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SUPERBRAIN SIGNED

Magneto-Plasmonic, Raman active Nanocapsules for Superior Pediatric Brain Cancer Therapy

Total Cost €

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EC-Contrib. €

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Partnership

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 SUPERBRAIN project word cloud

Explore the words cloud of the SUPERBRAIN project. It provides you a very rough idea of what is the project "SUPERBRAIN" about.

monitoring    cargo    anatomy    raman    domestic    molecular    pediatric    drugs    develops    combat    killing    modalities    advances    cancer    combines    exposure    simultaneous    infrared    adverse    protocols    nanoparticles    gt    excitation    fought    central    coupled    identification    destructive    resonance    mri    shell    chemotherapy    cells    concurrent    15    children    statistic    margins    plasmonic    multifunctional    tumors    death    vivo    radio    surface    techniques    nanocapsule    near    nevertheless    cancers    imaging    bioengineered    theranostics    vitro    magnetically    invasive    elaborate    therapeutic    survival    stimulated    99    nanocapsules    nir    cell    magnetic    brain    visualizing    rapid    3d    sers    tissues    paradigm    photonic    tumor    photothermal    accidents    35    guided    introduces    cure    nanocomposite    ing    nervous    multimodality    treatment    spectroscopy    limiting    enhanced    diagnosed    opportunity    diagnosis    termed    aptamer    chemotherapeutic    oncology    rates    potentially    visualization    microscopic    battle    gold    decorating    superbrain    additionally    light    minimally    radiation    fingerprint    cns    functionalized    standard    therapy    neurosurgery    biomolecule   

Project "SUPERBRAIN" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 224˙933.00

Map

 Project objective

Advances in neurosurgery, radio-chemotherapy resulting in improved survival/cure rates for children with brain tumors. Nevertheless, after domestic accidents, cancer remains the second leading cause of death in children with the overall 5-year survival statistic of 15-35%. Central nervous system (CNS) tumors are the second most diagnosed cancer in pediatric oncology. Radio-chemotherapy protocols for CNS cancers limiting therapeutic potential due to long-term concerns of radiation exposure and late adverse effects of chemotherapy in developing children. The battle against pediatric cancer is potentially much more effectively fought if the therapy is concurrent with diagnosis and monitoring modalities. SUPERBRAIN develops a multifunctional nanocomposite termed as nanocapsule that enables a simultaneous diagnosis, therapy and treatment monitoring (theranostics). It introduces a new paradigm of theranostics combines tumor targeting biomolecule (aptamer), chemotherapeutic cargo, Surface Enhanced Raman Spectroscopy (SERS) coupled with magnetic resonance imaging (MRI) and photothermal therapy to combat pediatric CNS cancer. We elaborate multimodality in one nanocapsule by decorating magnetic nanoparticles with plasmonic shell functionalized with chemotherapeutic drugs and CNS cancer cell targeting aptamer and magnetically guided nanocapsules in vivo delivery. Furthermore, non-destructive SERS together with Raman microscopic techniques is introduced here for rapid identification of a cancer cells ‘molecular fingerprint’ allowing visualization of brain tumor margins. Additionally, application of MRI for visualizing 3D brain anatomy is providing opportunity of therapy monitoring. These bioengineered nanocapsules can then be stimulated by near infrared (NIR) light for minimally invasive photonic excitation (photothermal therapy). Finally, we will demonstrate >99% killing of CNS brain tumor tissues (in vitro and in vivo) with this new paradigm as a gold standard theranostics.

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The information about "SUPERBRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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