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SyLeNCe SIGNED

Synapses between Leukaemia and its Neighbouring Cells

Total Cost €

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EC-Contrib. €

0

Partnership

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 SyLeNCe project word cloud

Explore the words cloud of the SyLeNCe project. It provides you a very rough idea of what is the project "SyLeNCe" about.

completion    sequencing    models    our    marrow    tightly    vitro    treatment    environment    myeloid    populations    cells    dimensional    transcriptional    biology    progression    fails    assays    complete    heterotypic    complexity    primary    interdisciplinary    description    constitute    limited    bone    genetic    interactions    tumor    proven    validate    perhaps    dissecting    rna    landscape    hope    vivo    intervention    candidate    efficient    acute    samples    transformation    homeostasis    tri    recognize    look    comprise    cytometry    time    function    stroma    single    molecular    neoplastic    human    gain    vulnerabilities    therapeutic    reductionist    input    quality    lineage    hence    experiments    ecosystem    stem    gathered    question    life    cellular    parametric    niches    mouse    appreciate    relationships    layers    exist    explored    tissues    cell    aml    list    murine    flow    opportunity    patients    therapeutically    first    organization    candidates    nature    disease    unidirectional    leukemia    map    leukaemia    survival    sylence    fashion    tissue    revealing    start    unravel    microenvironment    elegant    share    niche   

Project "SyLeNCe" data sheet

The following table provides information about the project.

Coordinator
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA 

Organization address
address: AVENIDA DE PIO XII 55
city: PAMPLONA
postcode: 31008
website: www.cima.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA ES (PAMPLONA) coordinator 160˙932.00

Map

 Project objective

Our understanding of the different layers of organization in tissues remains limited. Stem cell niches offer a tightly controlled environment and a unique opportunity to look into this question. Reductionist approaches have been proven highly efficient dissecting the complexity of stem cell niches in a unidirectional fashion. However, this approach fails to recognize the tri-dimensional complexity of tissue organization. Hence we propose a systems biology approach based on low input and single cell RNA sequencing of bone marrow niche populations in order to establish not only the molecular landscape of cells that comprise the stem cell niche in homeostasis and disease but also the lineage relationships that may exist between cells in the stroma. Using the mouse bone marrow niche during neoplastic transformation to acute myeloid leukemia (AML), we will first unravel the cellular and molecular interactions that constitute the tumor microenvironment during disease development and progression using multi parametric flow cytometry and RNA-sequencing. Information gathered from these experiments will also provide a list of molecular candidates for therapeutic intervention in AML. We will validate those candidate cell populations and genetic pathways by means of gain and loss-of-function assays in vitro and in vivo using murine models and primary human AML samples. Completion of our interdisciplinary project will provide, for the first time a complete transcriptional and cellular map of a tissue, revealing the heterotypic interactions that define the real nature of a tissue. Perhaps then we could start to appreciate the elegant complexity of the ecosystem that the stem cell and its niche share. I hope SyLeNCe will facilitate the description of novel vulnerabilities that could be explored therapeutically for the treatment of acute myeloid leukaemia having an impact on the quality of life and long-term survival of AML patients.

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The information about "SYLENCE" are provided by the European Opendata Portal: CORDIS opendata.

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