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MitoWild SIGNED

Counting the cost of living: mitochondrial efficiency, environmental conditions, and performance in the wild

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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 MitoWild project word cloud

Explore the words cloud of the MitoWild project. It provides you a very rough idea of what is the project "MitoWild" about.

experimental    attempt    textbook    conventional    consumption    living    estimating    animals    distance    efficiency    weaken    freshwater    fish    individuals    history    atp    performance    travelled    environmental    contains    edge    techniques    cutting    refer    rates    achieves    senescence    ecology    central    organism    oxygen    insights    physiology    habitats    shifting    an    capacity    rate    mitochondria    select    off    influences    hence    instead    natural    trait    link    significantly    equivalent    record    links    trade    weakness    life    ros    hidden    aerobic    completely    actually    re    dress    revealed    fitness    energy    examine    simultaneous    balance    expectation    totally    reveal    conceptual    constrains    minute    variation    ecological    indirectly    empirical    fold    evaluation    time    definitions    measuring    usual    mitochondrial    speed    generally    animal    laboratory    actual    car    metabolic    perform    phenotypes    predict    fuel    first    onto   

Project "MitoWild" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙445˙128 €
 EC max contribution 2˙445˙128 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 2˙445˙128.00

Map

 Project objective

An organism’s metabolic rate is a central trait that links its physiology with its ecology and life history. However, while textbook definitions of metabolic rate generally refer to the rate of energy use by the animal, most empirical studies instead record it very indirectly as whole-animal oxygen consumption rate, without any actual measurement of ATP production. This approach contains a conceptual weakness: it is equivalent to estimating a car’s capacity or efficiency by measuring its fuel consumption per minute, with no measurement of what that consumption actually achieves in terms of speed or distance travelled. This can significantly weaken our ability to link metabolic rates to ecological processes, and may explain why conventional measures of metabolic rate often do not predict performance or fitness. This ambitious project will therefore attempt to re-dress the balance by shifting the focus onto the efficiency with which mitochondria produce ATP, with the expectation that this will lead to completely new insights into how metabolic rate influences and constrains the behaviour and ecology of animals. It will use new techniques that we have developed for simultaneous measurement of both ATP and ROS production by the mitochondria; these have revealed two-fold variation among individuals in the efficiency of ATP production (and hence ability to perform aerobic work), totally hidden from usual measurements of metabolic rate. I will use these approaches to examine the impact of metabolic efficiency on performance and the trade-off between efficiency and rates of senescence, using freshwater fish as an experimental system. By applying cutting-edge methods, so far only used in the laboratory, to animals living in their natural habitats, the project will reveal for the first time how environmental conditions select for particular mitochondrial phenotypes and hence metabolic efficiency, so allowing a re-evaluation of the links between ecology and metabolic rate.

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The information about "MITOWILD" are provided by the European Opendata Portal: CORDIS opendata.

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