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Unlocking the antibiotic production potential in soil bacteria Streptomyces coelicolor

Total Cost €


EC-Contrib. €






Project "STREPUNLOCKED" data sheet

The following table provides information about the project.


Organization address
address: Bijenicka cesta 54
city: ZAGREB
postcode: 10000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Croatia [HR]
 Total cost 147˙463 €
 EC max contribution 147˙463 € (100%)
 Code Call H2020-WF-01-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-18   to  2021-10-17


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RUDER BOSKOVIC INSTITUTE HR (ZAGREB) coordinator 147˙463.00


 Project objective

We live in an era where once miracle drugs – antibiotics, cease to be efficient. The rise of antibiotic resistance is an immediate major global issue. There are several layers causing the problem – misuse, overuse, lack of proper guidelines etc. The only long-term efficient solutions are – pushing more antibiotics and vaccines into the discovery pipeline. More than 70% of the naturally produced antibiotics used today come from non-pathogenic bacteria from the Streptomyces genus. These bountiful bacteria still have a lot to give, as only one-third of their secondary metabolite pathways are characterized. The rest of their potential stays locked away, i.e., inaccessible with the currently available approaches/tools. In STREPUNLOCKED project, we suggest a study of an up-and-coming pathway involved in the regulation of antibiotic production/resistance – adenosine diphosphate (ADP)-ribosylation. In order to achieve these aims, we will use a multidisciplinary approach that combines several latest mass spectrometry techniques and analyses, genetic approaches, molecular modelling and bioinformatics’ tools to characterize the novel ADP-ribosylation pathways, their signalling context, and their role in antibiotic production. Using the deep dive strategy in order to understand this pathway in Streptomyces would have multiple benefits: opening the doors to the new tool for manipulating the Streptomyces metabolism, lead the way to new lines of basic research, discovery and practical applications – such as new antibiotic compounds.

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The information about "STREPUNLOCKED" are provided by the European Opendata Portal: CORDIS opendata.

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