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SyLeNCe SIGNED

Synapses between Leukaemia and its Neighbouring Cells

Total Cost €

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EC-Contrib. €

0

Partnership

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 SyLeNCe project word cloud

Explore the words cloud of the SyLeNCe project. It provides you a very rough idea of what is the project "SyLeNCe" about.

tumor    acute    tightly    reductionist    candidate    populations    completion    parametric    first    vitro    fashion    progression    vivo    hence    vulnerabilities    rna    relationships    comprise    therapeutic    single    recognize    bone    leukaemia    homeostasis    elegant    transformation    time    leukemia    tri    biology    transcriptional    organization    lineage    proven    quality    flow    layers    cell    nature    gathered    gain    cellular    aml    description    ecosystem    sequencing    murine    molecular    myeloid    marrow    cytometry    sylence    landscape    mouse    exist    models    revealing    dimensional    limited    start    fails    genetic    samples    cells    environment    our    unidirectional    share    dissecting    tissues    unravel    question    primary    intervention    experiments    complete    opportunity    assays    treatment    disease    stroma    constitute    niches    look    list    function    life    patients    interactions    explored    heterotypic    neoplastic    interdisciplinary    microenvironment    input    map    validate    candidates    efficient    tissue    survival    perhaps    therapeutically    human    stem    niche    hope    complexity    appreciate   

Project "SyLeNCe" data sheet

The following table provides information about the project.

Coordinator
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA 

Organization address
address: AVENIDA DE PIO XII 55
city: PAMPLONA
postcode: 31008
website: www.cima.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 160˙932 €
 EC max contribution 160˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA ES (PAMPLONA) coordinator 160˙932.00

Map

 Project objective

Our understanding of the different layers of organization in tissues remains limited. Stem cell niches offer a tightly controlled environment and a unique opportunity to look into this question. Reductionist approaches have been proven highly efficient dissecting the complexity of stem cell niches in a unidirectional fashion. However, this approach fails to recognize the tri-dimensional complexity of tissue organization. Hence we propose a systems biology approach based on low input and single cell RNA sequencing of bone marrow niche populations in order to establish not only the molecular landscape of cells that comprise the stem cell niche in homeostasis and disease but also the lineage relationships that may exist between cells in the stroma. Using the mouse bone marrow niche during neoplastic transformation to acute myeloid leukemia (AML), we will first unravel the cellular and molecular interactions that constitute the tumor microenvironment during disease development and progression using multi parametric flow cytometry and RNA-sequencing. Information gathered from these experiments will also provide a list of molecular candidates for therapeutic intervention in AML. We will validate those candidate cell populations and genetic pathways by means of gain and loss-of-function assays in vitro and in vivo using murine models and primary human AML samples. Completion of our interdisciplinary project will provide, for the first time a complete transcriptional and cellular map of a tissue, revealing the heterotypic interactions that define the real nature of a tissue. Perhaps then we could start to appreciate the elegant complexity of the ecosystem that the stem cell and its niche share. I hope SyLeNCe will facilitate the description of novel vulnerabilities that could be explored therapeutically for the treatment of acute myeloid leukaemia having an impact on the quality of life and long-term survival of AML patients.

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The information about "SYLENCE" are provided by the European Opendata Portal: CORDIS opendata.

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