Opendata, web and dolomites

nanoCellSense SIGNED

A nanotechnology-based approach for label-free single-cell analysis of cytoplasmic proteome

Total Cost €


EC-Contrib. €






 nanoCellSense project word cloud

Explore the words cloud of the nanoCellSense project. It provides you a very rough idea of what is the project "nanoCellSense" about.

relates    opportune    concentration    universal    biology    pipette    molecule    ionic    determined    nanopipette    live    proteomic    performing    inner    cells    dispersed    monolayer    possibility    detection    heterogeneity    morphological    aperture    binding    highlighting    characterisation    nanoprobe    label    protein    intracellular    piercing    scanning    possibilities    first    purpose    surface    cycle    dynamics    screening    sicm    fingerprint    living    point    immobilisation    single    last    occurs    followed    occlusion    flowing    antibodies    mechanical    proteome    framework    self    mechanisms    pathological    wall    hope    ion    molecular    ultra    microscope    conductivity    coating    time    free    physiology    advantage    cellular    sharp    view    coated    presently    assembled    insights    environment    extracellular    concentrations    functionalised    desired    interaction    endowed    fundamental    preservation    molecules    visualise    variation    cell    disease    mainly    stems    perturbative    detected    calibration    came    underlying    chemically    tools    membrane   

Project "nanoCellSense" data sheet

The following table provides information about the project.


Organization address
city: LONDON
postcode: SW7 2AZ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2021-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Presently there is a strong need to single-cell tools able to provide new insights into cellular proteome heterogeneity underlying dynamics, mechanisms and cell states in development and disease. Of particular interest in this framework is the possibility to have an effective intra-cellular proteomic detection in live cells. This mainly for three reasons: the first relates to preservation of higher protein concentration if the detection occurs before a molecule is dispersed in the extracellular environment; the second reason stems from the need to study in greater detail and in real time, single cell processes such as the molecular cell cycle or the molecular fingerprint in a label-free way; the last reason came up from the universal necessity to know the intracellular concentrations of many molecules involved in pathological and not-pathological cellular processes. I hope to achieve the desired goal taking advantage of a scanning ion conductivity microscope (SICM) endowed with a chemically functionalised ultra-sharp nanopipette to visualise living cells highlighting, from the morphological and mechanical point of view, specific target cells, that would be further investigated in their molecular fingerprint piercing the cell membrane and performing a molecular immobilisation screening. For this purpose, the inner surface of the nanopipette will be coated with a self-assembled monolayer of antibodies to target the protein of interest. The interaction between the protein and the coating of the nanopipette would result in a variation in the ionic current flowing through the pipette due to aperture occlusion. Effective binding of the protein to the inner wall of the pipette will be detected and followed in real time and, after opportune nanoprobe calibration, intracellular concentration determined. This low-perturbative, label-free approach for single cell proteome characterisation will open to new possibilities for fundamental research in cell biology and physiology.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NANOCELLSENSE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NANOCELLSENSE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

DEF2DEV (2019)

Identification of the mode of action of plant defensins during root development and plant defense responses.

Read More  

MBL-Fermions (2020)

Probing many-body localization dynamics using ultracold fermions in an optical lattice

Read More  

CO2COFs (2019)

New Heterogeneous Catalyst Materials for Hydrogenation of CO2 to Formic Acid: Metallophthalocyanine-Based 2D- and 3D Covalent Organic Frameworks

Read More