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MitoWild SIGNED

Counting the cost of living: mitochondrial efficiency, environmental conditions, and performance in the wild

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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 MitoWild project word cloud

Explore the words cloud of the MitoWild project. It provides you a very rough idea of what is the project "MitoWild" about.

mitochondria    hence    individuals    environmental    expectation    ecology    simultaneous    trait    measuring    onto    evaluation    re    conceptual    distance    rate    reveal    textbook    animals    techniques    efficiency    rates    instead    constrains    perform    life    metabolic    first    significantly    shifting    balance    record    revealed    an    off    car    contains    variation    completely    definitions    refer    weakness    senescence    indirectly    generally    history    physiology    conventional    predict    organism    ros    habitats    actual    hidden    fish    trade    attempt    estimating    dress    edge    phenotypes    central    influences    performance    examine    laboratory    speed    freshwater    fuel    minute    capacity    aerobic    atp    time    living    experimental    equivalent    mitochondrial    link    fold    cutting    natural    travelled    consumption    animal    empirical    insights    links    oxygen    actually    fitness    weaken    totally    achieves    select    energy    usual    ecological   

Project "MitoWild" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙445˙128 €
 EC max contribution 2˙445˙128 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 2˙445˙128.00

Map

 Project objective

An organism’s metabolic rate is a central trait that links its physiology with its ecology and life history. However, while textbook definitions of metabolic rate generally refer to the rate of energy use by the animal, most empirical studies instead record it very indirectly as whole-animal oxygen consumption rate, without any actual measurement of ATP production. This approach contains a conceptual weakness: it is equivalent to estimating a car’s capacity or efficiency by measuring its fuel consumption per minute, with no measurement of what that consumption actually achieves in terms of speed or distance travelled. This can significantly weaken our ability to link metabolic rates to ecological processes, and may explain why conventional measures of metabolic rate often do not predict performance or fitness. This ambitious project will therefore attempt to re-dress the balance by shifting the focus onto the efficiency with which mitochondria produce ATP, with the expectation that this will lead to completely new insights into how metabolic rate influences and constrains the behaviour and ecology of animals. It will use new techniques that we have developed for simultaneous measurement of both ATP and ROS production by the mitochondria; these have revealed two-fold variation among individuals in the efficiency of ATP production (and hence ability to perform aerobic work), totally hidden from usual measurements of metabolic rate. I will use these approaches to examine the impact of metabolic efficiency on performance and the trade-off between efficiency and rates of senescence, using freshwater fish as an experimental system. By applying cutting-edge methods, so far only used in the laboratory, to animals living in their natural habitats, the project will reveal for the first time how environmental conditions select for particular mitochondrial phenotypes and hence metabolic efficiency, so allowing a re-evaluation of the links between ecology and metabolic rate.

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The information about "MITOWILD" are provided by the European Opendata Portal: CORDIS opendata.

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