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SUPERBRAIN SIGNED

Magneto-Plasmonic, Raman active Nanocapsules for Superior Pediatric Brain Cancer Therapy

Total Cost €

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EC-Contrib. €

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Partnership

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 SUPERBRAIN project word cloud

Explore the words cloud of the SUPERBRAIN project. It provides you a very rough idea of what is the project "SUPERBRAIN" about.

fingerprint    concurrent    nanocapsules    combat    oncology    aptamer    stimulated    rates    diagnosed    infrared    pediatric    ing    neurosurgery    vivo    raman    cell    bioengineered    tumor    therapeutic    combines    multimodality    chemotherapeutic    introduces    radiation    termed    fought    elaborate    death    destructive    cells    minimally    enhanced    mri    gt    modalities    rapid    35    diagnosis    3d    visualization    photonic    additionally    shell    photothermal    theranostics    sers    resonance    anatomy    excitation    therapy    children    potentially    tissues    adverse    standard    nanocomposite    spectroscopy    accidents    cancers    exposure    nervous    nanoparticles    nir    microscopic    chemotherapy    nanocapsule    functionalized    vitro    superbrain    domestic    decorating    plasmonic    light    cancer    develops    margins    magnetic    biomolecule    imaging    killing    visualizing    advances    limiting    radio    gold    central    simultaneous    15    near    paradigm    cure    cargo    tumors    techniques    brain    magnetically    nevertheless    molecular    cns    surface    battle    protocols    guided    99    multifunctional    statistic    coupled    survival    drugs    treatment    monitoring    invasive    identification    opportunity   

Project "SUPERBRAIN" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 224˙933.00

Map

 Project objective

Advances in neurosurgery, radio-chemotherapy resulting in improved survival/cure rates for children with brain tumors. Nevertheless, after domestic accidents, cancer remains the second leading cause of death in children with the overall 5-year survival statistic of 15-35%. Central nervous system (CNS) tumors are the second most diagnosed cancer in pediatric oncology. Radio-chemotherapy protocols for CNS cancers limiting therapeutic potential due to long-term concerns of radiation exposure and late adverse effects of chemotherapy in developing children. The battle against pediatric cancer is potentially much more effectively fought if the therapy is concurrent with diagnosis and monitoring modalities. SUPERBRAIN develops a multifunctional nanocomposite termed as nanocapsule that enables a simultaneous diagnosis, therapy and treatment monitoring (theranostics). It introduces a new paradigm of theranostics combines tumor targeting biomolecule (aptamer), chemotherapeutic cargo, Surface Enhanced Raman Spectroscopy (SERS) coupled with magnetic resonance imaging (MRI) and photothermal therapy to combat pediatric CNS cancer. We elaborate multimodality in one nanocapsule by decorating magnetic nanoparticles with plasmonic shell functionalized with chemotherapeutic drugs and CNS cancer cell targeting aptamer and magnetically guided nanocapsules in vivo delivery. Furthermore, non-destructive SERS together with Raman microscopic techniques is introduced here for rapid identification of a cancer cells ‘molecular fingerprint’ allowing visualization of brain tumor margins. Additionally, application of MRI for visualizing 3D brain anatomy is providing opportunity of therapy monitoring. These bioengineered nanocapsules can then be stimulated by near infrared (NIR) light for minimally invasive photonic excitation (photothermal therapy). Finally, we will demonstrate >99% killing of CNS brain tumor tissues (in vitro and in vivo) with this new paradigm as a gold standard theranostics.

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The information about "SUPERBRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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