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MutANTs SIGNED

Mutation rate evolution in attine ants

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MutANTs project word cloud

Explore the words cloud of the MutANTs project. It provides you a very rough idea of what is the project "MutANTs" about.

jacobus    single    drives    leafcutter    renowned    genome    fungus    rate    guojie    span    ant    ecology    fungi    lineage    clades    reproduction    history    basic    estimates    stored    lived    ideal    queens    confounders    environmental    zhang    larger    crown    background    mutation    internationally    filling    ca    boomsma    monophyletic    gmr    life    gt    interdisciplinary    germline    biomedical    evolution    colony    hub    mutants    humans    farmed    species    genomes    dataset    outgroup    datasets    gap    pressures    quality    ants    enormously    sciences    jan    joint    theories    omics    base    yield    attine    predict    disciplines    size    presently    histories    15    branches    shaped    tree    extremely    age    varies    prevailing    variation    sizes    pursued    start    12    hosts    diversified    professors    biology    sperm    55    obtain    copenhagen    first    unclear    limited    parental    phylogenetic    20    gmrs    population    traits    phylogeny    genus    obligate    centre    data    food    dependence    evolutionary    230    social   

Project "MutANTs" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 219˙312 €
 EC max contribution 219˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 219˙312.00

Map

 Project objective

Germline mutation rate (GMR) is a key concept in all disciplines of biology, and particularly in evolutionary biology and the biomedical sciences. GMR varies both across and within species, but what drives this variation is unclear. Theories predict that GMR variation is shaped by environmental selection pressures, by effective population sizes, and by prevailing life-history traits (across species) and parental age at reproduction (within species). However, our understanding is extremely limited because within-species GMR variation has been investigated only to some extent in humans, and larger comparative genome-level datasets in other clades have not yet been pursued. I propose to start filling this gap by studying GMR in attine fungus-growing ants and a set of outgroup. non-attine ants. The attine ants, a ca. 55 MY old monophyletic lineage, are ideal for understanding GMR variation across and within species because their basic ecology is similar (obligate dependence of farmed fungi for food) but their life-histories diversified enormously from the base to the crown of their phylogenetic tree, which presently has 15 recognized genus-level branches and >230 species. Against a background dataset of ~20 high quality genomes, I propose to obtain genome-wide GMR estimates for 12 attine ants and 7 non-attine ants while controlling for confounders of phylogeny, colony size, life-span and effective population size. In addition, I will do an in-depth analysis of a single leafcutter ant species with long-lived queens and stored sperm of the same age, where I can also control for parental age. I will implement the MutANTs project at the Centre for Social Evolution in Copenhagen, an internationally renowned research hub for interdisciplinary omics research on ants, with Professors Guojie Zhang and Jacobus Jan Boomsma as joint hosts. I expect that in the two years available MutANTs will yield the first comparative data to predict GMRs across and within species.

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The information about "MUTANTS" are provided by the European Opendata Portal: CORDIS opendata.

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