Opendata, web and dolomites

ImmUne SIGNED

Towards identification of the unifying principles of vertebrate adaptive immunity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ImmUne project word cloud

Explore the words cloud of the ImmUne project. It provides you a very rough idea of what is the project "ImmUne" about.

mechanism    representing    conduct    basis    jawless    vertebrates    experiments    whereas    difficulty    immunodeficiency    jawed    lampreys    periods    aquatic    about    strategies    unifying    lineages    mediated    guiding    learned    vitro    modification    functional    context    failing    immunity    ranging    molecular    cas9    hagfishes    discrimination    receptor    functions    humans    view    sister    groups    mhc    unprecedented    nonself    cycle    time    fish    self    thymus    generation    principles    independently    hampered    crispr    discovered    antigen    assembly    methodological    life    locus    laboratory    cell    play    500    forms    stromal    striking    examine    immune    cellular    ago    identification    convergent    equivalent    site    principal    sharks    autoimmunity    fertilization    genetic    structure    components    evolution    potentially    treatment    husbandry    laying    extended    microenvironment    successful    foundations    fishes    function    lamprey    progress    adaptive    million    vertebrate    alternative    patients   

Project "ImmUne" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙498˙813 €
 EC max contribution 2˙498˙813 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 2˙498˙813.00

Map

 Project objective

About 500 million years ago, the two sister groups of vertebrates independently evolved alternative forms of adaptive immunity, representing a striking example of convergent evolution. Whereas the components and functions of the immune system in jawed vertebrates (ranging from sharks to humans) are well characterized, much remains to be learned about adaptive immunity in jawless vertebrates (lampreys and hagfishes). Up to now, progress in understanding immunity in jawless fishes was hampered by their complex life-cycle, long generation time, and the difficulty of raising fish in the laboratory for extended periods, particularly after in vitro fertilization. Based on our recent methodological advances in aquatic husbandry and successful CRISPR/Cas9-mediated genetic modification, we propose to conduct a large-scale analysis of cellular immunity in lampreys laying the foundations for the identification of the unifying principles of vertebrate immunity. Our experiments will address the development and characteristics of different T cell subsets, the molecular basis of antigen receptor assembly, and the function of the two principal T cell lineages during the immune response. We will also examine the structure and function of the stromal microenvironment in the lamprey thymus equivalent, which is considered to be the site of T cell development. A particular focus will be on the functional analysis of a recently discovered MHC-like locus in the context of T cell development, and in the essential self/nonself discrimination mechanism(s) at play during the immune response. We expect that the identification of common design principles of adaptive immunity in vertebrates will provide us with an unprecedented view on immune functions in humans, potentially guiding the development of novel strategies for the treatment of failing immunity in patients with immunodeficiency and/or autoimmunity.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IMMUNE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IMMUNE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ModGravTrial (2019)

Modified Gravity on Trial

Read More  

MiniEmbryoBlueprint (2019)

The mammalian body plan blueprint, an in vitro approach

Read More  

MuFLOART (2018)

Microbiological fluorescence observatory for antibiotic resistance tracking

Read More