disease    community    causes    core    power    identification    universe    network    first    logic    genetic    preposterous    protecting    self    goals    proteomics    avenues    diseases    neutralize    informatics    idyschart    genes    screens    endeavor    hypothesize    epistatic    predicting    modulation    gene    mount    interplay    tools    synergistic    immune    recognize    once    employing    claim    regulatory    dysregulation    relationships    sufficient    reconcile    pathophysiological    initial    signposts    autoimmune    resolution    anchor    though    create    autoimmunity    accuracy    satisfactory    feasibility    erc    molecular    biochemical    relevance    entire    strategy    immensely    certain    discovery    human   

Project "iDysChart" data sheet

The following table provides information about the project.

Coordinator
LUDWIG BOLTZMANN GESELLSCHAFT GMBH 

Organization address
address: NUSSDORFER STRASSE 64 6 STOCK
city: WIEN
postcode: 1090
website: www.lbg.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙999˙263 €
 EC max contribution 1˙999˙263 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG BOLTZMANN GESELLSCHAFT GMBH AT (WIEN) coordinator 757˙291.00
2    ST. ANNA KINDERKREBSFORSCHUNG AT (WIEN) participant 1˙241˙971.00

Map

 Project objective

The central challenge for the immune system is to efficiently recognize and neutralize foreign antigen while protecting self. If the latter fails, autoimmunity and/or autoinflammation may occur, as observed in many human diseases. Though several human genes involved in the process have been identified we still lack: i) a comprehensive appreciation of all contributing molecular pathways, ii) an understanding of the interplay and epistatic relationships among the various elements and iii) a satisfactory strategy to counteract dysregulation based on an understanding of the regulatory logic. I hypothesize that there is only a finite number of pathways involved and that it should be possible to mount a synergistic strategy to create a first chart of the entire “territory”. Key to this endeavor is the identification of sufficient elements by mapping immune dysregulation genes to “anchor” the chart onto signposts of which the human pathophysiological relevance is certain. From these signposts, contextualization and integration is achieved by interaction proteomics and network informatics mining the existing data universe, validated through biochemical and imaging tools to power an established set of immune assays. While it may be preposterous to claim feasibility with one ERC grant, I propose that once such a chart exists, even at initial low resolution, it can help reconcile disconnected observations and coalesce future work while being immensely improved in accuracy and mechanistic understanding by the entire community. iDysChart will work towards these goals by 1) identifying novel monogenic causes of autoimmune/autoinflammatory diseases, enabling elucidation of fundamental mechanisms, 2) creating a network-level understanding of molecular pathways of immune dysregulation and 3) employing chemical and genetic screens to complement human disease gene discovery in predicting the core human immune dysregulome and investigating potential avenues for therapeutic modulation.

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The information about "IDYSCHART" are provided by the European Opendata Portal: CORDIS opendata.

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