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PLAMORF SIGNED

Plant Mobile RNAs: Function, Transport and Features

Total Cost €

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EC-Contrib. €

0

Partnership

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 PLAMORF project word cloud

Explore the words cloud of the PLAMORF project. It provides you a very rough idea of what is the project "PLAMORF" about.

signals    occurs    signalling    affinity    contrast    micro    expertise    groups    transcriptomics    messenger    connected    mrnas    xylem    gain    structure    communication    pipelines    mobile    questions    determines    transferred    motifs    combine    class    vascular    small    rbps    function    binding    cells    metabolites    devoid    mathematical    predictive    proteins    agronomically    biology    rape    circular    insights    protein    intercellular    move    tissues    manner    molecules    advantages    mirnas    processed    thaliana    plant    rnas    wp2    single    wp1    efficient    mechanism    model    additional    tissue    regulated    biochemistry    consequence    destination    plants    developmental    dual    phloem    transport    bioinformatics    cytoplasm    body    plasmodesmata    rna    transfer    macromolecular    parts    functions    animals    metabolic    combines    coordinate    time    consisting    models    remarkably    cell    an    chimeric    transported    nuclei    flowering    distance    cellularity    oilseed   

Project "PLAMORF" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 6˙134˙102 €
 EC max contribution 6˙134˙102 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 2˙525˙000.00
2    UNIVERSITAET HAMBURG DE (HAMBURG) participant 2˙017˙790.00
3    JOHN INNES CENTRE UK (NORWICH) participant 1˙591˙312.00

Map

 Project objective

An essential consequence of multi-cellularity is the need for intercellular and tissue wide communication. As seen with animals, higher plants coordinate metabolic and developmental processes via signals transferred to different body parts. Plants use a dual vascular system consisting of phloem and xylem for long-distance transfer of metabolites and signalling molecules. In contrast to circular systems in animals, transport in flowering plants occurs in the phloem via the cytoplasm of connected cells devoid of nuclei. In addition to small molecules, a remarkably large number of so-called mobile micro RNAs (miRNAs), messenger RNAs (mRNAs), and phloem RNA-binding proteins (RBPs) were identified in the phloem and in chimeric plants. Mobile RNAs and RBPs move through plasmodesmata into and through the phloem to distinct tissues. Thus, mobile RNAs represent an additional class of signalling molecules, raising important questions in the field of intercellular signalling. This project combines the expertise of three research groups in the fields of cell biology/macromolecular transport, mathematical modelling/bioinformatics and phloem function/protein biochemistry. It addresses the questions: How are mobile miRNAs and mRNAs selected for transport? Is this process specific and regulated by RBPs and motifs? What determines their destination? And importantly, how are these signals processed in the destination cells? To address these questions, we will develop predictive models, using novel single cell transcriptomics pipelines to establish cell-type specific RNA transport and motifs (WP1), and studying the structure, affinity, and functions of phloem RBPs to gain insights in the RNA delivery mechanism (WP2). We will combine the advantages of the agronomically important plant oilseed rape to identify phloem RNAs and RBPs with the well-established A. thaliana model that allows us to identify and test cell-specific transported RNA signals and RBPs in a time-efficient manner.

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The information about "PLAMORF" are provided by the European Opendata Portal: CORDIS opendata.

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