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NPsVLCD SIGNED

Natural Product-Inspired Therapies for Leishmaniasis and Chagas Disease

Total Cost €

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EC-Contrib. €

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Partnership

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 NPsVLCD project word cloud

Explore the words cloud of the NPsVLCD project. It provides you a very rough idea of what is the project "NPsVLCD" about.

urgently    clinical    compound    people    parasitic    suffer    families    therapeutic    chemistry    drugs    amphotericin    read    dynamic    overarching    artemisinin    worldwide    evaluation    parasitologist    time    progress    leads    concise    antiparasitic    examples    strategies    expert    trials    made    ignored    accessibility    visceral    limitations    alkaloid    potentially    resistance    series    12    contrast    compliance    pharmacophores    andre    feedback    vl    efficiency    candidates    compounds    few    despite    pharmacokinetic    critically    parasite    cd    mode    leishmaniasis    disease    kevin    therapies    couple    synthetic    tempone    track    limited    refinement    malaria    prominent    informing    additionally    exploration    modular    patient    synthesis    severe    convergent    identification    dependent    leishmaniases    frontline       progressed    million    record    preclinical    largely    pharmacologist    central    chagas    treatments    dogma    prof    affe    collaborations    investment    bioactivity    multidisciplinary    modification    natural    pharmacophore    action    structurally    modes    thereby   

Project "NPsVLCD" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 212˙933.00

Map

 Project objective

The development of new therapies for leishmaniases (which affeThe development of new therapies for visceral leishmaniasis (affects ~12 million people worldwide) and Chagas disease (~6-7 million people worldwide) is critically dependent on the identification of novel pharmacophores with new modes of action. Current treatments suffer from severe side effects, high cost, patient compliance issues, and emerging resistance; as such, new therapeutic leads are urgently required. Despite significant investment, limited progress has been made with research into new 'synthetic' drugs: no candidates are in clinical trials (although two compounds have recently progressed to preclinical evaluation for VL). In contrast, research into natural product-derived drugs has been largely ignored, despite their track record as frontline treatments for VL (amphotericin B) and the most prominent parasitic disease, malaria (artemisinin). In this project, we challenge this dogma through the exploration of a series of structurally-related alkaloid natural product families, where highly promising antiparasitic bioactivity has been observed in the few examples studied. The selection of these families is additionally based on their accessibility through concise, modular and convergent synthetic strategies, which facilitate modification. We couple this central focus of synthetic chemistry with collaborations to evaluate bioactivity (with expert parasitologist Prof Andre Tempone), and identify pharmacokinetic/dynamic limitations (with expert pharmacologist Prof Kevin Read), thereby informing analogue refinement and synthesis. This multidisciplinary approach will greatly enhance the impact of the synthetic chemistry work by providing 'real-time' feedback into compound design, enhancing project efficiency and progress. Our overarching, long term impact objective is to identify a new pharmacophore (and potentially new parasite target / mode of action) for the potential development of VL/CD therapies.

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