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Hepatic Thermogenesi SIGNED

Study the functions of the hepatic sympathetic nerve and the receptor Adrb3 in liver-mediated adaptive thermogenesis.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Hepatic Thermogenesi project word cloud

Explore the words cloud of the Hepatic Thermogenesi project. It provides you a very rough idea of what is the project "Hepatic Thermogenesi" about.

proteomic    triggered    prolonged    whereby    homeothermic    fatty    interdisciplinary    adrb3    constants    ablation    metabolomics    temperature    existence    avenues    generate    breakthrough    technologies    characterization    molecular    argue    rewiring    knockout    disease    mice    hepatocytes    adaptive    anatomical    mechanisms    sympathetic    heating    exposed    treatment    nonalcoholic    exchange    ascertain    receptor    techniques    environment    thermogenic    beta    generation    cold    first    liver    combination    demonstrating    mechanism    sympathectomy    normally    chemistry    fundamental    data    species    transcriptomic    regulated    genetic    clinical    longstanding    guarded    physiology    surgical    extra    homoeothermic    demonstrated    physics    tissues    core    thermogenesis    edge    heat    physiological    adrenergic    body    metabolic    foundation    preliminary    sustain    observations    hepatic    nerve    regulating    evolution    cutting    purpose    regulation    omics   

Project "Hepatic Thermogenesi" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 203˙149.00

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 Project objective

Core body temperature is among the best-guarded constants in homeothermic species. It results from the evolution of physiological mechanisms capable of regulating the production as well as the exchange of heat with the environment. The objective of my proposal is to define a new role for the liver in adaptive thermogenesis whereby the liver will be involved in heat production under the regulation of the hepatic sympathetic nerve. I will first ascertain that the liver can generate extra heat when adaptive thermogenesis is triggered (Aim 1). Hepatic adaptive thermogenesis will be demonstrated using a combination of interdisciplinary, cutting-edge technologies normally applied to the fields of physics and chemistry. I will then determine the molecular foundation of this hepatic heat production (Aim 2). For this purpose, OMICs data (transcriptomic, proteomic and metabolomics) will be generated from cold-exposed liver tissues in order to identify: (1) the hepatic molecular heating mechanism; (2) the expected metabolic rewiring necessary to sustain prolonged heat production from thermogenic hepatocytes. Finally, I will study how hepatic adaptive thermogenesis is regulated by the hepatic sympathetic nerve at the anatomical level and by the adrenergic receptor Adrb3 at the molecular level (Aim 3). For this purpose, I will use a combination of surgical (hepatic sympathectomy) and genetic (generation of liver-specific beta-adrenergic receptor 3 knockout mice) ablation techniques. Longstanding observations, together with my own preliminary results argue for this existence of hepatic adaptive thermogenesis and its molecular characterization would certainly represent a major breakthrough for both our fundamental understanding of homoeothermic physiology as well as for future clinical applications. Demonstrating that the liver is involved in adaptive thermogenesis would certainly open new avenues for the treatment of nonalcoholic fatty liver disease, a major disease in Europe.

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