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MutANTs SIGNED

Mutation rate evolution in attine ants

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MutANTs project word cloud

Explore the words cloud of the MutANTs project. It provides you a very rough idea of what is the project "MutANTs" about.

disciplines    stored    theories    datasets    background    ants    centre    20    professors    leafcutter    gap    attine    sizes    colony    fungi    dataset    quality    hosts    single    confounders    genome    estimates    population    evolutionary    clades    zhang    base    copenhagen    basic    hub    ant    branches    history    age    gmr    rate    obtain    outgroup    mutation    first    phylogenetic    evolution    pursued    internationally    limited    biomedical    germline    15    ecology    guojie    unclear    species    omics    interdisciplinary    biology    gt    renowned    parental    social    pressures    obligate    start    mutants    presently    farmed    tree    variation    lived    230    filling    extremely    55    jan    joint    food    phylogeny    lineage    sperm    span    gmrs    traits    jacobus    prevailing    varies    size    larger    boomsma    humans    shaped    histories    crown    predict    genomes    environmental    genus    12    fungus    reproduction    monophyletic    ca    drives    life    queens    diversified    dependence    enormously    yield    sciences    data    ideal   

Project "MutANTs" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 219˙312 €
 EC max contribution 219˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 219˙312.00

Map

 Project objective

Germline mutation rate (GMR) is a key concept in all disciplines of biology, and particularly in evolutionary biology and the biomedical sciences. GMR varies both across and within species, but what drives this variation is unclear. Theories predict that GMR variation is shaped by environmental selection pressures, by effective population sizes, and by prevailing life-history traits (across species) and parental age at reproduction (within species). However, our understanding is extremely limited because within-species GMR variation has been investigated only to some extent in humans, and larger comparative genome-level datasets in other clades have not yet been pursued. I propose to start filling this gap by studying GMR in attine fungus-growing ants and a set of outgroup. non-attine ants. The attine ants, a ca. 55 MY old monophyletic lineage, are ideal for understanding GMR variation across and within species because their basic ecology is similar (obligate dependence of farmed fungi for food) but their life-histories diversified enormously from the base to the crown of their phylogenetic tree, which presently has 15 recognized genus-level branches and >230 species. Against a background dataset of ~20 high quality genomes, I propose to obtain genome-wide GMR estimates for 12 attine ants and 7 non-attine ants while controlling for confounders of phylogeny, colony size, life-span and effective population size. In addition, I will do an in-depth analysis of a single leafcutter ant species with long-lived queens and stored sperm of the same age, where I can also control for parental age. I will implement the MutANTs project at the Centre for Social Evolution in Copenhagen, an internationally renowned research hub for interdisciplinary omics research on ants, with Professors Guojie Zhang and Jacobus Jan Boomsma as joint hosts. I expect that in the two years available MutANTs will yield the first comparative data to predict GMRs across and within species.

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