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KiT-FIG SIGNED

Kidney Transplantation - Functional ImmunoGenomics

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 KiT-FIG project word cloud

Explore the words cloud of the KiT-FIG project. It provides you a very rough idea of what is the project "KiT-FIG" about.

chronic    progress    bioinformatics    accessible    world    immunogenetics    kir    esrd    immunogenetic    association    patient    generate    inference    half    ambitions    kidney    tools    transplantation    huge    alleles    genomics    functional    gene    immunogenomics    disease    requiring    outcomes    hla    cutting    rejection    modern    day    allocation    survival    clinical    mismatches    despite    kit    regulation    tolerance    host    mechanisms    humoral    treatments    unexplained    variability    population    complexity    genetic    diseases    additional    largely    immune    combine    unknown    patients    scientific    life    statistical    expand    innovative    edge    explore    perform    stage    rejections    immunological    10    capture    immunogenomic    biostatistics    cellular    immunosuppressive    gradually    unlock    underlying    ultimate    rely    bioinformatic    community    fig    precision    triggers    effect    gain    expression    leads    context    renal    graft    transplanted   

Project "KiT-FIG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE NANTES 

Organization address
address: QUAI DE TOURVILLE 1
city: NANTES CEDEX 1
postcode: 44035
website: www.univ-nantes.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE NANTES FR (NANTES CEDEX 1) coordinator 196˙707.00

Map

 Project objective

Chronic renal failure affects ~10% of the world population and can gradually lead to end-stage renal disease (ESRD) requiring kidney transplantation. Despite the huge progress of immunosuppressive treatments, the host immune response against the graft still leads to rejection in many cases, with an average graft half-life of 10 years. Triggers leading to graft rejection are still largely unknown and need to be studied beyond the well-recognized impact of HLA mismatches. I propose here to explore the effect of functional immunogenomic parameters beyond HLA mismatches (HLA alleles, HLA gene expression regulation, KIR...) on kidney transplantation outcomes (cellular and humoral rejections, tolerance). To achieve this present-day clinical challenge, I will combine innovative bioinformatics tools and modern genomics to perform cutting edge association studies: the Kidney Transplantation - Functional ImmunoGenomics (KiT-FIG) project. KiT-FIG ultimate goal is to provide new evidence to improve graft allocation and transplanted patients’ management. Objective A is to develop innovative methods of HLA statistical inference to gain precision and generate additional functional immunogenomic parameters. Objective B is to apply these novel methods to investigate the impact of immunogenetics on immunological outcomes related to kidney transplantation. This objective will rely on genetic association studies to unlock the major scientific challenge of large and unexplained variability observed in renal graft survival. KiT-FIG ambitions to develop new innovative bioinformatic and biostatistics tools to capture the complexity of HLA-related immune responses. These tools will be freely accessible to the community to expand immunogenetic studies of other diseases. The implementation of these tools in the context of kidney transplantation outcomes will increase the understanding of underlying immunological mechanisms and will contribute to improve graft survival and patient management.

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The information about "KIT-FIG" are provided by the European Opendata Portal: CORDIS opendata.

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