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KiT-FIG SIGNED

Kidney Transplantation - Functional ImmunoGenomics

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 KiT-FIG project word cloud

Explore the words cloud of the KiT-FIG project. It provides you a very rough idea of what is the project "KiT-FIG" about.

biostatistics    functional    statistical    host    cellular    world    regulation    esrd    modern    kir    huge    graft    treatments    gene    complexity    population    survival    chronic    clinical    community    gradually    generate    expression    rely    capture    immunogenetic    effect    largely    ultimate    disease    tolerance    expand    transplantation    immunogenetics    transplanted    triggers    allocation    stage    immune    10    combine    bioinformatic    day    patients    humoral    half    accessible    despite    life    rejections    fig    bioinformatics    context    explore    cutting    progress    perform    gain    leads    renal    unlock    diseases    patient    alleles    kit    immunosuppressive    association    outcomes    rejection    innovative    underlying    genetic    tools    mismatches    immunogenomic    inference    immunogenomics    variability    additional    scientific    hla    ambitions    unknown    mechanisms    kidney    unexplained    genomics    precision    requiring    edge    immunological   

Project "KiT-FIG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE NANTES 

Organization address
address: QUAI DE TOURVILLE 1
city: NANTES CEDEX 1
postcode: 44035
website: www.univ-nantes.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE NANTES FR (NANTES CEDEX 1) coordinator 196˙707.00

Map

 Project objective

Chronic renal failure affects ~10% of the world population and can gradually lead to end-stage renal disease (ESRD) requiring kidney transplantation. Despite the huge progress of immunosuppressive treatments, the host immune response against the graft still leads to rejection in many cases, with an average graft half-life of 10 years. Triggers leading to graft rejection are still largely unknown and need to be studied beyond the well-recognized impact of HLA mismatches. I propose here to explore the effect of functional immunogenomic parameters beyond HLA mismatches (HLA alleles, HLA gene expression regulation, KIR...) on kidney transplantation outcomes (cellular and humoral rejections, tolerance). To achieve this present-day clinical challenge, I will combine innovative bioinformatics tools and modern genomics to perform cutting edge association studies: the Kidney Transplantation - Functional ImmunoGenomics (KiT-FIG) project. KiT-FIG ultimate goal is to provide new evidence to improve graft allocation and transplanted patients’ management. Objective A is to develop innovative methods of HLA statistical inference to gain precision and generate additional functional immunogenomic parameters. Objective B is to apply these novel methods to investigate the impact of immunogenetics on immunological outcomes related to kidney transplantation. This objective will rely on genetic association studies to unlock the major scientific challenge of large and unexplained variability observed in renal graft survival. KiT-FIG ambitions to develop new innovative bioinformatic and biostatistics tools to capture the complexity of HLA-related immune responses. These tools will be freely accessible to the community to expand immunogenetic studies of other diseases. The implementation of these tools in the context of kidney transplantation outcomes will increase the understanding of underlying immunological mechanisms and will contribute to improve graft survival and patient management.

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The information about "KIT-FIG" are provided by the European Opendata Portal: CORDIS opendata.

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