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CLASSY SIGNED

Cell-Like ‘Molecular Assembly Lines’ of Programmable Reaction Sequences as Game-Changers in Chemical Synthesis

Total Cost €

EC-Contrib. €

Partnership

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CLASSY project word cloud

Explore the words cloud of the CLASSY project. It provides you a very rough idea of what is the project "CLASSY" about.

pillars constitute europe 25 synthesis efficiency vision networks reactors fine factory sustainability overarching scientists toward peptides catalysis chemistry vast effectors sequences manufactured regulate synthesise zero eliminate replication emissions tech technologies catalytic radically chemicals amounts self inefficient reaction goals close drugs brings chemical changer ing cell flow compartmentalise energetic compartmentalisation multitude assembly molecular enzyme specialised sustainable renewability combined waste perform lines microfluidic act multiple idea streams individual pharmaceutical sequence capability sme game expertise modulate replicating living true produces scientific programmable inspired peptide kg single interdisciplinary tools generate revolutionise reactor innovative classy

Project "CLASSY" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD AUTONOMA DE MADRID Organization address address: CALLE EINSTEIN 3 CIUDAD UNIV CANTOBLANCO RECTORADO city: MADRID postcode: 28049 website: http://www.uam.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	3˙078˙073 €
EC max contribution	3˙078˙073 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-2018-2019-2020-01
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-11-01 to 2023-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD AUTONOMA DE MADRID UNIVERSIDAD AUTONOMA DE MADRID Organization address address: CALLE EINSTEIN 3 CIUDAD UNIV CANTOBLANCO RECTORADO city: MADRID postcode: 28049 website: http://www.uam.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	492˙083.00
2	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	participant	585˙388.00
3	UNIVERSITAET GRAZ UNIVERSITAET GRAZ Organization address address: UNIVERSITATSPLATZ 3 city: GRAZ postcode: 8010 website: http://www.uni-graz.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (GRAZ)	participant	519˙600.00
4	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	490˙000.00
5	BEN-GURION UNIVERSITY OF THE NEGEV BEN-GURION UNIVERSITY OF THE NEGEV Organization address address: . city: BEER SHEVA postcode: 84105 website: www.bgu.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (BEER SHEVA)	participant	385˙396.00
6	MICRONIT MICROTECHNOLOGIES BV MICRONIT MICROTECHNOLOGIES BV Organization address address: COLOSSEUM 15 city: ENSCHEDE postcode: 7521 PV website: www.micronit.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ENSCHEDE)	participant	376˙173.00
7	ACCELOPMENT AG ACCELOPMENT AG Organization address address: SEEFELDSTRASSE 198 city: ZUERICH postcode: 8008 website: www.accelopment.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	participant	229˙431.00

Map

Project objective

Chemical synthesis requires several process steps, produces vast amounts of waste today, for example 25–100 kg of waste per kg of product for pharmaceutical drugs, and is thus inefficient and not sustainable. Our vision is to become a real game-changer for chemical synthesis and eliminate many process steps, resulting in close to zero waste streams and a sustainable ‘chemical factory of the future’. To make this vision come true, the overarching aim of CLASSY is to develop a radically new type of chemical reactor inspired by the way in which living systems manage to modulate catalytic activity. The idea is that these reactors can self-regulate and perform multiple programmable reaction sequences by compartmentalisation of individual steps of the reaction sequence and replication of the molecular effectors that control the reactor’s catalytic activity. The use of microfluidic technology to compartmentalise individual steps of the reaction sequence and replicating molecular effectors to control the reactor activity constitute unique and highly innovative tools toward the project goals.

CLASSY will result in new flow reactors that act as cell-like molecular assembly lines, being able to synthesise a multitude of complex products in a single chemical reactor. These will have the capability to revolutionise the way chemical products, for example, fine chemicals and pharmaceutical drugs, are manufactured today.

CLASSY brings together 5 leading scientists in systems chemistry, replicating peptides, complex reaction networks, and peptide/enzyme catalysis. Their expertise will be combined with new microfluidic technology developed by a high-tech SME and an SME specialised in dissemination and exploitation of results. This highly interdisciplinary consortium will generate new scientific knowledge and novel technologies to support essential pillars for Europe`s future, such as renewability, sustainability, zero waste emissions and energetic efficiency.

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