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Counting the cost of living: mitochondrial efficiency, environmental conditions, and performance in the wild

Total Cost €


EC-Contrib. €






 MitoWild project word cloud

Explore the words cloud of the MitoWild project. It provides you a very rough idea of what is the project "MitoWild" about.

rates    laboratory    weakness    definitions    textbook    experimental    insights    time    edge    onto    re    life    predict    attempt    history    minute    speed    conceptual    individuals    rate    environmental    consumption    actual    select    estimating    first    distance    car    senescence    variation    ecology    generally    weaken    empirical    reveal    refer    achieves    indirectly    hence    conventional    instead    links    mitochondria    ros    atp    metabolic    dress    perform    constrains    equivalent    ecological    revealed    central    measuring    natural    physiology    organism    trait    actually    living    balance    efficiency    fitness    energy    freshwater    examine    cutting    link    oxygen    fold    hidden    record    travelled    influences    completely    animals    techniques    totally    shifting    fish    capacity    animal    trade    mitochondrial    contains    expectation    significantly    usual    phenotypes    fuel    evaluation    performance    an    habitats    simultaneous    off    aerobic   

Project "MitoWild" data sheet

The following table provides information about the project.


Organization address
postcode: G12 8QQ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙445˙128 €
 EC max contribution 2˙445˙128 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 2˙445˙128.00


 Project objective

An organism’s metabolic rate is a central trait that links its physiology with its ecology and life history. However, while textbook definitions of metabolic rate generally refer to the rate of energy use by the animal, most empirical studies instead record it very indirectly as whole-animal oxygen consumption rate, without any actual measurement of ATP production. This approach contains a conceptual weakness: it is equivalent to estimating a car’s capacity or efficiency by measuring its fuel consumption per minute, with no measurement of what that consumption actually achieves in terms of speed or distance travelled. This can significantly weaken our ability to link metabolic rates to ecological processes, and may explain why conventional measures of metabolic rate often do not predict performance or fitness. This ambitious project will therefore attempt to re-dress the balance by shifting the focus onto the efficiency with which mitochondria produce ATP, with the expectation that this will lead to completely new insights into how metabolic rate influences and constrains the behaviour and ecology of animals. It will use new techniques that we have developed for simultaneous measurement of both ATP and ROS production by the mitochondria; these have revealed two-fold variation among individuals in the efficiency of ATP production (and hence ability to perform aerobic work), totally hidden from usual measurements of metabolic rate. I will use these approaches to examine the impact of metabolic efficiency on performance and the trade-off between efficiency and rates of senescence, using freshwater fish as an experimental system. By applying cutting-edge methods, so far only used in the laboratory, to animals living in their natural habitats, the project will reveal for the first time how environmental conditions select for particular mitochondrial phenotypes and hence metabolic efficiency, so allowing a re-evaluation of the links between ecology and metabolic rate.

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The information about "MITOWILD" are provided by the European Opendata Portal: CORDIS opendata.

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