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SyLeNCe SIGNED

Synapses between Leukaemia and its Neighbouring Cells

Total Cost €

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EC-Contrib. €

0

Partnership

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 SyLeNCe project word cloud

Explore the words cloud of the SyLeNCe project. It provides you a very rough idea of what is the project "SyLeNCe" about.

intervention    share    models    murine    tissue    molecular    leukemia    tightly    mouse    flow    layers    sequencing    explored    niche    map    dissecting    efficient    acute    parametric    candidate    question    vitro    validate    cell    unidirectional    experiments    assays    revealing    proven    candidates    heterotypic    complete    recognize    fails    interactions    human    our    dimensional    hence    unravel    quality    environment    cellular    elegant    input    organization    relationships    fashion    bone    treatment    start    populations    interdisciplinary    function    single    transformation    comprise    landscape    leukaemia    gathered    stroma    exist    nature    cytometry    lineage    neoplastic    progression    limited    cells    therapeutically    constitute    look    rna    sylence    life    marrow    samples    genetic    patients    myeloid    transcriptional    hope    list    appreciate    gain    microenvironment    completion    ecosystem    aml    tumor    reductionist    homeostasis    disease    time    primary    first    perhaps    vulnerabilities    description    complexity    opportunity    survival    tissues    vivo    tri    stem    biology    therapeutic    niches   

Project "SyLeNCe" data sheet

The following table provides information about the project.

Coordinator
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA 

Organization address
address: AVENIDA DE PIO XII 55
city: PAMPLONA
postcode: 31008
website: www.cima.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA ES (PAMPLONA) coordinator 160˙932.00

Map

 Project objective

Our understanding of the different layers of organization in tissues remains limited. Stem cell niches offer a tightly controlled environment and a unique opportunity to look into this question. Reductionist approaches have been proven highly efficient dissecting the complexity of stem cell niches in a unidirectional fashion. However, this approach fails to recognize the tri-dimensional complexity of tissue organization. Hence we propose a systems biology approach based on low input and single cell RNA sequencing of bone marrow niche populations in order to establish not only the molecular landscape of cells that comprise the stem cell niche in homeostasis and disease but also the lineage relationships that may exist between cells in the stroma. Using the mouse bone marrow niche during neoplastic transformation to acute myeloid leukemia (AML), we will first unravel the cellular and molecular interactions that constitute the tumor microenvironment during disease development and progression using multi parametric flow cytometry and RNA-sequencing. Information gathered from these experiments will also provide a list of molecular candidates for therapeutic intervention in AML. We will validate those candidate cell populations and genetic pathways by means of gain and loss-of-function assays in vitro and in vivo using murine models and primary human AML samples. Completion of our interdisciplinary project will provide, for the first time a complete transcriptional and cellular map of a tissue, revealing the heterotypic interactions that define the real nature of a tissue. Perhaps then we could start to appreciate the elegant complexity of the ecosystem that the stem cell and its niche share. I hope SyLeNCe will facilitate the description of novel vulnerabilities that could be explored therapeutically for the treatment of acute myeloid leukaemia having an impact on the quality of life and long-term survival of AML patients.

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The information about "SYLENCE" are provided by the European Opendata Portal: CORDIS opendata.

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