Explore the words cloud of the EarlyCause project. It provides you a very rough idea of what is the project "EarlyCause" about.
The following table provides information about the project.
UNIVERSITAT DE BARCELONA
|Coordinator Country||Spain [ES]|
|Total cost||5˙997˙381 €|
|EC max contribution||5˙997˙381 € (100%)|
1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
|Duration (year-month-day)||from 2020-01-01 to 2023-12-31|
Take a look of project's partnership.
|1||UNIVERSITAT DE BARCELONA||ES (BARCELONA)||coordinator||680˙937.00|
|2||UNIVERSITAT ZURICH||CH (ZURICH)||participant||581˙250.00|
|3||ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM||NL (ROTTERDAM)||participant||551˙250.00|
|4||OULUN YLIOPISTO||FI (OULU)||participant||508˙000.00|
|5||EUROPEAN MOLECULAR BIOLOGY LABORATORY||DE (HEIDELBERG)||participant||502˙950.00|
|6||KING'S COLLEGE LONDON||UK (LONDON)||participant||465˙685.00|
|7||EMPIRICA GESELLSCHAFT FUR KOMMUNIKATIONS UND TECHNOLOGIEFORSCHUNG MBH||DE (BONN)||participant||430˙625.00|
|8||STICHTING VUMC||NL (AMSTERDAM)||participant||419˙080.00|
|9||UNIVERSITY OF BATH||UK (BATH)||participant||418˙663.00|
|10||AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS||ES (MADRID)||participant||398˙427.00|
|11||COMBINOSTICS OY||FI (VALKEAKOSKI)||participant||325˙500.00|
|12||CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE||FR (ILLKIRCH GRAFFENSTADEN)||participant||323˙125.00|
|13||PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI||IT (BRESCIA)||participant||320˙950.00|
|14||UNIVERSIDAD POMPEU FABRA||ES (BARCELONA)||participant||70˙937.00|
EarlyCause will identify and demonstrate causative mechanisms and molecular pathways linking early life stress (ELS) to depression and two of its main physical comorbidities, namely coronary heart disease and diabetes. The consortium will disentangle the complex biological contributions from four key interconnected domains linked to ELS, namely epigenetics, inflammation, neuroendocrine system, and microbiome. Furthermore, modifying effects of environmental factors such as sex/gender, socioeconomics, lifestyle and behavior will be quantified, thus uncovering potential intervention targets that may reverse the causative mechanisms and reduce the impact of ELS on multi-morbidity development in high-risk individuals.
To achieve the goals of the project, this highly multi-disciplinary and experienced consortium will combine state-of-the-art and novel approaches from basic, pre-clinical and clinical research, including causal inference methods such as Mendelian randomisation, animal models of prenatal and postnatal stress, cellular models in various tissues, and integrative bioinformatics and machine learning methods. The consortium members will also enable access and exploitation of the largest set of European cohorts, comprising rich information on early stressors, biological and omics data, as well as depressive, cardiovascular and metabolic phenotypes. Generated data, tissue samples, experimental protocols and cell lines, as well as best practices, will be compiled and integrated into a new open-access research platform within ELIXIR to support future researchers in the emerging topics of ELS and multi-morbidity.
Finally, the project will ensure the research, clinical and socioeconomic impacts are adequately quantified and translated to allow full exploitation of the identified biomarkers and innovation outputs, in particular in relation to new integrated care pathways taking into account ELS-induced multi-morbidity in clinical practice.
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The information about "EARLYCAUSE" are provided by the European Opendata Portal: CORDIS opendata.