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Mutation rate evolution in attine ants

Total Cost €


EC-Contrib. €






 MutANTs project word cloud

Explore the words cloud of the MutANTs project. It provides you a very rough idea of what is the project "MutANTs" about.

stored    social    start    history    population    attine    evolutionary    pressures    varies    55    ants    gap    yield    ant    life    predict    ca    jacobus    gmr    estimates    fungus    colony    jan    dependence    genomes    food    disciplines    reproduction    clades    enormously    pursued    environmental    farmed    traits    size    variation    branches    internationally    lived    rate    outgroup    fungi    data    base    presently    genus    drives    hosts    ecology    quality    mutation    shaped    tree    obtain    sperm    hub    unclear    gt    crown    age    prevailing    sciences    centre    230    larger    diversified    20    leafcutter    theories    renowned    biomedical    humans    limited    guojie    dataset    phylogeny    ideal    extremely    germline    interdisciplinary    filling    single    first    monophyletic    copenhagen    basic    genome    biology    histories    queens    parental    professors    span    evolution    background    datasets    12    phylogenetic    species    gmrs    sizes    zhang    15    lineage    boomsma    omics    joint    mutants    obligate    confounders   

Project "MutANTs" data sheet

The following table provides information about the project.


Organization address
address: NORREGADE 10
postcode: 1165

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 219˙312 €
 EC max contribution 219˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 219˙312.00


 Project objective

Germline mutation rate (GMR) is a key concept in all disciplines of biology, and particularly in evolutionary biology and the biomedical sciences. GMR varies both across and within species, but what drives this variation is unclear. Theories predict that GMR variation is shaped by environmental selection pressures, by effective population sizes, and by prevailing life-history traits (across species) and parental age at reproduction (within species). However, our understanding is extremely limited because within-species GMR variation has been investigated only to some extent in humans, and larger comparative genome-level datasets in other clades have not yet been pursued. I propose to start filling this gap by studying GMR in attine fungus-growing ants and a set of outgroup. non-attine ants. The attine ants, a ca. 55 MY old monophyletic lineage, are ideal for understanding GMR variation across and within species because their basic ecology is similar (obligate dependence of farmed fungi for food) but their life-histories diversified enormously from the base to the crown of their phylogenetic tree, which presently has 15 recognized genus-level branches and >230 species. Against a background dataset of ~20 high quality genomes, I propose to obtain genome-wide GMR estimates for 12 attine ants and 7 non-attine ants while controlling for confounders of phylogeny, colony size, life-span and effective population size. In addition, I will do an in-depth analysis of a single leafcutter ant species with long-lived queens and stored sperm of the same age, where I can also control for parental age. I will implement the MutANTs project at the Centre for Social Evolution in Copenhagen, an internationally renowned research hub for interdisciplinary omics research on ants, with Professors Guojie Zhang and Jacobus Jan Boomsma as joint hosts. I expect that in the two years available MutANTs will yield the first comparative data to predict GMRs across and within species.

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The information about "MUTANTS" are provided by the European Opendata Portal: CORDIS opendata.

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