Opendata, web and dolomites

EarlyCause SIGNED

Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 EarlyCause project word cloud

Explore the words cloud of the EarlyCause project. It provides you a very rough idea of what is the project "EarlyCause" about.

basic    epigenetics    environmental    els    risk    innovation    relation    modifying    linked    domains    comorbidities    lines    reverse    prenatal    cellular    postnatal    linking    randomisation    practices    physical    translated    morbidity    biomarkers    integrative    gender    inflammation    tissues    learning    coronary    clinical    mechanisms    mendelian    models    cardiovascular    elixir    causal    sex    behavior    depressive    animal    stress    stressors    socioeconomics    biological    causative    omics    heart    impacts    microbiome    disciplinary    full    depression    neuroendocrine    uncovering    socioeconomic    tissue    compiled    outputs    contributions    inference    molecular    platform    phenotypes    individuals    bioinformatics    cell    quantified    data    interconnected    life    combine    machine    comprising    disentangle    reduce    lifestyle    experimental    earlycause    adequately    cohorts    intervention    samples    care    members    metabolic    disease    diabetes    protocols    goals   

Project "EarlyCause" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT DE BARCELONA 

Organization address
address: GRAN VIA DE LES CORTS CATALANES 585
city: BARCELONA
postcode: 8007
website: http://www.ub.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 5˙997˙381 €
 EC max contribution 5˙997˙381 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT DE BARCELONA ES (BARCELONA) coordinator 680˙937.00
2    UNIVERSITAT ZURICH CH (ZURICH) participant 581˙250.00
3    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 551˙250.00
4    OULUN YLIOPISTO FI (OULU) participant 508˙000.00
5    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 502˙950.00
6    KING'S COLLEGE LONDON UK (LONDON) participant 465˙685.00
7    EMPIRICA GESELLSCHAFT FUR KOMMUNIKATIONS UND TECHNOLOGIEFORSCHUNG MBH DE (BONN) participant 430˙625.00
8    STICHTING VUMC NL (AMSTERDAM) participant 419˙080.00
9    UNIVERSITY OF BATH UK (BATH) participant 418˙663.00
10    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 398˙427.00
11    COMBINOSTICS OY FI (VALKEAKOSKI) participant 325˙500.00
12    CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE FR (ILLKIRCH GRAFFENSTADEN) participant 323˙125.00
13    PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI IT (BRESCIA) participant 320˙950.00
14    UNIVERSIDAD POMPEU FABRA ES (BARCELONA) participant 70˙937.00

Map

 Project objective

EarlyCause will identify and demonstrate causative mechanisms and molecular pathways linking early life stress (ELS) to depression and two of its main physical comorbidities, namely coronary heart disease and diabetes. The consortium will disentangle the complex biological contributions from four key interconnected domains linked to ELS, namely epigenetics, inflammation, neuroendocrine system, and microbiome. Furthermore, modifying effects of environmental factors such as sex/gender, socioeconomics, lifestyle and behavior will be quantified, thus uncovering potential intervention targets that may reverse the causative mechanisms and reduce the impact of ELS on multi-morbidity development in high-risk individuals.

To achieve the goals of the project, this highly multi-disciplinary and experienced consortium will combine state-of-the-art and novel approaches from basic, pre-clinical and clinical research, including causal inference methods such as Mendelian randomisation, animal models of prenatal and postnatal stress, cellular models in various tissues, and integrative bioinformatics and machine learning methods. The consortium members will also enable access and exploitation of the largest set of European cohorts, comprising rich information on early stressors, biological and omics data, as well as depressive, cardiovascular and metabolic phenotypes. Generated data, tissue samples, experimental protocols and cell lines, as well as best practices, will be compiled and integrated into a new open-access research platform within ELIXIR to support future researchers in the emerging topics of ELS and multi-morbidity.

Finally, the project will ensure the research, clinical and socioeconomic impacts are adequately quantified and translated to allow full exploitation of the identified biomarkers and innovation outputs, in particular in relation to new integrated care pathways taking into account ELS-induced multi-morbidity in clinical practice.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EARLYCAUSE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EARLYCAUSE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.3.1.1.)

BIND (2020)

Brain Involvement iN Dystrophinopathies

Read More  

SoNAR-Global (2019)

A Global Social Sciences Network for Infectious Threats and Antimicrobial Resistance

Read More  

DC-ren (2020)

Drug combinations for rewriting trajectories of renal pathologies in type II diabetes (DC-ren)

Read More