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ONCORNET2.0 SIGNED

ONCOgenic Receptor Network of Excellence and Training 2.0

Total Cost €

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EC-Contrib. €

0

Partnership

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 ONCORNET2.0 project word cloud

Explore the words cloud of the ONCORNET2.0 project. It provides you a very rough idea of what is the project "ONCORNET2.0" about.

excellence    ackr3    cryo    multiple    rarely    play    groups    regulating    nanobodies    successfully    cell    gpcr    first    academically    multidisciplinary    discovery    brings    cas    fundamental    understand    biology    crispr    transferable    chemokine    gpcrs    breaking    burden    functions    builds    moving    yield    cancer    poorly    fast    protein    extensive    deaths    biological    therapeutic    strategies    delivered    expressed    health    technological    etn    interdisciplinary    oncornet2    training    pis    generation    photochemistry    commercialisation    cxcr4    intersectoral    incorporation    leads    stage    exposure    receptors    leveraging    critical    tumours    responsible    modulation    network    gender    successful    mechanisms    coupled    learning    surface    incorporate    ground    skill    progression    oncornet    talented    20    industries    skills    integral    young    scientific    demand    integrates    drug    proteins    oncogenic    blended    cellular    em    scientists    druggable    balanced    microscopy    esrs    15    team   

Project "ONCORNET2.0" data sheet

The following table provides information about the project.

Coordinator
STICHTING VU 

Organization address
address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV
website: www.vu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 4˙099˙781 €
 EC max contribution 4˙099˙781 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 1˙062˙479.00
2    THE UNIVERSITY OF NOTTINGHAM UK (NOTTINGHAM) participant 606˙345.00
3    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 549˙604.00
4    UNIVERSITY OF GLASGOW UK (GLASGOW) participant 303˙172.00
5    INTERAX BIOTECH AG CH (VILLINGEN) participant 281˙276.00
6    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 274˙802.00
7    QVQ HOLDING BV NL (UTRECHT) participant 265˙619.00
8    MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) DE (BERLIN) participant 252˙788.00
9    Universitätsklinikum Jena DE (Jena) participant 252˙788.00
10    UNIVERSIDAD AUTONOMA DE MADRID ES (MADRID) participant 250˙904.00

Map

 Project objective

Cancer is a major health burden responsible for 20% of European deaths. There is a critical need to understand its fundamental biological mechanisms. G protein-coupled receptors (GPCRs) are cell surface proteins which play an important role in regulating cellular functions integral to cancer biology and, as highly druggable proteins, oncogenic GPCRs are important therapeutic targets. ONCORNET2.0 builds on the success of ONCORNET (Oncogenic GPCR Network of Excellence and Training), a first-in-kind ETN in GPCR drug discovery that has successfully delivered scientific advance and training to talented early stage researchers (ESRs). ONCORNET2.0 will incorporate recent scientific and technological advances to understand and target two oncogenic GPCRs; the chemokine receptors CXCR4 and ACKR3. These are highly expressed in multiple tumours but their role in cancer progression remains poorly understood. We will develop new strategies for CXCR4/ACKR3 modulation (photochemistry, nanobodies) and investigate their effects on oncogenic responses, to yield key new knowledge and potential leads for drug development and commercialisation. ONCORNET2.0 will bring together the leading GPCR research groups in Europe and 15 ESRs. By leveraging on the success and experience of ONCORNET and recent ground-breaking advances in the field of GPCRs (e.g. cryo-EM, CRISPR-Cas, advanced microscopy), ONCORNET2.0 brings a young, gender-balanced team of PIs to target oncogenic GPCRs. The consortium will offer an extensive multidisciplinary training programme for ESRs ensuring their successful incorporation in today’s fast-moving drug development programmes. This programme integrates both research and transferable skill sets through blended learning. Our aim is that, through training these ESRs with interdisciplinary and intersectoral exposure, we will develop the next generation of scientists with skills that are in high demand by the drug development industries but rarely offered academically.

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The information about "ONCORNET2.0" are provided by the European Opendata Portal: CORDIS opendata.

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