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FunStructure SIGNED

Interdependence of functional and structural plasticity in cerebellar climbing fibers in health and disease

Total Cost €

0

EC-Contrib. €

0

Partnership

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 FunStructure project word cloud

Explore the words cloud of the FunStructure project. It provides you a very rough idea of what is the project "FunStructure" about.

slice    acutely    protein    cfs    function    silence    sk2    physiology    induce    43    respectively    confocal    mouse    largely    intrinsic    ms    effect    climbing    structural    chronically    transcription    circuits    plasticity    optogenetics    memory    analyze    modify    excitability    cf    voltage    expression    stimulate    synaptic    knockout    cerebellar    synergy    transduced    modifications    sclerosis    multiple    silencing    previously    potassium    microscopy    encode    calcium    brain    axonal    neuronal    pf    fibers    rules    alterations    nucleus    model    unclear    choosing    viral    inferior    gated    sides    diseases    significantly    conditional    neurons    vivo    rest    pathological    re1    sodium    electrophysiology    olive    originate    constructs    channels    disease    structure    circuit    shown    pathogenesis    relationship    encoding    engrams    modulate    corresponding    interdependence    morphology    understand    modified    gap    upregulation   

Project "FunStructure" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 171˙473 €
 EC max contribution 171˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 171˙473.00

Map

 Project objective

Modifications of the structure and intrinsic excitability of neurons (i.e. “structural plasticity” and “intrinsic plasticity”) have been proposed to contribute significantly in encoding memory in synergy with synaptic plasticity and have been shown to contribute to the pathogenesis of several diseases including multiple sclerosis (MS). However, it is still largely unclear how changes in intrinsic excitability affect structural plasticity and how this affects circuit function. A better understanding of this two-way interdependence is crucial to understand how brain circuits encode memory engrams and are affected by diseases. Here I propose to investigate the two sides of this function-structure relationship choosing cerebellar climbing fibers (CF) as a model. Using in vivo viral delivery in the inferior olive nucleus (where climbing fibers originate), electrophysiology, optogenetics and confocal microscopy I will modulate CF function or structure acutely in slice or chronically in vivo and analyze the corresponding effect on CF morphology or physiology, respectively. I will use previously developed viral constructs to silence the expression of the growth-associated protein 43 (GAP-43) or voltage-gated sodium channels to induce structural modifications or a reduction of excitability in CFs, respectively; I will also use optogenetics to specifically stimulate transduced CFs in slice and a recently established conditional knockout mouse for SK2-type calcium-gated potassium channels to increase CF excitability. In order to investigate how CF function and structure may be modified in pathological conditions I will focus on the effects of the upregulation of the RE1-Silencing Transcription Factor (REST) observed in MS and related to alterations of neuronal excitability and axonal structure. This project will show how CF activity can modify its structure and PF plasticity rules, contributing to memory formation and disease.

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The information about "FUNSTRUCTURE" are provided by the European Opendata Portal: CORDIS opendata.

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