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Exploring Triterpene Diversity in Monocots

Total Cost €


EC-Contrib. €






 EXTRIDIM project word cloud

Explore the words cloud of the EXTRIDIM project. It provides you a very rough idea of what is the project "EXTRIDIM" about.

expand    global    complementary    emergence    strengthen    timeliness    utilized    defense    researcher    clusters    will    discovery    interdisciplinary    largely    engineering    mechanisms    host    genomes    expression    genome    eudicot    potentially    skills    crops    distachyon    triterpenes    pathogen    little    introducing    drug    proof    metabolic    human    half    natural    caloric    food    background    expertise    serve    action    career    medicine    ultimately    engineered    relevance    compounds    protection    gene    coupled    possibility    group    roles    draw    diverse    cosmetics    combination    biology    intake    cereals    grasses    fungal    provides    brachypodium    indicate    recombinant    model    tolerance    monocots    scientific    plants    chemistry    publication    re    lab    biochemistry    biosynthetic    yeast    seek    combinatorial    fears    wheat    biosynthesis    groups    molecular    diversification    pathogens    genes    identification    plant    agriculturally    triterpene    monocot    extridim    entire    mined    cereal    synergistic    devastating   

Project "EXTRIDIM" data sheet

The following table provides information about the project.


Organization address
postcode: NR4 7UH

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JOHN INNES CENTRE UK (NORWICH) coordinator 224˙933.00


 Project objective

Triterpenes are one of the most diverse groups of plant natural products, with important roles in plant defense and wide use in medicine, food, and cosmetics. So far, studies on triterpene biosynthesis have largely focused on eudicot plants, while little is known about triterpene biosynthesis in monocots. Here, we seek to expand current knowledge of triterpene chemistry and biochemistry in monocots and to investigate mechanisms of metabolic diversification in this group of plants, and specifically in the cereals group, which together provides more than half of the global human caloric intake. Monocot genomes will be mined for identification of new triterpene-related genes and biosynthetic gene clusters. These will be utilized for biosynthesis of novel triterpene compounds via combinatorial recombinant expression in yeast and plant systems. Entire triterpene metabolic pathways will ultimately be introduced into the monocot model plant Brachypodium distachyon, and pathogen-tolerance of the engineered plants will be evaluated. This will serve as an important proof-of-concept for the possibility of introducing these pathways into agriculturally-important cereals and grasses. The recent publication of the common wheat genome, coupled with fears for re-emergence of devastating fungal wheat pathogens in Europe, indicate the timeliness and relevance of the proposed action. EXTRIDIM is a highly interdisciplinary project that will draw upon the synergistic combination of the expertise and well-established scientific approach of the host lab, together with the background and complementary skills of the researcher in plant molecular biology and metabolic engineering. The proposed research will greatly contribute to the researcher’s career development and strengthen the host lab, will advance our understanding of triterpene biosynthesis in the agriculturally-important cereal crops, and will potentially lead to new applications in plant protection and drug discovery.

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The information about "EXTRIDIM" are provided by the European Opendata Portal: CORDIS opendata.

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