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EarlyCause SIGNED

Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity

Total Cost €

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EC-Contrib. €

0

Partnership

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 EarlyCause project word cloud

Explore the words cloud of the EarlyCause project. It provides you a very rough idea of what is the project "EarlyCause" about.

integrative    cellular    randomisation    impacts    quantified    clinical    causal    combine    gender    machine    stressors    diabetes    protocols    inflammation    lines    tissue    phenotypes    contributions    prenatal    uncovering    physical    causative    reverse    translated    care    metabolic    microbiome    lifestyle    tissues    adequately    socioeconomic    inference    animal    earlycause    disease    comorbidities    relation    mechanisms    mendelian    depressive    modifying    omics    sex    postnatal    elixir    bioinformatics    interconnected    outputs    individuals    cardiovascular    els    neuroendocrine    biological    models    linked    comprising    goals    reduce    epigenetics    basic    samples    life    domains    compiled    morbidity    cohorts    coronary    disciplinary    data    members    molecular    heart    biomarkers    stress    innovation    full    socioeconomics    linking    platform    intervention    depression    environmental    behavior    learning    experimental    cell    risk    disentangle    practices   

Project "EarlyCause" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT DE BARCELONA 

Organization address
address: GRAN VIA DE LES CORTS CATALANES 585
city: BARCELONA
postcode: 8007
website: http://www.ub.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 5˙997˙381 €
 EC max contribution 5˙997˙381 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT DE BARCELONA ES (BARCELONA) coordinator 680˙937.00
2    UNIVERSITAT ZURICH CH (ZURICH) participant 581˙250.00
3    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 551˙250.00
4    OULUN YLIOPISTO FI (OULU) participant 508˙000.00
5    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 502˙950.00
6    KING'S COLLEGE LONDON UK (LONDON) participant 465˙685.00
7    EMPIRICA GESELLSCHAFT FUR KOMMUNIKATIONS UND TECHNOLOGIEFORSCHUNG MBH DE (BONN) participant 430˙625.00
8    STICHTING VUMC NL (AMSTERDAM) participant 419˙080.00
9    UNIVERSITY OF BATH UK (BATH) participant 418˙663.00
10    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 398˙427.00
11    COMBINOSTICS OY FI (VALKEAKOSKI) participant 325˙500.00
12    CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE FR (ILLKIRCH GRAFFENSTADEN) participant 323˙125.00
13    PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI IT (BRESCIA) participant 320˙950.00
14    UNIVERSIDAD POMPEU FABRA ES (BARCELONA) participant 70˙937.00

Map

 Project objective

EarlyCause will identify and demonstrate causative mechanisms and molecular pathways linking early life stress (ELS) to depression and two of its main physical comorbidities, namely coronary heart disease and diabetes. The consortium will disentangle the complex biological contributions from four key interconnected domains linked to ELS, namely epigenetics, inflammation, neuroendocrine system, and microbiome. Furthermore, modifying effects of environmental factors such as sex/gender, socioeconomics, lifestyle and behavior will be quantified, thus uncovering potential intervention targets that may reverse the causative mechanisms and reduce the impact of ELS on multi-morbidity development in high-risk individuals.

To achieve the goals of the project, this highly multi-disciplinary and experienced consortium will combine state-of-the-art and novel approaches from basic, pre-clinical and clinical research, including causal inference methods such as Mendelian randomisation, animal models of prenatal and postnatal stress, cellular models in various tissues, and integrative bioinformatics and machine learning methods. The consortium members will also enable access and exploitation of the largest set of European cohorts, comprising rich information on early stressors, biological and omics data, as well as depressive, cardiovascular and metabolic phenotypes. Generated data, tissue samples, experimental protocols and cell lines, as well as best practices, will be compiled and integrated into a new open-access research platform within ELIXIR to support future researchers in the emerging topics of ELS and multi-morbidity.

Finally, the project will ensure the research, clinical and socioeconomic impacts are adequately quantified and translated to allow full exploitation of the identified biomarkers and innovation outputs, in particular in relation to new integrated care pathways taking into account ELS-induced multi-morbidity in clinical practice.

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The information about "EARLYCAUSE" are provided by the European Opendata Portal: CORDIS opendata.

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