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MutANTs SIGNED

Mutation rate evolution in attine ants

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MutANTs project word cloud

Explore the words cloud of the MutANTs project. It provides you a very rough idea of what is the project "MutANTs" about.

histories    dataset    first    population    quality    base    boomsma    dependence    outgroup    yield    confounders    phylogenetic    parental    social    estimates    presently    prevailing    background    jacobus    obligate    55    crown    centre    genomes    obtain    enormously    gap    age    rate    ants    ideal    gt    biomedical    size    evolution    limited    span    biology    data    omics    gmr    branches    life    environmental    stored    attine    genus    shaped    ant    queens    professors    species    variation    fungi    disciplines    diversified    fungus    leafcutter    food    ecology    pursued    jan    12    interdisciplinary    predict    theories    evolutionary    genome    mutants    start    lineage    hosts    drives    history    humans    sperm    unclear    larger    hub    germline    traits    sciences    varies    guojie    230    renowned    lived    zhang    monophyletic    colony    datasets    ca    clades    farmed    20    single    mutation    pressures    copenhagen    filling    reproduction    sizes    extremely    phylogeny    internationally    basic    joint    15    gmrs    tree   

Project "MutANTs" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 219˙312 €
 EC max contribution 219˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 219˙312.00

Map

 Project objective

Germline mutation rate (GMR) is a key concept in all disciplines of biology, and particularly in evolutionary biology and the biomedical sciences. GMR varies both across and within species, but what drives this variation is unclear. Theories predict that GMR variation is shaped by environmental selection pressures, by effective population sizes, and by prevailing life-history traits (across species) and parental age at reproduction (within species). However, our understanding is extremely limited because within-species GMR variation has been investigated only to some extent in humans, and larger comparative genome-level datasets in other clades have not yet been pursued. I propose to start filling this gap by studying GMR in attine fungus-growing ants and a set of outgroup. non-attine ants. The attine ants, a ca. 55 MY old monophyletic lineage, are ideal for understanding GMR variation across and within species because their basic ecology is similar (obligate dependence of farmed fungi for food) but their life-histories diversified enormously from the base to the crown of their phylogenetic tree, which presently has 15 recognized genus-level branches and >230 species. Against a background dataset of ~20 high quality genomes, I propose to obtain genome-wide GMR estimates for 12 attine ants and 7 non-attine ants while controlling for confounders of phylogeny, colony size, life-span and effective population size. In addition, I will do an in-depth analysis of a single leafcutter ant species with long-lived queens and stored sperm of the same age, where I can also control for parental age. I will implement the MutANTs project at the Centre for Social Evolution in Copenhagen, an internationally renowned research hub for interdisciplinary omics research on ants, with Professors Guojie Zhang and Jacobus Jan Boomsma as joint hosts. I expect that in the two years available MutANTs will yield the first comparative data to predict GMRs across and within species.

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