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ImmUne SIGNED

Towards identification of the unifying principles of vertebrate adaptive immunity

Total Cost €

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EC-Contrib. €

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Partnership

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 ImmUne project word cloud

Explore the words cloud of the ImmUne project. It provides you a very rough idea of what is the project "ImmUne" about.

unprecedented    receptor    failing    cas9    convergent    million    immune    progress    hagfishes    whereas    view    evolution    equivalent    laboratory    vertebrate    unifying    forms    structure    laying    stromal    cellular    adaptive    husbandry    mechanism    difficulty    thymus    successful    time    methodological    crispr    lamprey    immunity    jawed    conduct    hampered    assembly    ranging    genetic    striking    discovered    humans    cell    fish    aquatic    play    autoimmunity    mhc    periods    locus    microenvironment    experiments    learned    alternative    500    molecular    lineages    vitro    generation    groups    patients    strategies    treatment    guiding    examine    life    principles    lampreys    potentially    representing    mediated    immunodeficiency    nonself    modification    jawless    fishes    about    antigen    principal    independently    sharks    sister    identification    context    extended    components    foundations    functions    ago    site    fertilization    function    vertebrates    basis    self    functional    cycle    discrimination   

Project "ImmUne" data sheet

The following table provides information about the project.

Coordinator		 MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Total cost 2˙498˙813 €
 EC max contribution 2˙498˙813 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 2˙498˙813.00

Map

 Project objective

About 500 million years ago, the two sister groups of vertebrates independently evolved alternative forms of adaptive immunity, representing a striking example of convergent evolution. Whereas the components and functions of the immune system in jawed vertebrates (ranging from sharks to humans) are well characterized, much remains to be learned about adaptive immunity in jawless vertebrates (lampreys and hagfishes). Up to now, progress in understanding immunity in jawless fishes was hampered by their complex life-cycle, long generation time, and the difficulty of raising fish in the laboratory for extended periods, particularly after in vitro fertilization. Based on our recent methodological advances in aquatic husbandry and successful CRISPR/Cas9-mediated genetic modification, we propose to conduct a large-scale analysis of cellular immunity in lampreys laying the foundations for the identification of the unifying principles of vertebrate immunity. Our experiments will address the development and characteristics of different T cell subsets, the molecular basis of antigen receptor assembly, and the function of the two principal T cell lineages during the immune response. We will also examine the structure and function of the stromal microenvironment in the lamprey thymus equivalent, which is considered to be the site of T cell development. A particular focus will be on the functional analysis of a recently discovered MHC-like locus in the context of T cell development, and in the essential self/nonself discrimination mechanism(s) at play during the immune response. We expect that the identification of common design principles of adaptive immunity in vertebrates will provide us with an unprecedented view on immune functions in humans, potentially guiding the development of novel strategies for the treatment of failing immunity in patients with immunodeficiency and/or autoimmunity.

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