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LIP-ATG SIGNED

The missing link: how do membrane lipids interplay with ATG proteins to instruct plant autophagy

Total Cost €

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EC-Contrib. €

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Partnership

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 LIP-ATG project word cloud

Explore the words cloud of the LIP-ATG project. It provides you a very rough idea of what is the project "LIP-ATG" about.

ap    life    maintaining    nutrient    largely    angle    cell    intracellular    date    initial    hinges    named    strategies    engulf    integrating    lipid    repartition    articulate    dynamic    intense    tackle    proteins    catabolic    re    de    lipids    remarkable    resolution    aps    eukaryotic    attacks    membrane    indispensable    lipidomics    novo    capacity    complete    bioinformatic    fundamental    remodelling    expands    contributions    critical    underlying    vision    phagophore    assemble    autophagosomes    structure    proteomic    physiology    group    half    picture    scarcity    implication    mechanisms    nature    autophagy    lytic    builds    vesicle    imaging    molecular    identity    function    programs    elucidate    reveal    components    survival    pathogen    shape    events    cup    interplay    3d    instruct    question    words    decrypt    drought    vacuole    unexplored    vesicles    heterogeneity    dynamics    expand    complementary    biogenesis    protein    exploring    plant    relies    atg    elusive    adaptive    signature    composition    ultrastructure    lateral    functions    despite    form    specialized   

Project "LIP-ATG" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙880 €
 EC max contribution 1˙499˙880 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2025-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙499˙880.00

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 Project objective

Autophagy is an intracellular catabolic process critical to eukaryotic life and indispensable for plant survival to drought, nutrient scarcity or pathogen attacks. Autophagy relies on the formation of specialized vesicles called autophagosomes (AP) which engulf and deliver cell components to the lytic vacuole. AP biogenesis is carried out by a group of dedicated proteins (named ATG) and hinges on intense remodelling events and on the remarkable capacity of an initial membrane, the phagophore, to assemble de novo, shape like a cup, expand while maintaining structure and function and re-shape to a complete vesicle. To date the molecular mechanisms underlying these events remain elusive. Research has focused on the role of autophagy proteins but, despite AP biogenesis being a membrane-based process, the fundamental contributions of lipids to AP membrane formation, identity and activities have been largely unexplored; in other words, when it comes to AP formation we are only looking at half of the picture.

I propose to address the fundamental question of how APs form and shape from a novel angle: by exploring how lipids’ nature, dynamics and lateral heterogeneity instruct the phagophore structure, its protein composition and its functions. The project builds on our recent results and expands on strategies that we have developed, integrating proteomic/bioinformatic approaches, lipidomics and high-resolution 3D imaging. We will tackle 3 complementary objectives: 1) Reveal the dynamic lipid signature of the phagophore, 2) Elucidate the implication of lipids nature and repartition in the phagophore ultrastructure, 3) Decrypt the molecular mechanisms by which lipids interplay with ATG proteins to control autophagy activity and plant physiology. Overall the project will articulate an integrated vision of the molecular processes controlling autophagy and provide fundamental knowledge in our understanding of plant adaptive programs.

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The information about "LIP-ATG" are provided by the European Opendata Portal: CORDIS opendata.

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