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PLAMORF SIGNED

Plant Mobile RNAs: Function, Transport and Features

Total Cost €

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EC-Contrib. €

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Partnership

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 PLAMORF project word cloud

Explore the words cloud of the PLAMORF project. It provides you a very rough idea of what is the project "PLAMORF" about.

rna    functions    cell    models    cells    transfer    bioinformatics    binding    circular    messenger    plants    agronomically    pipelines    destination    motifs    cellularity    signals    transcriptomics    coordinate    transferred    rape    class    oilseed    macromolecular    advantages    mirnas    wp2    additional    proteins    biochemistry    metabolites    protein    plant    metabolic    insights    determines    an    cytoplasm    contrast    groups    questions    consequence    nuclei    animals    chimeric    manner    molecules    mathematical    rnas    single    small    mobile    function    expertise    tissue    mechanism    time    transport    intercellular    distance    communication    vascular    thaliana    biology    transported    remarkably    developmental    mrnas    body    devoid    occurs    consisting    dual    rbps    regulated    combines    wp1    predictive    affinity    plasmodesmata    connected    structure    combine    flowering    xylem    micro    processed    move    model    efficient    signalling    tissues    parts    gain    phloem   

Project "PLAMORF" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 6˙134˙102 €
 EC max contribution 6˙134˙102 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2025-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 2˙525˙000.00
2    UNIVERSITAET HAMBURG DE (HAMBURG) participant 2˙017˙790.00
3    JOHN INNES CENTRE UK (NORWICH) participant 1˙591˙312.00

Map

 Project objective

An essential consequence of multi-cellularity is the need for intercellular and tissue wide communication. As seen with animals, higher plants coordinate metabolic and developmental processes via signals transferred to different body parts. Plants use a dual vascular system consisting of phloem and xylem for long-distance transfer of metabolites and signalling molecules. In contrast to circular systems in animals, transport in flowering plants occurs in the phloem via the cytoplasm of connected cells devoid of nuclei. In addition to small molecules, a remarkably large number of so-called mobile micro RNAs (miRNAs), messenger RNAs (mRNAs), and phloem RNA-binding proteins (RBPs) were identified in the phloem and in chimeric plants. Mobile RNAs and RBPs move through plasmodesmata into and through the phloem to distinct tissues. Thus, mobile RNAs represent an additional class of signalling molecules, raising important questions in the field of intercellular signalling. This project combines the expertise of three research groups in the fields of cell biology/macromolecular transport, mathematical modelling/bioinformatics and phloem function/protein biochemistry. It addresses the questions: How are mobile miRNAs and mRNAs selected for transport? Is this process specific and regulated by RBPs and motifs? What determines their destination? And importantly, how are these signals processed in the destination cells? To address these questions, we will develop predictive models, using novel single cell transcriptomics pipelines to establish cell-type specific RNA transport and motifs (WP1), and studying the structure, affinity, and functions of phloem RBPs to gain insights in the RNA delivery mechanism (WP2). We will combine the advantages of the agronomically important plant oilseed rape to identify phloem RNAs and RBPs with the well-established A. thaliana model that allows us to identify and test cell-specific transported RNA signals and RBPs in a time-efficient manner.

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The information about "PLAMORF" are provided by the European Opendata Portal: CORDIS opendata.

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