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ImmUne SIGNED

Towards identification of the unifying principles of vertebrate adaptive immunity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ImmUne project word cloud

Explore the words cloud of the ImmUne project. It provides you a very rough idea of what is the project "ImmUne" about.

context    principal    progress    genetic    about    evolution    cycle    vertebrates    examine    sister    mediated    laying    jawed    aquatic    representing    play    components    mhc    function    groups    striking    cellular    structure    jawless    functional    antigen    equivalent    learned    identification    crispr    failing    cell    microenvironment    principles    humans    basis    independently    foundations    modification    forms    site    view    500    lampreys    locus    immunodeficiency    autoimmunity    life    fish    cas9    functions    extended    stromal    difficulty    unifying    experiments    million    unprecedented    husbandry    mechanism    convergent    immune    molecular    vitro    generation    receptor    successful    potentially    conduct    nonself    time    fertilization    discrimination    thymus    vertebrate    discovered    fishes    self    methodological    strategies    guiding    adaptive    lamprey    treatment    sharks    patients    hampered    ranging    lineages    assembly    laboratory    alternative    ago    immunity    whereas    hagfishes    periods   

Project "ImmUne" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙498˙813 €
 EC max contribution 2˙498˙813 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 2˙498˙813.00

Map

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 Project objective

About 500 million years ago, the two sister groups of vertebrates independently evolved alternative forms of adaptive immunity, representing a striking example of convergent evolution. Whereas the components and functions of the immune system in jawed vertebrates (ranging from sharks to humans) are well characterized, much remains to be learned about adaptive immunity in jawless vertebrates (lampreys and hagfishes). Up to now, progress in understanding immunity in jawless fishes was hampered by their complex life-cycle, long generation time, and the difficulty of raising fish in the laboratory for extended periods, particularly after in vitro fertilization. Based on our recent methodological advances in aquatic husbandry and successful CRISPR/Cas9-mediated genetic modification, we propose to conduct a large-scale analysis of cellular immunity in lampreys laying the foundations for the identification of the unifying principles of vertebrate immunity. Our experiments will address the development and characteristics of different T cell subsets, the molecular basis of antigen receptor assembly, and the function of the two principal T cell lineages during the immune response. We will also examine the structure and function of the stromal microenvironment in the lamprey thymus equivalent, which is considered to be the site of T cell development. A particular focus will be on the functional analysis of a recently discovered MHC-like locus in the context of T cell development, and in the essential self/nonself discrimination mechanism(s) at play during the immune response. We expect that the identification of common design principles of adaptive immunity in vertebrates will provide us with an unprecedented view on immune functions in humans, potentially guiding the development of novel strategies for the treatment of failing immunity in patients with immunodeficiency and/or autoimmunity.

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