Opendata, web and dolomites

EarlyCause SIGNED

Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 EarlyCause project word cloud

Explore the words cloud of the EarlyCause project. It provides you a very rough idea of what is the project "EarlyCause" about.

stress    machine    mendelian    els    microbiome    sex    interconnected    prenatal    physical    earlycause    lines    linked    epigenetics    inference    depression    bioinformatics    gender    neuroendocrine    samples    biomarkers    translated    outputs    causal    animal    behavior    lifestyle    platform    omics    combine    modifying    comprising    care    causative    risk    individuals    diabetes    basic    molecular    socioeconomics    socioeconomic    members    environmental    metabolic    learning    stressors    tissue    goals    cohorts    disentangle    heart    integrative    domains    compiled    cellular    randomisation    phenotypes    data    mechanisms    morbidity    practices    biological    disease    intervention    quantified    disciplinary    depressive    clinical    contributions    reduce    adequately    protocols    life    uncovering    models    innovation    reverse    elixir    comorbidities    impacts    cardiovascular    experimental    cell    linking    inflammation    tissues    postnatal    full    relation    coronary   

Project "EarlyCause" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT DE BARCELONA 

Organization address
address: GRAN VIA DE LES CORTS CATALANES 585
city: BARCELONA
postcode: 8007
website: http://www.ub.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 5˙997˙381 €
 EC max contribution 5˙997˙381 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT DE BARCELONA ES (BARCELONA) coordinator 680˙937.00
2    UNIVERSITAT ZURICH CH (ZURICH) participant 581˙250.00
3    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 551˙250.00
4    OULUN YLIOPISTO FI (OULU) participant 508˙000.00
5    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 502˙950.00
6    KING'S COLLEGE LONDON UK (LONDON) participant 465˙685.00
7    EMPIRICA GESELLSCHAFT FUR KOMMUNIKATIONS UND TECHNOLOGIEFORSCHUNG MBH DE (BONN) participant 430˙625.00
8    STICHTING VUMC NL (AMSTERDAM) participant 419˙080.00
9    UNIVERSITY OF BATH UK (BATH) participant 418˙663.00
10    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 398˙427.00
11    COMBINOSTICS OY FI (VALKEAKOSKI) participant 325˙500.00
12    CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE FR (ILLKIRCH GRAFFENSTADEN) participant 323˙125.00
13    PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI IT (BRESCIA) participant 320˙950.00
14    UNIVERSIDAD POMPEU FABRA ES (BARCELONA) participant 70˙937.00

Map

 Project objective

EarlyCause will identify and demonstrate causative mechanisms and molecular pathways linking early life stress (ELS) to depression and two of its main physical comorbidities, namely coronary heart disease and diabetes. The consortium will disentangle the complex biological contributions from four key interconnected domains linked to ELS, namely epigenetics, inflammation, neuroendocrine system, and microbiome. Furthermore, modifying effects of environmental factors such as sex/gender, socioeconomics, lifestyle and behavior will be quantified, thus uncovering potential intervention targets that may reverse the causative mechanisms and reduce the impact of ELS on multi-morbidity development in high-risk individuals.

To achieve the goals of the project, this highly multi-disciplinary and experienced consortium will combine state-of-the-art and novel approaches from basic, pre-clinical and clinical research, including causal inference methods such as Mendelian randomisation, animal models of prenatal and postnatal stress, cellular models in various tissues, and integrative bioinformatics and machine learning methods. The consortium members will also enable access and exploitation of the largest set of European cohorts, comprising rich information on early stressors, biological and omics data, as well as depressive, cardiovascular and metabolic phenotypes. Generated data, tissue samples, experimental protocols and cell lines, as well as best practices, will be compiled and integrated into a new open-access research platform within ELIXIR to support future researchers in the emerging topics of ELS and multi-morbidity.

Finally, the project will ensure the research, clinical and socioeconomic impacts are adequately quantified and translated to allow full exploitation of the identified biomarkers and innovation outputs, in particular in relation to new integrated care pathways taking into account ELS-induced multi-morbidity in clinical practice.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EARLYCAUSE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EARLYCAUSE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.3.1.1.)

ESPACE (2020)

Human Cell Atlas of the Pancreas

Read More  

SoNAR-Global (2019)

A Global Social Sciences Network for Infectious Threats and Antimicrobial Resistance

Read More  

BIND (2020)

Brain Involvement iN Dystrophinopathies

Read More