Opendata, web and dolomites

HepEDOT SIGNED

Conductive, self-doping and biodegradable oligoEDOT-heparin biomaterial for improved electromechanical coupling, cardiac cell retention and delivery of paracrine factors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 HepEDOT project word cloud

Explore the words cloud of the HepEDOT project. It provides you a very rough idea of what is the project "HepEDOT" about.

placed    act    shield    showing    remuscularization    host    oligomer    world    translational    electrical    repair    impulses    environment    reverse    sink    post    biodegradable    implantation    materials    weeks    graft    arrhythmia    retention    cell    therapy    conductive    outcomes    academic    therapeutic    combined    cardiomyocyte    clinical    conductivity    few    cardiovascular    biological    regarding    envisaged    position    biggest    chemistry    bioelectronics    causing    vivo    myocardium    fellowship    heparin    biomaterial    injury    vitro    regardless    electromechanical    cardiac    ideally    medium    career    substantial    sufficient    bulk    medicine    consolidating    translation    overcome    tissue    infarct    collaborations    cells    expertise    loading    biomaterials    obstacles    capacity    oligoedot    models    insights    representing    prospects    synthesized    doping    protection    class    strategy    documented    interdisciplinary    sciences    regenerative    paracrine    besides    multiple    moiety    implanted    emerged    modest    fibrosis    edot    mismatched    size    self    scarce    severe   

Project "HepEDOT" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 224˙933.00

Map

 Project objective

Cell therapy has emerged as a promising therapeutic strategy for cardiac repair, showing modest cardiomyocyte protection and infarct size reduction. It is under debate whether these outcomes are due to the implanted cells or their paracrine factors, as cells are scarce within a few weeks post-implantation. Regardless, this is still not sufficient to promote cardiac remuscularization and reverse medium to severe myocardium injury and fibrosis. Improved cell retention has been achieved with a substantial bulk of implanted cells, but highly associated to graft-induced arrhythmia, representing a significant challenge for clinical translation. The present study seeks to promote cardiac remuscularization after infarct, by improving the retention of cardiac cells and their paracrine factors without causing graft-induced arrhythmia. To do so, a conductive, self-doping and biodegradable oligoEDOT-heparin biomaterial will be synthesized and studied on in vitro and in vivo cardiac infarct models. The conductive EDOT oligomer moiety is envisaged to act as an electrical sink to shield the cardiac tissue from mismatched electromechanical impulses, while heparin will facilitate cardiac cell support and loading of regenerative factors, besides its recently documented doping capacity. The results of this fellowship are expected to overcome low cell retention and graft-induced arrhythmia, two of the biggest obstacles for translation in cardiac cell therapy, but also contribute with new insights regarding conductivity in materials and biological systems, to multiple fields of materials chemistry, medicine and bioelectronics. The world-class academic environment, collaborations and combined interdisciplinary expertise in biomaterials and cardiovascular sciences make the proposed fellowship activities ideally placed for enhancing my career prospects and consolidating my host and Europe in a leading position for translational research.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HEPEDOT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HEPEDOT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

SIMIS (2020)

Strongly Interacting Mass Imbalanced Superfluid with ultracold fermions

Read More  

EPIC (2019)

Evolution of Planktonic Gastropod Calcification

Read More  

IPG_CORE (2019)

Looking for the Impersonal Core -- Impersonal Pronouns across Germanic languages

Read More