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MutANTs SIGNED

Mutation rate evolution in attine ants

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MutANTs project word cloud

Explore the words cloud of the MutANTs project. It provides you a very rough idea of what is the project "MutANTs" about.

datasets    gt    diversified    genomes    presently    55    evolutionary    renowned    interdisciplinary    social    jacobus    branches    boomsma    obligate    food    professors    gmr    mutants    first    ecology    species    yield    hosts    230    prevailing    obtain    size    gap    dependence    biomedical    data    sciences    colony    histories    humans    20    history    estimates    dataset    copenhagen    background    genome    12    limited    population    joint    tree    theories    ants    genus    base    age    centre    basic    attine    larger    confounders    internationally    farmed    stored    parental    filling    crown    outgroup    unclear    sizes    drives    sperm    jan    rate    life    phylogenetic    leafcutter    gmrs    quality    disciplines    biology    queens    variation    fungus    phylogeny    evolution    single    germline    extremely    guojie    pursued    reproduction    hub    ideal    lineage    shaped    span    environmental    ca    ant    omics    15    start    enormously    clades    pressures    monophyletic    varies    mutation    fungi    traits    lived    zhang    predict   

Project "MutANTs" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 219˙312 €
 EC max contribution 219˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 219˙312.00

Map

 Project objective

Germline mutation rate (GMR) is a key concept in all disciplines of biology, and particularly in evolutionary biology and the biomedical sciences. GMR varies both across and within species, but what drives this variation is unclear. Theories predict that GMR variation is shaped by environmental selection pressures, by effective population sizes, and by prevailing life-history traits (across species) and parental age at reproduction (within species). However, our understanding is extremely limited because within-species GMR variation has been investigated only to some extent in humans, and larger comparative genome-level datasets in other clades have not yet been pursued. I propose to start filling this gap by studying GMR in attine fungus-growing ants and a set of outgroup. non-attine ants. The attine ants, a ca. 55 MY old monophyletic lineage, are ideal for understanding GMR variation across and within species because their basic ecology is similar (obligate dependence of farmed fungi for food) but their life-histories diversified enormously from the base to the crown of their phylogenetic tree, which presently has 15 recognized genus-level branches and >230 species. Against a background dataset of ~20 high quality genomes, I propose to obtain genome-wide GMR estimates for 12 attine ants and 7 non-attine ants while controlling for confounders of phylogeny, colony size, life-span and effective population size. In addition, I will do an in-depth analysis of a single leafcutter ant species with long-lived queens and stored sperm of the same age, where I can also control for parental age. I will implement the MutANTs project at the Centre for Social Evolution in Copenhagen, an internationally renowned research hub for interdisciplinary omics research on ants, with Professors Guojie Zhang and Jacobus Jan Boomsma as joint hosts. I expect that in the two years available MutANTs will yield the first comparative data to predict GMRs across and within species.

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