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FA x Force SIGNED

Reconstitution and Structural Analysis of a Minimal Mechanosensitive Focal Adhesion Complex

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FA x Force project word cloud

Explore the words cloud of the FA x Force project. It provides you a very rough idea of what is the project "FA x Force" about.

light    cytoskeleton    integrin    therapeutic    maturation    experiments    mechanisms    deformation    vinculin    alone    biomedical    proteins    hierarchal    individual    effect    made    environment    image    augmented    manner    receptors    yielding    structural    cytoplasmic    microscopy    though    em    cells    inside    talin    interactions    network    macromolecular    view    ligands    regulating    actomyosin    vivo    reconstruction    observation    wise    components    filaments    ecm    fa    regulation    biochemically    impacts    outside    direct    fas    adhesions    triggered    force    interact    matrix    ideal    solving    obtain    benefit    extracellular    largely    carry    resolution    couple    structurally    unknown    activation    transduction    protein    receptor    regulate    tool    dynamic    assemble    generating    actin    dependent    structure    conformational    connect    focal    signaling    complexes    functional    questions    cryo    reconstructions    recruitment    innovative    molecular    multidisciplinary    core    assembly   

Project "FA x Force" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 159˙460.00

Map

 Project objective

Focal adhesions (FAs) are receptor complexes that couple the extracellular matrix (ECM) to the actin cytoskeleton, allowing inside-out and outside-in signaling between cells and their environment. FA formation is triggered by activation of integrin receptors, which interact with cytoplasmic ligands to connect with the actin cytoskeleton and regulate numerous signaling pathways. FA maturation requires force transduction between the actin cytoskeleton and ECM, which results in protein recruitment, likely through conformational changes and force-dependent protein deformation. The molecular mechanisms regulating this process are largely unknown, though many of the key components have been identified and are well characterized in vivo. I will carry out a hierarchal reconstruction of the core FA components, namely talin, vinculin, and integrin, both alone and in the presence of actin filaments or a force-generating actomyosin network. This will allow direct observation of (1) how core components of FAs assemble and regulate each other, (2) how actin impacts the formation and structure of this core complex, and (3) the effect of force on the assembly, overall complex structure, and conformational states of individual proteins. Interactions between key proteins will be analyzed both biochemically and structurally using cryo-EM in a step-wise manner to obtain a comprehensive image of FA assembly. Recent technical advances have made cryo-EM an ideal tool for solving high-resolution reconstructions of macromolecular complexes like FAs. Structural approaches will be augmented by light microscopy experiments, to provide a dynamic view of complex assembly and regulation. By using multidisciplinary, innovative approaches, this project will address both functional and structural questions about FA assembly, yielding insight into key interactions and therapeutic targets that will directly benefit biomedical research in this field.

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