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NPsVLCD SIGNED

Natural Product-Inspired Therapies for Leishmaniasis and Chagas Disease

Total Cost €

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EC-Contrib. €

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Partnership

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 NPsVLCD project word cloud

Explore the words cloud of the NPsVLCD project. It provides you a very rough idea of what is the project "NPsVLCD" about.

families    convergent    pharmacologist    limited    mode    feedback    therapies    dynamic    time    tempone    modular    largely    progress    despite    progressed    antiparasitic    parasite    identification    preclinical    leads    thereby    people    track    couple    compound    series    few    made    natural    modes    synthesis    dogma    worldwide    prof    leishmaniases    million    strategies    bioactivity    resistance    frontline    clinical    concise    overarching    12    structurally    malaria    compounds    parasitologist    chagas    leishmaniasis    suffer    parasitic    ignored       visceral    affe    expert    treatments    accessibility    action    andre    examples    contrast    compliance    central    potentially    collaborations    alkaloid    limitations    chemistry    drugs    read    artemisinin    dependent    efficiency    pharmacophores    informing    disease    therapeutic    severe    refinement    modification    additionally    critically    record    vl    urgently    kevin    pharmacokinetic    multidisciplinary    investment    evaluation    synthetic    prominent    trials    candidates    cd    amphotericin    pharmacophore    patient    exploration   

Project "NPsVLCD" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 212˙933.00

Map

 Project objective

The development of new therapies for leishmaniases (which affeThe development of new therapies for visceral leishmaniasis (affects ~12 million people worldwide) and Chagas disease (~6-7 million people worldwide) is critically dependent on the identification of novel pharmacophores with new modes of action. Current treatments suffer from severe side effects, high cost, patient compliance issues, and emerging resistance; as such, new therapeutic leads are urgently required. Despite significant investment, limited progress has been made with research into new 'synthetic' drugs: no candidates are in clinical trials (although two compounds have recently progressed to preclinical evaluation for VL). In contrast, research into natural product-derived drugs has been largely ignored, despite their track record as frontline treatments for VL (amphotericin B) and the most prominent parasitic disease, malaria (artemisinin). In this project, we challenge this dogma through the exploration of a series of structurally-related alkaloid natural product families, where highly promising antiparasitic bioactivity has been observed in the few examples studied. The selection of these families is additionally based on their accessibility through concise, modular and convergent synthetic strategies, which facilitate modification. We couple this central focus of synthetic chemistry with collaborations to evaluate bioactivity (with expert parasitologist Prof Andre Tempone), and identify pharmacokinetic/dynamic limitations (with expert pharmacologist Prof Kevin Read), thereby informing analogue refinement and synthesis. This multidisciplinary approach will greatly enhance the impact of the synthetic chemistry work by providing 'real-time' feedback into compound design, enhancing project efficiency and progress. Our overarching, long term impact objective is to identify a new pharmacophore (and potentially new parasite target / mode of action) for the potential development of VL/CD therapies.

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The information about "NPSVLCD" are provided by the European Opendata Portal: CORDIS opendata.

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