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Exploring Triterpene Diversity in Monocots

Total Cost €


EC-Contrib. €






 EXTRIDIM project word cloud

Explore the words cloud of the EXTRIDIM project. It provides you a very rough idea of what is the project "EXTRIDIM" about.

genes    seek    lab    medicine    coupled    monocot    identification    publication    compounds    caloric    group    career    diverse    host    little    global    proof    expertise    distachyon    monocots    triterpene    plants    mined    mechanisms    food    potentially    indicate    model    eudicot    metabolic    clusters    draw    emergence    introducing    discovery    human    defense    largely    biosynthesis    synergistic    background    plant    yeast    interdisciplinary    entire    agriculturally    natural    ultimately    recombinant    possibility    genome    pathogens    biosynthetic    complementary    drug    fungal    extridim    relevance    engineering    gene    engineered    half    tolerance    diversification    combinatorial    combination    molecular    timeliness    grasses    researcher    wheat    groups    chemistry    cosmetics    biology    scientific    utilized    biochemistry    strengthen    roles    will    devastating    cereal    expand    pathogen    crops    action    skills    re    cereals    brachypodium    fears    provides    genomes    expression    triterpenes    serve    protection    intake   

Project "EXTRIDIM" data sheet

The following table provides information about the project.


Organization address
postcode: NR4 7UH

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JOHN INNES CENTRE UK (NORWICH) coordinator 224˙933.00


 Project objective

Triterpenes are one of the most diverse groups of plant natural products, with important roles in plant defense and wide use in medicine, food, and cosmetics. So far, studies on triterpene biosynthesis have largely focused on eudicot plants, while little is known about triterpene biosynthesis in monocots. Here, we seek to expand current knowledge of triterpene chemistry and biochemistry in monocots and to investigate mechanisms of metabolic diversification in this group of plants, and specifically in the cereals group, which together provides more than half of the global human caloric intake. Monocot genomes will be mined for identification of new triterpene-related genes and biosynthetic gene clusters. These will be utilized for biosynthesis of novel triterpene compounds via combinatorial recombinant expression in yeast and plant systems. Entire triterpene metabolic pathways will ultimately be introduced into the monocot model plant Brachypodium distachyon, and pathogen-tolerance of the engineered plants will be evaluated. This will serve as an important proof-of-concept for the possibility of introducing these pathways into agriculturally-important cereals and grasses. The recent publication of the common wheat genome, coupled with fears for re-emergence of devastating fungal wheat pathogens in Europe, indicate the timeliness and relevance of the proposed action. EXTRIDIM is a highly interdisciplinary project that will draw upon the synergistic combination of the expertise and well-established scientific approach of the host lab, together with the background and complementary skills of the researcher in plant molecular biology and metabolic engineering. The proposed research will greatly contribute to the researcher’s career development and strengthen the host lab, will advance our understanding of triterpene biosynthesis in the agriculturally-important cereal crops, and will potentially lead to new applications in plant protection and drug discovery.

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The information about "EXTRIDIM" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-05-18 14:10:49) correctly updated