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SIMICA SIGNED

Site-selective protein-modification chemistries for antibody-drug conjugates (ADCs)

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SIMICA" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES 

Organization address
address: AVENIDA PROF EGAS MONIZ
city: LISBOA
postcode: 1649 028
website: www.imm.ul.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 800˙000 €
 EC max contribution 800˙000 € (100%)
 Programme 1. H2020-EU.4.b. (Twinning of research institutions)
 Code Call H2020-WIDESPREAD-2018-03
 Funding Scheme CSA
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) coordinator 350˙000.00
2    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 190˙000.00
3    PERCUROS BV NL (LEIDEN) participant 165˙000.00
4    ALLCYTE GMBH AT (WIEN) participant 60˙000.00
5    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 35˙000.00

Map

 Project objective

SIMICA will provide IMM with the opportunity to integrate the European circle of research excellence institutions by cementing a sustainable science, technology and innovation network with internationally-leading organisations in the field of protein drug-conjugates. The strategy of SIMICA is based on science- and innovation-driven clustering, and is focused on the exciting and upcoming area of designing and constructing the next generation of chemically-defined and innovative protein drug-conjugates for the targeted treatment of serious conditions such as cancer. The project will allow: i) strengthening the science and technology capacity of IMM and ii) leverage its research excellence and value creation through innovation with a beneficial and quantifiable impact for the entire research and development community at IMM, the Lisbon region and Portugal. The successful implementation of this strategy will rely on specific actions, including: 1) cementing of existing and the creation of new scientific, innovative and technical collaborations through short-term staff exchanges and short-term on-site training activities; 2) training, mentoring and international exposure of IMM’s young researchers and students; 3) building an innovation ecosystem centred at IMM; 4) igniting the entrepreneurial spirit among IMM’s research community; 5) increasing science awareness among the general public through targeted dissemination and communication activities; and 6) developing a sustainability strategy to sustain the cemented network beyond project terminus. Through the completion of these activities, IMM, supported by its twinning partners, is in the best temporal and spatial position to achieve an improved capability to compete for internationally competitive research funding and to access business stakeholders. By claiming its position in research and innovation networks IMM will effectively contribute to research excellence and value creation in health at European level.

 Publications

year authors and title journal last update
List of publications.
2016 Hélio Faustino, Maria J. S. A. Silva, Luís F. Veiros, Gonçalo J. L. Bernardes, Pedro M. P. Gois
Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation
published pages: 5052-5058, ISSN: 2041-6520, DOI: 10.1039/c6sc01520d
Chemical Science 7/8 2020-02-03
2017 P. Maturana, M. Martinez, M.E. Noguera, N.C. Santos, E.A. Disalvo, L. Semorile, P.C. Maffia, A. Hollmann
Lipid selectivity in novel antimicrobial peptides: Implication on antimicrobial and hemolytic activity
published pages: 152-159, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2017.02.003
Colloids and Surfaces B: Biointerfaces 153 2020-02-03
2018 Bernadette Lee, Shuang Sun, Ester Jiménez-Moreno, André A. Neves, Gonçalo J.L. Bernardes
Site-selective installation of an electrophilic handle on proteins for bioconjugation
published pages: 3060-3064, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2018.02.028
Bioorganic & Medicinal Chemistry 26/11 2020-02-03
2018 Natacha Couto, Leonard Schuele, Erwin C. Raangs, Miguel P. Machado, Catarina I. Mendes, Tiago F. Jesus, Monika Chlebowicz, Sigrid Rosema, Mário Ramirez, João A. Carriço, Ingo B. Autenrieth, Alex W. Friedrich, Silke Peter, John W. Rossen
Critical steps in clinical shotgun metagenomics for the concomitant detection and typing of microbial pathogens
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-31873-w
Scientific Reports 8/1 2020-02-03
2017 Max J. H. Worthington, Renata L. Kucera, Inês S. Albuquerque, Christopher T. Gibson, Alexander Sibley, Ashley D. Slattery, Jonathan A. Campbell, Salah F. K. Alboaiji, Katherine A. Muller, Jason Young, Nick Adamson, Jason R. Gascooke, Deshetti Jampaiah, Ylias M. Sabri, Suresh K. Bhargava, Samuel J. Ippolito, David A. Lewis, Jamie S. Quinton, Amanda V. Ellis, Alexander Johs, Gonçalo J. L. Bernarde
Laying Waste to Mercury: Inexpensive Sorbents Made from Sulfur and Recycled Cooking Oils
published pages: 16219-16230, ISSN: 0947-6539, DOI: 10.1002/chem.201702871
Chemistry - A European Journal 23/64 2020-02-03
2016 Padma Akkapeddi, Saara-Anne Azizi, Allyson M. Freedy, Pedro M. S. D. Cal, Pedro M. P. Gois, Gonçalo J. L. Bernardes
Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry
published pages: 2954-2963, ISSN: 2041-6520, DOI: 10.1039/c6sc00170j
Chemical Science 7/5 2020-02-03
2018 Shuang Sun, Ismael Compañón, Nuria Martínez-Sáez, João D. Seixas, Omar Boutureira, Francisco Corzana, Gonçalo J. L. Bernardes
Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides
published pages: 48-52, ISSN: 1439-4227, DOI: 10.1002/cbic.201700586
ChemBioChem 19/1 2020-02-03
2018 Pinto, Sandra N.; Dias, Susana Almeida; Cruz, Ana F.; Mil-Homens, Dalila; Fernandes, Fabio; Valle, Javier; Andreu, David; Prieto, Manuel; Castanho, Miguel; Coutinho, Ana; Veiga, Ana Salome
Activity of the viral-derived peptide pepR against Staphylococcus aureus biofilms and insights into the mechanism of action
published pages: , ISSN: , DOI:
JOURNAL OF PEPTIDE SCIENCE 2020-02-03
2018 Filipa Rijo-Ferreira, Tânia Carvalho, Cristina Afonso, Margarida Sanches-Vaz, Rui M Costa, Luísa M. Figueiredo, Joseph S. Takahashi
Sleeping sickness is a circadian disorder
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02484-2
Nature Communications 9/1 2020-02-03
2016 Maria Rebelo, Thomas Hänscheid
Flow Cytometry for Antimalarial Drug Testing: More than Meets the Eye
published pages: 817-817, ISSN: 0095-1137, DOI: 10.1128/jcm.03017-15
Journal of Clinical Microbiology 54/3 2020-02-03
2018 Akiko Noma, Carlas S. Smith, Maximiliaan Huisman, Robert M. Martin, Melissa J. Moore, David Grunwald
Advanced 3D Analysis and Optimization of Single-Molecule FISH in Drosophila Muscle
published pages: 1700324, ISSN: 2366-9608, DOI: 10.1002/smtd.201700324
Small Methods 2/9 2020-02-03
2016 Ricardo Ferraz, Joana Noronha, Fernanda Murtinheira, Fátima Nogueira, Marta Machado, Miguel Prudêncio, Silvia Parapini, Sarah D\'Alessandro, Cátia Teixeira, Ana Gomes, Cristina Prudêncio, Paula Gomes
Primaquine-based ionic liquids as a novel class of antimalarial hits
published pages: 56134-56138, ISSN: 2046-2069, DOI: 10.1039/c6ra10759a
RSC Advances 6/61 2020-02-03
2016 Sandra Casimiro, Arlindo Ferreira, André Mansinho, Irina Alho, Luis Costa
Molecular Mechanisms of Bone Metastasis: Which Targets Came from the Bench to the Bedside?
published pages: 1415, ISSN: 1422-0067, DOI: 10.3390/ijms17091415
International Journal of Molecular Sciences 17/9 2020-02-03
2017 Christine Cruz-Oliveira, Andreza F. Almeida, João M. Freire, Marjolly B. Caruso, Maria A. Morando, Vivian N. S. Ferreira, Iranaia Assunção-Miranda, Andre M. O. Gomes, Miguel A. R. B. Castanho, Andrea T. Da Poian
Mechanisms of Vesicular Stomatitis Virus Inactivation by Protoporphyrin IX, Zinc-Protoporphyrin IX, and Mesoporphyrin IX
published pages: , ISSN: 0066-4804, DOI: 10.1128/aac.00053-17
Antimicrobial Agents and Chemotherapy 61/6 2020-02-03
2016 C Bentow, G Lakos, P Martis, E Wahl, M Garcia, O Viñas, G Espinosa, R Cervera, C Sjöwall, D Carmona-Fernandes, M J Santos, J G Hanly, M Mahler
International multi-center evaluation of a novel chemiluminescence assay for the detection of anti-dsDNA antibodies
published pages: 864-872, ISSN: 0961-2033, DOI: 10.1177/0961203316640917
Lupus 25/8 2020-02-03
2018 Tiago N. Figueira, Diogo A. Mendonça, Diana Gaspar, Manuel N. Melo, Anne Moscona, Matteo Porotto, Miguel A. R. B. Castanho, Ana Salomé Veiga
Structure–Stability–Function Mechanistic Links in the Anti-Measles Virus Action of Tocopherol-Derivatized Peptide Nanoparticles
published pages: 9855-9865, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b01422
ACS Nano 12/10 2020-02-03
2017 Omar Boutureira, Nuria Martínez-Sáez, Kevin M. Brindle, André A. Neves, Francisco Corzana, Gonçalo J. L. Bernardes
Site-Selective Modification of Proteins with Oxetanes
published pages: 6483-6489, ISSN: 0947-6539, DOI: 10.1002/chem.201700745
Chemistry - A European Journal 23/27 2020-02-03
2017 Raquel Azevedo, Marija Markovic, Marta Machado, Blandine Franke-Fayard, António M. Mendes, Miguel Prudêncio
Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds
published pages: , ISSN: 0066-4804, DOI: 10.1128/aac.02699-16
Antimicrobial Agents and Chemotherapy 61/6 2020-02-03
2016 Correia, J.; Gano, L.; Santos, I.; Serrano, I. D.; Santos, S.; Ribeiro, M.; Perazzo, J.; Tavares, I.; Heras, M.; Bardaji, E.; Castanho, M. A.; Oliveira, M. C.
BIOLOGICAL EVALUATION OF RADIOIODINATED AMIDATED KYOTORPHIN
published pages: , ISSN: , DOI:
JOURNAL OF PEPTIDE SCIENCE 2020-02-03
2017 Sousa C. F., Coimbra J. T. S., Gomes I., Franco R., Fernandes P. A., Gameiro P.
The binding of free and copper-complexed fluoroquinolones to OmpF porins: an experimental and molecular docking study
published pages: 10009-10019, ISSN: 2046-2069, DOI: 10.1039/c6ra26466b
RSC Advances 7/17 2020-02-03
2018 Rita Capela, Joana Magalhães, Daniela Miranda, Marta Machado, Margarida Sanches-Vaz, Inês S. Albuquerque, Moni Sharma, Jiri Gut, Philip J. Rosenthal, Raquel Frade, Maria J. Perry, Rui Moreira, Miguel Prudêncio, Francisca Lopes
Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability
published pages: 69-78, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2018.02.048
European Journal of Medicinal Chemistry 149 2020-02-03
2017 Nuria Martínez-Sáez, Shuang Sun, Davide Oldrini, Pietro Sormanni, Omar Boutureira, Filippo Carboni, Ismael Compañón, Michael J. Deery, Michele Vendruscolo, Francisco Corzana, Roberto Adamo, Gonçalo J. L. Bernardes
Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo
published pages: 14963-14967, ISSN: 1433-7851, DOI: 10.1002/anie.201708847
Angewandte Chemie International Edition 56/47 2020-02-03
2016 A. S. Ribeiro, F. A. Carvalho, J. Figueiredo, R. Carvalho, T. Mestre, J. Monteiro, A. F. Guedes, M. Fonseca, J. Sanches, R. Seruca, N. C. Santos, J. Paredes
Atomic force microscopy and graph analysis to study the P-cadherin/SFK mechanotransduction signalling in breast cancer cells
published pages: 19390-19401, ISSN: 2040-3364, DOI: 10.1039/c6nr04465d
Nanoscale 8/46 2020-02-03
2018 Eva Cunha, Tiago Trovão, Ana Pinheiro, Telmo Nunes, Raquel Santos, Jorge Moreira da Silva, Berta São Braz, Luís Tavares, Ana Salomé Veiga, Manuela Oliveira
Potential of two delivery systems for nisin topical application to dental plaque biofilms in dogs
published pages: , ISSN: 1746-6148, DOI: 10.1186/s12917-018-1692-9
BMC Veterinary Research 14/1 2020-02-03
2018 Maria J. Matos, Bruno L. Oliveira, Nuria Martínez-Sáez, Ana Guerreiro, Pedro M. S. D. Cal, Jean Bertoldo, María Maneiro, Elizabeth Perkins, Julie Howard, Michael J. Deery, Justin M. Chalker, Francisco Corzana, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Chemo- and Regioselective Lysine Modification on Native Proteins
published pages: 4004-4017, ISSN: 0002-7863, DOI: 10.1021/jacs.7b12874
Journal of the American Chemical Society 140/11 2020-02-03
2018 Andreia N. Horácio, Catarina Silva-Costa, Elísia Lopes, Mário Ramirez, José Melo-Cristino
Conjugate vaccine serotypes persist as major causes of non-invasive pneumococcal pneumonia in Portugal despite declines in serotypes 3 and 19A (2012-2015)
published pages: e0206912, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0206912
PLOS ONE 13/11 2020-02-03
2018 Bernardes, Goncalo
Building linkerless ADCs and CO-releasing antibodies for cancer therapeutics
published pages: , ISSN: , DOI:
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 2020-02-03
2016 Bruno L. Oliveira, Zijian Guo, Omar Boutureira, Ana Guerreiro, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
A Minimal, Unstrained S-Allyl Handle for Pre-Targeting Diels-Alder Bioorthogonal Labeling in Live Cells
published pages: 14683-14687, ISSN: 1433-7851, DOI: 10.1002/anie.201608438
Angewandte Chemie International Edition 55/47 2020-02-03
2016 TAÍS S. MACEDO, LEGNA COLINA-VEGAS, MARCELO DA PAIXÃO, MARIBEL NAVARRO, BRENO C. BARRETO, POLIANA C. M. OLIVEIRA, SIMONE G. MACAMBIRA, MARTA MACHADO, MIGUEL PRUDÊNCIO, SARAH D\'ALESSANDRO, NICOLETTA BASILICO, DIOGO R. M. MOREIRA, ALZIR A. BATISTA, MILENA B. P. SOARES
Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents
published pages: 1543-1556, ISSN: 0031-1820, DOI: 10.1017/s0031182016001153
Parasitology 143/12 2020-02-03
2016 Carlos J.A. Ribeiro, Margarida Espadinha, Marta Machado, Jiri Gut, Lídia M. Gonçalves, Philip J. Rosenthal, Miguel Prudêncio, Rui Moreira, Maria M.M. Santos
Novel squaramides with in vitro liver stage antiplasmodial activity
published pages: 1786-1792, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2016.03.005
Bioorganic & Medicinal Chemistry 24/8 2020-02-03
2018 Kristina Pavić, Ivana Perković, Šárka Pospíšilová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Josef Jampilek, Aidan Coffey, Lorraine Endersen, Hrvoje Rimac, Branka Zorc
Primaquine hybrids as promising antimycobacterial and antimalarial agents
published pages: 769-779, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.11.083
European Journal of Medicinal Chemistry 143 2020-02-03
2016 Evans, Austin; Crockett, Michael; Worthington, Max; Albuquerque, Ines; Slattery, Ashley; Gibson, Christopher; Lewis, David; Campbell, Jonathan; Bernardes, Goncalo; Chalker, Justin
Sulfur-limonene polysulfide: A material synthesized entirely from industrial byproducts and its use in removing toxic metals from water and soil
published pages: , ISSN: , DOI:
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 2020-02-03
2018 Lucas Robke, Tiago Rodrigues, Peter Schröder, Daniel J. Foley, Gonçalo J.L. Bernardes, Luca Laraia, Herbert Waldmann
Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors
published pages: 4531-4537, ISSN: 0040-4020, DOI: 10.1016/j.tet.2018.07.021
Tetrahedron 74/35 2020-02-03
2017 Woo Gyum Kim, Mi Eun Kang, Jae Bin Lee, Min Ho Jeon, Sungmin Lee, Jungha Lee, Bongseo Choi, Pedro M. S. D. Cal, Sebyung Kang, Jung-Min Kee, Gonçalo J. L. Bernardes, Jan-Uwe Rohde, Wonyoung Choe, Sung You Hong
Nickel-Catalyzed Azide–Alkyne Cycloaddition To Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water
published pages: 12121-12124, ISSN: 0002-7863, DOI: 10.1021/jacs.7b06338
Journal of the American Chemical Society 139/35 2020-02-03
2016 Andreia N. Horácio, Catarina Silva-Costa, Jorge Diamantino-Miranda, Joana P. Lopes, Mario Ramirez, José Melo-Cristino
Population Structure of Streptococcus pneumoniae Causing Invasive Disease in Adults in Portugal before PCV13 Availability for Adults: 2008-2011
published pages: e0153602, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0153602
PLOS ONE 11/5 2020-02-03
2017 Marcelo T. Augusto, Axel Hollmann, Fulvia Troise, Ana S. Veiga, Antonello Pessi, Nuno C. Santos
Lipophilicity is a key factor to increase the antiviral activity of HIV neutralizing antibodies
published pages: 311-316, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2017.01.032
Colloids and Surfaces B: Biointerfaces 152 2020-02-03
2016 Adam Armada-Moreira, Essi Taipaleenmäki, Fabian Itel, Yan Zhang, Brigitte Städler
Droplet-microfluidics towards the assembly of advanced building blocks in cell mimicry
published pages: 19510-19522, ISSN: 2040-3364, DOI: 10.1039/c6nr07807a
Nanoscale 8/47 2020-02-03
2018 Felicio, Mario R.; Franco, Octavio; Santos, Nuno C.; Goncalves, Snia
PaMAP 1.9 and PaMAP 2: efficient multi-resistant antimicrobial peptides show evidence of anticancer activity
published pages: , ISSN: , DOI:
JOURNAL OF PEPTIDE SCIENCE 2020-02-03
2016 Axel Hollmann, Melina Martínez, Martín E. Noguera, Marcelo T. Augusto, Anibal Disalvo, Nuno C. Santos, Liliana Semorile, Paulo C. Maffía
Role of amphipathicity and hydrophobicity in the balance between hemolysis and peptide–membrane interactions of three related antimicrobial peptides
published pages: 528-536, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2016.02.003
Colloids and Surfaces B: Biointerfaces 141 2020-02-03
2018 Tiago Rodrigues, Gonçalo J. L. Bernardes
Development of Antibody-Directed Therapies: Quo Vadis ?
published pages: 2032-2034, ISSN: 1433-7851, DOI: 10.1002/anie.201712185
Angewandte Chemie International Edition 57/8 2020-02-03
2018 Perez-Peinado, Clara; Almeida Dias, Susana; Domingues, Marco M.; Benfield, Aurelie H.; Miguel Freire, Jodo; Radis-Baptista, Gandhi; Gaspar, Diana; Castanho, Miguel; Craik, David; Henriques, Sonia Troeira; Salome Veiga, Ana; Andreu, David
Mechanisms of bacterial membrane permeabilization of snake venom-derived peptides crotalicidin (Ctn) and Ctn[15-34]
published pages: , ISSN: , DOI:
JOURNAL OF PEPTIDE SCIENCE 2020-02-03
2017 Ricardo Sant’Anna, Maria Rosário Almeida, Nathalia Varejāo, Pablo Gallego, Sebastian Esperante, Priscila Ferreira, Alda Pereira-Henriques, Fernando L. Palhano, Mamede de Carvalho, Debora Foguel, David Reverter, Maria João Saraiva, Salvador Ventura
Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep44709
Scientific Reports 7/1 2020-02-03
2017 Tiago N. Figueira, Filipa D. Oliveira, Inês Almeida, Érica O. Mello, Valdirene M. Gomes, Miguel A. R. B. Castanho, Diana Gaspar
Challenging metastatic breast cancer with the natural defensin Pv D 1
published pages: 16887-16899, ISSN: 2040-3364, DOI: 10.1039/c7nr05872a
Nanoscale 9/43 2020-02-03
2017 Víctor J. Somovilla, Iris A. Bermejo, Inês S. Albuquerque, Nuria Martínez-Sáez, Jorge Castro-López, Fayna García-Martín, Ismael Compañón, Hiroshi Hinou, Shin-Ichiro Nishimura, Jesús Jiménez-Barbero, Juan L. Asensio, Alberto Avenoza, Jesús H. Busto, Ramón Hurtado-Guerrero, Jesús M. Peregrina, Gonçalo J. L. Bernardes, Francisco Corzana
The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer
published pages: 18255-18261, ISSN: 0002-7863, DOI: 10.1021/jacs.7b09447
Journal of the American Chemical Society 139/50 2020-02-03
2018 Neves, Vera; Aires-Da-Silva, Frederico; Gano, Lurdes; Corte-Real, Sofia; Correia, Joao D. G.; Castanho, Miguel
Trans-Blood brain barrier peptides to enhace delivery of therapeutic molecules to treat Alzheimer\'s disease
published pages: , ISSN: , DOI:
JOURNAL OF PEPTIDE SCIENCE 2020-02-03
2018 Jelmer Savelkoel, Klaas Hendrik Binnendijk, Rene Spijker, Michèle van Vugt, Kathrine Tan, Thomas Hänscheid, Patricia Schlagenhauf, Martin Peter Grobusch
Abbreviated atovaquone-proguanil prophylaxis regimens in travellers after leaving malaria-endemic areas: A systematic review
published pages: 3-20, ISSN: 1477-8939, DOI: 10.1016/j.tmaid.2017.12.005
Travel Medicine and Infectious Disease 21 2020-02-03
2016 Tiago Rodrigues, Florian Sieglitz, Gonçalo J. L. Bernardes
Natural product modulators of transient receptor potential (TRP) channels as potential anti-cancer agents
published pages: 6130-6137, ISSN: 0306-0012, DOI: 10.1039/c5cs00916b
Chemical Society Reviews 45/22 2020-02-03
2016 Nuno Rosa, Jéssica Marques, Eduardo Esteves, Mónica Fernandes, Vera M. Mendes, Ângela Afonso, Sérgio Dias, Joaquim Polido Pereira, Bruno Manadas, Maria José Correia, Marlene Barros
Protein Quality Assessment on Saliva Samples for Biobanking Purposes
published pages: 289-297, ISSN: 1947-5535, DOI: 10.1089/bio.2015.0054
Biopreservation and Biobanking 14/4 2020-02-03
2018 Tiago Rodrigues, Markus Werner, Jakob Roth, Eduardo H. G. da Cruz, Marta C. Marques, Padma Akkapeddi, Susana A. Lobo, Andreas Koeberle, Francisco Corzana, Eufrânio N. da Silva Júnior, Oliver Werz, Gonçalo J. L. Bernardes
Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor
published pages: 6899-6903, ISSN: 2041-6520, DOI: 10.1039/c8sc02634c
Chemical Science 9/34 2020-02-03
2018 Maja Beus, Zrinka Rajić, Dusica Maysinger, Zvonimir Mlinarić, Maja Antunović, Inga Marijanović, Diana Fontinha, Miguel Prudêncio, Jana Held, Sureyya Olgen, Branka Zorc
SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents
published pages: 624-638, ISSN: 2191-1363, DOI: 10.1002/open.201800117
ChemistryOpen 7/8 2020-02-03
2016 Andreia N. Horácio, Catarina Silva-Costa, Joana P. Lopes, Mário Ramirez, José Melo-Cristino
Serotype 3 Remains the Leading Cause of Invasive Pneumococcal Disease in Adults in Portugal (2012–2014) Despite Continued Reductions in Other 13-Valent Conjugate Vaccine Serotypes
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2016.01616
Frontiers in Microbiology 7 2020-02-03
2016 Gonçalo C. Justino, Pedro F. Pinheiro, Alexandra P. S. Roseiro, Ana S. O. Knittel, João Gonçalves, Marta C. Justino, M. Fernanda N. N. Carvalho
Camphor-based CCR5 blocker lead compounds – a computational and experimental approach
published pages: 56249-56259, ISSN: 2046-2069, DOI: 10.1039/c6ra09627a
RSC Advances 6/61 2020-02-03
2017 Terence T.-L. Kwan, Omar Boutureira, Elizabeth C. Frye, Stephen J. Walsh, Moni K. Gupta, Stephen Wallace, Yuteng Wu, Fengzhi Zhang, Hannah F. Sore, Warren R. J. D. Galloway, Jason W. Chin, Martin Welch, Gonçalo J. L. Bernardes, David R. Spring
Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium( ii ) catalyst
published pages: 3871-3878, ISSN: 2041-6520, DOI: 10.1039/c6sc05313k
Chemical Science 8/5 2020-02-03
2016 Wesley C. Van Voorhis, John H. Adams, Roberto Adelfio, Vida Ahyong, Myles H. Akabas, Pietro Alano, Aintzane Alday, Yesmalie Alemán Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T. Andrews, Simon V. Avery, Vicky M. Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta Bhatia, Quentin Bickle, Lotfi Bounaadja, Tana Bowling, Jürgen Bosch, Lauren E. Boucher, Fabrice F. B
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
published pages: e1005763, ISSN: 1553-7366, DOI: 10.1371/journal.ppat.1005763
PLOS Pathogens 12/7 2020-02-03
2018 Stępień E, Marina C Costa, Szczepan Kurc, Anna Drożdż, Nuno Cortez-Dias, Francisco J Enguita
The circulating non-coding RNA landscape for biomarker research: lessons and prospects from cardiovascular diseases
published pages: 1085-1099, ISSN: 1671-4083, DOI: 10.1038/aps.2018.35
Acta Pharmacologica Sinica 39/7 2020-02-03
2016 Terzic, Natasa; Konstantinovic, Jelena; Tot, Miklos; Burojevic, Jovana; Djurkovic-Djakovic, Olgica; Srbljanovic, Jelena; Stajner, Tijana; Verbic, Tatjana; Zlatovic, Mario; Machado, Marta; Albuquerque, Ines S.; Prudencio, Miguel; Sciotii, Richard J.; Pecic, Stevan; D\'Alessandro, Sarah; Taramelli, Donatella; Solaja, Bogdan A.
Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?
published pages: , ISSN: 0022-2623, DOI:
JOURNAL OF MEDICINAL CHEMISTRY 2020-02-03
2018 Miguel Peixoto de Almeida, Pedro Quaresma, Susana Sousa, Cláudia Couto, Inês Gomes, Ludwig Krippahl, Ricardo Franco, Eulália Pereira
Measurement of adsorption constants of laccase on gold nanoparticles to evaluate the enhancement in enzyme activity of adsorbed laccase
published pages: 16761-16769, ISSN: 1463-9076, DOI: 10.1039/c8cp03116a
Physical Chemistry Chemical Physics 20/24 2020-02-03
2017 Pedro M. S. D. Cal, Maria J. Matos, Gonçalo J. L. Bernardes
Trends in therapeutic drug conjugates for bacterial diseases: a patent review
published pages: 179-189, ISSN: 1354-3776, DOI: 10.1080/13543776.2017.1259411
Expert Opinion on Therapeutic Patents 27/2 2020-02-03
2017 M.L. Pinto, E. Rios, A.C. Silva, S.C. Neves, H.R. Caires, A.T. Pinto, C. Durães, F.A. Carvalho, A.P. Cardoso, N.C. Santos, C.C. Barrias, D.S. Nascimento, P. Pinto-do-Ó, M.A. Barbosa, F. Carneiro, M.J. Oliveira
Decellularized human colorectal cancer matrices polarize macrophages towards an anti-inflammatory phenotype promoting cancer cell invasion via CCL18
published pages: 211-224, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2017.02.004
Biomaterials 124 2020-02-03
2017 João Lopes, David Alves, Tânia S. Morais, Paulo J. Costa, M. Fátima M. Piedade, Fernanda Marques, Maria J. Villa de Brito, M. Helena Garcia
New copper(I) and heteronuclear copper(I)–ruthenium(II) complexes: Synthesis, structural characterization and cytotoxicity
published pages: 68-78, ISSN: 0162-0134, DOI: 10.1016/j.jinorgbio.2017.01.007
Journal of Inorganic Biochemistry 169 2020-02-03
2016 Osmar N. Silva, Eliane S. F. Alves, César de la Fuente-Núñez, Suzana M. Ribeiro, Santi M. Mandal, Diana Gaspar, Ana S. Veiga, Miguel A. R. B. Castanho, Cesar A. S. Andrade, Jessica M. Nascimento, Isabel C. M. Fensterseifer, William F. Porto, Jose R. Correa, Robert. E. W. Hancock, Suresh Korpole, Aline L. Oliveira, Luciano M. Liao, Octavio L. Franco
Structural Studies of a Lipid-Binding Peptide from Tunicate Hemocytes with Anti-Biofilm Activity
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep27128
Scientific Reports 6/1 2020-02-03
2018 Ana Armada-Moreira, Bo Thingholm, Kristine Andreassen, Ana M. Sebastião, Sandra H. Vaz, Brigitte Städler
On the Assembly of Microreactors with Parallel Enzymatic Pathways
published pages: 1700244, ISSN: 2366-7478, DOI: 10.1002/adbi.201700244
Advanced Biosystems 2/5 2020-02-03
2016 Tiago Rodrigues, Florian Sieglitz, Víctor J. Somovilla, Pedro M. S. D. Cal, Antony Galione, Francisco Corzana, Gonçalo J. L. Bernardes
Unveiling (−)-Englerin A as a Modulator of L-Type Calcium Channels
published pages: 11077-11081, ISSN: 1433-7851, DOI: 10.1002/anie.201604336
Angewandte Chemie International Edition 55/37 2020-02-03
2018 Thais P. Pivetta, Sandra Simões, Margarete M. Araújo, Tânia Carvalho, Caroline Arruda, Priscyla D. Marcato
Development of nanoparticles from natural lipids for topical delivery of thymol: Investigation of its anti-inflammatory properties
published pages: 281-290, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2018.01.053
Colloids and Surfaces B: Biointerfaces 164 2020-02-03
2017 Ana F. Guedes, Filomena A. Carvalho, Carlos Moreira, José B. Nogueira, Nuno C. Santos
Essential arterial hypertension patients present higher cell adhesion forces, contributing to fibrinogen-dependent cardiovascular risk
published pages: 14897-14906, ISSN: 2040-3364, DOI: 10.1039/c7nr03891g
Nanoscale 9/39 2020-02-03
2017 Allyson M. Freedy, Maria J. Matos, Omar Boutureira, Francisco Corzana, Ana Guerreiro, Padma Akkapeddi, Víctor J. Somovilla, Tiago Rodrigues, Karl Nicholls, Bangwen Xie, Gonzalo Jiménez-Osés, Kevin M. Brindle, André A. Neves, Gonçalo J. L. Bernardes
Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation
published pages: 18365-18375, ISSN: 0002-7863, DOI: 10.1021/jacs.7b10702
Journal of the American Chemical Society 139/50 2020-02-03
2016 Elena M. Sánchez Fernández, Claudio D. Navo, Nuria Martínez-Sáez, Rita Gonçalves-Pereira, Víctor J. Somovilla, Alberto Avenoza, Jesús H. Busto, Gonçalo J. L. Bernardes, Gonzalo Jiménez-Osés, Francisco Corzana, José M. García Fernández, Carmen Ortiz Mellet, Jesús M. Peregrina
Tn Antigen Mimics Based on sp 2 -Iminosugars with Affinity for an anti-MUC1 Antibody
published pages: 3890-3893, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.6b01899
Organic Letters 18/15 2020-02-03
2018 Benjamin J. Stenton, Bruno L. Oliveira, Maria J. Matos, Laura Sinatra, Gonçalo J. L. Bernardes
A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging
published pages: 4185-4189, ISSN: 2041-6520, DOI: 10.1039/c8sc00256h
Chemical Science 9/17 2020-02-03
2018 Carlos AV Rodrigues, Teresa P Silva, Diogo ES Nogueira, Tiago G Fernandes, Yas Hashimura, Robin Wesselschmidt, Maria Margarida Diogo, Brian Lee, Joaquim MS Cabral
Scalable culture of human induced pluripotent cells on microcarriers under xeno-free conditions using single-use vertical-wheelâ„¢ bioreactors
published pages: 3597-3606, ISSN: 0268-2575, DOI: 10.1002/jctb.5738
Journal of Chemical Technology & Biotechnology 93/12 2020-02-03
2017 Goreti Ribeiro Morais, Elisa Palma, Fernanda Marques, Lurdes Gano, Maria Cristina Oliveira, Antero Abrunhosa, Hugo Vicente Miranda, Tiago F. Outeiro, Isabel Santos, Antonio Paulo
Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents
published pages: 255-267, ISSN: 0022-152X, DOI: 10.1002/jhet.2575
Journal of Heterocyclic Chemistry 54/1 2020-02-03
2017 Tiago Rodrigues
Harnessing the potential of natural products in drug discovery from a cheminformatics vantage point
published pages: 9275-9282, ISSN: 1477-0520, DOI: 10.1039/c7ob02193c
Organic & Biomolecular Chemistry 15/44 2020-02-03
2018 Patrícia M. Carvalho, Mário R. Felício, Nuno C. Santos, Sónia Gonçalves, Marco M. Domingues
Application of Light Scattering Techniques to Nanoparticle Characterization and Development
published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2018.00237
Frontiers in Chemistry 6 2020-02-03
2017 Pedro M. S. D. Cal, Florian Sieglitz, Fábio M. F. Santos, Cátia Parente Carvalho, Ana Guerreiro, Jean B. Bertoldo, Uwe Pischel, Pedro M. P. Gois, Gonçalo J. L. Bernardes
Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells
published pages: 368-371, ISSN: 1359-7345, DOI: 10.1039/c6cc08671c
Chemical Communications 53/2 2020-02-03
2017 Pedro D. Pereira, Ana Serra-Caetano, Marisa Cabrita, Evguenia Bekman, José Braga, José Rino, Renè Santus, Paulo L. Filipe, Ana E. Sousa, João A. Ferreira
\"Quantification of cell cycle kinetics by EdU (5-ethynyl-2′-deoxyuridine)-coupled-fluorescence-intensity analysis\"
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.17121
Oncotarget 8/25 2020-02-03
2017 Marcelo Augusto, Axel Hollmann, Matteo Porotto, Anne Moscona, Nuno Santos
Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length
published pages: 1190, ISSN: 1420-3049, DOI: 10.3390/molecules22071190
Molecules 22/7 2020-02-03
2018 Elísia Lopes, Tânia Fernandes, Miguel P Machado, João André Carriço, José Melo-Cristino, Mário Ramirez, Elisabete R Martins
Increasing macrolide resistance among Streptococcus agalactiae causing invasive disease in non-pregnant adults was driven by a single capsular-transformed lineage, Portugal, 2009 to 2015
published pages: , ISSN: 1560-7917, DOI: 10.2807/1560-7917.es.2018.23.21.1700473
Eurosurveillance 23/21 2020-02-03
2017 Kawaljit Singh, John Okombo, Christel Brunschwig, Ferdinand Ndubi, Linley Barnard, Chad Wilkinson, Peter M. Njogu, Mathew Njoroge, Lizahn Laing, Marta Machado, Miguel Prudêncio, Janette Reader, Mariette Botha, Sindisiwe Nondaba, Lyn-Marie Birkholtz, Sonja Lauterbach, Alisje Churchyard, Theresa L. Coetzer, Jeremy N. Burrows, Clive Yeates, Paolo Denti, Lubbe Wiesner, Timothy J. Egan, Sergio Wittlin
Antimalarial Pyrido[1,2- a ]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model
published pages: 1432-1448, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01641
Journal of Medicinal Chemistry 60/4 2020-02-03
2017 Gonzalo Scalese, M. Florencia Mosquillo, Santiago Rostán, Jorge Castiglioni, Irina Alho, Leticia Pérez, Isabel Correia, Fernanda Marques, João Costa Pessoa, Dinorah Gambino
Heteroleptic oxidovanadium(IV) complexes of 2-hydroxynaphtylaldimine and polypyridyl ligands against Trypanosoma cruzi and prostate cancer cells
published pages: 154-166, ISSN: 0162-0134, DOI: 10.1016/j.jinorgbio.2017.07.014
Journal of Inorganic Biochemistry 175 2020-02-03
2017 Sara Neves-Coelho, Rute Eleutério, Francisco Enguita, Vera Neves, Miguel Castanho
A New Noncanonical Anionic Peptide That Translocates a Cellular Blood–Brain Barrier Model
published pages: 1753, ISSN: 1420-3049, DOI: 10.3390/molecules22101753
Molecules 22/10 2020-02-03
2017 Nádia Ribeiro, Somnath Roy, Nataliya Butenko, Isabel Cavaco, Teresa Pinheiro, Irina Alho, Fernanda Marques, Fernando Avecilla, João Costa Pessoa, Isabel Correia
New Cu(II) complexes with pyrazolyl derived Schiff base ligands: Synthesis and biological evaluation
published pages: 63-75, ISSN: 0162-0134, DOI: 10.1016/j.jinorgbio.2017.05.011
Journal of Inorganic Biochemistry 174 2020-02-03
2018 Bárbara Gomes, Sónia Gonçalves, Anibal Disalvo, Axel Hollmann, Nuno C. Santos
Effect of 25-hydroxycholesterol in viral membrane fusion: Insights on HIV inhibition
published pages: 1171-1178, ISSN: 0005-2736, DOI: 10.1016/j.bbamem.2018.02.001
Biochimica et Biophysica Acta (BBA) - Biomembranes 1860/5 2020-02-03
2017 Mário R. Felício, Osmar N. Silva, Sônia Gonçalves, Nuno C. Santos, Octávio L. Franco
Peptides with Dual Antimicrobial and Anticancer Activities
published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2017.00005
Frontiers in Chemistry 5 2020-02-03
2017 B. L. Oliveira, Z. Guo, G. J. L. Bernardes
Inverse electron demand Diels–Alder reactions in chemical biology
published pages: 4895-4950, ISSN: 0306-0012, DOI: 10.1039/c7cs00184c
Chemical Society Reviews 46/16 2020-02-03
2018 Bárbara Gomes, Marcelo T. Augusto, Mário R. Felício, Axel Hollmann, Octávio L. Franco, Sónia Gonçalves, Nuno C. Santos
Designing improved active peptides for therapeutic approaches against infectious diseases
published pages: 415-429, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2018.01.004
Biotechnology Advances 36/2 2020-02-03
2018 Sarah Davies, Benjamin J. Stenton, Gonçalo J. L. Bernardes
Bioorthogonal Decaging Reactions for Targeted Drug Activation
published pages: 771-776, ISSN: 0009-4293, DOI: 10.2533/chimia.2018.771
CHIMIA International Journal for Chemistry 72/11 2020-02-03
2016 J. Marto, L.F. Gouveia, L.M. Gonçalves, D.P. Gaspar, P. Pinto, F.A. Carvalho, E. Oliveira, H.M. Ribeiro, A.J. Almeida
A Quality by design (QbD) approach on starch-based nanocapsules: A promising platform for topical drug delivery
published pages: 177-185, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2016.03.039
Colloids and Surfaces B: Biointerfaces 143 2020-02-03
2018 T. N. Figueira, M. T. Augusto, K. Rybkina, D. Stelitano, M. G. Noval, O. E. Harder, A. S. Veiga, D. Huey, C. A. Alabi, S. Biswas, S. Niewiesk, A. Moscona, N. C. Santos, M. A. R. B. Castanho, M. Porotto
Effective in Vivo Targeting of Influenza Virus through a Cell-Penetrating/Fusion Inhibitor Tandem Peptide Anchored to the Plasma Membrane
published pages: 3362-3376, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00527
Bioconjugate Chemistry 29/10 2020-02-03
2018 Shuang Sun, Bruno L. Oliveira, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Radical-Mediated Thiol-Ene Strategy: Photoactivation of Thiol-Containing Drugs in Cancer Cells
published pages: 15832-15835, ISSN: 1433-7851, DOI: 10.1002/anie.201811338
Angewandte Chemie International Edition 57/48 2020-02-03
2016 Miguel A. S. Cavadas, Marco P. Monopoli, Cláudia Sá e Cunha, Miguel Prudêncio, Eulália Pereira, Iseult Lynch, Kenneth A. Dawson, Ricardo Franco
Unravelling Malaria Antigen Binding to Antibody-Gold Nanoparticle Conjugates
published pages: 906-915, ISSN: 0934-0866, DOI: 10.1002/ppsc.201600187
Particle & Particle Systems Characterization 33/12 2020-02-03
2016 Diana Montes-Grajales, Gonçalo J. L. Bernardes, Jesus Olivero-Verbel
Urban Endocrine Disruptors Targeting Breast Cancer Proteins
published pages: 150-161, ISSN: 0893-228X, DOI: 10.1021/acs.chemrestox.5b00342
Chemical Research in Toxicology 29/2 2020-02-03
2018 Maria J. Matos, Carlos Labão-Almeida, Claire Sayers, Oyinlola Dada, Matthias Tacke, Gonçalo J. L. Bernardes
Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC*-Au-Albumin and -Trastuzumab Bioconjugates
published pages: 12250-12253, ISSN: 0947-6539, DOI: 10.1002/chem.201800872
Chemistry - A European Journal 24/47 2020-02-03
2018 Cátia Caneiras, Filipa Calisto, Gabriela Jorge da Silva, Luis Lito, José Melo-Cristino, Aida Duarte
First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal
published pages: 96, ISSN: 2079-6382, DOI: 10.3390/antibiotics7040096
Antibiotics 7/4 2020-02-03
2017 Bárbara Gomes, Nuno Santos, Matteo Porotto
Biophysical Properties and Antiviral Activities of Measles Fusion Protein Derived Peptide Conjugated with 25-Hydroxycholesterol
published pages: 1869, ISSN: 1420-3049, DOI: 10.3390/molecules22111869
Molecules 22/11 2020-02-03
2016 Michael P. Crockett, Austin M. Evans, Max J. H. Worthington, Inês S. Albuquerque, Ashley D. Slattery, Christopher T. Gibson, Jonathan A. Campbell, David A. Lewis, Gonçalo J. L. Bernardes, Justin M. Chalker
Sulfur-Limonene Polysulfide: A Material Synthesized Entirely from Industrial By-Products and Its Use in Removing Toxic Metals from Water and Soil
published pages: 1714-1718, ISSN: 1433-7851, DOI: 10.1002/anie.201508708
Angewandte Chemie International Edition 55/5 2020-02-03
2016 Nikolaus Krall, Filipa P. da Cruz, Omar Boutureira, Gonçalo J. L. Bernardes
Site-selective protein-modification chemistry for basic biology and drug development
published pages: 103-113, ISSN: 1755-4330, DOI: 10.1038/nchem.2393
Nature Chemistry 8/2 2020-02-03
2018 Marcela Šafratová, Anna Hošťálková, Daniela Hulcová, Kateřina Breiterová, Veronika Hrabcová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Jiří Kuneš, Jakub Chlebek, Daniel Jun, Martina Hrabinová, Lucie Nováková, Radim Havelek, Martina Seifrtová, Lubomír Opletal, Lucie Cahlíková
Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity
published pages: 208-218, ISSN: 0253-6269, DOI: 10.1007/s12272-017-1000-4
Archives of Pharmacal Research 41/2 2020-02-03
2017 João Miguel Freire, Inês Rego de Figueiredo, Javier Valle, Ana Salomé Veiga, David Andreu, Francisco J. Enguita, Miguel A.R.B. Castanho
siRNA-cell-penetrating peptides complexes as a combinatorial therapy against chronic myeloid leukemia using BV173 cell line as model
published pages: 127-136, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2016.11.027
Journal of Controlled Release 245 2020-02-03
2017 Tiago N. Figueira, João M. Freire, Catarina Cunha-Santos, Montserrat Heras, João Gonçalves, Anne Moscona, Matteo Porotto, Ana Salomé Veiga, Miguel A. R. B. Castanho
Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep45647
Scientific Reports 7/1 2020-02-03
2016 Tiago F. Jorge, João A. Rodrigues, Camila Caldana, Romy Schmidt, Joost T. van Dongen, Jane Thomas-Oates, Carla António
Mass spectrometry-based plant metabolomics: Metabolite responses to abiotic stress
published pages: 620-649, ISSN: 0277-7037, DOI: 10.1002/mas.21449
Mass Spectrometry Reviews 35/5 2020-02-03
2017 Carlota Saldanha
Human Erythrocyte Acetylcholinesterase in Health and Disease
published pages: 1499, ISSN: 1420-3049, DOI: 10.3390/molecules22091499
Molecules 22/9 2020-02-03
2017 A. R. Henriques, J. Melo Cristino, M. J. Fraqueza
Genetic Characterization of Listeria monocytogenes Isolates from Industrial and Retail Ready-to-Eat Meat-Based Foods and Their Relationship with Clinical Strains from Human Listeriosis in Portugal
published pages: 551-560, ISSN: 0362-028X, DOI: 10.4315/0362-028x.jfp-16-310
Journal of Food Protection 80/4 2020-02-03
2017 Annabel Kitowski, Ester Jiménez-Moreno, Míriam Salvadó, Jordi Mestre, Sergio Castillón, Gonzalo Jiménez-Osés, Omar Boutureira, Gonçalo J. L. Bernardes
Oxidative Activation of C–S Bonds with an Electropositive Nitrogen Promoter Enables Orthogonal Glycosylation of Alkyl over Phenyl Thioglycosides
published pages: 5490-5493, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b02886
Organic Letters 19/19 2020-02-03
2016 Christopher Leija, Filipa Rijo-Ferreira, Lisa N. Kinch, Nick V. Grishin, Nicole Nischan, Jennifer J. Kohler, Zeping Hu, Margaret A. Phillips
Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei
published pages: e1006010, ISSN: 1553-7366, DOI: 10.1371/journal.ppat.1006010
PLOS Pathogens 12/11 2020-02-03
2017 Jean B. Bertoldo, Tiago Rodrigues, Lavinia Dunsmore, Francesco A. Aprile, Marta C. Marques, Leonardo A. Rosado, Omar Boutureira, Thomas B. Steinbrecher, Woody Sherman, Francisco Corzana, Hernán Terenzi, Gonçalo J.L. Bernardes
A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases
published pages: 665-677, ISSN: 2451-9294, DOI: 10.1016/j.chempr.2017.07.009
Chem 3/4 2020-02-03
2017 Jitka Dadová, Kuan-Jung Wu, Patrick G. Isenegger, James C. Errey, Gonçalo J. L. Bernardes, Justin M. Chalker, Lluís Raich, Carme Rovira, Benjamin G. Davis
Precise Probing of Residue Roles by Post-Translational β,γ-C,N Aza-Michael Mutagenesis in Enzyme Active Sites
published pages: 1168-1173, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00341
ACS Central Science 3/11 2020-02-03
2018 Alexandra Carreira, João Boavida Ferreira, Iliana Pereira, João Ferreira, Paulo Filipe, Ricardo Boavida Ferreira, Sara Monteiro
Blad-containing oligomer: a novel fungicide used in crop protection as an alternative treatment for tinea pedis and tinea versicolor
published pages: 198-207, ISSN: 0022-2615, DOI: 10.1099/jmm.0.000675
Journal of Medical Microbiology 67/2 2020-02-03
2018 Makowski, Marcin; Felicio, Mario R.; Franco, Octavio; Goncalves, Sonia; Melo, Manuel N.; Santos, Nuno C.
Exploring the membrane activity of a designed antimicrobial peptide with fusogenic properties
published pages: , ISSN: , DOI:
JOURNAL OF PEPTIDE SCIENCE 2020-02-03
2016 Diana Lousa, Antónia R. T. Pinto, Bruno L. Victor, Alessandro Laio, Ana S. Veiga, Miguel A. R. B. Castanho, Cláudio M. Soares
Fusing simulation and experiment: The effect of mutations on the structure and activity of the influenza fusion peptide
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep28099
Scientific Reports 6/1 2020-02-03
2018 Jessica G. M. Bevan, Eva C. Lourenço, Miguel Chaves-Ferreira, João A. Rodrigues, M. Rita Ventura
Immobilization of UDP-Galactose on an Amphiphilic Resin
published pages: 908-914, ISSN: 1434-193X, DOI: 10.1002/ejoc.201701620
European Journal of Organic Chemistry 2018/7 2020-02-03
2018 Ana Filipa Guedes, Filomena A. Carvalho, Marco M. Domingues, Fraser L. Macrae, Helen R. McPherson, Nuno C. Santos, Robert A.S. Ariёns
Sensing adhesion forces between erythrocytes and γ’ fibrinogen, modulating fibrin clot architecture and function
published pages: 909-918, ISSN: 1549-9634, DOI: 10.1016/j.nano.2018.01.006
Nanomedicine: Nanotechnology, Biology and Medicine 14/3 2020-02-03
2016 Dejanira Almeida, Elisabete Cristovam, Daniel Caldeira, Joaquim J. Ferreira, Teresa Marques
Are there effective interventions to prevent hospital-acquired Legionnaires\' disease or to reduce environmental reservoirs of Legionella in hospitals? A systematic review
published pages: e183-e188, ISSN: 0196-6553, DOI: 10.1016/j.ajic.2016.06.018
American Journal of Infection Control 44/11 2020-02-03
2017 Matos, Cristina P.; Alemu, Yemataw A.; Nunes, Patrique; Barroso, Sonia; Alho, Irina; Matos, Antonio P.; Marques, Fernanda; Pessoa, Joao Costa; Correia, Isabel
Cytotoxic activity of phenanthroline salicylaldimine zinc(II) complexes
published pages: , ISSN: 0949-8257, DOI:
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 2020-02-03
2017 Leonardo Ermini, Elena Morganti, Alexander Post, Behzad Yeganeh, Isabella Caniggia, Michael Leadley, Claudia C. Faria, James T. Rutka, Martin Post
Imaging mass spectrometry identifies prognostic ganglioside species in rodent intracranial transplants of glioma and medulloblastoma
published pages: e0176254, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0176254
PLOS ONE 12/5 2020-02-03
2016 Sofia B. Carvalho, João M. Freire, Mafalda G. Moleirinho, Francisca Monteiro, Diana Gaspar, Miguel A. R. B. Castanho, Manuel J. T. Carrondo, Paula M. Alves, Gonçalo J. L. Bernardes, Cristina Peixoto
Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles
published pages: 2386-2399, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.6b00372
Bioconjugate Chemistry 27/10 2020-02-03
2018 Hélia F. Jeremias, Diana Lousa, Axel Hollmann, Ana C. Coelho, Carla S. Baltazar, João D. Seixas, Ana R. Marques, Nuno C. Santos, Carlos C. Romão, Cláudio M. Soares
Study of the interactions of bovine serum albumin with a molybdenum(II) carbonyl complex by spectroscopic and molecular simulation methods
published pages: e0204624, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0204624
PLOS ONE 13/9 2020-02-03
2017 Ester Jiménez-Moreno, Zijian Guo, Bruno L. Oliveira, Inês S. Albuquerque, Annabel Kitowski, Ana Guerreiro, Omar Boutureira, Tiago Rodrigues, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells
published pages: 243-247, ISSN: 1433-7851, DOI: 10.1002/anie.201609607
Angewandte Chemie International Edition 56/1 2020-02-03
2017 António M. Mendes, Inês S. Albuquerque, Marta Machado, Joana Pissarra, Patrícia Meireles, Miguel Prudêncio
Inhibition of Plasmodium liver infection by ivermectin
published pages: AAC.02005-16, ISSN: 0066-4804, DOI: 10.1128/aac.02005-16
Antimicrobial Agents and Chemotherapy 2020-02-03
2018 Clara Pérez-Peinado, Susana Almeida Dias, Marco M. Domingues, Aurélie H. Benfield, João Miguel Freire, Gandhi Rádis-Baptista, Diana Gaspar, Miguel A. R. B. Castanho, David J. Craik, Sónia Troeira Henriques, Ana Salomé Veiga, David Andreu
Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15–34), antimicrobial peptides from rattlesnake venom
published pages: 1536-1549, ISSN: 0021-9258, DOI: 10.1074/jbc.ra117.000125
Journal of Biological Chemistry 293/5 2020-02-03
2018 Itaru Hamachi, Gonçalo J. L. Bernardes
Protein engineering through chemical, genetic and computational manipulation
published pages: 8977-8979, ISSN: 0306-0012, DOI: 10.1039/c8cs90125b
Chemical Society Reviews 47/24 2020-02-03
2017 Carina Peres, Ana I. Matos, João Conniot, Vanessa Sainz, Eva Zupančič, Joana M. Silva, Luís Graça, Rogério Sá Gaspar, Véronique Préat, Helena F. Florindo
Poly(lactic acid)-based particulate systems are promising tools for immune modulation
published pages: 41-57, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2016.11.012
Acta Biomaterialia 48 2020-02-03
2016 Raquel Santos, Diana Gomes, Hermes Macedo, Diogo Barros, Catarina Tibério, Ana Salomé Veiga, Luís Tavares, Miguel Castanho, Manuela Oliveira
Guar gum as a new antimicrobial peptide delivery system against diabetic foot ulcers Staphylococcus aureus isolates
published pages: 1092-1099, ISSN: 0022-2615, DOI: 10.1099/jmm.0.000329
Journal of Medical Microbiology 65/10 2020-02-03
2016 E.S. Björnsdóttir, E.R. Martins, H. Erlendsdóttir, G. Haraldsson, J. Melo-Cristino, K.G. Kristinsson, M. Ramirez
Changing epidemiology of group B streptococcal infections among adults in Iceland: 1975–2014
published pages: 379.e9-379.e16, ISSN: 1198-743X, DOI: 10.1016/j.cmi.2015.11.020
Clinical Microbiology and Infection 22/4 2020-02-03
2017 Helena Luna Pais, Irina Alho, Inês Vendrell, André Mansinho, Luís Costa
Radionuclides in oncology clinical practice – review of the literature
published pages: 14475-14487, ISSN: 1477-9226, DOI: 10.1039/c7dt01929g
Dalton Transactions 46/42 2020-02-03
2016 Sofia Santos Costa, Cláudia Palma, Kristina Kadlec, Andrea T. Fessler, Miguel Viveiros, José Melo-Cristino, Stefan Schwarz, Isabel Couto
Plasmid-Borne Antimicrobial Resistance of Staphylococcus aureus Isolated in a Hospital in Lisbon, Portugal
published pages: 617-626, ISSN: 1076-6294, DOI: 10.1089/mdr.2015.0352
Microbial Drug Resistance 22/8 2020-02-03
2018 Lisa J. Alcock, Kyle D. Farrell, Mawey T. Akol, Gregory H. Jones, Matthew M. Tierney, Holger B. Kramer, Tara L. Pukala, Gonçalo J.L. Bernardes, Michael V. Perkins, Justin M. Chalker
Norbornene probes for the study of cysteine oxidation
published pages: 1220-1228, ISSN: 0040-4020, DOI: 10.1016/j.tet.2017.11.011
Tetrahedron 74/12 2020-02-03

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SIMICA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SIMICA" are provided by the European Opendata Portal: CORDIS opendata.

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