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ImmUne SIGNED

Towards identification of the unifying principles of vertebrate adaptive immunity

Total Cost €

0

EC-Contrib. €

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Partnership

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 ImmUne project word cloud

Explore the words cloud of the ImmUne project. It provides you a very rough idea of what is the project "ImmUne" about.

function    forms    foundations    sister    independently    self    lamprey    autoimmunity    discrimination    cycle    context    generation    basis    cas9    thymus    immunity    vitro    lineages    time    genetic    humans    stromal    jawless    fertilization    million    potentially    alternative    fishes    aquatic    experiments    identification    microenvironment    molecular    hampered    vertebrates    strategies    unprecedented    play    principles    hagfishes    functions    learned    equivalent    laboratory    laying    principal    extended    unifying    site    assembly    mediated    immunodeficiency    adaptive    jawed    successful    lampreys    mechanism    methodological    immune    examine    representing    cellular    guiding    receptor    structure    progress    groups    components    ago    treatment    periods    discovered    conduct    nonself    vertebrate    striking    cell    life    locus    difficulty    about    whereas    patients    antigen    fish    ranging    sharks    evolution    husbandry    functional    500    convergent    failing    modification    mhc    view    crispr   

Project "ImmUne" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙498˙813 €
 EC max contribution 2˙498˙813 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 2˙498˙813.00

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 Project objective

About 500 million years ago, the two sister groups of vertebrates independently evolved alternative forms of adaptive immunity, representing a striking example of convergent evolution. Whereas the components and functions of the immune system in jawed vertebrates (ranging from sharks to humans) are well characterized, much remains to be learned about adaptive immunity in jawless vertebrates (lampreys and hagfishes). Up to now, progress in understanding immunity in jawless fishes was hampered by their complex life-cycle, long generation time, and the difficulty of raising fish in the laboratory for extended periods, particularly after in vitro fertilization. Based on our recent methodological advances in aquatic husbandry and successful CRISPR/Cas9-mediated genetic modification, we propose to conduct a large-scale analysis of cellular immunity in lampreys laying the foundations for the identification of the unifying principles of vertebrate immunity. Our experiments will address the development and characteristics of different T cell subsets, the molecular basis of antigen receptor assembly, and the function of the two principal T cell lineages during the immune response. We will also examine the structure and function of the stromal microenvironment in the lamprey thymus equivalent, which is considered to be the site of T cell development. A particular focus will be on the functional analysis of a recently discovered MHC-like locus in the context of T cell development, and in the essential self/nonself discrimination mechanism(s) at play during the immune response. We expect that the identification of common design principles of adaptive immunity in vertebrates will provide us with an unprecedented view on immune functions in humans, potentially guiding the development of novel strategies for the treatment of failing immunity in patients with immunodeficiency and/or autoimmunity.

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