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PEPREP SIGNED

Peptide based self-replicating coacervate protocells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PEPREP project word cloud

Explore the words cloud of the PEPREP project. It provides you a very rough idea of what is the project "PEPREP" about.

create    stable    building    catalyzing    indicate    temperature    compartments    dissolved    prebiotically    ionic    imine    protocell    template    droplets    radically    life    cycling    ligation    ph    fundamental    naturally    lacking    form    coacervate    periodic    reversible    aromatic    collection    inorganic    chemical    recognition    inherently    native    dimerize    blocks    alkene    unstable    preliminary    cross    microreactor    stabilizing    dimerization    valuable    replication    rna    potent    prebiotic    peptides    pigments    coacervates    spontaneously    plausible    self    molecules    concentrate    model    coacervation    elementary    peptide    nanoparticles    replicating    mechanism    protocells    biology    spontaneous    nucleotides    lipid    one    recondensed    inanimate    bonds    templating    metathesis    concentrating    yielding    designed    disulfide    irreversible    solution    dimerized    questions    insights    chemistry    origin    bond    repeated    directed    chains   

Project "PEPREP" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-16   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 187˙572.00

Map

 Project objective

One of the most fundamental questions in chemistry and biology is how a self-replicating protocell could form from collection of inanimate molecules. Self-replicating RNA molecules in lipid compartments have been widely studied, but these systems are inherently unstable and a plausible mechanism for their spontaneous formation and repeated replication is still lacking. Here, I propose to use coacervation of self-templating peptides as a radically new approach to create stable self-replicating protocells. We will use short peptide building blocks with aromatic and ionic side chains that are designed for self- or cross-recognition. The building blocks can dimerize through reversible or irreversible chemical bond formation, including disulfide, imine, alkene (metathesis) and peptide (native chemical ligation) bonds. Preliminary results indicate that these peptides spontaneously form coacervate droplets when dimerized. The coacervates enhance the self-replication by naturally concentrating the peptide building blocks, catalyzing the template-directed peptide dimerization and stabilizing the product. By periodic cycling of the solution temperature or pH, the coacervate protocells can be dissolved and recondensed, yielding an elementary system of self-replicating protocells. These coacervate protocells not only concentrate peptides, but also nucleotides, inorganic nanoparticles and pigments, creating a potent microreactor for prebiotic chemistry. Developing these model system will provide valuable insights in new prebiotically plausible pathways to self-replication and the origin of life.

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The information about "PEPREP" are provided by the European Opendata Portal: CORDIS opendata.

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