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LIP-ATG SIGNED

The missing link: how do membrane lipids interplay with ATG proteins to instruct plant autophagy

Total Cost €

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EC-Contrib. €

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Partnership

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 LIP-ATG project word cloud

Explore the words cloud of the LIP-ATG project. It provides you a very rough idea of what is the project "LIP-ATG" about.

shape    resolution    specialized    autophagy    largely    complete    named    protein    despite    life    underlying    3d    maintaining    survival    unexplored    mechanisms    picture    nutrient    implication    biogenesis    heterogeneity    fundamental    identity    catabolic    articulate    drought    integrating    events    bioinformatic    initial    critical    membrane    elusive    indispensable    exploring    date    structure    physiology    components    pathogen    imaging    words    decrypt    intense    remarkable    interplay    dynamics    engulf    reveal    de    plant    capacity    phagophore    lateral    vision    eukaryotic    novo    proteomic    proteins    vesicles    assemble    re    programs    complementary    function    functions    attacks    question    autophagosomes    lipids    cup    molecular    half    instruct    strategies    lipid    scarcity    lipidomics    tackle    lytic    elucidate    contributions    intracellular    ultrastructure    repartition    hinges    expands    signature    dynamic    atg    expand    remodelling    composition    angle    cell    vacuole    nature    adaptive    ap    relies    aps    builds    form    vesicle    group   

Project "LIP-ATG" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙880 €
 EC max contribution 1˙499˙880 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2025-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙499˙880.00

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 Project objective

Autophagy is an intracellular catabolic process critical to eukaryotic life and indispensable for plant survival to drought, nutrient scarcity or pathogen attacks. Autophagy relies on the formation of specialized vesicles called autophagosomes (AP) which engulf and deliver cell components to the lytic vacuole. AP biogenesis is carried out by a group of dedicated proteins (named ATG) and hinges on intense remodelling events and on the remarkable capacity of an initial membrane, the phagophore, to assemble de novo, shape like a cup, expand while maintaining structure and function and re-shape to a complete vesicle. To date the molecular mechanisms underlying these events remain elusive. Research has focused on the role of autophagy proteins but, despite AP biogenesis being a membrane-based process, the fundamental contributions of lipids to AP membrane formation, identity and activities have been largely unexplored; in other words, when it comes to AP formation we are only looking at half of the picture.

I propose to address the fundamental question of how APs form and shape from a novel angle: by exploring how lipids’ nature, dynamics and lateral heterogeneity instruct the phagophore structure, its protein composition and its functions. The project builds on our recent results and expands on strategies that we have developed, integrating proteomic/bioinformatic approaches, lipidomics and high-resolution 3D imaging. We will tackle 3 complementary objectives: 1) Reveal the dynamic lipid signature of the phagophore, 2) Elucidate the implication of lipids nature and repartition in the phagophore ultrastructure, 3) Decrypt the molecular mechanisms by which lipids interplay with ATG proteins to control autophagy activity and plant physiology. Overall the project will articulate an integrated vision of the molecular processes controlling autophagy and provide fundamental knowledge in our understanding of plant adaptive programs.

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The information about "LIP-ATG" are provided by the European Opendata Portal: CORDIS opendata.

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