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FA x Force SIGNED

Reconstitution and Structural Analysis of a Minimal Mechanosensitive Focal Adhesion Complex

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FA x Force project word cloud

Explore the words cloud of the FA x Force project. It provides you a very rough idea of what is the project "FA x Force" about.

observation    signaling    unknown    maturation    transduction    fas    filaments    vinculin    conformational    triggered    core    focal    fa    adhesions    structural    regulation    couple    regulate    innovative    activation    manner    view    environment    impacts    molecular    carry    macromolecular    em    effect    connect    mechanisms    protein    obtain    therapeutic    recruitment    deformation    interactions    though    cells    experiments    vivo    talin    resolution    individual    extracellular    interact    biochemically    cytoplasmic    structure    force    inside    outside    generating    alone    assembly    reconstructions    reconstruction    network    ligands    complexes    regulating    microscopy    biomedical    wise    light    receptor    multidisciplinary    dependent    augmented    ideal    yielding    proteins    matrix    actomyosin    ecm    direct    cytoskeleton    solving    components    hierarchal    structurally    made    largely    image    benefit    questions    assemble    tool    actin    dynamic    functional    integrin    receptors    cryo   

Project "FA x Force" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 159˙460.00

Map

 Project objective

Focal adhesions (FAs) are receptor complexes that couple the extracellular matrix (ECM) to the actin cytoskeleton, allowing inside-out and outside-in signaling between cells and their environment. FA formation is triggered by activation of integrin receptors, which interact with cytoplasmic ligands to connect with the actin cytoskeleton and regulate numerous signaling pathways. FA maturation requires force transduction between the actin cytoskeleton and ECM, which results in protein recruitment, likely through conformational changes and force-dependent protein deformation. The molecular mechanisms regulating this process are largely unknown, though many of the key components have been identified and are well characterized in vivo. I will carry out a hierarchal reconstruction of the core FA components, namely talin, vinculin, and integrin, both alone and in the presence of actin filaments or a force-generating actomyosin network. This will allow direct observation of (1) how core components of FAs assemble and regulate each other, (2) how actin impacts the formation and structure of this core complex, and (3) the effect of force on the assembly, overall complex structure, and conformational states of individual proteins. Interactions between key proteins will be analyzed both biochemically and structurally using cryo-EM in a step-wise manner to obtain a comprehensive image of FA assembly. Recent technical advances have made cryo-EM an ideal tool for solving high-resolution reconstructions of macromolecular complexes like FAs. Structural approaches will be augmented by light microscopy experiments, to provide a dynamic view of complex assembly and regulation. By using multidisciplinary, innovative approaches, this project will address both functional and structural questions about FA assembly, yielding insight into key interactions and therapeutic targets that will directly benefit biomedical research in this field.

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The information about "FA X FORCE" are provided by the European Opendata Portal: CORDIS opendata.

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