Explore the words cloud of the MetEpiClock project. It provides you a very rough idea of what is the project "MetEpiClock" about.
The following table provides information about the project.
|Coordinator Country||Italy [IT]|
|Total cost||262˙269 €|
|EC max contribution||262˙269 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-11-01 to 2021-11-01|
Take a look of project's partnership.
|1||HUMANITAS UNIVERSITY||IT (PIEVE EMANUELE)||coordinator||262˙269.00|
|2||THE REGENTS OF THE UNIVERSITY OF CALIFORNIA||US (OAKLAND CA)||partner||0.00|
The circadian clock directs almost all aspects of diurnal physiology, including metabolism. Defects in circadian rhythms influence physiology and behavior with implications for numerous pathological conditions, including cancer, metabolic syndrome, obesity, diabetes and cardiovascular diseases. By controlling metabolic homeostasis at the cellular level, the clock can directly influence cellular regulatory networks, including those that govern chromatin dynamics. The goal of this proposal is to investigate if metabolic pathways able to influence gene expression via chromatin dynamics are under circadian control and whether these regulatory networks are crucial for the maintenance of a correct metabolic homeostasis. We will test if the clock governs the “methylation potential” of the cell by regulating the diurnal expression of rate-limiting enzymes of methionine metabolism. By using metabolite restriction, pharmacological and gene editing approaches we will disrupt circadian rhythmicity of SAM and SAH. We will then use state-of-the-art methods including, transcriptomics, epigenomics and metabolomics to investigate the impact of this regulatory network on circadian transcriptional regulation, histone methylation dynamics and metabolic homeostasis. By dissecting how circadian regulation, metabolism and epigenetics are interconnected we will gain novel insights into how these factors contribute to normal physiology and disease. At UCI I will exploit the expertise of the outgoing supervisor in the area of circadian biology, molecular metabolism and epigenetics. Then, at Humanitas University I will refine the knowledge and skills acquired during the outgoing phase, with the final aim of applying them to the cardiovascular field. This will place me in a privileged position to establish myself as a competent researcher within the European Community, in the field of cardiovascular biology, metabolism and epigenetics.
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The information about "METEPICLOCK" are provided by the European Opendata Portal: CORDIS opendata.
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