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SyLeNCe SIGNED

Synapses between Leukaemia and its Neighbouring Cells

Total Cost €

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EC-Contrib. €

0

Partnership

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 SyLeNCe project word cloud

Explore the words cloud of the SyLeNCe project. It provides you a very rough idea of what is the project "SyLeNCe" about.

question    unravel    bone    hence    survival    models    intervention    appreciate    input    vivo    complete    tri    description    exist    neoplastic    myeloid    time    vulnerabilities    assays    perhaps    limited    look    candidates    nature    primary    biology    function    mouse    revealing    marrow    vitro    flow    niches    dimensional    efficient    transcriptional    list    comprise    sequencing    stroma    layers    life    our    microenvironment    leukemia    therapeutically    tightly    disease    share    constitute    samples    fashion    first    cells    parametric    molecular    dissecting    tissue    leukaemia    candidate    reductionist    start    tumor    patients    elegant    murine    recognize    complexity    sylence    cytometry    environment    genetic    tissues    quality    stem    hope    interactions    heterotypic    experiments    ecosystem    homeostasis    proven    niche    therapeutic    single    landscape    interdisciplinary    lineage    progression    transformation    cellular    rna    validate    cell    unidirectional    aml    completion    gain    treatment    explored    gathered    acute    opportunity    human    relationships    fails    organization    map    populations   

Project "SyLeNCe" data sheet

The following table provides information about the project.

Coordinator
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA 

Organization address
address: AVENIDA DE PIO XII 55
city: PAMPLONA
postcode: 31008
website: www.cima.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA ES (PAMPLONA) coordinator 160˙932.00

Map

 Project objective

Our understanding of the different layers of organization in tissues remains limited. Stem cell niches offer a tightly controlled environment and a unique opportunity to look into this question. Reductionist approaches have been proven highly efficient dissecting the complexity of stem cell niches in a unidirectional fashion. However, this approach fails to recognize the tri-dimensional complexity of tissue organization. Hence we propose a systems biology approach based on low input and single cell RNA sequencing of bone marrow niche populations in order to establish not only the molecular landscape of cells that comprise the stem cell niche in homeostasis and disease but also the lineage relationships that may exist between cells in the stroma. Using the mouse bone marrow niche during neoplastic transformation to acute myeloid leukemia (AML), we will first unravel the cellular and molecular interactions that constitute the tumor microenvironment during disease development and progression using multi parametric flow cytometry and RNA-sequencing. Information gathered from these experiments will also provide a list of molecular candidates for therapeutic intervention in AML. We will validate those candidate cell populations and genetic pathways by means of gain and loss-of-function assays in vitro and in vivo using murine models and primary human AML samples. Completion of our interdisciplinary project will provide, for the first time a complete transcriptional and cellular map of a tissue, revealing the heterotypic interactions that define the real nature of a tissue. Perhaps then we could start to appreciate the elegant complexity of the ecosystem that the stem cell and its niche share. I hope SyLeNCe will facilitate the description of novel vulnerabilities that could be explored therapeutically for the treatment of acute myeloid leukaemia having an impact on the quality of life and long-term survival of AML patients.

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The information about "SYLENCE" are provided by the European Opendata Portal: CORDIS opendata.

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