Opendata, web and dolomites

ImmUne SIGNED

Towards identification of the unifying principles of vertebrate adaptive immunity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ImmUne project word cloud

Explore the words cloud of the ImmUne project. It provides you a very rough idea of what is the project "ImmUne" about.

lineages    aquatic    groups    principles    context    representing    lamprey    conduct    adaptive    discrimination    foundations    extended    about    forms    methodological    components    time    crispr    immunodeficiency    view    ago    laying    striking    function    cell    examine    husbandry    play    discovered    convergent    difficulty    vertebrates    hampered    vitro    vertebrate    modification    thymus    mediated    sister    progress    fertilization    lampreys    potentially    failing    molecular    life    evolution    whereas    site    receptor    strategies    laboratory    independently    jawless    alternative    self    experiments    hagfishes    cas9    assembly    equivalent    antigen    successful    basis    humans    500    generation    fishes    autoimmunity    locus    million    cycle    ranging    mhc    periods    microenvironment    functional    unifying    fish    principal    nonself    jawed    immunity    treatment    learned    genetic    immune    patients    cellular    unprecedented    guiding    mechanism    sharks    structure    functions    stromal    identification   

Project "ImmUne" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙498˙813 €
 EC max contribution 2˙498˙813 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 2˙498˙813.00

Map

 Project objective

About 500 million years ago, the two sister groups of vertebrates independently evolved alternative forms of adaptive immunity, representing a striking example of convergent evolution. Whereas the components and functions of the immune system in jawed vertebrates (ranging from sharks to humans) are well characterized, much remains to be learned about adaptive immunity in jawless vertebrates (lampreys and hagfishes). Up to now, progress in understanding immunity in jawless fishes was hampered by their complex life-cycle, long generation time, and the difficulty of raising fish in the laboratory for extended periods, particularly after in vitro fertilization. Based on our recent methodological advances in aquatic husbandry and successful CRISPR/Cas9-mediated genetic modification, we propose to conduct a large-scale analysis of cellular immunity in lampreys laying the foundations for the identification of the unifying principles of vertebrate immunity. Our experiments will address the development and characteristics of different T cell subsets, the molecular basis of antigen receptor assembly, and the function of the two principal T cell lineages during the immune response. We will also examine the structure and function of the stromal microenvironment in the lamprey thymus equivalent, which is considered to be the site of T cell development. A particular focus will be on the functional analysis of a recently discovered MHC-like locus in the context of T cell development, and in the essential self/nonself discrimination mechanism(s) at play during the immune response. We expect that the identification of common design principles of adaptive immunity in vertebrates will provide us with an unprecedented view on immune functions in humans, potentially guiding the development of novel strategies for the treatment of failing immunity in patients with immunodeficiency and/or autoimmunity.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IMMUNE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IMMUNE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

SUExp (2018)

Strategic Uncertainty: An Experimental Investigation

Read More  

DISINTEGRATION (2019)

The Mass Politics of Disintegration

Read More  

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More  
lastchecktime (2022-08-07 19:55:07) correctly updated