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PEPREP SIGNED

Peptide based self-replicating coacervate protocells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PEPREP project word cloud

Explore the words cloud of the PEPREP project. It provides you a very rough idea of what is the project "PEPREP" about.

solution    native    irreversible    rna    protocell    chemistry    cycling    chains    collection    indicate    ionic    spontaneously    nucleotides    dimerized    fundamental    periodic    insights    compartments    building    dissolved    stable    recognition    dimerization    metathesis    alkene    lacking    preliminary    yielding    valuable    repeated    microreactor    ph    prebiotically    replicating    peptides    spontaneous    radically    inherently    blocks    coacervate    imine    catalyzing    recondensed    molecules    ligation    coacervation    elementary    naturally    plausible    potent    stabilizing    temperature    prebiotic    bonds    pigments    questions    inorganic    peptide    coacervates    unstable    dimerize    cross    self    create    concentrating    disulfide    template    nanoparticles    droplets    aromatic    one    concentrate    lipid    life    model    bond    biology    reversible    origin    replication    chemical    protocells    templating    form    designed    inanimate    mechanism    directed   

Project "PEPREP" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-16   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 187˙572.00

Map

 Project objective

One of the most fundamental questions in chemistry and biology is how a self-replicating protocell could form from collection of inanimate molecules. Self-replicating RNA molecules in lipid compartments have been widely studied, but these systems are inherently unstable and a plausible mechanism for their spontaneous formation and repeated replication is still lacking. Here, I propose to use coacervation of self-templating peptides as a radically new approach to create stable self-replicating protocells. We will use short peptide building blocks with aromatic and ionic side chains that are designed for self- or cross-recognition. The building blocks can dimerize through reversible or irreversible chemical bond formation, including disulfide, imine, alkene (metathesis) and peptide (native chemical ligation) bonds. Preliminary results indicate that these peptides spontaneously form coacervate droplets when dimerized. The coacervates enhance the self-replication by naturally concentrating the peptide building blocks, catalyzing the template-directed peptide dimerization and stabilizing the product. By periodic cycling of the solution temperature or pH, the coacervate protocells can be dissolved and recondensed, yielding an elementary system of self-replicating protocells. These coacervate protocells not only concentrate peptides, but also nucleotides, inorganic nanoparticles and pigments, creating a potent microreactor for prebiotic chemistry. Developing these model system will provide valuable insights in new prebiotically plausible pathways to self-replication and the origin of life.

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The information about "PEPREP" are provided by the European Opendata Portal: CORDIS opendata.

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