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LIP-ATG SIGNED

The missing link: how do membrane lipids interplay with ATG proteins to instruct plant autophagy

Total Cost €

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EC-Contrib. €

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Partnership

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 LIP-ATG project word cloud

Explore the words cloud of the LIP-ATG project. It provides you a very rough idea of what is the project "LIP-ATG" about.

contributions    programs    physiology    survival    vision    elucidate    heterogeneity    dynamic    molecular    complementary    expand    relies    life    functions    vesicles    articulate    imaging    capacity    components    integrating    identity    underlying    phagophore    implication    resolution    remarkable    biogenesis    group    largely    mechanisms    lipid    catabolic    hinges    expands    indispensable    assemble    protein    initial    date    cell    half    function    vesicle    plant    shape    angle    novo    re    autophagy    bioinformatic    ap    despite    fundamental    question    pathogen    membrane    proteomic    de    drought    decrypt    elusive    structure    picture    engulf    repartition    atg    intense    proteins    dynamics    unexplored    instruct    lytic    events    lipidomics    adaptive    specialized    lipids    ultrastructure    aps    reveal    form    eukaryotic    interplay    maintaining    lateral    cup    attacks    vacuole    3d    critical    complete    signature    named    remodelling    exploring    autophagosomes    tackle    scarcity    builds    composition    nature    intracellular    nutrient    strategies    words   

Project "LIP-ATG" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙880 €
 EC max contribution 1˙499˙880 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2025-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙499˙880.00

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 Project objective

Autophagy is an intracellular catabolic process critical to eukaryotic life and indispensable for plant survival to drought, nutrient scarcity or pathogen attacks. Autophagy relies on the formation of specialized vesicles called autophagosomes (AP) which engulf and deliver cell components to the lytic vacuole. AP biogenesis is carried out by a group of dedicated proteins (named ATG) and hinges on intense remodelling events and on the remarkable capacity of an initial membrane, the phagophore, to assemble de novo, shape like a cup, expand while maintaining structure and function and re-shape to a complete vesicle. To date the molecular mechanisms underlying these events remain elusive. Research has focused on the role of autophagy proteins but, despite AP biogenesis being a membrane-based process, the fundamental contributions of lipids to AP membrane formation, identity and activities have been largely unexplored; in other words, when it comes to AP formation we are only looking at half of the picture.

I propose to address the fundamental question of how APs form and shape from a novel angle: by exploring how lipids’ nature, dynamics and lateral heterogeneity instruct the phagophore structure, its protein composition and its functions. The project builds on our recent results and expands on strategies that we have developed, integrating proteomic/bioinformatic approaches, lipidomics and high-resolution 3D imaging. We will tackle 3 complementary objectives: 1) Reveal the dynamic lipid signature of the phagophore, 2) Elucidate the implication of lipids nature and repartition in the phagophore ultrastructure, 3) Decrypt the molecular mechanisms by which lipids interplay with ATG proteins to control autophagy activity and plant physiology. Overall the project will articulate an integrated vision of the molecular processes controlling autophagy and provide fundamental knowledge in our understanding of plant adaptive programs.

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The information about "LIP-ATG" are provided by the European Opendata Portal: CORDIS opendata.

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